| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Aspirin | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -5.93 | -6.16 | -6.49 | 43.48% | CHEMBL2112766 |
| Mesalazine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -6.01 | -6.05 | -5.73 | 32.93% | CHEMBL110317 |
| Sulfasalazine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.91 | -10.09 | -10.51 | 38.99% | CHEMBL97637 |
| Methotrimeprazine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -7.40 | -7.59 | -7.37 | 29.03% | CHEMBL3126382 |
| Ketamine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -7.43 | -7.35 | -7.88 | 40.91% | CHEMBL191460 |
| Aspirin | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -6.45 | -6.45 | N/A | 43.42% | CHEMBL272942 |
| Mesalazine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -5.66 | -5.84 | N/A | 38.75% | CHEMBL698 |
| Sulfasalazine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -10.32 | -10.60 | N/A | 39.22% | CHEMBL395501 |
| Methotrimeprazine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.68 | -7.42 | N/A | 36.54% | CHEMBL1201203 |
| Ketamine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -6.95 | -7.44 | N/A | 52.63% | CHEMBL443128 |
| Aspirin | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.36 | -6.53 | -6.65 | 44.62% | CHEMBL558 |
| Mesalazine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.53 | -6.35 | -6.49 | 32.99% | CHEMBL86 |
| Sulfasalazine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -9.50 | -9.80 | -10.25 | 35.07% | CHEMBL88571 |
| Methotrimeprazine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -7.27 | -7.02 | -7.85 | 36.54% | CHEMBL1201203 |
| Ketamine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -7.04 | -6.61 | -6.86 | 58.89% | CHEMBL1909048 |
| Aspirin | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.40 | -6.78 | N/A | 43.42% | CHEMBL272942 |
| Mesalazine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.02 | -5.68 | N/A | 32.53% | CHEMBL194588 |
| Sulfasalazine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -9.56 | -9.93 | N/A | 39.22% | CHEMBL395501 |
| Methotrimeprazine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -7.07 | -7.45 | N/A | 36.54% | CHEMBL1201203 |
| Ketamine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.73 | -8.32 | N/A | 56.84% | CHEMBL1092029 |
| Aspirin | AA1R_HUMAN | adenosine A1 receptor | -5.58 | -5.62 | -6.41 | 32.77% | CHEMBL2151131 |
| Mesalazine | AA1R_HUMAN | adenosine A1 receptor | -5.24 | -5.57 | -5.79 | 38.10% | CHEMBL196375 |
| Sulfasalazine | AA1R_HUMAN | adenosine A1 receptor | -9.15 | -8.38 | -8.45 | 43.50% | CHEMBL208705 |
| Methotrimeprazine | AA1R_HUMAN | adenosine A1 receptor | -7.37 | -7.06 | -7.16 | 28.73% | CHEMBL596460 |
| Ketamine | AA1R_HUMAN | adenosine A1 receptor | -7.53 | -6.86 | -7.05 | 34.15% | CHEMBL2435536 |
| Aspirin | AA2AR_HUMAN | adenosine A2a receptor | -5.99 | -5.92 | -6.00 | 32.79% | CHEMBL197359 |
| Mesalazine | AA2AR_HUMAN | adenosine A2a receptor | -5.16 | -5.72 | -5.74 | 39.13% | CHEMBL600008 |
| Sulfasalazine | AA2AR_HUMAN | adenosine A2a receptor | -8.47 | -8.50 | -9.23 | 36.20% | CHEMBL196375 |
| Methotrimeprazine | AA2AR_HUMAN | adenosine A2a receptor | -6.33 | -6.60 | -7.72 | 28.73% | CHEMBL596460 |
| Ketamine | AA2AR_HUMAN | adenosine A2a receptor | -7.51 | -7.54 | -8.12 | 32.58% | CHEMBL2368363 |
| Aspirin | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -6.60 | -6.51 | -7.23 | 52.78% | CHEMBL139330 |
| Mesalazine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -6.06 | -6.37 | -6.60 | 43.18% | CHEMBL58521 |
| Sulfasalazine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.12 | -9.81 | -9.03 | 37.10% | CHEMBL477772 |
| Methotrimeprazine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.59 | -7.95 | -7.17 | 37.88% | CHEMBL1783526 |
| Ketamine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.99 | -7.52 | -7.68 | 63.41% | CHEMBL552832 |
| Aspirin | ACE_HUMAN | angiotensin I converting enzyme | -5.96 | -6.16 | -5.95 | 29.69% | CHEMBL254493 |
| Mesalazine | ACE_HUMAN | angiotensin I converting enzyme | -5.98 | -5.55 | -5.25 | 25.47% | CHEMBL457317 |
| Sulfasalazine | ACE_HUMAN | angiotensin I converting enzyme | -9.48 | -9.29 | -8.20 | 31.50% | CHEMBL514138 |
| Methotrimeprazine | ACE_HUMAN | angiotensin I converting enzyme | -6.82 | -6.96 | -6.78 | 42.97% | CHEMBL1907755 |
| Ketamine | ACE_HUMAN | angiotensin I converting enzyme | -6.52 | -6.67 | -6.18 | 48.67% | CHEMBL435360 |
| Aspirin | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.08 | N/A | N/A | 13.51% | CHEMBL386114 |
| Mesalazine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -4.88 | N/A | N/A | 15.52% | CHEMBL386114 |
| Sulfasalazine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.43 | N/A | N/A | 21.40% | CHEMBL386114 |
| Methotrimeprazine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.68 | N/A | N/A | 22.46% | CHEMBL386114 |
| Ketamine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.67 | N/A | N/A | 25.27% | CHEMBL386114 |
| Aspirin | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.20 | -6.43 | -6.82 | N/A | N/A |
| Mesalazine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.27 | -5.99 | -6.10 | N/A | N/A |
| Sulfasalazine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.55 | -7.37 | -6.59 | N/A | N/A |
| Methotrimeprazine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -4.37 | -4.32 | -4.62 | N/A | N/A |
| Ketamine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -4.92 | -6.02 | -6.28 | N/A | N/A |
| Aspirin | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -6.75 | -6.89 | N/A | 40.26% | CHEMBL4102555 |
| Mesalazine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -5.96 | -6.55 | N/A | 38.00% | CHEMBL608112 |
| Sulfasalazine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.52 | 0.73 | N/A | 32.93% | CHEMBL3290084 |
| Methotrimeprazine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.94 | -0.04 | N/A | 53.93% | CHEMBL170977 |
| Ketamine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.01 | -2.68 | N/A | 51.46% | CHEMBL10309 |
| Aspirin | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -6.68 | -6.42 | N/A | 37.18% | CHEMBL55 |
| Mesalazine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -5.96 | -5.80 | N/A | 31.03% | CHEMBL58 |
| Sulfasalazine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.27 | -8.10 | N/A | 31.85% | CHEMBL1455766 |
| Methotrimeprazine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.50 | -7.29 | N/A | 39.13% | CHEMBL2146598 |
| Ketamine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.03 | -7.04 | N/A | 51.02% | CHEMBL809 |
| Aspirin | ADRB2_HUMAN | adrenoceptor beta 2 | -6.71 | -6.84 | -6.72 | 46.59% | CHEMBL1704973 |
| Mesalazine | ADRB2_HUMAN | adrenoceptor beta 2 | -6.22 | -6.71 | -6.38 | 42.22% | CHEMBL3290996 |
| Sulfasalazine | ADRB2_HUMAN | adrenoceptor beta 2 | -10.02 | -10.76 | -10.61 | 53.85% | CHEMBL1557985 |
| Methotrimeprazine | ADRB2_HUMAN | adrenoceptor beta 2 | -6.35 | -6.29 | -7.54 | 31.34% | CHEMBL1083363 |
| Ketamine | ADRB2_HUMAN | adrenoceptor beta 2 | -6.86 | -7.85 | -6.97 | 48.48% | CHEMBL1524289 |
| Aspirin | AGTR2_HUMAN | angiotensin II receptor type 2 | -5.94 | -6.11 | -6.00 | 26.25% | CHEMBL158557 |
| Mesalazine | AGTR2_HUMAN | angiotensin II receptor type 2 | -5.22 | -5.20 | -5.37 | 24.32% | CHEMBL376286 |
| Sulfasalazine | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.13 | -9.15 | -8.74 | 30.21% | CHEMBL346728 |
| Methotrimeprazine | AGTR2_HUMAN | angiotensin II receptor type 2 | -6.93 | -6.79 | -6.70 | 25.60% | CHEMBL190286 |
| Ketamine | AGTR2_HUMAN | angiotensin II receptor type 2 | -6.92 | -6.75 | -6.77 | 38.02% | CHEMBL128416 |
| Aspirin | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.22 | -7.08 | -7.23 | 43.52% | CHEMBL110030 |
| Mesalazine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -6.86 | -5.85 | -6.90 | 34.18% | CHEMBL51483 |
| Sulfasalazine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.76 | -9.69 | -11.07 | 33.54% | CHEMBL282245 |
| Methotrimeprazine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.41 | -6.62 | -7.48 | 20.54% | CHEMBL139666 |
| Ketamine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.08 | -7.10 | -7.47 | 38.89% | CHEMBL278584 |
| Aspirin | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.66 | -6.67 | -6.27 | 25.00% | CHEMBL3805817 |
| Mesalazine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.80 | -6.09 | -5.82 | 20.65% | CHEMBL3805817 |
| Sulfasalazine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -9.23 | -9.15 | -8.93 | 22.65% | CHEMBL1077591 |
| Methotrimeprazine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.92 | -7.35 | -6.97 | 34.62% | CHEMBL3298945 |
| Ketamine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.77 | -7.43 | -7.28 | 45.79% | CHEMBL2332518 |
| Aspirin | AOFA_HUMAN | monoamine oxidase A | -6.45 | -6.62 | -6.98 | 45.88% | CHEMBL2391739 |
| Mesalazine | AOFA_HUMAN | monoamine oxidase A | -6.29 | -6.22 | -6.14 | 36.90% | CHEMBL2391739 |
| Sulfasalazine | AOFA_HUMAN | monoamine oxidase A | -10.14 | -10.36 | -10.97 | 28.42% | CHEMBL1258719 |
| Methotrimeprazine | AOFA_HUMAN | monoamine oxidase A | -7.09 | -7.44 | -6.97 | 26.87% | CHEMBL4072860 |
| Ketamine | AOFA_HUMAN | monoamine oxidase A | -8.23 | -8.16 | -8.14 | 41.98% | CHEMBL3330339 |
| Aspirin | AOFB_HUMAN | monoamine oxidase B | -6.78 | -6.62 | -6.63 | 53.73% | CHEMBL3278090 |
| Mesalazine | AOFB_HUMAN | monoamine oxidase B | -6.24 | -6.16 | -6.36 | 45.78% | CHEMBL3769905 |
| Sulfasalazine | AOFB_HUMAN | monoamine oxidase B | -10.66 | -11.03 | -10.70 | 29.61% | CHEMBL3319255 |
| Methotrimeprazine | AOFB_HUMAN | monoamine oxidase B | -7.64 | -6.91 | -7.14 | 31.86% | CHEMBL597372 |
| Ketamine | AOFB_HUMAN | monoamine oxidase B | -7.97 | -8.09 | -8.48 | 46.25% | CHEMBL2094026 |
| Aspirin | BACE1_HUMAN | beta-secretase 1 | -5.11 | -5.52 | -5.98 | 35.64% | CHEMBL3586198 |
| Mesalazine | BACE1_HUMAN | beta-secretase 1 | -5.24 | -4.95 | -5.39 | 34.88% | CHEMBL3586204 |
| Sulfasalazine | BACE1_HUMAN | beta-secretase 1 | -7.30 | -8.24 | -8.55 | 36.63% | CHEMBL1210351 |
| Methotrimeprazine | BACE1_HUMAN | beta-secretase 1 | -6.11 | -6.65 | -7.10 | 41.33% | CHEMBL1917912 |
| Ketamine | BACE1_HUMAN | beta-secretase 1 | -5.85 | -5.87 | -6.83 | 49.61% | CHEMBL2011990 |
| Aspirin | CAH2_HUMAN | carbonic anhydrase 2 | -6.29 | -6.27 | -6.25 | 59.32% | CHEMBL2333586 |
| Mesalazine | CAH2_HUMAN | carbonic anhydrase 2 | -6.28 | -6.27 | -5.96 | 63.46% | CHEMBL2333586 |
| Sulfasalazine | CAH2_HUMAN | carbonic anhydrase 2 | -8.28 | -8.30 | -7.83 | 53.12% | CHEMBL2164736 |
| Methotrimeprazine | CAH2_HUMAN | carbonic anhydrase 2 | -6.53 | -6.55 | -6.41 | 30.93% | CHEMBL3400807 |
| Ketamine | CAH2_HUMAN | carbonic anhydrase 2 | -7.48 | -7.36 | -6.72 | 41.46% | CHEMBL206830 |
| Aspirin | CASP1_HUMAN | caspase 1 | -4.81 | -5.70 | -4.75 | 39.20% | CHEMBL101145 |
| Mesalazine | CASP1_HUMAN | caspase 1 | -4.97 | -5.38 | -5.54 | 26.42% | CHEMBL597796 |
| Sulfasalazine | CASP1_HUMAN | caspase 1 | -7.91 | -7.84 | -7.29 | 34.62% | CHEMBL422849 |
| Methotrimeprazine | CASP1_HUMAN | caspase 1 | -5.35 | -5.87 | -4.95 | 32.79% | CHEMBL221870 |
| Ketamine | CASP1_HUMAN | caspase 1 | -5.98 | -6.06 | -4.75 | 48.96% | CHEMBL466565 |
| Aspirin | CDK5_HUMAN | cyclin dependent kinase 5 | -6.17 | -6.63 | -6.92 | 36.19% | CHEMBL2007296 |
| Mesalazine | CDK5_HUMAN | cyclin dependent kinase 5 | -5.81 | -6.05 | -6.45 | 42.86% | CHEMBL1986666 |
| Sulfasalazine | CDK5_HUMAN | cyclin dependent kinase 5 | -8.09 | -8.03 | -9.16 | 40.88% | CHEMBL2004892 |
| Methotrimeprazine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.77 | -7.69 | -5.90 | 22.22% | CHEMBL1969843 |
| Ketamine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.50 | -6.74 | -6.29 | 37.07% | CHEMBL1982413 |
| Aspirin | CHLE_HUMAN | butyrylcholinesterase | -6.69 | -6.27 | -6.40 | 36.79% | CHEMBL544592 |
| Mesalazine | CHLE_HUMAN | butyrylcholinesterase | -6.04 | -5.98 | -6.16 | 32.69% | CHEMBL577112 |
| Sulfasalazine | CHLE_HUMAN | butyrylcholinesterase | -8.62 | -8.90 | -8.84 | 28.63% | CHEMBL3925612 |
| Methotrimeprazine | CHLE_HUMAN | butyrylcholinesterase | -7.54 | -7.48 | -7.81 | 37.88% | CHEMBL1783526 |
| Ketamine | CHLE_HUMAN | butyrylcholinesterase | -7.26 | -6.93 | -7.20 | 42.86% | CHEMBL174710 |
| Aspirin | CNR1_HUMAN | cannabinoid receptor 1 | -5.65 | -6.37 | -6.45 | 47.83% | CHEMBL243334 |
| Mesalazine | CNR1_HUMAN | cannabinoid receptor 1 | -4.87 | -6.19 | -6.09 | 38.81% | CHEMBL243334 |
| Sulfasalazine | CNR1_HUMAN | cannabinoid receptor 1 | -10.11 | -10.90 | -9.35 | 41.81% | CHEMBL247332 |
| Methotrimeprazine | CNR1_HUMAN | cannabinoid receptor 1 | -7.83 | -7.87 | -7.65 | 39.29% | CHEMBL1800731 |
| Ketamine | CNR1_HUMAN | cannabinoid receptor 1 | -7.99 | -6.78 | -7.30 | 56.44% | CHEMBL1095690 |
| Aspirin | CNR2_HUMAN | cannabinoid receptor 2 | -6.25 | -6.47 | N/A | 47.83% | CHEMBL243334 |
| Mesalazine | CNR2_HUMAN | cannabinoid receptor 2 | -5.68 | -5.62 | N/A | 38.81% | CHEMBL243334 |
| Sulfasalazine | CNR2_HUMAN | cannabinoid receptor 2 | -9.87 | -10.07 | N/A | 39.57% | CHEMBL245876 |
| Methotrimeprazine | CNR2_HUMAN | cannabinoid receptor 2 | -8.20 | -8.44 | N/A | 39.29% | CHEMBL1800731 |
| Ketamine | CNR2_HUMAN | cannabinoid receptor 2 | -7.95 | -7.64 | N/A | 56.44% | CHEMBL1095690 |
| Aspirin | COLI_HUMAN | proopiomelanocortin | -6.37 | -6.26 | -5.32 | N/A | N/A |
| Mesalazine | COLI_HUMAN | proopiomelanocortin | -5.77 | -5.83 | -5.37 | N/A | N/A |
| Sulfasalazine | COLI_HUMAN | proopiomelanocortin | -9.81 | -9.84 | -8.93 | N/A | N/A |
| Methotrimeprazine | COLI_HUMAN | proopiomelanocortin | -7.12 | -6.91 | -6.51 | N/A | N/A |
| Ketamine | COLI_HUMAN | proopiomelanocortin | -6.66 | -6.75 | -5.75 | N/A | N/A |
| Aspirin | COMT_HUMAN | catechol-O-methyltransferase | -5.38 | -5.25 | -5.76 | 25.62% | CHEMBL3980370 |
| Mesalazine | COMT_HUMAN | catechol-O-methyltransferase | -5.32 | -4.99 | -5.81 | 37.36% | CHEMBL1324 |
| Sulfasalazine | COMT_HUMAN | catechol-O-methyltransferase | -6.43 | -6.32 | -6.82 | 29.78% | CHEMBL3798524 |
| Methotrimeprazine | COMT_HUMAN | catechol-O-methyltransferase | -5.09 | -5.17 | -4.98 | 26.48% | CHEMBL3819488 |
| Ketamine | COMT_HUMAN | catechol-O-methyltransferase | -4.80 | -5.61 | -4.69 | 27.94% | CHEMBL3425731 |
| Aspirin | CRP_HUMAN | C-reactive protein | -4.90 | -5.22 | N/A | N/A | N/A |
| Mesalazine | CRP_HUMAN | C-reactive protein | -4.73 | -4.91 | N/A | N/A | N/A |
| Sulfasalazine | CRP_HUMAN | C-reactive protein | -6.85 | -7.11 | N/A | N/A | N/A |
| Methotrimeprazine | CRP_HUMAN | C-reactive protein | -4.92 | -4.83 | N/A | N/A | N/A |
| Ketamine | CRP_HUMAN | C-reactive protein | -4.88 | -4.85 | N/A | N/A | N/A |
| Aspirin | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.85 | N/A | N/A | 23.78% | CHEMBL464302 |
| Mesalazine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.60 | N/A | N/A | 30.23% | CHEMBL464302 |
| Sulfasalazine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -4.95 | N/A | N/A | 27.86% | CHEMBL376621 |
| Methotrimeprazine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -4.38 | N/A | N/A | 21.35% | CHEMBL3891755 |
| Ketamine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.53 | N/A | N/A | 34.38% | CHEMBL191413 |
| Aspirin | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.56 | -5.81 | -5.82 | 30.00% | CHEMBL126657 |
| Mesalazine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -5.98 | -5.83 | -5.68 | 27.37% | CHEMBL126657 |
| Sulfasalazine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.85 | -7.91 | -7.49 | 28.44% | CHEMBL4100900 |
| Methotrimeprazine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.94 | -5.96 | -7.15 | 30.11% | CHEMBL2170299 |
| Ketamine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.83 | -5.28 | -7.24 | 41.18% | CHEMBL2170299 |
| Aspirin | DRD2_HUMAN | dopamine receptor D2 | -5.97 | N/A | N/A | 40.26% | CHEMBL128313 |
| Mesalazine | DRD2_HUMAN | dopamine receptor D2 | -6.01 | N/A | N/A | 37.74% | CHEMBL3104523 |
| Sulfasalazine | DRD2_HUMAN | dopamine receptor D2 | -10.06 | N/A | N/A | 39.47% | CHEMBL231326 |
| Methotrimeprazine | DRD2_HUMAN | dopamine receptor D2 | -6.72 | N/A | N/A | 37.14% | CHEMBL3799986 |
| Ketamine | DRD2_HUMAN | dopamine receptor D2 | -6.96 | N/A | N/A | 55.10% | CHEMBL239539 |
| Aspirin | DRD3_HUMAN | dopamine receptor D3 | -6.08 | N/A | N/A | 39.24% | CHEMBL334545 |
| Mesalazine | DRD3_HUMAN | dopamine receptor D3 | -5.72 | N/A | N/A | 39.13% | CHEMBL286494 |
| Sulfasalazine | DRD3_HUMAN | dopamine receptor D3 | -9.80 | N/A | N/A | 39.47% | CHEMBL231326 |
| Methotrimeprazine | DRD3_HUMAN | dopamine receptor D3 | -6.78 | N/A | N/A | 36.54% | CHEMBL1201203 |
| Ketamine | DRD3_HUMAN | dopamine receptor D3 | -7.09 | N/A | N/A | 55.10% | CHEMBL239539 |
| Aspirin | DRD4_HUMAN | dopamine receptor D4 | -7.02 | -6.67 | N/A | 42.86% | CHEMBL59326 |
| Mesalazine | DRD4_HUMAN | dopamine receptor D4 | -6.59 | -6.22 | N/A | 35.37% | CHEMBL184772 |
| Sulfasalazine | DRD4_HUMAN | dopamine receptor D4 | -10.37 | -10.44 | N/A | 33.33% | CHEMBL3409256 |
| Methotrimeprazine | DRD4_HUMAN | dopamine receptor D4 | -7.71 | -7.53 | N/A | 36.61% | CHEMBL351611 |
| Ketamine | DRD4_HUMAN | dopamine receptor D4 | -7.03 | -7.19 | N/A | 54.64% | CHEMBL61090 |
| Aspirin | EDN1_HUMAN | endothelin 1 | -6.27 | N/A | N/A | N/A | N/A |
| Mesalazine | EDN1_HUMAN | endothelin 1 | -5.62 | N/A | N/A | N/A | N/A |
| Sulfasalazine | EDN1_HUMAN | endothelin 1 | -8.43 | N/A | N/A | N/A | N/A |
| Methotrimeprazine | EDN1_HUMAN | endothelin 1 | -6.52 | N/A | N/A | N/A | N/A |
| Ketamine | EDN1_HUMAN | endothelin 1 | -6.17 | N/A | N/A | N/A | N/A |
| Aspirin | ESR1_HUMAN | estrogen receptor 1 | -6.08 | -5.90 | -5.70 | 63.08% | CHEMBL1082743 |
| Mesalazine | ESR1_HUMAN | estrogen receptor 1 | -5.85 | -5.91 | -5.78 | 46.15% | CHEMBL2071180 |
| Sulfasalazine | ESR1_HUMAN | estrogen receptor 1 | -8.95 | -8.43 | -8.64 | 41.84% | CHEMBL202691 |
| Methotrimeprazine | ESR1_HUMAN | estrogen receptor 1 | -7.68 | -7.16 | -7.65 | 40.16% | CHEMBL1627354 |
| Ketamine | ESR1_HUMAN | estrogen receptor 1 | -7.58 | -7.35 | -7.31 | 44.12% | CHEMBL1222035 |
| Aspirin | FABP5_HUMAN | fatty acid binding protein 5 | -6.12 | -4.52 | -4.52 | 53.49% | CHEMBL247298 |
| Mesalazine | FABP5_HUMAN | fatty acid binding protein 5 | -5.54 | -4.62 | -4.54 | 38.20% | CHEMBL247298 |
| Sulfasalazine | FABP5_HUMAN | fatty acid binding protein 5 | -8.20 | -6.61 | -6.49 | 29.23% | CHEMBL3941588 |
| Methotrimeprazine | FABP5_HUMAN | fatty acid binding protein 5 | -7.52 | -5.26 | -5.08 | 15.34% | CHEMBL3941588 |
| Ketamine | FABP5_HUMAN | fatty acid binding protein 5 | -6.59 | -4.81 | -4.83 | 27.04% | CHEMBL3941588 |
| Aspirin | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.04 | N/A | N/A | 32.00% | CHEMBL2004025 |
| Mesalazine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -5.55 | N/A | N/A | 41.10% | CHEMBL1975923 |
| Sulfasalazine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.47 | N/A | N/A | 37.10% | CHEMBL477772 |
| Methotrimeprazine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.60 | N/A | N/A | 29.36% | CHEMBL407135 |
| Ketamine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.65 | N/A | N/A | 37.07% | CHEMBL1982413 |
| Aspirin | GLRA3_HUMAN | glycine receptor alpha 3 | -6.77 | -6.95 | -6.81 | 10.96% | CHEMBL4070615 |
| Aspirin | GLRA3_HUMAN | glycine receptor alpha 3 | -6.59 | N/A | N/A | 10.96% | CHEMBL4070615 |
| Mesalazine | GLRA3_HUMAN | glycine receptor alpha 3 | -5.72 | -5.78 | -5.85 | 11.96% | CHEMBL4070615 |
| Mesalazine | GLRA3_HUMAN | glycine receptor alpha 3 | -6.43 | N/A | N/A | 11.96% | CHEMBL4070615 |
| Sulfasalazine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.10 | -8.73 | -9.00 | 26.42% | CHEMBL4070615 |
| Sulfasalazine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.30 | N/A | N/A | 26.42% | CHEMBL4070615 |
| Methotrimeprazine | GLRA3_HUMAN | glycine receptor alpha 3 | -7.95 | -8.02 | -7.51 | 15.93% | CHEMBL4070615 |
| Methotrimeprazine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.13 | N/A | N/A | 15.93% | CHEMBL4070615 |
| Ketamine | GLRA3_HUMAN | glycine receptor alpha 3 | -7.80 | -7.36 | -7.51 | 16.52% | CHEMBL4070615 |
| Ketamine | GLRA3_HUMAN | glycine receptor alpha 3 | -7.79 | N/A | N/A | 16.52% | CHEMBL4070615 |
| Aspirin | GRM5_HUMAN | glutamate metabotropic receptor 5 | -6.61 | -7.52 | -7.37 | 51.65% | CHEMBL1682821 |
| Mesalazine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -6.69 | -6.64 | -6.57 | 33.94% | CHEMBL381764 |
| Sulfasalazine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -9.39 | -5.81 | -7.02 | 34.63% | CHEMBL1682833 |
| Methotrimeprazine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -3.49 | -1.70 | -3.17 | 28.91% | CHEMBL3087513 |
| Ketamine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.73 | -6.74 | -5.99 | 50.00% | CHEMBL2338576 |
| Aspirin | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.04 | -6.12 | -7.11 | 33.33% | CHEMBL2035654 |
| Mesalazine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -5.56 | -6.08 | -6.46 | 30.77% | CHEMBL2035654 |
| Sulfasalazine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.84 | -8.80 | -9.25 | 27.18% | CHEMBL3934642 |
| Methotrimeprazine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.34 | -5.35 | -5.43 | 20.69% | CHEMBL3698278 |
| Ketamine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.01 | -5.36 | -5.45 | 26.39% | CHEMBL3650224 |
| Aspirin | HRH1_HUMAN | histamine receptor H1 | -7.17 | N/A | N/A | 38.46% | CHEMBL2158833 |
| Mesalazine | HRH1_HUMAN | histamine receptor H1 | -6.60 | N/A | N/A | 39.81% | CHEMBL2158823 |
| Sulfasalazine | HRH1_HUMAN | histamine receptor H1 | -10.76 | N/A | N/A | 35.78% | CHEMBL1077908 |
| Methotrimeprazine | HRH1_HUMAN | histamine receptor H1 | -5.66 | N/A | N/A | 36.54% | CHEMBL1201203 |
| Ketamine | HRH1_HUMAN | histamine receptor H1 | -7.69 | N/A | N/A | 51.49% | CHEMBL3818047 |
| Aspirin | HYES_HUMAN | epoxide hydrolase 2 | -6.41 | -6.70 | -6.36 | 47.92% | CHEMBL244407 |
| Mesalazine | HYES_HUMAN | epoxide hydrolase 2 | -6.19 | -5.95 | -6.21 | 47.83% | CHEMBL477046 |
| Sulfasalazine | HYES_HUMAN | epoxide hydrolase 2 | -10.43 | -9.66 | -9.50 | 39.31% | CHEMBL2392745 |
| Methotrimeprazine | HYES_HUMAN | epoxide hydrolase 2 | -7.00 | -6.97 | -7.15 | 38.00% | CHEMBL561665 |
| Ketamine | HYES_HUMAN | epoxide hydrolase 2 | -7.51 | -7.09 | -6.06 | 53.19% | CHEMBL1933676 |
| Aspirin | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.20 | N/A | N/A | 32.98% | CHEMBL3318321 |
| Mesalazine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.03 | N/A | N/A | 37.50% | CHEMBL504261 |
| Sulfasalazine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.44 | N/A | N/A | 39.22% | CHEMBL473080 |
| Methotrimeprazine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.91 | N/A | N/A | 33.95% | CHEMBL1672879 |
| Ketamine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.34 | N/A | N/A | 32.41% | CHEMBL3318321 |
| Aspirin | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.01 | -5.60 | N/A | 42.00% | CHEMBL9352 |
| Mesalazine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -5.43 | -5.79 | N/A | 57.41% | CHEMBL278172 |
| Sulfasalazine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -9.81 | -8.69 | N/A | 34.34% | CHEMBL595995 |
| Methotrimeprazine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.35 | -6.36 | N/A | 35.79% | CHEMBL1201219 |
| Ketamine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.21 | -6.32 | N/A | 48.31% | CHEMBL2398176 |
| Aspirin | MIF_HUMAN | macrophage migration inhibitory factor | -5.01 | -6.21 | -5.15 | 32.94% | CHEMBL224086 |
| Mesalazine | MIF_HUMAN | macrophage migration inhibitory factor | -6.22 | -6.19 | -5.57 | 36.84% | CHEMBL224086 |
| Sulfasalazine | MIF_HUMAN | macrophage migration inhibitory factor | -7.54 | -8.00 | -6.92 | 28.14% | CHEMBL3799453 |
| Methotrimeprazine | MIF_HUMAN | macrophage migration inhibitory factor | -5.34 | -5.71 | -4.97 | 19.19% | CHEMBL554271 |
| Ketamine | MIF_HUMAN | macrophage migration inhibitory factor | -5.42 | -5.96 | -5.78 | 29.11% | CHEMBL554271 |
| Aspirin | MK01_HUMAN | mitogen-activated protein kinase 1 | -5.92 | -5.73 | -6.23 | 33.33% | CHEMBL2004872 |
| Mesalazine | MK01_HUMAN | mitogen-activated protein kinase 1 | -5.52 | -5.71 | -5.93 | 37.65% | CHEMBL24944 |
| Sulfasalazine | MK01_HUMAN | mitogen-activated protein kinase 1 | -8.32 | -7.71 | -7.58 | 39.87% | CHEMBL3590110 |
| Methotrimeprazine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.56 | -6.72 | -6.43 | 23.03% | CHEMBL4106550 |
| Ketamine | MK01_HUMAN | mitogen-activated protein kinase 1 | -5.46 | -6.07 | -5.58 | 35.25% | CHEMBL3752989 |
| Aspirin | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.05 | -6.28 | -6.48 | 31.45% | CHEMBL3797548 |
| Mesalazine | MK03_HUMAN | mitogen-activated protein kinase 3 | -5.62 | -5.79 | -5.95 | 30.77% | CHEMBL3798109 |
| Sulfasalazine | MK03_HUMAN | mitogen-activated protein kinase 3 | -9.36 | -8.98 | -8.81 | 33.13% | CHEMBL3798109 |
| Methotrimeprazine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.42 | -7.61 | -6.62 | 19.82% | CHEMBL554497 |
| Ketamine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.83 | -7.65 | -7.18 | 32.80% | CHEMBL3113587 |
| Aspirin | MTOR_HUMAN | mechanistic target of rapamycin kinase | -6.33 | -6.36 | -6.18 | 28.80% | CHEMBL1241300 |
| Mesalazine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -5.46 | -5.55 | -5.61 | 31.36% | CHEMBL1667869 |
| Sulfasalazine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.06 | -9.63 | -9.04 | 45.96% | CHEMBL3594042 |
| Methotrimeprazine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.66 | -7.55 | -7.71 | 30.28% | CHEMBL3972399 |
| Ketamine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.43 | -8.16 | -7.40 | 31.28% | CHEMBL4100500 |
| Aspirin | NEP_HUMAN | membrane metalloendopeptidase | -6.69 | -6.58 | -6.88 | 29.69% | CHEMBL254493 |
| Mesalazine | NEP_HUMAN | membrane metalloendopeptidase | -6.03 | -6.39 | -6.14 | 27.36% | CHEMBL273672 |
| Sulfasalazine | NEP_HUMAN | membrane metalloendopeptidase | -8.53 | -8.71 | -9.19 | 22.82% | CHEMBL92949 |
| Methotrimeprazine | NEP_HUMAN | membrane metalloendopeptidase | -6.26 | -6.23 | -6.12 | 36.89% | CHEMBL3298941 |
| Ketamine | NEP_HUMAN | membrane metalloendopeptidase | -5.94 | -7.39 | -6.96 | 47.87% | CHEMBL378050 |
| Aspirin | NK1R_HUMAN | tachykinin receptor 1 | -6.09 | -6.16 | -6.29 | 30.43% | CHEMBL93909 |
| Mesalazine | NK1R_HUMAN | tachykinin receptor 1 | -5.53 | -5.74 | -5.35 | 28.46% | CHEMBL424301 |
| Sulfasalazine | NK1R_HUMAN | tachykinin receptor 1 | -8.87 | -8.55 | -8.50 | 34.72% | CHEMBL453314 |
| Methotrimeprazine | NK1R_HUMAN | tachykinin receptor 1 | -7.35 | -7.29 | -6.97 | 34.67% | CHEMBL119990 |
| Ketamine | NK1R_HUMAN | tachykinin receptor 1 | -7.09 | -6.95 | -6.75 | 59.14% | CHEMBL1817821 |
| Aspirin | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.35 | -6.92 | -7.27 | 16.67% | CHEMBL2333945 |
| Mesalazine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -6.58 | -6.30 | -6.53 | 16.00% | CHEMBL2333945 |
| Sulfasalazine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.76 | -10.68 | -10.46 | 27.59% | CHEMBL2333945 |
| Methotrimeprazine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -5.93 | -5.98 | -6.09 | 13.39% | CHEMBL284237 |
| Ketamine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.37 | -8.56 | -8.33 | 32.41% | CHEMBL284237 |
| Aspirin | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -6.83 | -6.61 | -7.18 | 32.14% | CHEMBL161421 |
| Mesalazine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -6.17 | -5.78 | -6.35 | 31.73% | CHEMBL2013202 |
| Sulfasalazine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.39 | -9.61 | -9.43 | 26.01% | CHEMBL218017 |
| Methotrimeprazine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.00 | -7.81 | -6.17 | 32.11% | CHEMBL147355 |
| Ketamine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.14 | -7.55 | -6.65 | 48.28% | CHEMBL3357785 |
| Aspirin | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.32 | -6.93 | -7.27 | 22.47% | CHEMBL162577 |
| Mesalazine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -6.53 | -6.43 | -6.53 | 26.36% | CHEMBL163916 |
| Sulfasalazine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -10.22 | -10.76 | -10.46 | 37.57% | CHEMBL164322 |
| Methotrimeprazine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -6.07 | -6.63 | -6.09 | 18.69% | CHEMBL399075 |
| Ketamine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.30 | -8.54 | -8.33 | 30.88% | CHEMBL325825 |
| Aspirin | NOS1_HUMAN | nitric oxide synthase 1 | -6.64 | -6.86 | -6.31 | 33.03% | CHEMBL4060083 |
| Mesalazine | NOS1_HUMAN | nitric oxide synthase 1 | -7.56 | -7.24 | -6.64 | 39.68% | CHEMBL542431 |
| Sulfasalazine | NOS1_HUMAN | nitric oxide synthase 1 | -9.75 | -9.90 | -9.04 | 29.11% | CHEMBL4086610 |
| Methotrimeprazine | NOS1_HUMAN | nitric oxide synthase 1 | -7.64 | -7.44 | -6.89 | 29.69% | CHEMBL1270460 |
| Ketamine | NOS1_HUMAN | nitric oxide synthase 1 | -6.29 | -6.52 | -7.21 | 44.21% | CHEMBL258348 |
| Aspirin | NOS2_HUMAN | nitric oxide synthase 2 | -5.95 | -5.83 | -6.25 | 35.92% | CHEMBL1762473 |
| Mesalazine | NOS2_HUMAN | nitric oxide synthase 2 | -7.28 | -5.92 | -6.56 | 29.70% | CHEMBL1762473 |
| Sulfasalazine | NOS2_HUMAN | nitric oxide synthase 2 | -8.04 | -9.86 | -1.95 | 30.80% | CHEMBL223838 |
| Methotrimeprazine | NOS2_HUMAN | nitric oxide synthase 2 | -6.09 | -6.62 | -6.94 | 40.00% | CHEMBL114551 |
| Ketamine | NOS2_HUMAN | nitric oxide synthase 2 | -5.56 | -6.65 | -6.78 | 44.21% | CHEMBL258348 |
| Aspirin | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.38 | -6.45 | -6.31 | 32.00% | CHEMBL2004025 |
| Mesalazine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -5.86 | -5.77 | -5.62 | 35.65% | CHEMBL2004025 |
| Sulfasalazine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.33 | -9.32 | -8.51 | 43.48% | CHEMBL2152285 |
| Methotrimeprazine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.91 | -7.05 | -7.11 | 24.07% | CHEMBL1997617 |
| Ketamine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.19 | -7.14 | -7.04 | 37.07% | CHEMBL1982413 |
| Aspirin | OPRD_HUMAN | opioid receptor delta 1 | -5.82 | -4.82 | -5.15 | 34.75% | CHEMBL149074 |
| Mesalazine | OPRD_HUMAN | opioid receptor delta 1 | -5.50 | -4.67 | -5.17 | 36.36% | CHEMBL416930 |
| Sulfasalazine | OPRD_HUMAN | opioid receptor delta 1 | -7.42 | -6.97 | -7.42 | 29.41% | CHEMBL191987 |
| Methotrimeprazine | OPRD_HUMAN | opioid receptor delta 1 | -6.36 | -5.97 | -5.91 | 38.95% | CHEMBL300662 |
| Ketamine | OPRD_HUMAN | opioid receptor delta 1 | -6.90 | -5.99 | -6.72 | 54.74% | CHEMBL4062974 |
| Aspirin | OPRK_HUMAN | opioid receptor kappa 1 | -5.96 | -6.23 | -6.36 | 37.36% | CHEMBL942 |
| Mesalazine | OPRK_HUMAN | opioid receptor kappa 1 | -5.75 | -5.72 | -6.51 | 36.56% | CHEMBL283552 |
| Sulfasalazine | OPRK_HUMAN | opioid receptor kappa 1 | -8.85 | -8.92 | -9.45 | 33.74% | CHEMBL1713635 |
| Methotrimeprazine | OPRK_HUMAN | opioid receptor kappa 1 | -8.28 | -8.04 | -6.88 | 38.95% | CHEMBL300662 |
| Ketamine | OPRK_HUMAN | opioid receptor kappa 1 | -7.17 | -7.64 | -7.91 | 66.67% | CHEMBL512414 |
| Aspirin | OPRM_MOUSE | Mu-type opioid receptor | -6.50 | -5.50 | N/A | 28.97% | CHEMBL13470 |
| Mesalazine | OPRM_MOUSE | Mu-type opioid receptor | -4.90 | -5.24 | N/A | 36.56% | CHEMBL283552 |
| Sulfasalazine | OPRM_MOUSE | Mu-type opioid receptor | -8.75 | -9.00 | N/A | 24.27% | CHEMBL605510 |
| Methotrimeprazine | OPRM_MOUSE | Mu-type opioid receptor | -7.06 | -6.82 | N/A | 33.05% | CHEMBL440765 |
| Ketamine | OPRM_MOUSE | Mu-type opioid receptor | -7.35 | -6.82 | N/A | 48.15% | CHEMBL2017149 |
| Aspirin | OPRX_HUMAN | opioid related nociceptin receptor 1 | -5.82 | -5.74 | -5.84 | 35.00% | CHEMBL201805 |
| Mesalazine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -5.36 | -5.64 | -5.52 | 32.17% | CHEMBL422641 |
| Sulfasalazine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.19 | -8.33 | -9.28 | 27.42% | CHEMBL140580 |
| Methotrimeprazine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.50 | -6.38 | -6.19 | 37.93% | CHEMBL357076 |
| Ketamine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.32 | -6.25 | -6.64 | 66.67% | CHEMBL512414 |
| Aspirin | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.33 | -4.52 | -4.69 | 28.57% | CHEMBL3919713 |
| Mesalazine | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.82 | -4.87 | -5.00 | 28.45% | CHEMBL3926652 |
| Sulfasalazine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.82 | -6.42 | -6.86 | 40.21% | CHEMBL2376118 |
| Methotrimeprazine | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.69 | -4.76 | -4.93 | 24.48% | CHEMBL3679748 |
| Ketamine | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.83 | -4.75 | -4.80 | 38.78% | CHEMBL3679792 |
| Aspirin | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.87 | -6.37 | -6.94 | 33.64% | CHEMBL327374 |
| Mesalazine | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.08 | -6.29 | -6.21 | 31.37% | CHEMBL327374 |
| Sulfasalazine | P2Y12_HUMAN | purinergic receptor P2Y12 | -9.70 | -8.38 | -9.64 | 36.89% | CHEMBL2402273 |
| Methotrimeprazine | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.60 | -3.62 | -5.17 | 26.72% | CHEMBL509456 |
| Ketamine | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.75 | -7.12 | -7.89 | 37.69% | CHEMBL88799 |
| Aspirin | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.46 | N/A | N/A | 30.00% | CHEMBL2048425 |
| Mesalazine | PAR1_HUMAN | coagulation factor II thrombin receptor | -6.22 | N/A | N/A | 33.03% | CHEMBL97706 |
| Sulfasalazine | PAR1_HUMAN | coagulation factor II thrombin receptor | -10.23 | N/A | N/A | 28.89% | CHEMBL98805 |
| Methotrimeprazine | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.06 | N/A | N/A | 32.26% | CHEMBL80672 |
| Ketamine | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.02 | N/A | N/A | 43.14% | CHEMBL3658406 |
| Aspirin | PDE4B_HUMAN | phosphodiesterase 4B | -6.36 | -7.14 | -7.15 | 32.69% | CHEMBL2172710 |
| Mesalazine | PDE4B_HUMAN | phosphodiesterase 4B | -6.08 | -6.33 | -6.28 | 32.67% | CHEMBL3315270 |
| Sulfasalazine | PDE4B_HUMAN | phosphodiesterase 4B | -9.73 | -9.54 | -8.96 | 40.94% | CHEMBL576479 |
| Methotrimeprazine | PDE4B_HUMAN | phosphodiesterase 4B | -7.08 | -7.06 | -7.10 | 25.36% | CHEMBL35486 |
| Ketamine | PDE4B_HUMAN | phosphodiesterase 4B | -6.80 | -6.55 | -7.23 | 36.22% | CHEMBL3315258 |
| Aspirin | PDE5A_HUMAN | phosphodiesterase 5A | -6.61 | -6.38 | -6.44 | 40.57% | CHEMBL363889 |
| Mesalazine | PDE5A_HUMAN | phosphodiesterase 5A | -6.33 | -6.03 | -5.92 | 32.73% | CHEMBL116818 |
| Sulfasalazine | PDE5A_HUMAN | phosphodiesterase 5A | -9.56 | -10.11 | -9.91 | 33.19% | CHEMBL79579 |
| Methotrimeprazine | PDE5A_HUMAN | phosphodiesterase 5A | -6.66 | -8.36 | -6.64 | 24.52% | CHEMBL8132 |
| Ketamine | PDE5A_HUMAN | phosphodiesterase 5A | -6.58 | -7.58 | -7.00 | 33.09% | CHEMBL190423 |
| Aspirin | PERM_HUMAN | myeloperoxidase | -6.04 | -7.00 | -5.98 | 38.24% | CHEMBL309339 |
| Mesalazine | PERM_HUMAN | myeloperoxidase | -6.59 | -6.65 | -6.17 | 49.25% | CHEMBL686 |
| Sulfasalazine | PERM_HUMAN | myeloperoxidase | -8.51 | -8.92 | -8.58 | 28.12% | CHEMBL3741401 |
| Methotrimeprazine | PERM_HUMAN | myeloperoxidase | -6.63 | -6.57 | -6.62 | 31.50% | CHEMBL490 |
| Ketamine | PERM_HUMAN | myeloperoxidase | -6.62 | -7.15 | -7.03 | 40.45% | CHEMBL3892909 |
| Aspirin | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.16 | -6.65 | -6.06 | 100.00% | CHEMBL25 |
| Mesalazine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.05 | -5.81 | -6.43 | 51.56% | CHEMBL25 |
| Sulfasalazine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -9.54 | -9.57 | -9.55 | 32.14% | CHEMBL298031 |
| Methotrimeprazine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.10 | -6.10 | -6.36 | 31.53% | CHEMBL1096320 |
| Ketamine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.69 | -7.69 | -7.90 | 39.76% | CHEMBL1945285 |
| Aspirin | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.19 | -6.20 | -6.55 | 72.60% | CHEMBL1958348 |
| Mesalazine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.31 | -6.28 | -5.98 | 49.25% | CHEMBL686 |
| Sulfasalazine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.37 | -7.37 | -8.72 | 43.15% | CHEMBL405744 |
| Methotrimeprazine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -2.49 | -4.75 | -5.63 | 23.53% | CHEMBL432260 |
| Ketamine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.81 | -5.99 | -7.45 | 40.48% | CHEMBL441414 |
| Aspirin | PPAP_HUMAN | acid phosphatase 3 | -6.47 | N/A | N/A | 22.02% | CHEMBL507996 |
| Mesalazine | PPAP_HUMAN | acid phosphatase 3 | -6.06 | N/A | N/A | 18.10% | CHEMBL507996 |
| Sulfasalazine | PPAP_HUMAN | acid phosphatase 3 | -9.14 | N/A | N/A | 16.86% | CHEMBL507996 |
| Methotrimeprazine | PPAP_HUMAN | acid phosphatase 3 | -6.45 | N/A | N/A | 11.76% | CHEMBL507996 |
| Ketamine | PPAP_HUMAN | acid phosphatase 3 | -6.83 | N/A | N/A | 28.04% | CHEMBL501717 |
| Aspirin | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -5.58 | -6.46 | -5.74 | 46.99% | CHEMBL207570 |
| Mesalazine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -5.41 | -5.51 | -5.56 | 48.53% | CHEMBL2057864 |
| Sulfasalazine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -8.86 | -9.20 | -8.38 | 50.28% | CHEMBL2331784 |
| Methotrimeprazine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.62 | -6.61 | -6.88 | 29.70% | CHEMBL377213 |
| Ketamine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.50 | -6.39 | -6.32 | 42.31% | CHEMBL3765141 |
| Aspirin | PRGR_HUMAN | progesterone receptor | -6.28 | -6.24 | -6.04 | 32.46% | CHEMBL50849 |
| Mesalazine | PRGR_HUMAN | progesterone receptor | -6.11 | -5.99 | -5.87 | 34.67% | CHEMBL350283 |
| Sulfasalazine | PRGR_HUMAN | progesterone receptor | -5.93 | -4.66 | -7.63 | 43.54% | CHEMBL3961285 |
| Methotrimeprazine | PRGR_HUMAN | progesterone receptor | -6.23 | -6.15 | -7.40 | 25.41% | CHEMBL3765823 |
| Ketamine | PRGR_HUMAN | progesterone receptor | -7.62 | -7.82 | -7.32 | 45.61% | CHEMBL1163480 |
| Aspirin | PTGES_HUMAN | prostaglandin E synthase | -5.88 | N/A | N/A | 42.72% | CHEMBL3134416 |
| Mesalazine | PTGES_HUMAN | prostaglandin E synthase | -5.89 | N/A | N/A | 33.93% | CHEMBL484092 |
| Sulfasalazine | PTGES_HUMAN | prostaglandin E synthase | -9.14 | N/A | N/A | 43.37% | CHEMBL3092270 |
| Methotrimeprazine | PTGES_HUMAN | prostaglandin E synthase | -5.29 | N/A | N/A | 31.86% | CHEMBL3919693 |
| Ketamine | PTGES_HUMAN | prostaglandin E synthase | -5.34 | N/A | N/A | 41.09% | CHEMBL4102262 |
| Aspirin | SC6A4_HUMAN | solute carrier family 6 member 4 | -6.16 | -6.18 | -6.35 | 41.03% | CHEMBL272002 |
| Mesalazine | SC6A4_HUMAN | solute carrier family 6 member 4 | -6.07 | -5.99 | -5.97 | 35.06% | CHEMBL204199 |
| Sulfasalazine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.64 | -9.22 | -9.97 | 35.15% | CHEMBL1836102 |
| Methotrimeprazine | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.55 | -7.73 | -7.29 | 40.62% | CHEMBL1172744 |
| Ketamine | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.37 | -7.42 | -7.56 | 63.10% | CHEMBL2407327 |
| Aspirin | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.07 | N/A | N/A | 34.15% | CHEMBL3945925 |
| Mesalazine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.02 | N/A | N/A | 38.75% | CHEMBL698 |
| Sulfasalazine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -9.11 | N/A | N/A | 48.35% | CHEMBL2324393 |
| Methotrimeprazine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -5.30 | N/A | N/A | 28.35% | CHEMBL3632696 |
| Ketamine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.87 | N/A | N/A | 58.59% | CHEMBL206758 |
| Aspirin | TLR4_HUMAN | toll like receptor 4 | -5.66 | -6.08 | -6.26 | 29.70% | CHEMBL1223752 |
| Mesalazine | TLR4_HUMAN | toll like receptor 4 | -5.50 | -5.20 | -5.92 | 28.10% | CHEMBL4071705 |
| Sulfasalazine | TLR4_HUMAN | toll like receptor 4 | -8.11 | -8.69 | -8.76 | 30.86% | CHEMBL3823499 |
| Methotrimeprazine | TLR4_HUMAN | toll like receptor 4 | -6.60 | -6.47 | -6.80 | 26.74% | CHEMBL2386454 |
| Ketamine | TLR4_HUMAN | toll like receptor 4 | -6.76 | -6.47 | -6.88 | 26.76% | CHEMBL2419455 |
| Aspirin | TNFA_HUMAN | tumor necrosis factor | -5.73 | N/A | N/A | 27.43% | CHEMBL1700405 |
| Mesalazine | TNFA_HUMAN | tumor necrosis factor | -5.52 | N/A | N/A | 31.07% | CHEMBL1700405 |
| Sulfasalazine | TNFA_HUMAN | tumor necrosis factor | -7.92 | N/A | N/A | 32.78% | CHEMBL1465706 |
| Methotrimeprazine | TNFA_HUMAN | tumor necrosis factor | -6.91 | N/A | N/A | 26.02% | CHEMBL3805615 |
| Ketamine | TNFA_HUMAN | tumor necrosis factor | -6.97 | N/A | N/A | 36.67% | CHEMBL306090 |
| Aspirin | TRBM_HUMAN | thrombomodulin | -5.81 | -5.48 | N/A | N/A | N/A |
| Mesalazine | TRBM_HUMAN | thrombomodulin | -6.39 | -5.68 | N/A | N/A | N/A |
| Sulfasalazine | TRBM_HUMAN | thrombomodulin | -9.44 | -8.25 | N/A | N/A | N/A |
| Methotrimeprazine | TRBM_HUMAN | thrombomodulin | -5.81 | -6.77 | N/A | N/A | N/A |
| Ketamine | TRBM_HUMAN | thrombomodulin | -5.96 | -6.31 | N/A | N/A | N/A |
| Aspirin | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -5.91 | -5.58 | N/A | N/A | N/A |
| Mesalazine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.22 | -5.61 | N/A | N/A | N/A |
| Sulfasalazine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -8.60 | -7.70 | N/A | N/A | N/A |
| Methotrimeprazine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.38 | -5.77 | N/A | N/A | N/A |
| Ketamine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.26 | -5.85 | N/A | N/A | N/A |
| Aspirin | TRPM8_FICAL | Uncharacterized protein | -6.35 | N/A | N/A | N/A | N/A |
| Mesalazine | TRPM8_FICAL | Uncharacterized protein | -5.69 | N/A | N/A | N/A | N/A |
| Sulfasalazine | TRPM8_FICAL | Uncharacterized protein | -10.50 | N/A | N/A | N/A | N/A |
| Methotrimeprazine | TRPM8_FICAL | Uncharacterized protein | -7.65 | N/A | N/A | N/A | N/A |
| Ketamine | TRPM8_FICAL | Uncharacterized protein | -7.02 | N/A | N/A | N/A | N/A |
| Aspirin | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.79 | N/A | N/A | 33.33% | CHEMBL1779679 |
| Mesalazine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.68 | N/A | N/A | 58.57% | CHEMBL1779679 |
| Sulfasalazine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -9.09 | N/A | N/A | 37.16% | CHEMBL214880 |
| Methotrimeprazine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.49 | N/A | N/A | 28.68% | CHEMBL101775 |
| Ketamine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.15 | N/A | N/A | 44.00% | CHEMBL2057845 |
| Aspirin | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -5.66 | -6.16 | N/A | N/A | N/A |
| Mesalazine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.41 | -5.86 | N/A | N/A | N/A |
| Sulfasalazine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.82 | -9.06 | N/A | N/A | N/A |
| Methotrimeprazine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.87 | -6.12 | N/A | N/A | N/A |
| Ketamine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.71 | -7.21 | N/A | N/A | N/A |
| Aspirin | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.23 | -5.53 | N/A | 24.22% | CHEMBL3692228 |
| Mesalazine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -4.84 | -5.09 | N/A | 21.95% | CHEMBL3692228 |
| Sulfasalazine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.51 | -7.84 | N/A | 27.59% | CHEMBL3692265 |
| Methotrimeprazine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.19 | -6.21 | N/A | 21.82% | CHEMBL3664218 |
| Ketamine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.85 | -6.70 | N/A | 40.85% | CHEMBL3664218 |
| Aspirin | TRXR1_HUMAN | thioredoxin reductase 1 | -6.51 | -6.54 | -5.09 | N/A | N/A |
| Mesalazine | TRXR1_HUMAN | thioredoxin reductase 1 | -5.85 | -5.98 | -4.41 | N/A | N/A |
| Sulfasalazine | TRXR1_HUMAN | thioredoxin reductase 1 | -7.91 | -10.21 | -7.35 | N/A | N/A |
| Methotrimeprazine | TRXR1_HUMAN | thioredoxin reductase 1 | -7.30 | -6.62 | -5.93 | N/A | N/A |
| Ketamine | TRXR1_HUMAN | thioredoxin reductase 1 | -6.96 | -6.53 | -5.51 | N/A | N/A |
| Aspirin | TRY1_HUMAN | serine protease 1 | -5.51 | N/A | N/A | 62.35% | CHEMBL148957 |
| Mesalazine | TRY1_HUMAN | serine protease 1 | -6.35 | N/A | N/A | 45.57% | CHEMBL149324 |
| Sulfasalazine | TRY1_HUMAN | serine protease 1 | -7.71 | N/A | N/A | 41.03% | CHEMBL348038 |
| Methotrimeprazine | TRY1_HUMAN | serine protease 1 | -4.97 | N/A | N/A | 32.50% | CHEMBL312647 |
| Ketamine | TRY1_HUMAN | serine protease 1 | -4.95 | N/A | N/A | 51.61% | CHEMBL156472 |