| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Sulfasalazine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.91 | -10.09 | -10.51 | 38.99% | CHEMBL97637 |
| Aceclofenac | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.34 | -8.48 | -8.48 | 32.08% | CHEMBL234448 |
| Alclofenac | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -6.45 | -6.25 | -6.51 | 43.24% | CHEMBL2260934 |
| Curcumin | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.00 | -8.85 | -9.17 | 33.09% | CHEMBL344127 |
| Fentanyl | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.36 | -8.48 | -9.08 | 60.00% | CHEMBL361061 |
| Sulfasalazine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -10.32 | -10.60 | N/A | 39.22% | CHEMBL395501 |
| Aceclofenac | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.43 | -8.82 | N/A | 39.83% | CHEMBL415 |
| Alclofenac | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -6.63 | -6.51 | N/A | 52.50% | CHEMBL272942 |
| Curcumin | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.44 | -9.37 | N/A | 39.66% | CHEMBL3736516 |
| Fentanyl | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.08 | -8.90 | N/A | 57.69% | CHEMBL352194 |
| Sulfasalazine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -9.50 | -9.80 | -10.25 | 35.07% | CHEMBL88571 |
| Aceclofenac | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.42 | -8.49 | -8.62 | 39.83% | CHEMBL415 |
| Alclofenac | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.63 | -6.62 | -7.03 | 52.50% | CHEMBL272942 |
| Curcumin | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.97 | -9.66 | -8.45 | 34.48% | CHEMBL26687 |
| Fentanyl | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.81 | -9.10 | -9.38 | 56.67% | CHEMBL3919861 |
| Sulfasalazine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -9.56 | -9.93 | N/A | 39.22% | CHEMBL395501 |
| Aceclofenac | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.34 | -8.29 | N/A | 39.83% | CHEMBL415 |
| Alclofenac | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -7.06 | -6.79 | N/A | 52.50% | CHEMBL272942 |
| Curcumin | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.95 | -9.15 | N/A | 43.16% | CHEMBL83 |
| Fentanyl | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.49 | -9.12 | N/A | 57.69% | CHEMBL352194 |
| Sulfasalazine | AA1R_HUMAN | adenosine A1 receptor | -9.15 | -8.38 | -8.45 | 43.50% | CHEMBL208705 |
| Aceclofenac | AA1R_HUMAN | adenosine A1 receptor | -7.77 | -7.55 | -8.04 | 28.06% | CHEMBL2260640 |
| Alclofenac | AA1R_HUMAN | adenosine A1 receptor | -6.14 | -6.34 | -6.85 | 36.11% | CHEMBL1544 |
| Curcumin | AA1R_HUMAN | adenosine A1 receptor | -8.38 | -8.49 | -8.85 | 27.98% | CHEMBL2382439 |
| Fentanyl | AA1R_HUMAN | adenosine A1 receptor | -8.66 | -8.83 | -7.66 | 36.02% | CHEMBL1095812 |
| Sulfasalazine | AA2AR_HUMAN | adenosine A2a receptor | -8.47 | -8.50 | -9.23 | 36.20% | CHEMBL196375 |
| Aceclofenac | AA2AR_HUMAN | adenosine A2a receptor | -7.92 | -8.07 | -8.42 | 31.15% | CHEMBL603094 |
| Alclofenac | AA2AR_HUMAN | adenosine A2a receptor | -6.38 | -6.84 | -6.63 | 41.86% | CHEMBL496 |
| Curcumin | AA2AR_HUMAN | adenosine A2a receptor | -8.21 | -8.73 | -9.19 | 54.95% | CHEMBL2042091 |
| Fentanyl | AA2AR_HUMAN | adenosine A2a receptor | -7.45 | -8.09 | -8.77 | 47.29% | CHEMBL539454 |
| Sulfasalazine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.12 | -9.81 | -9.03 | 37.10% | CHEMBL477772 |
| Aceclofenac | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.21 | -8.40 | -9.02 | 33.10% | CHEMBL1085858 |
| Alclofenac | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.20 | -6.81 | -7.99 | 37.62% | CHEMBL158242 |
| Curcumin | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.81 | -8.99 | -9.94 | 54.90% | CHEMBL2381390 |
| Fentanyl | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.87 | -9.06 | -7.24 | 65.43% | CHEMBL141853 |
| Sulfasalazine | ACE_HUMAN | angiotensin I converting enzyme | -9.48 | -9.29 | -8.20 | 31.50% | CHEMBL514138 |
| Aceclofenac | ACE_HUMAN | angiotensin I converting enzyme | -7.43 | -7.84 | -7.68 | 41.90% | CHEMBL80667 |
| Alclofenac | ACE_HUMAN | angiotensin I converting enzyme | -6.23 | -6.24 | -5.79 | 34.13% | CHEMBL254703 |
| Curcumin | ACE_HUMAN | angiotensin I converting enzyme | -8.79 | -8.00 | -7.88 | 25.58% | CHEMBL515834 |
| Fentanyl | ACE_HUMAN | angiotensin I converting enzyme | -8.15 | -8.40 | -6.98 | 50.00% | CHEMBL98 |
| Sulfasalazine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.43 | N/A | N/A | 21.40% | CHEMBL386114 |
| Aceclofenac | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.10 | N/A | N/A | 16.19% | CHEMBL386114 |
| Alclofenac | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.61 | N/A | N/A | 16.75% | CHEMBL386114 |
| Curcumin | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.58 | N/A | N/A | 12.00% | CHEMBL386114 |
| Fentanyl | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.45 | N/A | N/A | 28.57% | CHEMBL386114 |
| Sulfasalazine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.55 | -7.37 | -6.59 | N/A | N/A |
| Aceclofenac | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.02 | -8.54 | -7.09 | N/A | N/A |
| Alclofenac | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.03 | -6.80 | -6.51 | N/A | N/A |
| Curcumin | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.31 | -9.81 | -7.00 | N/A | N/A |
| Fentanyl | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.17 | -6.86 | -4.84 | N/A | N/A |
| Sulfasalazine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.52 | 0.73 | N/A | 32.93% | CHEMBL3290084 |
| Aceclofenac | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.88 | -5.71 | N/A | 42.98% | CHEMBL72219 |
| Alclofenac | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.22 | -6.52 | N/A | 43.33% | CHEMBL37372 |
| Curcumin | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.13 | -6.92 | N/A | 43.16% | CHEMBL83 |
| Fentanyl | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.03 | -2.80 | N/A | 73.91% | CHEMBL1243110 |
| Sulfasalazine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.27 | -8.10 | N/A | 31.85% | CHEMBL1455766 |
| Aceclofenac | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.62 | -8.11 | N/A | 40.00% | CHEMBL2106570 |
| Alclofenac | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.08 | -6.81 | N/A | 43.33% | CHEMBL37372 |
| Curcumin | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.84 | -8.60 | N/A | 43.16% | CHEMBL83 |
| Fentanyl | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.29 | -7.78 | N/A | 68.48% | CHEMBL3354065 |
| Sulfasalazine | ADRB2_HUMAN | adrenoceptor beta 2 | -10.02 | -10.76 | -10.61 | 53.85% | CHEMBL1557985 |
| Aceclofenac | ADRB2_HUMAN | adrenoceptor beta 2 | -7.65 | -8.33 | -9.08 | 41.86% | CHEMBL1581214 |
| Alclofenac | ADRB2_HUMAN | adrenoceptor beta 2 | -6.30 | -6.66 | -6.68 | 48.00% | CHEMBL284782 |
| Curcumin | ADRB2_HUMAN | adrenoceptor beta 2 | -9.39 | -8.84 | -9.85 | 33.74% | CHEMBL4106289 |
| Fentanyl | ADRB2_HUMAN | adrenoceptor beta 2 | -7.73 | -8.30 | -9.28 | 54.72% | CHEMBL1306990 |
| Sulfasalazine | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.13 | -9.15 | -8.74 | 30.21% | CHEMBL346728 |
| Aceclofenac | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.73 | -7.58 | -7.07 | 27.92% | CHEMBL40381 |
| Alclofenac | AGTR2_HUMAN | angiotensin II receptor type 2 | -6.37 | -6.36 | -6.39 | 31.71% | CHEMBL156165 |
| Curcumin | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.96 | -8.50 | -8.56 | 24.84% | CHEMBL155987 |
| Fentanyl | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.61 | -9.85 | -9.62 | 36.50% | CHEMBL268815 |
| Sulfasalazine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.76 | -9.69 | -11.07 | 33.54% | CHEMBL282245 |
| Aceclofenac | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.26 | -8.55 | -7.83 | 30.99% | CHEMBL261703 |
| Alclofenac | ALDR_HUMAN | aldo-keto reductase family 1 member B | -6.94 | -7.10 | -7.44 | 47.44% | CHEMBL77283 |
| Curcumin | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.87 | -9.81 | -10.38 | 50.57% | CHEMBL133714 |
| Fentanyl | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.41 | -7.68 | -9.72 | 39.07% | CHEMBL281620 |
| Sulfasalazine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -9.23 | -9.15 | -8.93 | 22.65% | CHEMBL1077591 |
| Aceclofenac | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.81 | -8.41 | -7.45 | 26.21% | CHEMBL3764432 |
| Alclofenac | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.20 | -7.23 | -5.96 | 30.77% | CHEMBL3806197 |
| Curcumin | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.42 | -8.93 | -8.26 | 27.42% | CHEMBL2204950 |
| Fentanyl | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.02 | -8.37 | -7.69 | 41.38% | CHEMBL3764432 |
| Sulfasalazine | AOFA_HUMAN | monoamine oxidase A | -10.14 | -10.36 | -10.97 | 28.42% | CHEMBL1258719 |
| Aceclofenac | AOFA_HUMAN | monoamine oxidase A | -8.18 | -8.33 | -9.04 | 34.38% | CHEMBL1642676 |
| Alclofenac | AOFA_HUMAN | monoamine oxidase A | -6.86 | -7.05 | -7.52 | 46.08% | CHEMBL2391873 |
| Curcumin | AOFA_HUMAN | monoamine oxidase A | -9.52 | -9.82 | -9.62 | 100.00% | CHEMBL140 |
| Fentanyl | AOFA_HUMAN | monoamine oxidase A | -10.09 | -9.07 | -8.63 | 57.45% | CHEMBL3781494 |
| Sulfasalazine | AOFB_HUMAN | monoamine oxidase B | -10.66 | -11.03 | -10.70 | 29.61% | CHEMBL3319255 |
| Aceclofenac | AOFB_HUMAN | monoamine oxidase B | -8.92 | -8.46 | -8.91 | 34.38% | CHEMBL1642676 |
| Alclofenac | AOFB_HUMAN | monoamine oxidase B | -7.06 | -7.76 | -7.40 | 54.88% | CHEMBL3771258 |
| Curcumin | AOFB_HUMAN | monoamine oxidase B | -8.92 | -9.86 | -9.89 | 55.00% | CHEMBL3918471 |
| Fentanyl | AOFB_HUMAN | monoamine oxidase B | -8.68 | -8.70 | -10.07 | 50.51% | CHEMBL3604126 |
| Sulfasalazine | BACE1_HUMAN | beta-secretase 1 | -7.30 | -8.24 | -8.55 | 36.63% | CHEMBL1210351 |
| Aceclofenac | BACE1_HUMAN | beta-secretase 1 | -6.90 | -7.39 | -7.72 | 34.48% | CHEMBL3897096 |
| Alclofenac | BACE1_HUMAN | beta-secretase 1 | -5.35 | -5.45 | -6.38 | 37.50% | CHEMBL3672399 |
| Curcumin | BACE1_HUMAN | beta-secretase 1 | -6.76 | -7.70 | -8.72 | 93.06% | CHEMBL3672434 |
| Fentanyl | BACE1_HUMAN | beta-secretase 1 | -6.92 | -7.39 | -8.46 | 59.60% | CHEMBL2181988 |
| Sulfasalazine | CAH2_HUMAN | carbonic anhydrase 2 | -8.28 | -8.30 | -7.83 | 53.12% | CHEMBL2164736 |
| Aceclofenac | CAH2_HUMAN | carbonic anhydrase 2 | -7.90 | -7.70 | -7.30 | 38.38% | CHEMBL23832 |
| Alclofenac | CAH2_HUMAN | carbonic anhydrase 2 | -6.32 | -5.98 | -6.12 | 43.75% | CHEMBL2407314 |
| Curcumin | CAH2_HUMAN | carbonic anhydrase 2 | -7.67 | -6.95 | -6.83 | 61.80% | CHEMBL116438 |
| Fentanyl | CAH2_HUMAN | carbonic anhydrase 2 | -7.37 | -7.43 | -7.59 | 61.62% | CHEMBL182523 |
| Sulfasalazine | CASP1_HUMAN | caspase 1 | -7.91 | -7.84 | -7.29 | 34.62% | CHEMBL422849 |
| Aceclofenac | CASP1_HUMAN | caspase 1 | -6.75 | -7.25 | -6.51 | 38.73% | CHEMBL78154 |
| Alclofenac | CASP1_HUMAN | caspase 1 | -5.25 | -5.96 | -5.52 | 38.53% | CHEMBL1221503 |
| Curcumin | CASP1_HUMAN | caspase 1 | -6.30 | -7.38 | -6.15 | 28.12% | CHEMBL602331 |
| Fentanyl | CASP1_HUMAN | caspase 1 | -6.46 | -6.95 | -6.03 | 46.88% | CHEMBL1221597 |
| Sulfasalazine | CDK5_HUMAN | cyclin dependent kinase 5 | -8.09 | -8.03 | -9.16 | 40.88% | CHEMBL2004892 |
| Aceclofenac | CDK5_HUMAN | cyclin dependent kinase 5 | -7.08 | -7.99 | -7.94 | 38.61% | CHEMBL1991734 |
| Alclofenac | CDK5_HUMAN | cyclin dependent kinase 5 | -6.67 | -6.92 | -7.45 | 30.77% | CHEMBL1998121 |
| Curcumin | CDK5_HUMAN | cyclin dependent kinase 5 | -7.35 | -8.05 | -8.05 | 30.14% | CHEMBL2002407 |
| Fentanyl | CDK5_HUMAN | cyclin dependent kinase 5 | -7.76 | -7.70 | -7.16 | 43.33% | CHEMBL1998121 |
| Sulfasalazine | CHLE_HUMAN | butyrylcholinesterase | -8.62 | -8.90 | -8.84 | 28.63% | CHEMBL3925612 |
| Aceclofenac | CHLE_HUMAN | butyrylcholinesterase | -8.62 | -8.12 | -8.40 | 40.52% | CHEMBL3087676 |
| Alclofenac | CHLE_HUMAN | butyrylcholinesterase | -6.97 | -6.80 | -6.78 | 42.72% | CHEMBL288482 |
| Curcumin | CHLE_HUMAN | butyrylcholinesterase | -9.31 | -8.76 | -8.78 | 54.90% | CHEMBL2381390 |
| Fentanyl | CHLE_HUMAN | butyrylcholinesterase | -8.47 | -8.99 | -9.56 | 52.63% | CHEMBL4077192 |
| Sulfasalazine | CNR1_HUMAN | cannabinoid receptor 1 | -10.11 | -10.90 | -9.35 | 41.81% | CHEMBL247332 |
| Aceclofenac | CNR1_HUMAN | cannabinoid receptor 1 | -8.53 | -8.27 | -9.05 | 44.96% | CHEMBL3936647 |
| Alclofenac | CNR1_HUMAN | cannabinoid receptor 1 | -7.04 | -6.94 | -7.07 | 49.38% | CHEMBL244607 |
| Curcumin | CNR1_HUMAN | cannabinoid receptor 1 | -6.96 | -9.02 | -9.92 | 42.62% | CHEMBL395230 |
| Fentanyl | CNR1_HUMAN | cannabinoid receptor 1 | -8.98 | -9.23 | -9.76 | 55.95% | CHEMBL479095 |
| Sulfasalazine | CNR2_HUMAN | cannabinoid receptor 2 | -9.87 | -10.07 | N/A | 39.57% | CHEMBL245876 |
| Aceclofenac | CNR2_HUMAN | cannabinoid receptor 2 | -8.81 | -8.56 | N/A | 34.85% | CHEMBL3899579 |
| Alclofenac | CNR2_HUMAN | cannabinoid receptor 2 | -6.87 | -6.88 | N/A | 47.44% | CHEMBL243334 |
| Curcumin | CNR2_HUMAN | cannabinoid receptor 2 | -8.97 | -9.40 | N/A | 45.22% | CHEMBL3410833 |
| Fentanyl | CNR2_HUMAN | cannabinoid receptor 2 | -9.18 | -9.97 | N/A | 70.11% | CHEMBL2338188 |
| Sulfasalazine | COLI_HUMAN | proopiomelanocortin | -9.81 | -9.84 | -8.93 | N/A | N/A |
| Aceclofenac | COLI_HUMAN | proopiomelanocortin | -8.10 | -8.33 | -6.85 | N/A | N/A |
| Alclofenac | COLI_HUMAN | proopiomelanocortin | -6.87 | -6.50 | -5.77 | N/A | N/A |
| Curcumin | COLI_HUMAN | proopiomelanocortin | -9.24 | -9.50 | -8.03 | N/A | N/A |
| Fentanyl | COLI_HUMAN | proopiomelanocortin | -8.18 | -7.94 | -7.52 | N/A | N/A |
| Sulfasalazine | COMT_HUMAN | catechol-O-methyltransferase | -6.43 | -6.32 | -6.82 | 29.78% | CHEMBL3798524 |
| Aceclofenac | COMT_HUMAN | catechol-O-methyltransferase | -6.19 | -6.03 | -6.68 | 22.39% | CHEMBL1089630 |
| Alclofenac | COMT_HUMAN | catechol-O-methyltransferase | -4.99 | -5.23 | -5.25 | 23.53% | CHEMBL1324 |
| Curcumin | COMT_HUMAN | catechol-O-methyltransferase | -6.38 | -6.70 | -7.04 | 33.59% | CHEMBL953 |
| Fentanyl | COMT_HUMAN | catechol-O-methyltransferase | -5.90 | -6.36 | -5.94 | 25.74% | CHEMBL3425731 |
| Sulfasalazine | CRP_HUMAN | C-reactive protein | -6.85 | -7.11 | N/A | N/A | N/A |
| Aceclofenac | CRP_HUMAN | C-reactive protein | -6.11 | -5.50 | N/A | N/A | N/A |
| Alclofenac | CRP_HUMAN | C-reactive protein | -5.36 | -5.45 | N/A | N/A | N/A |
| Curcumin | CRP_HUMAN | C-reactive protein | -6.41 | -6.09 | N/A | N/A | N/A |
| Fentanyl | CRP_HUMAN | C-reactive protein | -6.37 | -5.93 | N/A | N/A | N/A |
| Sulfasalazine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -4.95 | N/A | N/A | 27.86% | CHEMBL376621 |
| Aceclofenac | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -8.24 | N/A | N/A | 80.46% | CHEMBL139 |
| Alclofenac | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.98 | N/A | N/A | 37.37% | CHEMBL139 |
| Curcumin | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -4.78 | N/A | N/A | 23.32% | CHEMBL220182 |
| Fentanyl | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -5.19 | N/A | N/A | 31.10% | CHEMBL561812 |
| Sulfasalazine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.85 | -7.91 | -7.49 | 28.44% | CHEMBL4100900 |
| Aceclofenac | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.87 | -7.11 | -7.41 | 25.40% | CHEMBL3908835 |
| Alclofenac | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.96 | -5.81 | -6.03 | 38.83% | CHEMBL126657 |
| Curcumin | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -9.34 | -6.96 | -7.12 | 60.00% | CHEMBL126657 |
| Fentanyl | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.98 | -6.61 | -7.56 | 41.88% | CHEMBL2371850 |
| Sulfasalazine | DRD2_HUMAN | dopamine receptor D2 | -10.06 | N/A | N/A | 39.47% | CHEMBL231326 |
| Aceclofenac | DRD2_HUMAN | dopamine receptor D2 | -7.06 | N/A | N/A | 39.83% | CHEMBL415 |
| Alclofenac | DRD2_HUMAN | dopamine receptor D2 | -6.14 | N/A | N/A | 41.12% | CHEMBL203734 |
| Curcumin | DRD2_HUMAN | dopamine receptor D2 | -8.52 | N/A | N/A | 43.40% | CHEMBL2112285 |
| Fentanyl | DRD2_HUMAN | dopamine receptor D2 | -7.60 | N/A | N/A | 70.79% | CHEMBL4091231 |
| Sulfasalazine | DRD3_HUMAN | dopamine receptor D3 | -9.80 | N/A | N/A | 39.47% | CHEMBL231326 |
| Aceclofenac | DRD3_HUMAN | dopamine receptor D3 | -7.74 | N/A | N/A | 39.83% | CHEMBL415 |
| Alclofenac | DRD3_HUMAN | dopamine receptor D3 | -6.75 | N/A | N/A | 41.76% | CHEMBL131484 |
| Curcumin | DRD3_HUMAN | dopamine receptor D3 | -9.29 | N/A | N/A | 43.40% | CHEMBL2112285 |
| Fentanyl | DRD3_HUMAN | dopamine receptor D3 | -8.25 | N/A | N/A | 70.79% | CHEMBL4091231 |
| Sulfasalazine | DRD4_HUMAN | dopamine receptor D4 | -10.37 | -10.44 | N/A | 33.33% | CHEMBL3409256 |
| Aceclofenac | DRD4_HUMAN | dopamine receptor D4 | -8.02 | -7.90 | N/A | 34.25% | CHEMBL330108 |
| Alclofenac | DRD4_HUMAN | dopamine receptor D4 | -6.24 | -6.36 | N/A | 41.76% | CHEMBL131484 |
| Curcumin | DRD4_HUMAN | dopamine receptor D4 | -9.78 | -9.85 | N/A | 43.40% | CHEMBL2112284 |
| Fentanyl | DRD4_HUMAN | dopamine receptor D4 | -8.89 | -8.94 | N/A | 70.79% | CHEMBL4074104 |
| Sulfasalazine | EDN1_HUMAN | endothelin 1 | -8.43 | N/A | N/A | N/A | N/A |
| Aceclofenac | EDN1_HUMAN | endothelin 1 | -7.06 | N/A | N/A | N/A | N/A |
| Alclofenac | EDN1_HUMAN | endothelin 1 | -6.62 | N/A | N/A | N/A | N/A |
| Curcumin | EDN1_HUMAN | endothelin 1 | -8.05 | N/A | N/A | N/A | N/A |
| Fentanyl | EDN1_HUMAN | endothelin 1 | -7.64 | N/A | N/A | N/A | N/A |
| Sulfasalazine | ESR1_HUMAN | estrogen receptor 1 | -8.95 | -8.43 | -8.64 | 41.84% | CHEMBL202691 |
| Aceclofenac | ESR1_HUMAN | estrogen receptor 1 | -7.81 | -7.78 | -7.85 | 32.71% | CHEMBL2071175 |
| Alclofenac | ESR1_HUMAN | estrogen receptor 1 | -6.44 | -6.57 | -6.50 | 48.75% | CHEMBL335412 |
| Curcumin | ESR1_HUMAN | estrogen receptor 1 | -8.48 | -7.86 | -8.18 | 61.45% | CHEMBL4101656 |
| Fentanyl | ESR1_HUMAN | estrogen receptor 1 | -8.30 | -8.48 | -8.48 | 50.89% | CHEMBL3360843 |
| Sulfasalazine | FABP5_HUMAN | fatty acid binding protein 5 | -8.20 | -6.61 | -6.49 | 29.23% | CHEMBL3941588 |
| Aceclofenac | FABP5_HUMAN | fatty acid binding protein 5 | -7.49 | -5.51 | -5.44 | 34.31% | CHEMBL437489 |
| Alclofenac | FABP5_HUMAN | fatty acid binding protein 5 | -6.20 | -4.38 | -4.49 | 47.57% | CHEMBL212860 |
| Curcumin | FABP5_HUMAN | fatty acid binding protein 5 | -8.03 | -6.03 | -5.84 | 27.50% | CHEMBL212860 |
| Fentanyl | FABP5_HUMAN | fatty acid binding protein 5 | -7.92 | -6.05 | -6.03 | 30.07% | CHEMBL3941588 |
| Sulfasalazine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.47 | N/A | N/A | 37.10% | CHEMBL477772 |
| Aceclofenac | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.24 | N/A | N/A | 38.61% | CHEMBL1991734 |
| Alclofenac | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.36 | N/A | N/A | 35.92% | CHEMBL221753 |
| Curcumin | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.52 | N/A | N/A | 35.86% | CHEMBL1097700 |
| Fentanyl | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.45 | N/A | N/A | 43.33% | CHEMBL1998121 |
| Sulfasalazine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.10 | -8.73 | -9.00 | 26.42% | CHEMBL4070615 |
| Sulfasalazine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.30 | N/A | N/A | 26.42% | CHEMBL4070615 |
| Aceclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.46 | -8.70 | -8.70 | 13.99% | CHEMBL4070615 |
| Aceclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -9.03 | N/A | N/A | 13.99% | CHEMBL4070615 |
| Alclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -6.89 | -7.00 | -6.81 | 14.80% | CHEMBL4070615 |
| Alclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -6.93 | N/A | N/A | 14.80% | CHEMBL4070615 |
| Curcumin | GLRA3_HUMAN | glycine receptor alpha 3 | -8.48 | -8.42 | -8.36 | 15.25% | CHEMBL4070615 |
| Curcumin | GLRA3_HUMAN | glycine receptor alpha 3 | -8.72 | N/A | N/A | 15.25% | CHEMBL4070615 |
| Fentanyl | GLRA3_HUMAN | glycine receptor alpha 3 | -9.32 | -8.16 | -8.77 | 28.19% | CHEMBL4074873 |
| Fentanyl | GLRA3_HUMAN | glycine receptor alpha 3 | -9.63 | N/A | N/A | 28.19% | CHEMBL4074873 |
| Sulfasalazine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -9.39 | -5.81 | -7.02 | 34.63% | CHEMBL1682833 |
| Aceclofenac | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.45 | -8.20 | -7.52 | 35.46% | CHEMBL239594 |
| Alclofenac | GRM5_HUMAN | glutamate metabotropic receptor 5 | -6.94 | -7.54 | -7.39 | 44.44% | CHEMBL1682815 |
| Curcumin | GRM5_HUMAN | glutamate metabotropic receptor 5 | -10.66 | -9.91 | -11.08 | 29.06% | CHEMBL1682796 |
| Fentanyl | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.50 | -6.98 | -7.52 | 47.52% | CHEMBL2338572 |
| Sulfasalazine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.84 | -8.80 | -9.25 | 27.18% | CHEMBL3934642 |
| Aceclofenac | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.47 | -6.38 | -7.10 | 30.22% | CHEMBL572528 |
| Alclofenac | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.42 | -6.38 | -6.71 | 19.74% | CHEMBL3425959 |
| Curcumin | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.94 | -8.01 | -8.38 | 23.87% | CHEMBL3698258 |
| Fentanyl | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.25 | -7.69 | -7.23 | 45.24% | CHEMBL3425957 |
| Sulfasalazine | HRH1_HUMAN | histamine receptor H1 | -10.76 | N/A | N/A | 35.78% | CHEMBL1077908 |
| Aceclofenac | HRH1_HUMAN | histamine receptor H1 | -8.79 | N/A | N/A | 42.22% | CHEMBL2158825 |
| Alclofenac | HRH1_HUMAN | histamine receptor H1 | -8.04 | N/A | N/A | 47.75% | CHEMBL2158820 |
| Curcumin | HRH1_HUMAN | histamine receptor H1 | -9.17 | N/A | N/A | 39.02% | CHEMBL292275 |
| Fentanyl | HRH1_HUMAN | histamine receptor H1 | -8.53 | N/A | N/A | 61.82% | CHEMBL1242923 |
| Sulfasalazine | HYES_HUMAN | epoxide hydrolase 2 | -10.43 | -9.66 | -9.50 | 39.31% | CHEMBL2392745 |
| Aceclofenac | HYES_HUMAN | epoxide hydrolase 2 | -7.65 | -8.37 | -8.32 | 41.48% | CHEMBL3818107 |
| Alclofenac | HYES_HUMAN | epoxide hydrolase 2 | -6.48 | -6.78 | -6.44 | 53.10% | CHEMBL3114610 |
| Curcumin | HYES_HUMAN | epoxide hydrolase 2 | -8.74 | -8.73 | -8.91 | 65.79% | CHEMBL32969 |
| Fentanyl | HYES_HUMAN | epoxide hydrolase 2 | -8.50 | -8.26 | -8.71 | 68.18% | CHEMBL1672132 |
| Sulfasalazine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.44 | N/A | N/A | 39.22% | CHEMBL473080 |
| Aceclofenac | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.96 | N/A | N/A | 30.11% | CHEMBL3823943 |
| Alclofenac | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.25 | N/A | N/A | 28.97% | CHEMBL3318321 |
| Curcumin | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.67 | N/A | N/A | 52.08% | CHEMBL3125821 |
| Fentanyl | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.28 | N/A | N/A | 40.91% | CHEMBL3823257 |
| Sulfasalazine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -9.81 | -8.69 | N/A | 34.34% | CHEMBL595995 |
| Aceclofenac | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.77 | -7.75 | N/A | 34.82% | CHEMBL72 |
| Alclofenac | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -5.90 | -5.93 | N/A | 42.68% | CHEMBL1236356 |
| Curcumin | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.04 | -8.03 | N/A | 65.06% | CHEMBL33943 |
| Fentanyl | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.93 | -8.39 | N/A | 46.34% | CHEMBL2398178 |
| Sulfasalazine | MIF_HUMAN | macrophage migration inhibitory factor | -7.54 | -8.00 | -6.92 | 28.14% | CHEMBL3799453 |
| Aceclofenac | MIF_HUMAN | macrophage migration inhibitory factor | -6.86 | -7.05 | -6.40 | 23.44% | CHEMBL223319 |
| Alclofenac | MIF_HUMAN | macrophage migration inhibitory factor | -6.24 | -6.54 | -6.15 | 34.31% | CHEMBL223319 |
| Curcumin | MIF_HUMAN | macrophage migration inhibitory factor | -6.34 | -8.78 | -6.10 | 27.82% | CHEMBL3797437 |
| Fentanyl | MIF_HUMAN | macrophage migration inhibitory factor | -8.01 | -8.45 | -7.18 | 25.78% | CHEMBL1604170 |
| Sulfasalazine | MK01_HUMAN | mitogen-activated protein kinase 1 | -8.32 | -7.71 | -7.58 | 39.87% | CHEMBL3590110 |
| Aceclofenac | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.94 | -6.94 | -8.02 | 33.13% | CHEMBL3590115 |
| Alclofenac | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.25 | -5.87 | -6.05 | 42.55% | CHEMBL1909070 |
| Curcumin | MK01_HUMAN | mitogen-activated protein kinase 1 | -8.55 | -7.55 | -8.28 | 48.35% | CHEMBL319244 |
| Fentanyl | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.20 | -7.37 | -7.83 | 47.06% | CHEMBL3356128 |
| Sulfasalazine | MK03_HUMAN | mitogen-activated protein kinase 3 | -9.36 | -8.98 | -8.81 | 33.13% | CHEMBL3798109 |
| Aceclofenac | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.46 | -8.04 | -7.31 | 26.67% | CHEMBL3798624 |
| Alclofenac | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.36 | -6.65 | -5.82 | 29.37% | CHEMBL3797756 |
| Curcumin | MK03_HUMAN | mitogen-activated protein kinase 3 | -8.16 | -9.48 | -8.12 | 28.22% | CHEMBL555017 |
| Fentanyl | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.90 | -8.11 | -8.19 | 38.14% | CHEMBL3113587 |
| Sulfasalazine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.06 | -9.63 | -9.04 | 45.96% | CHEMBL3594042 |
| Aceclofenac | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.68 | -8.86 | -7.96 | 33.33% | CHEMBL2348411 |
| Alclofenac | MTOR_HUMAN | mechanistic target of rapamycin kinase | -6.86 | -6.96 | -6.76 | 27.61% | CHEMBL1091882 |
| Curcumin | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.06 | -8.97 | -8.50 | 28.22% | CHEMBL1091882 |
| Fentanyl | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.53 | -9.08 | -8.99 | 39.01% | CHEMBL592619 |
| Sulfasalazine | NEP_HUMAN | membrane metalloendopeptidase | -8.53 | -8.71 | -9.19 | 22.82% | CHEMBL92949 |
| Aceclofenac | NEP_HUMAN | membrane metalloendopeptidase | -8.69 | -7.00 | -7.04 | 25.56% | CHEMBL225085 |
| Alclofenac | NEP_HUMAN | membrane metalloendopeptidase | -6.53 | -6.76 | -7.30 | 34.13% | CHEMBL254703 |
| Curcumin | NEP_HUMAN | membrane metalloendopeptidase | -7.38 | -9.06 | -8.51 | 29.73% | CHEMBL81232 |
| Fentanyl | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.21 | -7.56 | 50.00% | CHEMBL467602 |
| Sulfasalazine | NK1R_HUMAN | tachykinin receptor 1 | -8.87 | -8.55 | -8.50 | 34.72% | CHEMBL453314 |
| Aceclofenac | NK1R_HUMAN | tachykinin receptor 1 | -7.95 | -8.09 | -7.56 | 36.70% | CHEMBL92032 |
| Alclofenac | NK1R_HUMAN | tachykinin receptor 1 | -6.17 | -6.50 | -6.58 | 42.24% | CHEMBL369498 |
| Curcumin | NK1R_HUMAN | tachykinin receptor 1 | -8.63 | -8.36 | -8.11 | 33.06% | CHEMBL1817884 |
| Fentanyl | NK1R_HUMAN | tachykinin receptor 1 | -8.76 | -8.19 | -7.69 | 63.92% | CHEMBL89245 |
| Sulfasalazine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.76 | -10.68 | -10.46 | 27.59% | CHEMBL2333945 |
| Aceclofenac | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.15 | -7.65 | -8.53 | 16.77% | CHEMBL2333945 |
| Alclofenac | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.23 | -6.81 | -7.33 | 16.78% | CHEMBL2333945 |
| Curcumin | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -10.11 | -8.84 | -9.59 | 17.80% | CHEMBL284237 |
| Fentanyl | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.31 | -7.38 | -7.70 | 28.44% | CHEMBL284237 |
| Sulfasalazine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.39 | -9.61 | -9.43 | 26.01% | CHEMBL218017 |
| Aceclofenac | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.75 | -8.80 | -8.66 | 24.48% | CHEMBL219114 |
| Alclofenac | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.34 | -6.57 | -7.34 | 34.31% | CHEMBL161180 |
| Curcumin | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.33 | -9.69 | -9.91 | 32.11% | CHEMBL247323 |
| Fentanyl | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.06 | -10.50 | -6.61 | 43.64% | CHEMBL444384 |
| Sulfasalazine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -10.22 | -10.76 | -10.46 | 37.57% | CHEMBL164322 |
| Aceclofenac | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.91 | -7.99 | -8.53 | 27.57% | CHEMBL401253 |
| Alclofenac | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.16 | -6.97 | -7.33 | 22.70% | CHEMBL325825 |
| Curcumin | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -10.17 | -9.67 | -9.59 | 17.17% | CHEMBL162577 |
| Fentanyl | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.18 | -7.40 | -7.70 | 29.46% | CHEMBL419399 |
| Sulfasalazine | NOS1_HUMAN | nitric oxide synthase 1 | -9.75 | -9.90 | -9.04 | 29.11% | CHEMBL4086610 |
| Aceclofenac | NOS1_HUMAN | nitric oxide synthase 1 | -8.50 | -8.16 | -8.06 | 30.23% | CHEMBL49881 |
| Alclofenac | NOS1_HUMAN | nitric oxide synthase 1 | -7.13 | -7.16 | -7.08 | 28.23% | CHEMBL3736597 |
| Curcumin | NOS1_HUMAN | nitric oxide synthase 1 | -9.04 | -8.97 | -9.24 | 24.78% | CHEMBL500923 |
| Fentanyl | NOS1_HUMAN | nitric oxide synthase 1 | -8.43 | -8.29 | -8.20 | 43.51% | CHEMBL3216789 |
| Sulfasalazine | NOS2_HUMAN | nitric oxide synthase 2 | -8.04 | -9.86 | -1.95 | 30.80% | CHEMBL223838 |
| Aceclofenac | NOS2_HUMAN | nitric oxide synthase 2 | -7.88 | -8.58 | -8.44 | 30.23% | CHEMBL49881 |
| Alclofenac | NOS2_HUMAN | nitric oxide synthase 2 | -7.12 | -7.01 | -7.20 | 45.79% | CHEMBL1762471 |
| Curcumin | NOS2_HUMAN | nitric oxide synthase 2 | -8.67 | -8.49 | -6.06 | 28.69% | CHEMBL1762471 |
| Fentanyl | NOS2_HUMAN | nitric oxide synthase 2 | -6.98 | -8.72 | -8.17 | 44.92% | CHEMBL112747 |
| Sulfasalazine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.33 | -9.32 | -8.51 | 43.48% | CHEMBL2152285 |
| Aceclofenac | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.98 | -8.29 | -8.42 | 38.61% | CHEMBL1991734 |
| Alclofenac | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.88 | -6.79 | -6.77 | 27.56% | CHEMBL261849 |
| Curcumin | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.75 | -9.16 | -9.04 | 38.33% | CHEMBL1978371 |
| Fentanyl | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.73 | -9.20 | -9.11 | 43.00% | CHEMBL1984131 |
| Sulfasalazine | OPRD_HUMAN | opioid receptor delta 1 | -7.42 | -6.97 | -7.42 | 29.41% | CHEMBL191987 |
| Aceclofenac | OPRD_HUMAN | opioid receptor delta 1 | -6.96 | -6.40 | -6.81 | 36.67% | CHEMBL1642757 |
| Alclofenac | OPRD_HUMAN | opioid receptor delta 1 | -6.10 | -5.58 | -5.94 | 41.96% | CHEMBL4082214 |
| Curcumin | OPRD_HUMAN | opioid receptor delta 1 | -7.99 | -7.00 | -6.91 | 46.15% | CHEMBL411 |
| Fentanyl | OPRD_HUMAN | opioid receptor delta 1 | -8.18 | -7.13 | -7.16 | 100.00% | CHEMBL12391 |
| Sulfasalazine | OPRK_HUMAN | opioid receptor kappa 1 | -8.85 | -8.92 | -9.45 | 33.74% | CHEMBL1713635 |
| Aceclofenac | OPRK_HUMAN | opioid receptor kappa 1 | -8.40 | -8.36 | -7.57 | 36.67% | CHEMBL1642757 |
| Alclofenac | OPRK_HUMAN | opioid receptor kappa 1 | -6.57 | -6.79 | -6.67 | 41.96% | CHEMBL4082214 |
| Curcumin | OPRK_HUMAN | opioid receptor kappa 1 | -8.58 | -8.42 | -8.77 | 41.13% | CHEMBL318215 |
| Fentanyl | OPRK_HUMAN | opioid receptor kappa 1 | -9.67 | -8.24 | -8.53 | 100.00% | CHEMBL12391 |
| Sulfasalazine | OPRM_MOUSE | Mu-type opioid receptor | -8.75 | -9.00 | N/A | 24.27% | CHEMBL605510 |
| Aceclofenac | OPRM_MOUSE | Mu-type opioid receptor | -7.71 | -7.16 | N/A | 26.17% | CHEMBL2311157 |
| Alclofenac | OPRM_MOUSE | Mu-type opioid receptor | -6.02 | -5.87 | N/A | 30.65% | CHEMBL542150 |
| Curcumin | OPRM_MOUSE | Mu-type opioid receptor | -8.10 | -7.32 | N/A | 40.28% | CHEMBL361720 |
| Fentanyl | OPRM_MOUSE | Mu-type opioid receptor | -8.44 | -8.64 | N/A | 100.00% | CHEMBL596 |
| Sulfasalazine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.19 | -8.33 | -9.28 | 27.42% | CHEMBL140580 |
| Aceclofenac | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.35 | -7.16 | -7.37 | 33.08% | CHEMBL186300 |
| Alclofenac | OPRX_HUMAN | opioid related nociceptin receptor 1 | -5.99 | -6.13 | -6.15 | 37.30% | CHEMBL512612 |
| Curcumin | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.88 | -7.95 | -8.26 | 30.97% | CHEMBL228964 |
| Fentanyl | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.55 | -7.44 | -7.63 | 80.00% | CHEMBL317152 |
| Sulfasalazine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.82 | -6.42 | -6.86 | 40.21% | CHEMBL2376118 |
| Aceclofenac | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.56 | -5.12 | -5.72 | 40.50% | CHEMBL3958199 |
| Alclofenac | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.63 | -4.67 | -5.10 | 34.23% | CHEMBL3958199 |
| Curcumin | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.54 | -5.71 | -6.69 | 28.31% | CHEMBL3091630 |
| Fentanyl | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.63 | -5.63 | -6.10 | 42.34% | CHEMBL3669705 |
| Sulfasalazine | P2Y12_HUMAN | purinergic receptor P2Y12 | -9.70 | -8.38 | -9.64 | 36.89% | CHEMBL2402273 |
| Aceclofenac | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.78 | -6.79 | -7.56 | 30.41% | CHEMBL509572 |
| Alclofenac | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.29 | -7.63 | -7.20 | 32.50% | CHEMBL92158 |
| Curcumin | P2Y12_HUMAN | purinergic receptor P2Y12 | -9.41 | -9.01 | -8.84 | 26.56% | CHEMBL88730 |
| Fentanyl | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.13 | -7.40 | -7.05 | 36.72% | CHEMBL88708 |
| Sulfasalazine | PAR1_HUMAN | coagulation factor II thrombin receptor | -10.23 | N/A | N/A | 28.89% | CHEMBL98805 |
| Aceclofenac | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.36 | N/A | N/A | 27.94% | CHEMBL2049115 |
| Alclofenac | PAR1_HUMAN | coagulation factor II thrombin receptor | -6.54 | N/A | N/A | 31.08% | CHEMBL334510 |
| Curcumin | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.18 | N/A | N/A | 39.13% | CHEMBL387441 |
| Fentanyl | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.10 | N/A | N/A | 73.91% | CHEMBL3658401 |
| Sulfasalazine | PDE4B_HUMAN | phosphodiesterase 4B | -9.73 | -9.54 | -8.96 | 40.94% | CHEMBL576479 |
| Aceclofenac | PDE4B_HUMAN | phosphodiesterase 4B | -8.71 | -8.31 | -8.15 | 48.44% | CHEMBL3315251 |
| Alclofenac | PDE4B_HUMAN | phosphodiesterase 4B | -6.68 | -6.96 | -6.98 | 37.27% | CHEMBL511115 |
| Curcumin | PDE4B_HUMAN | phosphodiesterase 4B | -8.61 | -8.73 | -8.97 | 35.97% | CHEMBL403367 |
| Fentanyl | PDE4B_HUMAN | phosphodiesterase 4B | -7.99 | -8.12 | -8.66 | 39.84% | CHEMBL37386 |
| Sulfasalazine | PDE5A_HUMAN | phosphodiesterase 5A | -9.56 | -10.11 | -9.91 | 33.19% | CHEMBL79579 |
| Aceclofenac | PDE5A_HUMAN | phosphodiesterase 5A | -8.21 | -8.64 | -8.52 | 28.57% | CHEMBL332898 |
| Alclofenac | PDE5A_HUMAN | phosphodiesterase 5A | -6.45 | -6.64 | -6.46 | 33.33% | CHEMBL291127 |
| Curcumin | PDE5A_HUMAN | phosphodiesterase 5A | -8.48 | -8.80 | -8.40 | 29.61% | CHEMBL158374 |
| Fentanyl | PDE5A_HUMAN | phosphodiesterase 5A | -8.25 | -8.36 | -8.02 | 31.82% | CHEMBL555171 |
| Sulfasalazine | PERM_HUMAN | myeloperoxidase | -8.51 | -8.92 | -8.58 | 28.12% | CHEMBL3741401 |
| Aceclofenac | PERM_HUMAN | myeloperoxidase | -8.18 | -8.48 | -8.09 | 36.19% | CHEMBL686 |
| Alclofenac | PERM_HUMAN | myeloperoxidase | -7.69 | -7.67 | -7.62 | 33.63% | CHEMBL86 |
| Curcumin | PERM_HUMAN | myeloperoxidase | -7.54 | -7.99 | -7.74 | 27.47% | CHEMBL3925807 |
| Fentanyl | PERM_HUMAN | myeloperoxidase | -7.81 | -8.46 | -8.03 | 38.94% | CHEMBL2347029 |
| Sulfasalazine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -9.54 | -9.57 | -9.55 | 32.14% | CHEMBL298031 |
| Aceclofenac | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -7.02 | -8.47 | -8.57 | 80.46% | CHEMBL139 |
| Alclofenac | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.52 | -6.90 | -6.82 | 59.70% | CHEMBL12952 |
| Curcumin | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -8.92 | -9.47 | -9.61 | 54.64% | CHEMBL229955 |
| Fentanyl | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -9.40 | -8.71 | -8.01 | 40.83% | CHEMBL3775653 |
| Sulfasalazine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.37 | -7.37 | -8.72 | 43.15% | CHEMBL405744 |
| Aceclofenac | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.46 | -7.86 | -8.70 | 80.46% | CHEMBL139 |
| Alclofenac | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.35 | -6.38 | -7.09 | 59.70% | CHEMBL12952 |
| Curcumin | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.59 | -8.25 | -7.95 | 60.24% | CHEMBL456619 |
| Fentanyl | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.93 | -5.22 | -6.33 | 44.63% | CHEMBL49775 |
| Sulfasalazine | PPAP_HUMAN | acid phosphatase 3 | -9.14 | N/A | N/A | 16.86% | CHEMBL507996 |
| Aceclofenac | PPAP_HUMAN | acid phosphatase 3 | -7.86 | N/A | N/A | 15.17% | CHEMBL507996 |
| Alclofenac | PPAP_HUMAN | acid phosphatase 3 | -6.34 | N/A | N/A | 30.36% | CHEMBL507996 |
| Curcumin | PPAP_HUMAN | acid phosphatase 3 | -8.28 | N/A | N/A | 23.53% | CHEMBL507996 |
| Fentanyl | PPAP_HUMAN | acid phosphatase 3 | -8.05 | N/A | N/A | 24.07% | CHEMBL501717 |
| Sulfasalazine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -8.86 | -9.20 | -8.38 | 50.28% | CHEMBL2331784 |
| Aceclofenac | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -8.15 | -7.78 | -7.61 | 45.45% | CHEMBL167963 |
| Alclofenac | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.28 | -6.30 | -6.37 | 59.52% | CHEMBL205665 |
| Curcumin | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -8.91 | -9.56 | -9.27 | 60.19% | CHEMBL237225 |
| Fentanyl | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.69 | -9.34 | -7.47 | 47.11% | CHEMBL340011 |
| Sulfasalazine | PRGR_HUMAN | progesterone receptor | -5.93 | -4.66 | -7.63 | 43.54% | CHEMBL3961285 |
| Aceclofenac | PRGR_HUMAN | progesterone receptor | -8.15 | -8.64 | -8.30 | 41.94% | CHEMBL117612 |
| Alclofenac | PRGR_HUMAN | progesterone receptor | -6.46 | -6.69 | -6.49 | 36.97% | CHEMBL235063 |
| Curcumin | PRGR_HUMAN | progesterone receptor | -7.06 | -7.82 | -7.75 | 54.64% | CHEMBL49978 |
| Fentanyl | PRGR_HUMAN | progesterone receptor | -8.55 | -7.85 | -9.53 | 48.00% | CHEMBL332502 |
| Sulfasalazine | PTGES_HUMAN | prostaglandin E synthase | -9.14 | N/A | N/A | 43.37% | CHEMBL3092270 |
| Aceclofenac | PTGES_HUMAN | prostaglandin E synthase | -6.91 | N/A | N/A | 33.95% | CHEMBL1683861 |
| Alclofenac | PTGES_HUMAN | prostaglandin E synthase | -5.37 | N/A | N/A | 36.29% | CHEMBL3604186 |
| Curcumin | PTGES_HUMAN | prostaglandin E synthase | -7.57 | N/A | N/A | 100.00% | CHEMBL140 |
| Fentanyl | PTGES_HUMAN | prostaglandin E synthase | -6.97 | N/A | N/A | 53.33% | CHEMBL4086788 |
| Sulfasalazine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.64 | -9.22 | -9.97 | 35.15% | CHEMBL1836102 |
| Aceclofenac | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.52 | -8.09 | -8.62 | 43.31% | CHEMBL3799596 |
| Alclofenac | SC6A4_HUMAN | solute carrier family 6 member 4 | -6.99 | -6.93 | -7.08 | 46.53% | CHEMBL451178 |
| Curcumin | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.26 | -9.12 | -9.49 | 43.90% | CHEMBL612232 |
| Fentanyl | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.64 | -9.19 | -9.51 | 65.48% | CHEMBL564288 |
| Sulfasalazine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -9.11 | N/A | N/A | 48.35% | CHEMBL2324393 |
| Aceclofenac | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.21 | N/A | N/A | 36.84% | CHEMBL3581050 |
| Alclofenac | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.09 | N/A | N/A | 39.82% | CHEMBL3657901 |
| Curcumin | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.52 | N/A | N/A | 29.03% | CHEMBL203440 |
| Fentanyl | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.54 | N/A | N/A | 59.09% | CHEMBL2152693 |
| Sulfasalazine | TLR4_HUMAN | toll like receptor 4 | -8.11 | -8.69 | -8.76 | 30.86% | CHEMBL3823499 |
| Aceclofenac | TLR4_HUMAN | toll like receptor 4 | -6.89 | -6.96 | -6.87 | 24.68% | CHEMBL2419465 |
| Alclofenac | TLR4_HUMAN | toll like receptor 4 | -6.08 | -5.80 | -6.59 | 26.88% | CHEMBL1223751 |
| Curcumin | TLR4_HUMAN | toll like receptor 4 | -7.67 | -8.11 | -7.96 | 34.85% | CHEMBL4071705 |
| Fentanyl | TLR4_HUMAN | toll like receptor 4 | -8.33 | -8.16 | -8.74 | 39.05% | CHEMBL1223752 |
| Sulfasalazine | TNFA_HUMAN | tumor necrosis factor | -7.92 | N/A | N/A | 32.78% | CHEMBL1465706 |
| Aceclofenac | TNFA_HUMAN | tumor necrosis factor | -7.01 | N/A | N/A | 29.85% | CHEMBL1612423 |
| Alclofenac | TNFA_HUMAN | tumor necrosis factor | -5.87 | N/A | N/A | 35.20% | CHEMBL72511 |
| Curcumin | TNFA_HUMAN | tumor necrosis factor | -7.28 | N/A | N/A | 32.43% | CHEMBL2337619 |
| Fentanyl | TNFA_HUMAN | tumor necrosis factor | -7.78 | N/A | N/A | 44.86% | CHEMBL1612423 |
| Sulfasalazine | TRBM_HUMAN | thrombomodulin | -9.44 | -8.25 | N/A | N/A | N/A |
| Aceclofenac | TRBM_HUMAN | thrombomodulin | -7.34 | -7.26 | N/A | N/A | N/A |
| Alclofenac | TRBM_HUMAN | thrombomodulin | -6.05 | -5.96 | N/A | N/A | N/A |
| Curcumin | TRBM_HUMAN | thrombomodulin | -8.50 | -6.87 | N/A | N/A | N/A |
| Fentanyl | TRBM_HUMAN | thrombomodulin | -7.60 | -6.70 | N/A | N/A | N/A |
| Sulfasalazine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -8.60 | -7.70 | N/A | N/A | N/A |
| Aceclofenac | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.67 | -6.48 | N/A | N/A | N/A |
| Alclofenac | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -5.42 | -5.93 | N/A | N/A | N/A |
| Curcumin | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -8.80 | -7.22 | N/A | N/A | N/A |
| Fentanyl | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.92 | -7.11 | N/A | N/A | N/A |
| Sulfasalazine | TRPM8_FICAL | Uncharacterized protein | -10.50 | N/A | N/A | N/A | N/A |
| Aceclofenac | TRPM8_FICAL | Uncharacterized protein | -8.09 | N/A | N/A | N/A | N/A |
| Alclofenac | TRPM8_FICAL | Uncharacterized protein | -6.37 | N/A | N/A | N/A | N/A |
| Curcumin | TRPM8_FICAL | Uncharacterized protein | -8.64 | N/A | N/A | N/A | N/A |
| Fentanyl | TRPM8_FICAL | Uncharacterized protein | -9.23 | N/A | N/A | N/A | N/A |
| Sulfasalazine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -9.09 | N/A | N/A | 37.16% | CHEMBL214880 |
| Aceclofenac | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.51 | N/A | N/A | 37.21% | CHEMBL258265 |
| Alclofenac | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.03 | N/A | N/A | 53.47% | CHEMBL2057854 |
| Curcumin | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.35 | N/A | N/A | 44.55% | CHEMBL294199 |
| Fentanyl | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.17 | N/A | N/A | 47.37% | CHEMBL2057855 |
| Sulfasalazine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.82 | -9.06 | N/A | N/A | N/A |
| Aceclofenac | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.72 | -8.16 | N/A | N/A | N/A |
| Alclofenac | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.40 | -6.24 | N/A | N/A | N/A |
| Curcumin | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.54 | -8.09 | N/A | N/A | N/A |
| Fentanyl | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.27 | -8.55 | N/A | N/A | N/A |
| Sulfasalazine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.51 | -7.84 | N/A | 27.59% | CHEMBL3692265 |
| Aceclofenac | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.72 | -6.96 | N/A | 27.14% | CHEMBL3828278 |
| Alclofenac | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.33 | -5.99 | N/A | 34.48% | CHEMBL3664218 |
| Curcumin | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.56 | -6.79 | N/A | 25.64% | CHEMBL3664218 |
| Fentanyl | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.99 | -6.85 | N/A | 36.24% | CHEMBL3943107 |
| Sulfasalazine | TRXR1_HUMAN | thioredoxin reductase 1 | -7.91 | -10.21 | -7.35 | N/A | N/A |
| Aceclofenac | TRXR1_HUMAN | thioredoxin reductase 1 | -7.13 | -7.26 | -6.19 | N/A | N/A |
| Alclofenac | TRXR1_HUMAN | thioredoxin reductase 1 | -6.04 | -6.13 | -4.93 | N/A | N/A |
| Curcumin | TRXR1_HUMAN | thioredoxin reductase 1 | -7.44 | -8.57 | -6.63 | N/A | N/A |
| Fentanyl | TRXR1_HUMAN | thioredoxin reductase 1 | -8.00 | -7.73 | -6.52 | N/A | N/A |
| Sulfasalazine | TRY1_HUMAN | serine protease 1 | -7.71 | N/A | N/A | 41.03% | CHEMBL348038 |
| Aceclofenac | TRY1_HUMAN | serine protease 1 | -6.15 | N/A | N/A | 37.86% | CHEMBL590799 |
| Alclofenac | TRY1_HUMAN | serine protease 1 | -5.55 | N/A | N/A | 41.23% | CHEMBL433135 |
| Curcumin | TRY1_HUMAN | serine protease 1 | -7.17 | N/A | N/A | 31.43% | CHEMBL85154 |
| Fentanyl | TRY1_HUMAN | serine protease 1 | -6.25 | N/A | N/A | 48.28% | CHEMBL421370 |