| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Amitriptyline | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.01 | -8.74 | -9.17 | 34.75% | CHEMBL81191 |
| Tramadol | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -7.29 | -7.11 | -7.34 | 55.96% | CHEMBL515472 |
| Ibuprofen | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -6.95 | -7.25 | -7.17 | 38.89% | CHEMBL73281 |
| Fenbufen | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.42 | -8.41 | -8.65 | 34.65% | CHEMBL191460 |
| Diclofenac | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.19 | -8.46 | -8.22 | 30.37% | CHEMBL71091 |
| Amitriptyline | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.52 | -9.21 | N/A | 100.00% | CHEMBL445 |
| Tramadol | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.55 | -7.70 | N/A | 64.00% | CHEMBL493129 |
| Ibuprofen | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.38 | -7.27 | N/A | 50.00% | CHEMBL104088 |
| Fenbufen | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.03 | -8.54 | N/A | 50.53% | CHEMBL3104518 |
| Diclofenac | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.06 | -8.28 | N/A | 46.53% | CHEMBL415 |
| Amitriptyline | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.74 | -8.87 | -8.77 | 100.00% | CHEMBL445 |
| Tramadol | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.72 | -7.21 | -7.11 | 64.00% | CHEMBL493129 |
| Ibuprofen | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -7.22 | -8.14 | -7.29 | 52.00% | CHEMBL475643 |
| Fenbufen | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.11 | -8.49 | -8.55 | 46.03% | CHEMBL475643 |
| Diclofenac | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.22 | -8.68 | -8.66 | 46.53% | CHEMBL415 |
| Amitriptyline | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -9.03 | -9.66 | N/A | 100.00% | CHEMBL445 |
| Tramadol | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -7.14 | -7.76 | N/A | 64.00% | CHEMBL493129 |
| Ibuprofen | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.00 | -8.13 | N/A | 52.00% | CHEMBL475643 |
| Fenbufen | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.05 | -8.88 | N/A | 46.03% | CHEMBL475643 |
| Diclofenac | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.44 | -8.58 | N/A | 46.53% | CHEMBL415 |
| Amitriptyline | AA1R_HUMAN | adenosine A1 receptor | -8.56 | -8.94 | -9.39 | 27.04% | CHEMBL2382438 |
| Tramadol | AA1R_HUMAN | adenosine A1 receptor | -7.41 | -7.22 | -7.24 | 37.91% | CHEMBL3317576 |
| Ibuprofen | AA1R_HUMAN | adenosine A1 receptor | -7.23 | -7.03 | -7.92 | 31.46% | CHEMBL1544 |
| Fenbufen | AA1R_HUMAN | adenosine A1 receptor | -8.39 | -9.30 | -8.69 | 30.36% | CHEMBL221407 |
| Diclofenac | AA1R_HUMAN | adenosine A1 receptor | -7.29 | -7.36 | -7.74 | 29.75% | CHEMBL2260644 |
| Amitriptyline | AA2AR_HUMAN | adenosine A2a receptor | -9.09 | -9.38 | -9.90 | 30.85% | CHEMBL86771 |
| Tramadol | AA2AR_HUMAN | adenosine A2a receptor | -6.78 | -6.92 | -8.10 | 37.91% | CHEMBL3317576 |
| Ibuprofen | AA2AR_HUMAN | adenosine A2a receptor | -7.12 | -7.39 | -7.43 | 26.39% | CHEMBL86771 |
| Fenbufen | AA2AR_HUMAN | adenosine A2a receptor | -8.52 | -8.62 | -8.64 | 29.31% | CHEMBL225460 |
| Diclofenac | AA2AR_HUMAN | adenosine A2a receptor | -7.76 | -7.71 | -8.16 | 34.91% | CHEMBL603094 |
| Amitriptyline | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.17 | -9.24 | -9.47 | 42.86% | CHEMBL52347 |
| Tramadol | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.73 | -7.87 | -7.81 | 65.05% | CHEMBL1083056 |
| Ibuprofen | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.67 | -7.22 | -8.03 | 52.73% | CHEMBL157327 |
| Fenbufen | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.61 | -8.39 | -9.47 | 58.73% | CHEMBL157327 |
| Diclofenac | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.71 | -8.16 | -9.38 | 35.43% | CHEMBL1085858 |
| Amitriptyline | ACE_HUMAN | angiotensin I converting enzyme | -8.29 | -8.25 | -7.14 | 24.77% | CHEMBL10247 |
| Tramadol | ACE_HUMAN | angiotensin I converting enzyme | -6.78 | -6.84 | -6.72 | 45.53% | CHEMBL254495 |
| Ibuprofen | ACE_HUMAN | angiotensin I converting enzyme | -6.79 | -6.29 | -5.89 | 46.27% | CHEMBL80667 |
| Fenbufen | ACE_HUMAN | angiotensin I converting enzyme | -8.59 | -7.26 | -7.07 | 43.82% | CHEMBL258333 |
| Diclofenac | ACE_HUMAN | angiotensin I converting enzyme | -7.45 | -7.41 | -7.29 | 29.63% | CHEMBL23849 |
| Amitriptyline | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.18 | N/A | N/A | 14.21% | CHEMBL386114 |
| Tramadol | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.61 | N/A | N/A | 25.14% | CHEMBL386114 |
| Ibuprofen | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.85 | N/A | N/A | 16.97% | CHEMBL386114 |
| Fenbufen | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.17 | N/A | N/A | 20.81% | CHEMBL386114 |
| Diclofenac | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.09 | N/A | N/A | 17.01% | CHEMBL386114 |
| Amitriptyline | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.20 | -4.23 | -7.20 | N/A | N/A |
| Tramadol | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.39 | -7.14 | -6.62 | N/A | N/A |
| Ibuprofen | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.64 | -8.03 | -7.08 | N/A | N/A |
| Fenbufen | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.00 | -8.38 | -8.60 | N/A | N/A |
| Diclofenac | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.54 | -8.23 | -6.56 | N/A | N/A |
| Amitriptyline | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.10 | -2.87 | N/A | 100.00% | CHEMBL445 |
| Tramadol | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.66 | -4.80 | N/A | 73.68% | CHEMBL1490 |
| Ibuprofen | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.76 | -7.22 | N/A | 51.52% | CHEMBL2164888 |
| Fenbufen | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.91 | -7.13 | N/A | 46.34% | CHEMBL2107687 |
| Diclofenac | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.76 | -4.91 | N/A | 46.53% | CHEMBL415 |
| Amitriptyline | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.85 | -9.42 | N/A | 100.00% | CHEMBL445 |
| Tramadol | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.43 | -7.15 | N/A | 73.68% | CHEMBL1490 |
| Ibuprofen | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.86 | -7.83 | N/A | 50.00% | CHEMBL2377392 |
| Fenbufen | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.85 | -8.71 | N/A | 46.34% | CHEMBL2107687 |
| Diclofenac | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.67 | -7.51 | N/A | 46.53% | CHEMBL415 |
| Amitriptyline | ADRB2_HUMAN | adrenoceptor beta 2 | -8.59 | -8.28 | -9.13 | 31.62% | CHEMBL120278 |
| Tramadol | ADRB2_HUMAN | adrenoceptor beta 2 | -7.28 | -7.71 | -7.58 | 60.67% | CHEMBL3099663 |
| Ibuprofen | ADRB2_HUMAN | adrenoceptor beta 2 | -6.74 | -8.09 | -7.38 | 37.33% | CHEMBL1332942 |
| Fenbufen | ADRB2_HUMAN | adrenoceptor beta 2 | -7.91 | -9.23 | -8.67 | 39.80% | CHEMBL270964 |
| Diclofenac | ADRB2_HUMAN | adrenoceptor beta 2 | -7.35 | -8.61 | -8.50 | 44.95% | CHEMBL154419 |
| Amitriptyline | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.58 | -8.35 | -8.46 | 26.15% | CHEMBL128416 |
| Tramadol | AGTR2_HUMAN | angiotensin II receptor type 2 | -6.93 | -6.94 | -6.63 | 38.89% | CHEMBL154057 |
| Ibuprofen | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.17 | -7.19 | -6.89 | 30.69% | CHEMBL128416 |
| Fenbufen | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.87 | -8.93 | -8.57 | 31.71% | CHEMBL290286 |
| Diclofenac | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.57 | -7.50 | -7.34 | 25.67% | CHEMBL40381 |
| Amitriptyline | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.40 | -8.55 | -8.17 | 35.51% | CHEMBL538917 |
| Tramadol | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.61 | -7.90 | -7.04 | 42.02% | CHEMBL70190 |
| Ibuprofen | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.64 | -7.40 | -8.22 | 54.55% | CHEMBL77283 |
| Fenbufen | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.70 | -8.63 | -9.33 | 44.30% | CHEMBL51483 |
| Diclofenac | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.93 | -7.61 | -7.76 | 35.23% | CHEMBL77283 |
| Amitriptyline | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.26 | -8.78 | -8.43 | 30.38% | CHEMBL414393 |
| Tramadol | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.55 | -7.16 | -6.77 | 34.71% | CHEMBL1941150 |
| Ibuprofen | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.84 | -7.66 | -6.20 | 42.00% | CHEMBL414393 |
| Fenbufen | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.31 | -9.30 | -7.68 | 48.19% | CHEMBL1821978 |
| Diclofenac | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.15 | -8.06 | -7.99 | 29.69% | CHEMBL3764432 |
| Amitriptyline | AOFA_HUMAN | monoamine oxidase A | -8.92 | -9.02 | -9.91 | 48.86% | CHEMBL24172 |
| Tramadol | AOFA_HUMAN | monoamine oxidase A | -7.93 | -7.60 | -8.51 | 47.52% | CHEMBL3288291 |
| Ibuprofen | AOFA_HUMAN | monoamine oxidase A | -7.48 | -7.53 | -8.08 | 48.15% | CHEMBL3330339 |
| Fenbufen | AOFA_HUMAN | monoamine oxidase A | -8.69 | -8.78 | -10.02 | 44.62% | CHEMBL1070 |
| Diclofenac | AOFA_HUMAN | monoamine oxidase A | -8.04 | -8.37 | -8.67 | 35.65% | CHEMBL1642672 |
| Amitriptyline | AOFB_HUMAN | monoamine oxidase B | -10.28 | -9.38 | -10.05 | 40.00% | CHEMBL122279 |
| Tramadol | AOFB_HUMAN | monoamine oxidase B | -8.15 | -8.24 | -8.28 | 59.78% | CHEMBL4113794 |
| Ibuprofen | AOFB_HUMAN | monoamine oxidase B | -7.95 | -8.03 | -7.84 | 48.15% | CHEMBL3330339 |
| Fenbufen | AOFB_HUMAN | monoamine oxidase B | -9.21 | -9.71 | -9.59 | 44.32% | CHEMBL3288305 |
| Diclofenac | AOFB_HUMAN | monoamine oxidase B | -8.49 | -8.36 | -8.88 | 36.44% | CHEMBL3319243 |
| Amitriptyline | BACE1_HUMAN | beta-secretase 1 | -7.01 | -7.82 | -8.44 | 38.85% | CHEMBL3747026 |
| Tramadol | BACE1_HUMAN | beta-secretase 1 | -6.40 | -6.38 | -6.93 | 58.42% | CHEMBL142715 |
| Ibuprofen | BACE1_HUMAN | beta-secretase 1 | -5.95 | -6.06 | -6.89 | 32.14% | CHEMBL1092504 |
| Fenbufen | BACE1_HUMAN | beta-secretase 1 | -6.67 | -7.56 | -8.43 | 38.04% | CHEMBL1092504 |
| Diclofenac | BACE1_HUMAN | beta-secretase 1 | -6.69 | -6.82 | -7.46 | 33.06% | CHEMBL3627961 |
| Amitriptyline | CAH2_HUMAN | carbonic anhydrase 2 | -7.58 | -8.59 | -8.74 | 29.47% | CHEMBL926 |
| Tramadol | CAH2_HUMAN | carbonic anhydrase 2 | -6.87 | -6.94 | -6.39 | 62.82% | CHEMBL4089410 |
| Ibuprofen | CAH2_HUMAN | carbonic anhydrase 2 | -6.86 | -6.55 | -6.63 | 43.75% | CHEMBL451332 |
| Fenbufen | CAH2_HUMAN | carbonic anhydrase 2 | -7.34 | -7.20 | -7.33 | 47.44% | CHEMBL4068228 |
| Diclofenac | CAH2_HUMAN | carbonic anhydrase 2 | -7.31 | -7.42 | -7.15 | 44.58% | CHEMBL23832 |
| Amitriptyline | CASP1_HUMAN | caspase 1 | -5.96 | -7.72 | -6.36 | 25.00% | CHEMBL466565 |
| Tramadol | CASP1_HUMAN | caspase 1 | -5.45 | -6.85 | -5.11 | 50.96% | CHEMBL1221503 |
| Ibuprofen | CASP1_HUMAN | caspase 1 | -5.84 | -6.94 | -5.64 | 38.46% | CHEMBL466565 |
| Fenbufen | CASP1_HUMAN | caspase 1 | -6.42 | -7.66 | -6.64 | 41.76% | CHEMBL1221546 |
| Diclofenac | CASP1_HUMAN | caspase 1 | -5.75 | -6.77 | -5.58 | 32.35% | CHEMBL78154 |
| Amitriptyline | CDK5_HUMAN | cyclin dependent kinase 5 | -8.26 | -8.43 | -6.60 | 66.25% | CHEMBL1988201 |
| Tramadol | CDK5_HUMAN | cyclin dependent kinase 5 | -6.74 | -6.59 | -6.43 | 37.00% | CHEMBL1988201 |
| Ibuprofen | CDK5_HUMAN | cyclin dependent kinase 5 | -7.10 | -7.44 | -8.10 | 30.23% | CHEMBL1974288 |
| Fenbufen | CDK5_HUMAN | cyclin dependent kinase 5 | -8.10 | -8.22 | -9.49 | 37.63% | CHEMBL1974288 |
| Diclofenac | CDK5_HUMAN | cyclin dependent kinase 5 | -7.33 | -7.84 | -8.35 | 46.43% | CHEMBL1991734 |
| Amitriptyline | CHLE_HUMAN | butyrylcholinesterase | -9.56 | -9.11 | -9.29 | 33.98% | CHEMBL2381387 |
| Tramadol | CHLE_HUMAN | butyrylcholinesterase | -7.62 | -7.29 | -7.44 | 53.00% | CHEMBL3818250 |
| Ibuprofen | CHLE_HUMAN | butyrylcholinesterase | -7.66 | -7.36 | -7.33 | 41.54% | CHEMBL51931 |
| Fenbufen | CHLE_HUMAN | butyrylcholinesterase | -8.19 | -8.11 | -8.28 | 47.95% | CHEMBL51931 |
| Diclofenac | CHLE_HUMAN | butyrylcholinesterase | -8.65 | -8.20 | -8.70 | 45.59% | CHEMBL3087676 |
| Amitriptyline | CNR1_HUMAN | cannabinoid receptor 1 | -9.35 | -9.46 | -10.12 | 47.41% | CHEMBL148805 |
| Tramadol | CNR1_HUMAN | cannabinoid receptor 1 | -6.91 | -8.21 | -8.13 | 68.97% | CHEMBL3321781 |
| Ibuprofen | CNR1_HUMAN | cannabinoid receptor 1 | -7.43 | -7.51 | -7.98 | 51.61% | CHEMBL391380 |
| Fenbufen | CNR1_HUMAN | cannabinoid receptor 1 | -8.19 | -8.76 | -9.17 | 62.50% | CHEMBL234014 |
| Diclofenac | CNR1_HUMAN | cannabinoid receptor 1 | -7.80 | -8.14 | -8.82 | 46.55% | CHEMBL3936647 |
| Amitriptyline | CNR2_HUMAN | cannabinoid receptor 2 | -9.87 | -10.01 | N/A | 47.41% | CHEMBL148805 |
| Tramadol | CNR2_HUMAN | cannabinoid receptor 2 | -8.02 | -8.23 | N/A | 63.73% | CHEMBL1765250 |
| Ibuprofen | CNR2_HUMAN | cannabinoid receptor 2 | -7.61 | -7.51 | N/A | 55.32% | CHEMBL264412 |
| Fenbufen | CNR2_HUMAN | cannabinoid receptor 2 | -9.28 | -9.03 | N/A | 62.50% | CHEMBL234014 |
| Diclofenac | CNR2_HUMAN | cannabinoid receptor 2 | -8.58 | -8.70 | N/A | 38.18% | CHEMBL2326302 |
| Amitriptyline | COLI_HUMAN | proopiomelanocortin | -8.35 | -8.47 | -6.96 | N/A | N/A |
| Tramadol | COLI_HUMAN | proopiomelanocortin | -6.76 | -6.89 | -6.49 | N/A | N/A |
| Ibuprofen | COLI_HUMAN | proopiomelanocortin | -7.62 | -7.61 | -6.34 | N/A | N/A |
| Fenbufen | COLI_HUMAN | proopiomelanocortin | -8.41 | -8.60 | -7.59 | N/A | N/A |
| Diclofenac | COLI_HUMAN | proopiomelanocortin | -7.40 | -7.19 | -7.23 | N/A | N/A |
| Amitriptyline | COMT_HUMAN | catechol-O-methyltransferase | -7.06 | -6.68 | -6.95 | 21.13% | CHEMBL953 |
| Tramadol | COMT_HUMAN | catechol-O-methyltransferase | -5.26 | -5.22 | -5.33 | 32.58% | CHEMBL3425731 |
| Ibuprofen | COMT_HUMAN | catechol-O-methyltransferase | -5.73 | -5.76 | -6.03 | 23.16% | CHEMBL1324 |
| Fenbufen | COMT_HUMAN | catechol-O-methyltransferase | -6.42 | -7.03 | -6.90 | 26.35% | CHEMBL3425740 |
| Diclofenac | COMT_HUMAN | catechol-O-methyltransferase | -6.26 | -6.12 | -6.36 | 22.76% | CHEMBL1324 |
| Amitriptyline | CRP_HUMAN | C-reactive protein | -6.95 | -5.78 | N/A | N/A | N/A |
| Tramadol | CRP_HUMAN | C-reactive protein | -5.16 | -5.33 | N/A | N/A | N/A |
| Ibuprofen | CRP_HUMAN | C-reactive protein | -5.53 | -5.09 | N/A | N/A | N/A |
| Fenbufen | CRP_HUMAN | C-reactive protein | -5.91 | -6.04 | N/A | N/A | N/A |
| Diclofenac | CRP_HUMAN | C-reactive protein | -5.84 | -5.77 | N/A | N/A | N/A |
| Amitriptyline | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.20 | N/A | N/A | 24.75% | CHEMBL191413 |
| Tramadol | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.34 | N/A | N/A | 26.88% | CHEMBL490688 |
| Ibuprofen | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.43 | N/A | N/A | 44.62% | CHEMBL191413 |
| Fenbufen | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.43 | N/A | N/A | 30.95% | CHEMBL191413 |
| Diclofenac | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.66 | N/A | N/A | 100.00% | CHEMBL139 |
| Amitriptyline | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.26 | -6.94 | -8.06 | 28.32% | CHEMBL126657 |
| Tramadol | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.88 | -6.22 | -6.65 | 37.25% | CHEMBL1644072 |
| Ibuprofen | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.11 | -5.46 | -6.38 | 25.00% | CHEMBL2180085 |
| Fenbufen | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.31 | -7.00 | -7.54 | 27.20% | CHEMBL366033 |
| Diclofenac | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.70 | -6.68 | -7.09 | 28.18% | CHEMBL3908835 |
| Amitriptyline | DRD2_HUMAN | dopamine receptor D2 | -8.63 | N/A | N/A | 100.00% | CHEMBL629 |
| Tramadol | DRD2_HUMAN | dopamine receptor D2 | -6.64 | N/A | N/A | 64.00% | CHEMBL1946122 |
| Ibuprofen | DRD2_HUMAN | dopamine receptor D2 | -7.04 | N/A | N/A | 38.89% | CHEMBL1258270 |
| Fenbufen | DRD2_HUMAN | dopamine receptor D2 | -9.03 | N/A | N/A | 45.00% | CHEMBL1258270 |
| Diclofenac | DRD2_HUMAN | dopamine receptor D2 | -7.22 | N/A | N/A | 46.53% | CHEMBL415 |
| Amitriptyline | DRD3_HUMAN | dopamine receptor D3 | -8.14 | N/A | N/A | 100.00% | CHEMBL629 |
| Tramadol | DRD3_HUMAN | dopamine receptor D3 | -6.73 | N/A | N/A | 64.00% | CHEMBL3321789 |
| Ibuprofen | DRD3_HUMAN | dopamine receptor D3 | -7.07 | N/A | N/A | 39.71% | CHEMBL1765637 |
| Fenbufen | DRD3_HUMAN | dopamine receptor D3 | -8.20 | N/A | N/A | 45.00% | CHEMBL1258270 |
| Diclofenac | DRD3_HUMAN | dopamine receptor D3 | -7.96 | N/A | N/A | 46.53% | CHEMBL415 |
| Amitriptyline | DRD4_HUMAN | dopamine receptor D4 | -8.96 | -9.15 | N/A | 53.45% | CHEMBL91350 |
| Tramadol | DRD4_HUMAN | dopamine receptor D4 | -7.13 | -7.05 | N/A | 60.00% | CHEMBL135944 |
| Ibuprofen | DRD4_HUMAN | dopamine receptor D4 | -7.20 | -7.21 | N/A | 38.89% | CHEMBL1258270 |
| Fenbufen | DRD4_HUMAN | dopamine receptor D4 | -7.94 | -8.05 | N/A | 45.00% | CHEMBL1258270 |
| Diclofenac | DRD4_HUMAN | dopamine receptor D4 | -8.10 | -8.17 | N/A | 38.84% | CHEMBL322326 |
| Amitriptyline | EDN1_HUMAN | endothelin 1 | -7.26 | N/A | N/A | N/A | N/A |
| Tramadol | EDN1_HUMAN | endothelin 1 | -6.17 | N/A | N/A | N/A | N/A |
| Ibuprofen | EDN1_HUMAN | endothelin 1 | -7.29 | N/A | N/A | N/A | N/A |
| Fenbufen | EDN1_HUMAN | endothelin 1 | -7.91 | N/A | N/A | N/A | N/A |
| Diclofenac | EDN1_HUMAN | endothelin 1 | -6.83 | N/A | N/A | N/A | N/A |
| Amitriptyline | ESR1_HUMAN | estrogen receptor 1 | -9.19 | -9.23 | -9.04 | 57.14% | CHEMBL48352 |
| Tramadol | ESR1_HUMAN | estrogen receptor 1 | -7.53 | -7.51 | -7.48 | 57.45% | CHEMBL1222035 |
| Ibuprofen | ESR1_HUMAN | estrogen receptor 1 | -7.15 | -6.98 | -7.31 | 61.82% | CHEMBL335412 |
| Fenbufen | ESR1_HUMAN | estrogen receptor 1 | -8.25 | -7.71 | -7.78 | 47.14% | CHEMBL45068 |
| Diclofenac | ESR1_HUMAN | estrogen receptor 1 | -7.95 | -7.67 | -7.73 | 36.63% | CHEMBL3234617 |
| Amitriptyline | FABP5_HUMAN | fatty acid binding protein 5 | -8.43 | -5.88 | -5.67 | 15.85% | CHEMBL3959018 |
| Tramadol | FABP5_HUMAN | fatty acid binding protein 5 | -6.95 | -5.24 | -4.86 | 35.54% | CHEMBL378857 |
| Ibuprofen | FABP5_HUMAN | fatty acid binding protein 5 | -6.80 | -4.79 | -5.02 | 35.56% | CHEMBL212860 |
| Fenbufen | FABP5_HUMAN | fatty acid binding protein 5 | -7.50 | -5.37 | -5.85 | 26.79% | CHEMBL82293 |
| Diclofenac | FABP5_HUMAN | fatty acid binding protein 5 | -7.55 | -5.19 | -5.40 | 34.48% | CHEMBL212860 |
| Amitriptyline | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.93 | N/A | N/A | 28.32% | CHEMBL305660 |
| Tramadol | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.28 | N/A | N/A | 44.66% | CHEMBL305660 |
| Ibuprofen | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.96 | N/A | N/A | 41.79% | CHEMBL1975923 |
| Fenbufen | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.63 | N/A | N/A | 48.00% | CHEMBL1975923 |
| Diclofenac | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.93 | N/A | N/A | 46.43% | CHEMBL1991734 |
| Amitriptyline | GLRA3_HUMAN | glycine receptor alpha 3 | -9.47 | -8.76 | -8.84 | 14.76% | CHEMBL4074873 |
| Amitriptyline | GLRA3_HUMAN | glycine receptor alpha 3 | -9.35 | N/A | N/A | 14.76% | CHEMBL4074873 |
| Tramadol | GLRA3_HUMAN | glycine receptor alpha 3 | -7.30 | -7.39 | -7.23 | 23.00% | CHEMBL4070615 |
| Tramadol | GLRA3_HUMAN | glycine receptor alpha 3 | -8.42 | N/A | N/A | 23.00% | CHEMBL4070615 |
| Ibuprofen | GLRA3_HUMAN | glycine receptor alpha 3 | -7.26 | -7.35 | -7.50 | 11.17% | CHEMBL4074873 |
| Ibuprofen | GLRA3_HUMAN | glycine receptor alpha 3 | -7.98 | N/A | N/A | 11.17% | CHEMBL4074873 |
| Fenbufen | GLRA3_HUMAN | glycine receptor alpha 3 | -8.02 | -8.18 | -8.10 | 13.08% | CHEMBL4070615 |
| Fenbufen | GLRA3_HUMAN | glycine receptor alpha 3 | -9.70 | N/A | N/A | 13.08% | CHEMBL4070615 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.85 | -8.83 | -8.93 | 13.55% | CHEMBL4074873 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.66 | N/A | N/A | 13.55% | CHEMBL4074873 |
| Amitriptyline | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.87 | -5.71 | -5.23 | 28.18% | CHEMBL1289626 |
| Tramadol | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.10 | -5.15 | -5.49 | 49.48% | CHEMBL1289626 |
| Ibuprofen | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.45 | -8.06 | -8.11 | 42.65% | CHEMBL1682794 |
| Fenbufen | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.83 | -9.77 | -9.42 | 53.95% | CHEMBL1682795 |
| Diclofenac | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.67 | -7.54 | -6.82 | 37.01% | CHEMBL239594 |
| Amitriptyline | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -9.02 | -7.11 | -6.84 | 20.34% | CHEMBL3698265 |
| Tramadol | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.90 | -5.55 | -5.43 | 28.40% | CHEMBL3698265 |
| Ibuprofen | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.73 | -6.80 | -7.49 | 22.45% | CHEMBL3907283 |
| Fenbufen | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.14 | -7.68 | -8.68 | 31.58% | CHEMBL2035656 |
| Diclofenac | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.28 | -6.68 | -7.62 | 30.18% | CHEMBL572528 |
| Amitriptyline | HRH1_HUMAN | histamine receptor H1 | -9.96 | N/A | N/A | 100.00% | CHEMBL629 |
| Tramadol | HRH1_HUMAN | histamine receptor H1 | -6.54 | N/A | N/A | 59.22% | CHEMBL476839 |
| Ibuprofen | HRH1_HUMAN | histamine receptor H1 | -8.05 | N/A | N/A | 54.55% | CHEMBL914 |
| Fenbufen | HRH1_HUMAN | histamine receptor H1 | -8.41 | N/A | N/A | 48.72% | CHEMBL570033 |
| Diclofenac | HRH1_HUMAN | histamine receptor H1 | -8.69 | N/A | N/A | 47.06% | CHEMBL2158825 |
| Amitriptyline | HYES_HUMAN | epoxide hydrolase 2 | -8.23 | -8.51 | -8.03 | 31.96% | CHEMBL556303 |
| Tramadol | HYES_HUMAN | epoxide hydrolase 2 | -7.17 | -6.93 | -6.57 | 52.38% | CHEMBL244406 |
| Ibuprofen | HYES_HUMAN | epoxide hydrolase 2 | -7.03 | -7.58 | -7.41 | 38.71% | CHEMBL3763278 |
| Fenbufen | HYES_HUMAN | epoxide hydrolase 2 | -8.36 | -8.76 | -9.08 | 47.67% | CHEMBL3765160 |
| Diclofenac | HYES_HUMAN | epoxide hydrolase 2 | -8.00 | -8.24 | -6.89 | 37.61% | CHEMBL478147 |
| Amitriptyline | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.66 | N/A | N/A | 32.64% | CHEMBL602534 |
| Tramadol | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.62 | N/A | N/A | 45.45% | CHEMBL3318321 |
| Ibuprofen | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.80 | N/A | N/A | 36.71% | CHEMBL3318321 |
| Fenbufen | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.69 | N/A | N/A | 53.09% | CHEMBL3318321 |
| Diclofenac | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.95 | N/A | N/A | 29.66% | CHEMBL3823257 |
| Amitriptyline | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.67 | -8.21 | N/A | 100.00% | CHEMBL629 |
| Tramadol | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.73 | -6.84 | N/A | 69.51% | CHEMBL637 |
| Ibuprofen | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.53 | -6.95 | N/A | 54.55% | CHEMBL914 |
| Fenbufen | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.62 | -8.67 | N/A | 47.14% | CHEMBL45068 |
| Diclofenac | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.33 | -7.51 | N/A | 41.05% | CHEMBL72 |
| Amitriptyline | MIF_HUMAN | macrophage migration inhibitory factor | -7.71 | -7.21 | -6.71 | 21.28% | CHEMBL3797437 |
| Tramadol | MIF_HUMAN | macrophage migration inhibitory factor | -6.41 | -6.39 | -6.76 | 33.12% | CHEMBL554271 |
| Ibuprofen | MIF_HUMAN | macrophage migration inhibitory factor | -7.81 | -7.69 | -8.05 | 25.45% | CHEMBL209588 |
| Fenbufen | MIF_HUMAN | macrophage migration inhibitory factor | -8.65 | -8.63 | -8.70 | 31.62% | CHEMBL209588 |
| Diclofenac | MIF_HUMAN | macrophage migration inhibitory factor | -6.09 | -6.49 | -5.81 | 25.89% | CHEMBL223319 |
| Amitriptyline | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.41 | -8.39 | -6.87 | 32.04% | CHEMBL1909070 |
| Tramadol | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.56 | -6.41 | -5.69 | 41.88% | CHEMBL3752989 |
| Ibuprofen | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.63 | -6.30 | -6.59 | 36.84% | CHEMBL1909070 |
| Fenbufen | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.85 | -7.57 | -7.26 | 40.40% | CHEMBL1998545 |
| Diclofenac | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.07 | -7.62 | -7.94 | 33.06% | CHEMBL2003341 |
| Amitriptyline | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.41 | -8.46 | -8.05 | 19.05% | CHEMBL3798926 |
| Tramadol | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.09 | -6.81 | -6.47 | 32.54% | CHEMBL3113587 |
| Ibuprofen | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.04 | -6.86 | -5.94 | 23.58% | CHEMBL3113587 |
| Fenbufen | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.94 | -8.42 | -7.09 | 32.50% | CHEMBL3798926 |
| Diclofenac | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.75 | -7.65 | -7.67 | 25.49% | CHEMBL3798624 |
| Amitriptyline | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.47 | -9.34 | -9.78 | 28.09% | CHEMBL1256461 |
| Tramadol | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.22 | -7.29 | -7.50 | 33.96% | CHEMBL3972399 |
| Ibuprofen | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.90 | -7.89 | -7.42 | 32.89% | CHEMBL2348411 |
| Fenbufen | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.95 | -9.15 | -8.98 | 36.05% | CHEMBL2348411 |
| Diclofenac | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.87 | -8.29 | -8.13 | 37.76% | CHEMBL2348411 |
| Amitriptyline | NEP_HUMAN | membrane metalloendopeptidase | -7.67 | -6.82 | -6.71 | 25.86% | CHEMBL81710 |
| Tramadol | NEP_HUMAN | membrane metalloendopeptidase | -6.48 | -7.37 | -7.99 | 54.95% | CHEMBL213404 |
| Ibuprofen | NEP_HUMAN | membrane metalloendopeptidase | -8.04 | -7.32 | -7.52 | 42.86% | CHEMBL4070297 |
| Fenbufen | NEP_HUMAN | membrane metalloendopeptidase | -8.34 | -8.95 | -9.29 | 68.12% | CHEMBL4070297 |
| Diclofenac | NEP_HUMAN | membrane metalloendopeptidase | -7.82 | -6.90 | -7.67 | 28.21% | CHEMBL225085 |
| Amitriptyline | NK1R_HUMAN | tachykinin receptor 1 | -8.65 | -9.50 | -8.35 | 45.28% | CHEMBL433107 |
| Tramadol | NK1R_HUMAN | tachykinin receptor 1 | -7.03 | -7.91 | -7.23 | 58.16% | CHEMBL140101 |
| Ibuprofen | NK1R_HUMAN | tachykinin receptor 1 | -6.92 | -7.25 | -6.57 | 43.75% | CHEMBL56811 |
| Fenbufen | NK1R_HUMAN | tachykinin receptor 1 | -7.96 | -8.33 | -7.98 | 39.56% | CHEMBL212173 |
| Diclofenac | NK1R_HUMAN | tachykinin receptor 1 | -7.55 | -8.35 | -7.84 | 34.69% | CHEMBL92032 |
| Amitriptyline | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.76 | -7.63 | -7.43 | 45.83% | CHEMBL284237 |
| Tramadol | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.68 | -7.36 | -7.75 | 26.32% | CHEMBL284237 |
| Ibuprofen | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.13 | -7.89 | -8.40 | 24.14% | CHEMBL284237 |
| Fenbufen | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.33 | -9.23 | -9.43 | 21.57% | CHEMBL284237 |
| Diclofenac | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.50 | -8.80 | -8.42 | 15.54% | CHEMBL2333945 |
| Amitriptyline | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -10.22 | -9.57 | -8.95 | 37.65% | CHEMBL296601 |
| Tramadol | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.56 | -7.87 | -6.57 | 74.16% | CHEMBL3357783 |
| Ibuprofen | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.30 | -8.29 | -8.32 | 33.78% | CHEMBL305187 |
| Fenbufen | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.47 | -9.15 | -9.90 | 32.89% | CHEMBL296601 |
| Diclofenac | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.62 | -8.19 | -9.62 | 25.53% | CHEMBL161977 |
| Amitriptyline | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.00 | -7.48 | -7.43 | 22.79% | CHEMBL419399 |
| Tramadol | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.72 | -7.57 | -7.75 | 34.65% | CHEMBL419399 |
| Ibuprofen | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.17 | -8.01 | -8.40 | 26.17% | CHEMBL419399 |
| Fenbufen | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -9.34 | -9.04 | -9.43 | 24.79% | CHEMBL419399 |
| Diclofenac | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.66 | -8.55 | -8.42 | 28.82% | CHEMBL401253 |
| Amitriptyline | NOS1_HUMAN | nitric oxide synthase 1 | -8.69 | -8.45 | -8.09 | 26.52% | CHEMBL2036264 |
| Tramadol | NOS1_HUMAN | nitric oxide synthase 1 | -6.93 | -7.08 | -7.36 | 43.33% | CHEMBL85613 |
| Ibuprofen | NOS1_HUMAN | nitric oxide synthase 1 | -7.96 | -7.83 | -7.40 | 36.84% | CHEMBL298404 |
| Fenbufen | NOS1_HUMAN | nitric oxide synthase 1 | -9.56 | -9.59 | -8.52 | 33.33% | CHEMBL298404 |
| Diclofenac | NOS1_HUMAN | nitric oxide synthase 1 | -8.26 | -8.29 | -8.68 | 34.82% | CHEMBL49881 |
| Amitriptyline | NOS2_HUMAN | nitric oxide synthase 2 | -6.75 | -8.32 | -8.65 | 30.68% | CHEMBL450583 |
| Tramadol | NOS2_HUMAN | nitric oxide synthase 2 | -5.70 | -7.07 | -7.08 | 50.94% | CHEMBL1762475 |
| Ibuprofen | NOS2_HUMAN | nitric oxide synthase 2 | -7.52 | -7.58 | -7.92 | 33.87% | CHEMBL450583 |
| Fenbufen | NOS2_HUMAN | nitric oxide synthase 2 | -8.18 | -8.45 | -8.46 | 29.13% | CHEMBL49881 |
| Diclofenac | NOS2_HUMAN | nitric oxide synthase 2 | -7.09 | -7.50 | -8.02 | 34.82% | CHEMBL49881 |
| Amitriptyline | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -9.32 | -9.47 | -9.51 | 30.92% | CHEMBL175321 |
| Tramadol | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.16 | -7.21 | -7.18 | 35.29% | CHEMBL1992125 |
| Ibuprofen | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.78 | -8.23 | -8.00 | 23.85% | CHEMBL1978371 |
| Fenbufen | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.84 | -8.98 | -8.89 | 31.87% | CHEMBL1976290 |
| Diclofenac | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.08 | -8.11 | -8.12 | 46.43% | CHEMBL1991734 |
| Amitriptyline | OPRD_HUMAN | opioid receptor delta 1 | -8.00 | -7.77 | -7.62 | 52.48% | CHEMBL126884 |
| Tramadol | OPRD_HUMAN | opioid receptor delta 1 | -6.46 | -5.71 | -5.96 | 100.00% | CHEMBL1237044 |
| Ibuprofen | OPRD_HUMAN | opioid receptor delta 1 | -6.63 | -6.50 | -6.30 | 38.46% | CHEMBL201038 |
| Fenbufen | OPRD_HUMAN | opioid receptor delta 1 | -7.27 | -6.72 | -6.68 | 44.87% | CHEMBL126918 |
| Diclofenac | OPRD_HUMAN | opioid receptor delta 1 | -7.03 | -6.28 | -7.00 | 39.26% | CHEMBL1642757 |
| Amitriptyline | OPRK_HUMAN | opioid receptor kappa 1 | -9.21 | -9.69 | -8.53 | 42.59% | CHEMBL126141 |
| Tramadol | OPRK_HUMAN | opioid receptor kappa 1 | -7.47 | -7.43 | -6.53 | 100.00% | CHEMBL1237044 |
| Ibuprofen | OPRK_HUMAN | opioid receptor kappa 1 | -7.68 | -7.49 | -6.96 | 42.86% | CHEMBL651 |
| Fenbufen | OPRK_HUMAN | opioid receptor kappa 1 | -8.29 | -8.06 | -8.69 | 54.43% | CHEMBL2022019 |
| Diclofenac | OPRK_HUMAN | opioid receptor kappa 1 | -8.51 | -8.39 | -7.73 | 39.26% | CHEMBL1642757 |
| Amitriptyline | OPRM_MOUSE | Mu-type opioid receptor | -8.22 | -8.62 | N/A | 39.66% | CHEMBL362331 |
| Tramadol | OPRM_MOUSE | Mu-type opioid receptor | -7.61 | -6.57 | N/A | 57.14% | CHEMBL592 |
| Ibuprofen | OPRM_MOUSE | Mu-type opioid receptor | -6.47 | -6.85 | N/A | 31.58% | CHEMBL151341 |
| Fenbufen | OPRM_MOUSE | Mu-type opioid receptor | -7.99 | -7.75 | N/A | 33.96% | CHEMBL71301 |
| Diclofenac | OPRM_MOUSE | Mu-type opioid receptor | -7.68 | -7.10 | N/A | 30.19% | CHEMBL596 |
| Amitriptyline | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.00 | -7.36 | -7.66 | 37.17% | CHEMBL425225 |
| Tramadol | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.20 | -6.91 | -6.68 | 69.66% | CHEMBL233494 |
| Ibuprofen | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.35 | -6.38 | -6.89 | 41.86% | CHEMBL186300 |
| Fenbufen | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.53 | -7.37 | -7.57 | 40.00% | CHEMBL3937167 |
| Diclofenac | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.11 | -6.85 | 34.78% | CHEMBL317152 |
| Amitriptyline | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.68 | -5.30 | -5.79 | 28.24% | CHEMBL3679791 |
| Tramadol | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.15 | -4.88 | -5.21 | 39.86% | CHEMBL596234 |
| Ibuprofen | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.85 | -4.65 | -5.29 | 23.86% | CHEMBL2180149 |
| Fenbufen | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.89 | -5.87 | -6.13 | 31.94% | CHEMBL3669699 |
| Diclofenac | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.89 | -4.93 | -5.45 | 45.71% | CHEMBL3958199 |
| Amitriptyline | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.50 | -5.05 | -6.93 | 20.38% | CHEMBL455536 |
| Tramadol | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.25 | -6.61 | -7.16 | 40.62% | CHEMBL88799 |
| Ibuprofen | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.79 | -8.09 | -8.16 | 35.11% | CHEMBL91127 |
| Fenbufen | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.61 | -9.03 | -8.77 | 39.81% | CHEMBL420980 |
| Diclofenac | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.30 | -6.08 | -7.72 | 30.00% | CHEMBL223344 |
| Amitriptyline | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.29 | N/A | N/A | 26.95% | CHEMBL3091987 |
| Tramadol | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.82 | N/A | N/A | 43.18% | CHEMBL80942 |
| Ibuprofen | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.30 | N/A | N/A | 30.59% | CHEMBL3658406 |
| Fenbufen | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.15 | N/A | N/A | 37.70% | CHEMBL2012487 |
| Diclofenac | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.31 | N/A | N/A | 29.75% | CHEMBL2049115 |
| Amitriptyline | PDE4B_HUMAN | phosphodiesterase 4B | -9.89 | -9.08 | -9.37 | 22.58% | CHEMBL36724 |
| Tramadol | PDE4B_HUMAN | phosphodiesterase 4B | -6.42 | -7.31 | -7.54 | 55.36% | CHEMBL144499 |
| Ibuprofen | PDE4B_HUMAN | phosphodiesterase 4B | -7.37 | -7.59 | -7.75 | 31.68% | CHEMBL3315269 |
| Fenbufen | PDE4B_HUMAN | phosphodiesterase 4B | -8.63 | -9.00 | -8.92 | 39.13% | CHEMBL253083 |
| Diclofenac | PDE4B_HUMAN | phosphodiesterase 4B | -8.10 | -8.03 | -8.13 | 51.82% | CHEMBL3315269 |
| Amitriptyline | PDE5A_HUMAN | phosphodiesterase 5A | -8.08 | -10.38 | -9.19 | 22.60% | CHEMBL422006 |
| Tramadol | PDE5A_HUMAN | phosphodiesterase 5A | -6.42 | -7.24 | -6.80 | 41.09% | CHEMBL190423 |
| Ibuprofen | PDE5A_HUMAN | phosphodiesterase 5A | -7.69 | -7.38 | -7.24 | 22.94% | CHEMBL362755 |
| Fenbufen | PDE5A_HUMAN | phosphodiesterase 5A | -8.55 | -8.56 | -9.13 | 27.56% | CHEMBL190423 |
| Diclofenac | PDE5A_HUMAN | phosphodiesterase 5A | -7.21 | -8.35 | -7.97 | 28.36% | CHEMBL332898 |
| Amitriptyline | PERM_HUMAN | myeloperoxidase | -9.05 | -9.45 | -9.20 | 31.58% | CHEMBL3920217 |
| Tramadol | PERM_HUMAN | myeloperoxidase | -6.98 | -7.15 | -7.06 | 47.79% | CHEMBL490 |
| Ibuprofen | PERM_HUMAN | myeloperoxidase | -6.67 | -6.65 | -6.70 | 32.35% | CHEMBL3892909 |
| Fenbufen | PERM_HUMAN | myeloperoxidase | -7.94 | -8.57 | -7.98 | 32.53% | CHEMBL4096954 |
| Diclofenac | PERM_HUMAN | myeloperoxidase | -7.60 | -7.78 | -7.78 | 41.57% | CHEMBL686 |
| Amitriptyline | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.36 | -9.88 | -8.43 | 44.00% | CHEMBL376583 |
| Tramadol | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.51 | -7.31 | -7.59 | 42.11% | CHEMBL3774686 |
| Ibuprofen | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -7.27 | -7.29 | -7.36 | 100.00% | CHEMBL175 |
| Fenbufen | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -8.54 | -8.46 | -8.03 | 56.90% | CHEMBL317434 |
| Diclofenac | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.22 | -8.31 | -8.48 | 100.00% | CHEMBL139 |
| Amitriptyline | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.08 | -7.03 | -8.69 | 50.47% | CHEMBL80047 |
| Tramadol | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.91 | -5.51 | -7.05 | 43.40% | CHEMBL226109 |
| Ibuprofen | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.38 | -7.47 | -7.29 | 100.00% | CHEMBL427526 |
| Fenbufen | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -8.12 | -8.38 | -8.37 | 57.14% | CHEMBL441414 |
| Diclofenac | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.37 | -7.98 | -8.14 | 100.00% | CHEMBL139 |
| Amitriptyline | PPAP_HUMAN | acid phosphatase 3 | -7.98 | N/A | N/A | 19.64% | CHEMBL501717 |
| Tramadol | PPAP_HUMAN | acid phosphatase 3 | -6.57 | N/A | N/A | 29.91% | CHEMBL507996 |
| Ibuprofen | PPAP_HUMAN | acid phosphatase 3 | -6.28 | N/A | N/A | 20.00% | CHEMBL501717 |
| Fenbufen | PPAP_HUMAN | acid phosphatase 3 | -7.82 | N/A | N/A | 18.00% | CHEMBL501717 |
| Diclofenac | PPAP_HUMAN | acid phosphatase 3 | -7.69 | N/A | N/A | 17.24% | CHEMBL501717 |
| Amitriptyline | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -8.70 | -8.29 | -8.73 | 38.10% | CHEMBL515204 |
| Tramadol | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.11 | -7.49 | -6.66 | 51.92% | CHEMBL119097 |
| Ibuprofen | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.46 | -6.84 | -6.75 | 55.00% | CHEMBL396109 |
| Fenbufen | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.52 | -8.69 | -8.31 | 51.39% | CHEMBL396109 |
| Diclofenac | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.57 | -7.17 | -7.92 | 38.89% | CHEMBL167963 |
| Amitriptyline | PRGR_HUMAN | progesterone receptor | -8.49 | -8.16 | -9.05 | 55.67% | CHEMBL3120320 |
| Tramadol | PRGR_HUMAN | progesterone receptor | -7.58 | -7.33 | -6.97 | 54.65% | CHEMBL511812 |
| Ibuprofen | PRGR_HUMAN | progesterone receptor | -7.33 | -7.39 | -6.85 | 45.31% | CHEMBL566982 |
| Fenbufen | PRGR_HUMAN | progesterone receptor | -8.74 | -8.53 | -8.54 | 70.31% | CHEMBL566982 |
| Diclofenac | PRGR_HUMAN | progesterone receptor | -8.19 | -8.40 | -7.81 | 45.87% | CHEMBL117612 |
| Amitriptyline | PTGES_HUMAN | prostaglandin E synthase | -6.84 | N/A | N/A | 33.83% | CHEMBL3608859 |
| Tramadol | PTGES_HUMAN | prostaglandin E synthase | -6.12 | N/A | N/A | 43.31% | CHEMBL4084995 |
| Ibuprofen | PTGES_HUMAN | prostaglandin E synthase | -6.31 | N/A | N/A | 34.48% | CHEMBL584927 |
| Fenbufen | PTGES_HUMAN | prostaglandin E synthase | -6.92 | N/A | N/A | 37.04% | CHEMBL3608374 |
| Diclofenac | PTGES_HUMAN | prostaglandin E synthase | -6.52 | N/A | N/A | 35.14% | CHEMBL1683859 |
| Amitriptyline | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.83 | -9.58 | -8.92 | 100.00% | CHEMBL445 |
| Tramadol | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.47 | -7.86 | -8.30 | 100.00% | CHEMBL1237044 |
| Ibuprofen | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.42 | -7.28 | -7.76 | 51.06% | CHEMBL3769872 |
| Fenbufen | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.90 | -8.60 | -8.50 | 55.22% | CHEMBL2111613 |
| Diclofenac | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.20 | -8.33 | -8.76 | 46.53% | CHEMBL415 |
| Amitriptyline | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.14 | N/A | N/A | 29.63% | CHEMBL2152693 |
| Tramadol | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.09 | N/A | N/A | 57.14% | CHEMBL203440 |
| Ibuprofen | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.75 | N/A | N/A | 30.12% | CHEMBL381488 |
| Fenbufen | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -9.31 | N/A | N/A | 36.63% | CHEMBL206758 |
| Diclofenac | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.61 | N/A | N/A | 37.41% | CHEMBL3581050 |
| Amitriptyline | TLR4_HUMAN | toll like receptor 4 | -8.90 | -8.43 | -8.81 | 17.76% | CHEMBL4071705 |
| Tramadol | TLR4_HUMAN | toll like receptor 4 | -6.92 | -6.80 | -6.52 | 37.50% | CHEMBL382272 |
| Ibuprofen | TLR4_HUMAN | toll like receptor 4 | -7.22 | -7.80 | -7.59 | 25.00% | CHEMBL2419464 |
| Fenbufen | TLR4_HUMAN | toll like receptor 4 | -7.89 | -8.43 | -7.89 | 25.35% | CHEMBL382272 |
| Diclofenac | TLR4_HUMAN | toll like receptor 4 | -7.37 | -7.23 | -7.52 | 23.74% | CHEMBL2419459 |
| Amitriptyline | TNFA_HUMAN | tumor necrosis factor | -7.85 | N/A | N/A | 28.12% | CHEMBL2337619 |
| Tramadol | TNFA_HUMAN | tumor necrosis factor | -6.91 | N/A | N/A | 37.80% | CHEMBL72511 |
| Ibuprofen | TNFA_HUMAN | tumor necrosis factor | -6.38 | N/A | N/A | 32.99% | CHEMBL306090 |
| Fenbufen | TNFA_HUMAN | tumor necrosis factor | -6.98 | N/A | N/A | 29.46% | CHEMBL306090 |
| Diclofenac | TNFA_HUMAN | tumor necrosis factor | -7.40 | N/A | N/A | 30.83% | CHEMBL1612423 |
| Amitriptyline | TRBM_HUMAN | thrombomodulin | -6.87 | -7.23 | N/A | N/A | N/A |
| Tramadol | TRBM_HUMAN | thrombomodulin | -6.33 | -6.11 | N/A | N/A | N/A |
| Ibuprofen | TRBM_HUMAN | thrombomodulin | -6.25 | -6.32 | N/A | N/A | N/A |
| Fenbufen | TRBM_HUMAN | thrombomodulin | -7.81 | -6.69 | N/A | N/A | N/A |
| Diclofenac | TRBM_HUMAN | thrombomodulin | -6.91 | -6.85 | N/A | N/A | N/A |
| Amitriptyline | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.48 | -6.86 | N/A | N/A | N/A |
| Tramadol | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.33 | -6.01 | N/A | N/A | N/A |
| Ibuprofen | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.09 | -6.20 | N/A | N/A | N/A |
| Fenbufen | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.87 | -6.67 | N/A | N/A | N/A |
| Diclofenac | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.40 | -6.18 | N/A | N/A | N/A |
| Amitriptyline | TRPM8_FICAL | Uncharacterized protein | -9.80 | N/A | N/A | N/A | N/A |
| Tramadol | TRPM8_FICAL | Uncharacterized protein | -7.46 | N/A | N/A | N/A | N/A |
| Ibuprofen | TRPM8_FICAL | Uncharacterized protein | -7.50 | N/A | N/A | N/A | N/A |
| Fenbufen | TRPM8_FICAL | Uncharacterized protein | -8.36 | N/A | N/A | N/A | N/A |
| Diclofenac | TRPM8_FICAL | Uncharacterized protein | -8.27 | N/A | N/A | N/A | N/A |
| Amitriptyline | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -9.19 | N/A | N/A | 43.28% | CHEMBL1940387 |
| Tramadol | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.19 | N/A | N/A | 53.06% | CHEMBL2057857 |
| Ibuprofen | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.72 | N/A | N/A | 39.02% | CHEMBL2057857 |
| Fenbufen | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.71 | N/A | N/A | 34.78% | CHEMBL183835 |
| Diclofenac | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.36 | N/A | N/A | 37.74% | CHEMBL258265 |
| Amitriptyline | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.88 | -7.79 | N/A | N/A | N/A |
| Tramadol | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.14 | -7.05 | N/A | N/A | N/A |
| Ibuprofen | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.29 | -7.13 | N/A | N/A | N/A |
| Fenbufen | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.76 | -8.14 | N/A | N/A | N/A |
| Diclofenac | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.84 | -7.88 | N/A | N/A | N/A |
| Amitriptyline | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.89 | -7.85 | N/A | 25.61% | CHEMBL3692335 |
| Tramadol | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.06 | -7.26 | N/A | 41.55% | CHEMBL3664218 |
| Ibuprofen | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.89 | -6.72 | N/A | 29.59% | CHEMBL3828278 |
| Fenbufen | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.75 | -7.74 | N/A | 28.83% | CHEMBL3828278 |
| Diclofenac | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.34 | -6.87 | N/A | 30.89% | CHEMBL3828278 |
| Amitriptyline | TRXR1_HUMAN | thioredoxin reductase 1 | -8.07 | -7.72 | -6.52 | N/A | N/A |
| Tramadol | TRXR1_HUMAN | thioredoxin reductase 1 | -6.63 | -6.67 | -5.62 | N/A | N/A |
| Ibuprofen | TRXR1_HUMAN | thioredoxin reductase 1 | -6.10 | -6.37 | -4.92 | N/A | N/A |
| Fenbufen | TRXR1_HUMAN | thioredoxin reductase 1 | -7.33 | -7.33 | -6.07 | N/A | N/A |
| Diclofenac | TRXR1_HUMAN | thioredoxin reductase 1 | -7.83 | -7.25 | -6.24 | N/A | N/A |
| Amitriptyline | TRY1_HUMAN | serine protease 1 | -7.14 | N/A | N/A | 31.72% | CHEMBL99630 |
| Tramadol | TRY1_HUMAN | serine protease 1 | -5.28 | N/A | N/A | 47.92% | CHEMBL156472 |
| Ibuprofen | TRY1_HUMAN | serine protease 1 | -5.41 | N/A | N/A | 44.44% | CHEMBL102081 |
| Fenbufen | TRY1_HUMAN | serine protease 1 | -6.34 | N/A | N/A | 55.70% | CHEMBL155871 |
| Diclofenac | TRY1_HUMAN | serine protease 1 | -6.30 | N/A | N/A | 34.23% | CHEMBL3926197 |