| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Oxycodone | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.02 | -9.36 | -8.14 | 59.87% | CHEMBL29951 |
| Morphine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.33 | -9.08 | -8.37 | 52.63% | CHEMBL29951 |
| Methadone | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -7.52 | -7.61 | -8.09 | 42.67% | CHEMBL146942 |
| Pethidine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -7.07 | -6.78 | -7.40 | 46.09% | CHEMBL79693 |
| Fentanyl | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.36 | -8.48 | -9.08 | 60.00% | CHEMBL361061 |
| Oxycodone | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.57 | -7.38 | N/A | 60.90% | CHEMBL3695433 |
| Morphine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.75 | -7.83 | N/A | 51.96% | CHEMBL3695438 |
| Methadone | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.98 | -8.35 | N/A | 69.09% | CHEMBL594138 |
| Pethidine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.07 | -7.28 | N/A | 54.74% | CHEMBL1277770 |
| Fentanyl | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.08 | -8.90 | N/A | 57.69% | CHEMBL352194 |
| Oxycodone | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.44 | -8.51 | -8.60 | 58.33% | CHEMBL445106 |
| Morphine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.36 | -8.86 | -8.85 | 51.06% | CHEMBL445106 |
| Methadone | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -7.37 | -7.82 | -7.58 | 62.12% | CHEMBL21731 |
| Pethidine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.53 | -6.71 | -7.29 | 62.92% | CHEMBL422931 |
| Fentanyl | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.81 | -9.10 | -9.38 | 56.67% | CHEMBL3919861 |
| Oxycodone | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -7.85 | -9.67 | N/A | 58.33% | CHEMBL445106 |
| Morphine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.46 | -8.95 | N/A | 51.06% | CHEMBL445106 |
| Methadone | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -7.96 | -8.56 | N/A | 66.07% | CHEMBL492700 |
| Pethidine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.99 | -8.02 | N/A | 64.37% | CHEMBL517712 |
| Fentanyl | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.49 | -9.12 | N/A | 57.69% | CHEMBL352194 |
| Oxycodone | AA1R_HUMAN | adenosine A1 receptor | -8.75 | -8.51 | -6.84 | 35.88% | CHEMBL1544 |
| Morphine | AA1R_HUMAN | adenosine A1 receptor | -7.48 | -8.06 | -4.86 | 29.96% | CHEMBL3317575 |
| Methadone | AA1R_HUMAN | adenosine A1 receptor | -8.02 | -7.76 | -7.12 | 34.55% | CHEMBL2435536 |
| Pethidine | AA1R_HUMAN | adenosine A1 receptor | -7.17 | -6.99 | -7.16 | 34.23% | CHEMBL1544 |
| Fentanyl | AA1R_HUMAN | adenosine A1 receptor | -8.66 | -8.83 | -7.66 | 36.02% | CHEMBL1095812 |
| Oxycodone | AA2AR_HUMAN | adenosine A2a receptor | -7.44 | -7.35 | -9.34 | 42.25% | CHEMBL541219 |
| Morphine | AA2AR_HUMAN | adenosine A2a receptor | -8.43 | -9.22 | -10.22 | 34.24% | CHEMBL559023 |
| Methadone | AA2AR_HUMAN | adenosine A2a receptor | -7.03 | -8.59 | -9.17 | 34.35% | CHEMBL539454 |
| Pethidine | AA2AR_HUMAN | adenosine A2a receptor | -7.26 | -7.19 | -7.94 | 34.21% | CHEMBL3350613 |
| Fentanyl | AA2AR_HUMAN | adenosine A2a receptor | -7.45 | -8.09 | -8.77 | 47.29% | CHEMBL539454 |
| Oxycodone | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.80 | -9.61 | -8.26 | 64.71% | CHEMBL3764305 |
| Morphine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.83 | -8.98 | -9.46 | 66.01% | CHEMBL569978 |
| Methadone | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.81 | -7.99 | -9.29 | 56.76% | CHEMBL1082433 |
| Pethidine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.95 | -6.78 | -8.53 | 48.86% | CHEMBL156763 |
| Fentanyl | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.87 | -9.06 | -7.24 | 65.43% | CHEMBL141853 |
| Oxycodone | ACE_HUMAN | angiotensin I converting enzyme | -8.57 | -8.46 | -7.63 | 46.15% | CHEMBL58042 |
| Morphine | ACE_HUMAN | angiotensin I converting enzyme | -8.51 | -8.63 | -7.98 | 37.12% | CHEMBL1165 |
| Methadone | ACE_HUMAN | angiotensin I converting enzyme | -7.30 | -7.61 | -7.03 | 49.45% | CHEMBL86915 |
| Pethidine | ACE_HUMAN | angiotensin I converting enzyme | -6.66 | -6.45 | -6.57 | 49.07% | CHEMBL578 |
| Fentanyl | ACE_HUMAN | angiotensin I converting enzyme | -8.15 | -8.40 | -6.98 | 50.00% | CHEMBL98 |
| Oxycodone | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.73 | N/A | N/A | 27.39% | CHEMBL386114 |
| Morphine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.15 | N/A | N/A | 21.72% | CHEMBL386114 |
| Methadone | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.98 | N/A | N/A | 24.85% | CHEMBL386114 |
| Pethidine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.82 | N/A | N/A | 29.31% | CHEMBL386114 |
| Fentanyl | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.45 | N/A | N/A | 28.57% | CHEMBL386114 |
| Oxycodone | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.68 | -2.98 | -7.00 | N/A | N/A |
| Morphine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.01 | -3.34 | -5.84 | N/A | N/A |
| Methadone | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -3.73 | -3.15 | -6.59 | N/A | N/A |
| Pethidine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.46 | -6.95 | -7.06 | N/A | N/A |
| Fentanyl | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.17 | -6.86 | -4.84 | N/A | N/A |
| Oxycodone | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.32 | 4.58 | N/A | 50.00% | CHEMBL343236 |
| Morphine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.58 | 3.64 | N/A | 45.66% | CHEMBL343236 |
| Methadone | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.67 | 0.67 | N/A | 63.51% | CHEMBL2112956 |
| Pethidine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.37 | -4.81 | N/A | 75.90% | CHEMBL3629534 |
| Fentanyl | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.03 | -2.80 | N/A | 73.91% | CHEMBL1243110 |
| Oxycodone | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -10.21 | -6.87 | N/A | 48.50% | CHEMBL1346 |
| Morphine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.92 | -6.06 | N/A | 39.27% | CHEMBL1346 |
| Methadone | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.48 | -7.16 | N/A | 63.51% | CHEMBL2112956 |
| Pethidine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.60 | -7.24 | N/A | 75.00% | CHEMBL285898 |
| Fentanyl | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.29 | -7.78 | N/A | 68.48% | CHEMBL3354065 |
| Oxycodone | ADRB2_HUMAN | adrenoceptor beta 2 | -8.33 | -8.50 | -8.83 | 49.08% | CHEMBL1773265 |
| Morphine | ADRB2_HUMAN | adrenoceptor beta 2 | -8.82 | -7.96 | -9.08 | 43.26% | CHEMBL513389 |
| Methadone | ADRB2_HUMAN | adrenoceptor beta 2 | -6.74 | -7.80 | -8.08 | 55.13% | CHEMBL1332942 |
| Pethidine | ADRB2_HUMAN | adrenoceptor beta 2 | -6.84 | -7.74 | -7.67 | 50.91% | CHEMBL1346 |
| Fentanyl | ADRB2_HUMAN | adrenoceptor beta 2 | -7.73 | -8.30 | -9.28 | 54.72% | CHEMBL1306990 |
| Oxycodone | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.32 | -8.29 | -8.18 | 51.50% | CHEMBL154057 |
| Morphine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.07 | -7.98 | -7.83 | 42.67% | CHEMBL154057 |
| Methadone | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.28 | -8.10 | -8.21 | 35.14% | CHEMBL128416 |
| Pethidine | AGTR2_HUMAN | angiotensin II receptor type 2 | -6.94 | -7.23 | -6.66 | 39.53% | CHEMBL3350599 |
| Fentanyl | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.61 | -9.85 | -9.62 | 36.50% | CHEMBL268815 |
| Oxycodone | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.02 | -8.24 | -7.54 | 44.77% | CHEMBL71562 |
| Morphine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.72 | -6.73 | -7.11 | 32.54% | CHEMBL311679 |
| Methadone | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.71 | -6.98 | -7.38 | 32.32% | CHEMBL538917 |
| Pethidine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.36 | -7.73 | -7.27 | 39.29% | CHEMBL77283 |
| Fentanyl | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.41 | -7.68 | -9.72 | 39.07% | CHEMBL281620 |
| Oxycodone | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.11 | -8.58 | -8.55 | 40.10% | CHEMBL1077584 |
| Morphine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.15 | -8.35 | -7.95 | 33.78% | CHEMBL1782887 |
| Methadone | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.00 | -7.38 | -7.24 | 52.78% | CHEMBL1668623 |
| Pethidine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.61 | -7.00 | -6.91 | 40.40% | CHEMBL1821978 |
| Fentanyl | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.02 | -8.37 | -7.69 | 41.38% | CHEMBL3764432 |
| Oxycodone | AOFA_HUMAN | monoamine oxidase A | -8.95 | -10.08 | -8.28 | 40.54% | CHEMBL4073457 |
| Morphine | AOFA_HUMAN | monoamine oxidase A | -8.81 | -9.57 | -8.37 | 34.30% | CHEMBL4073457 |
| Methadone | AOFA_HUMAN | monoamine oxidase A | -8.01 | -8.01 | -8.03 | 55.56% | CHEMBL3330339 |
| Pethidine | AOFA_HUMAN | monoamine oxidase A | -8.01 | -7.94 | -7.72 | 47.37% | CHEMBL3330339 |
| Fentanyl | AOFA_HUMAN | monoamine oxidase A | -10.09 | -9.07 | -8.63 | 57.45% | CHEMBL3781494 |
| Oxycodone | AOFB_HUMAN | monoamine oxidase B | -10.39 | -8.26 | -8.64 | 42.77% | CHEMBL3288304 |
| Morphine | AOFB_HUMAN | monoamine oxidase B | -10.09 | -8.81 | -9.35 | 35.75% | CHEMBL4113794 |
| Methadone | AOFB_HUMAN | monoamine oxidase B | -8.40 | -7.97 | -8.88 | 55.56% | CHEMBL3330339 |
| Pethidine | AOFB_HUMAN | monoamine oxidase B | -8.27 | -8.05 | -8.14 | 47.37% | CHEMBL3330339 |
| Fentanyl | AOFB_HUMAN | monoamine oxidase B | -8.68 | -8.70 | -10.07 | 50.51% | CHEMBL3604126 |
| Oxycodone | BACE1_HUMAN | beta-secretase 1 | -7.34 | -7.75 | -9.18 | 48.58% | CHEMBL3955763 |
| Morphine | BACE1_HUMAN | beta-secretase 1 | -6.97 | -7.49 | -8.60 | 43.53% | CHEMBL3955763 |
| Methadone | BACE1_HUMAN | beta-secretase 1 | -6.33 | -6.76 | -7.56 | 48.28% | CHEMBL1092504 |
| Pethidine | BACE1_HUMAN | beta-secretase 1 | -6.12 | -6.43 | -7.25 | 45.92% | CHEMBL1092504 |
| Fentanyl | BACE1_HUMAN | beta-secretase 1 | -6.92 | -7.39 | -8.46 | 59.60% | CHEMBL2181988 |
| Oxycodone | CAH2_HUMAN | carbonic anhydrase 2 | -7.56 | -8.24 | -7.98 | 45.73% | CHEMBL3786651 |
| Morphine | CAH2_HUMAN | carbonic anhydrase 2 | -7.64 | -7.31 | -6.88 | 40.44% | CHEMBL3786651 |
| Methadone | CAH2_HUMAN | carbonic anhydrase 2 | -6.32 | -6.82 | -6.73 | 47.30% | CHEMBL926 |
| Pethidine | CAH2_HUMAN | carbonic anhydrase 2 | -7.20 | -7.18 | -6.98 | 45.98% | CHEMBL2023729 |
| Fentanyl | CAH2_HUMAN | carbonic anhydrase 2 | -7.37 | -7.43 | -7.59 | 61.62% | CHEMBL182523 |
| Oxycodone | CASP1_HUMAN | caspase 1 | -7.33 | -7.41 | -6.28 | 45.00% | CHEMBL2371932 |
| Morphine | CASP1_HUMAN | caspase 1 | -6.83 | -7.27 | -7.14 | 34.62% | CHEMBL3898379 |
| Methadone | CASP1_HUMAN | caspase 1 | -5.34 | -6.87 | -5.43 | 57.50% | CHEMBL466565 |
| Pethidine | CASP1_HUMAN | caspase 1 | -5.35 | -6.55 | -5.21 | 53.85% | CHEMBL466565 |
| Fentanyl | CASP1_HUMAN | caspase 1 | -6.46 | -6.95 | -6.03 | 46.88% | CHEMBL1221597 |
| Oxycodone | CDK5_HUMAN | cyclin dependent kinase 5 | -7.89 | -7.65 | -5.47 | 33.04% | CHEMBL422897 |
| Morphine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.31 | -6.75 | -5.24 | 29.55% | CHEMBL422897 |
| Methadone | CDK5_HUMAN | cyclin dependent kinase 5 | -6.37 | -7.20 | -5.95 | 52.56% | CHEMBL1988201 |
| Pethidine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.47 | -7.02 | -6.69 | 35.71% | CHEMBL1988201 |
| Fentanyl | CDK5_HUMAN | cyclin dependent kinase 5 | -7.76 | -7.70 | -7.16 | 43.33% | CHEMBL1998121 |
| Oxycodone | CHLE_HUMAN | butyrylcholinesterase | -9.35 | -9.12 | -9.35 | 46.43% | CHEMBL3410956 |
| Morphine | CHLE_HUMAN | butyrylcholinesterase | -9.67 | -9.79 | -10.03 | 43.52% | CHEMBL366411 |
| Methadone | CHLE_HUMAN | butyrylcholinesterase | -8.32 | -8.14 | -8.01 | 40.62% | CHEMBL3818250 |
| Pethidine | CHLE_HUMAN | butyrylcholinesterase | -6.93 | -7.66 | -7.04 | 47.92% | CHEMBL229105 |
| Fentanyl | CHLE_HUMAN | butyrylcholinesterase | -8.47 | -8.99 | -9.56 | 52.63% | CHEMBL4077192 |
| Oxycodone | CNR1_HUMAN | cannabinoid receptor 1 | -7.59 | -8.42 | -8.55 | 53.46% | CHEMBL228349 |
| Morphine | CNR1_HUMAN | cannabinoid receptor 1 | -8.84 | -8.17 | -8.42 | 56.82% | CHEMBL303479 |
| Methadone | CNR1_HUMAN | cannabinoid receptor 1 | -7.65 | -7.54 | -8.00 | 61.76% | CHEMBL502133 |
| Pethidine | CNR1_HUMAN | cannabinoid receptor 1 | -6.91 | -7.66 | -7.86 | 49.40% | CHEMBL502133 |
| Fentanyl | CNR1_HUMAN | cannabinoid receptor 1 | -8.98 | -9.23 | -9.76 | 55.95% | CHEMBL479095 |
| Oxycodone | CNR2_HUMAN | cannabinoid receptor 2 | -8.87 | -9.55 | N/A | 53.16% | CHEMBL223990 |
| Morphine | CNR2_HUMAN | cannabinoid receptor 2 | -9.81 | -9.01 | N/A | 56.82% | CHEMBL303479 |
| Methadone | CNR2_HUMAN | cannabinoid receptor 2 | -8.71 | -8.28 | N/A | 61.76% | CHEMBL478624 |
| Pethidine | CNR2_HUMAN | cannabinoid receptor 2 | -7.68 | -8.10 | N/A | 52.69% | CHEMBL1765274 |
| Fentanyl | CNR2_HUMAN | cannabinoid receptor 2 | -9.18 | -9.97 | N/A | 70.11% | CHEMBL2338188 |
| Oxycodone | COLI_HUMAN | proopiomelanocortin | -8.01 | -8.17 | -7.46 | N/A | N/A |
| Morphine | COLI_HUMAN | proopiomelanocortin | -7.69 | -7.95 | -6.85 | N/A | N/A |
| Methadone | COLI_HUMAN | proopiomelanocortin | -7.25 | -7.06 | -6.04 | N/A | N/A |
| Pethidine | COLI_HUMAN | proopiomelanocortin | -6.92 | -6.54 | -5.65 | N/A | N/A |
| Fentanyl | COLI_HUMAN | proopiomelanocortin | -8.18 | -7.94 | -7.52 | N/A | N/A |
| Oxycodone | COMT_HUMAN | catechol-O-methyltransferase | -5.86 | -5.75 | -5.72 | 25.55% | CHEMBL3425740 |
| Morphine | COMT_HUMAN | catechol-O-methyltransferase | -6.47 | -6.72 | -5.80 | 22.70% | CHEMBL3819488 |
| Methadone | COMT_HUMAN | catechol-O-methyltransferase | -5.40 | -5.45 | -5.17 | 28.69% | CHEMBL3425731 |
| Pethidine | COMT_HUMAN | catechol-O-methyltransferase | -5.45 | -5.42 | -5.22 | 25.74% | CHEMBL3425731 |
| Fentanyl | COMT_HUMAN | catechol-O-methyltransferase | -5.90 | -6.36 | -5.94 | 25.74% | CHEMBL3425731 |
| Oxycodone | CRP_HUMAN | C-reactive protein | -6.15 | -6.24 | N/A | N/A | N/A |
| Morphine | CRP_HUMAN | C-reactive protein | -6.18 | -6.46 | N/A | N/A | N/A |
| Methadone | CRP_HUMAN | C-reactive protein | -5.45 | -4.83 | N/A | N/A | N/A |
| Pethidine | CRP_HUMAN | C-reactive protein | -4.87 | -5.46 | N/A | N/A | N/A |
| Fentanyl | CRP_HUMAN | C-reactive protein | -6.37 | -5.93 | N/A | N/A | N/A |
| Oxycodone | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.74 | N/A | N/A | 27.64% | CHEMBL490688 |
| Morphine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.20 | N/A | N/A | 28.19% | CHEMBL490688 |
| Methadone | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.45 | N/A | N/A | 38.27% | CHEMBL191413 |
| Pethidine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.04 | N/A | N/A | 32.63% | CHEMBL191413 |
| Fentanyl | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -5.19 | N/A | N/A | 31.10% | CHEMBL561812 |
| Oxycodone | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.66 | -7.05 | -8.07 | 36.61% | CHEMBL3963508 |
| Morphine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.79 | -6.35 | -7.26 | 33.92% | CHEMBL2029611 |
| Methadone | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.09 | -6.03 | -7.23 | 39.32% | CHEMBL364295 |
| Pethidine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.35 | -6.11 | -6.43 | 41.13% | CHEMBL366033 |
| Fentanyl | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.98 | -6.61 | -7.56 | 41.88% | CHEMBL2371850 |
| Oxycodone | DRD2_HUMAN | dopamine receptor D2 | -8.66 | N/A | N/A | 61.94% | CHEMBL170976 |
| Morphine | DRD2_HUMAN | dopamine receptor D2 | -7.30 | N/A | N/A | 55.49% | CHEMBL170976 |
| Methadone | DRD2_HUMAN | dopamine receptor D2 | -6.73 | N/A | N/A | 63.24% | CHEMBL1242950 |
| Pethidine | DRD2_HUMAN | dopamine receptor D2 | -6.84 | N/A | N/A | 60.18% | CHEMBL399396 |
| Fentanyl | DRD2_HUMAN | dopamine receptor D2 | -7.60 | N/A | N/A | 70.79% | CHEMBL4091231 |
| Oxycodone | DRD3_HUMAN | dopamine receptor D3 | -8.09 | N/A | N/A | 61.94% | CHEMBL170976 |
| Morphine | DRD3_HUMAN | dopamine receptor D3 | -8.50 | N/A | N/A | 55.49% | CHEMBL170976 |
| Methadone | DRD3_HUMAN | dopamine receptor D3 | -6.48 | N/A | N/A | 62.12% | CHEMBL21731 |
| Pethidine | DRD3_HUMAN | dopamine receptor D3 | -6.35 | N/A | N/A | 60.18% | CHEMBL399396 |
| Fentanyl | DRD3_HUMAN | dopamine receptor D3 | -8.25 | N/A | N/A | 70.79% | CHEMBL4091231 |
| Oxycodone | DRD4_HUMAN | dopamine receptor D4 | -8.53 | -8.57 | N/A | 52.57% | CHEMBL132261 |
| Morphine | DRD4_HUMAN | dopamine receptor D4 | -7.93 | -8.18 | N/A | 47.67% | CHEMBL132261 |
| Methadone | DRD4_HUMAN | dopamine receptor D4 | -6.99 | -7.21 | N/A | 63.24% | CHEMBL1242950 |
| Pethidine | DRD4_HUMAN | dopamine receptor D4 | -6.84 | -6.88 | N/A | 57.14% | CHEMBL1258270 |
| Fentanyl | DRD4_HUMAN | dopamine receptor D4 | -8.89 | -8.94 | N/A | 70.79% | CHEMBL4074104 |
| Oxycodone | EDN1_HUMAN | endothelin 1 | -7.38 | N/A | N/A | N/A | N/A |
| Morphine | EDN1_HUMAN | endothelin 1 | -7.23 | N/A | N/A | N/A | N/A |
| Methadone | EDN1_HUMAN | endothelin 1 | -6.46 | N/A | N/A | N/A | N/A |
| Pethidine | EDN1_HUMAN | endothelin 1 | -6.29 | N/A | N/A | N/A | N/A |
| Fentanyl | EDN1_HUMAN | endothelin 1 | -7.64 | N/A | N/A | N/A | N/A |
| Oxycodone | ESR1_HUMAN | estrogen receptor 1 | -7.92 | -8.16 | -8.16 | 52.33% | CHEMBL33890 |
| Morphine | ESR1_HUMAN | estrogen receptor 1 | -8.83 | -8.68 | -8.57 | 44.56% | CHEMBL178559 |
| Methadone | ESR1_HUMAN | estrogen receptor 1 | -8.32 | -7.45 | -8.51 | 48.39% | CHEMBL2403361 |
| Pethidine | ESR1_HUMAN | estrogen receptor 1 | -7.23 | -7.39 | -7.44 | 53.16% | CHEMBL335412 |
| Fentanyl | ESR1_HUMAN | estrogen receptor 1 | -8.30 | -8.48 | -8.48 | 50.89% | CHEMBL3360843 |
| Oxycodone | FABP5_HUMAN | fatty acid binding protein 5 | -8.45 | -6.12 | -6.57 | 33.33% | CHEMBL212860 |
| Morphine | FABP5_HUMAN | fatty acid binding protein 5 | -8.69 | -7.14 | -6.40 | 30.54% | CHEMBL437489 |
| Methadone | FABP5_HUMAN | fatty acid binding protein 5 | -7.59 | -5.14 | -4.93 | 21.71% | CHEMBL3941588 |
| Pethidine | FABP5_HUMAN | fatty acid binding protein 5 | -6.68 | -4.79 | -4.65 | 29.41% | CHEMBL212860 |
| Fentanyl | FABP5_HUMAN | fatty acid binding protein 5 | -7.92 | -6.05 | -6.03 | 30.07% | CHEMBL3941588 |
| Oxycodone | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.22 | N/A | N/A | 32.29% | CHEMBL432649 |
| Morphine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.61 | N/A | N/A | 28.72% | CHEMBL221753 |
| Methadone | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.45 | N/A | N/A | 50.57% | CHEMBL305660 |
| Pethidine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.81 | N/A | N/A | 49.48% | CHEMBL305660 |
| Fentanyl | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.45 | N/A | N/A | 43.33% | CHEMBL1998121 |
| Oxycodone | GLRA3_HUMAN | glycine receptor alpha 3 | -9.12 | -8.68 | -8.75 | 25.93% | CHEMBL4070615 |
| Oxycodone | GLRA3_HUMAN | glycine receptor alpha 3 | -9.65 | N/A | N/A | 25.93% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -7.94 | -7.85 | -7.59 | 24.31% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.62 | N/A | N/A | 24.31% | CHEMBL4070615 |
| Methadone | GLRA3_HUMAN | glycine receptor alpha 3 | -8.08 | -8.45 | -8.33 | 19.02% | CHEMBL4070615 |
| Methadone | GLRA3_HUMAN | glycine receptor alpha 3 | -8.19 | N/A | N/A | 19.02% | CHEMBL4070615 |
| Pethidine | GLRA3_HUMAN | glycine receptor alpha 3 | -6.99 | -7.15 | -7.19 | 20.00% | CHEMBL4070615 |
| Pethidine | GLRA3_HUMAN | glycine receptor alpha 3 | -7.83 | N/A | N/A | 20.00% | CHEMBL4070615 |
| Fentanyl | GLRA3_HUMAN | glycine receptor alpha 3 | -9.32 | -8.16 | -8.77 | 28.19% | CHEMBL4074873 |
| Fentanyl | GLRA3_HUMAN | glycine receptor alpha 3 | -9.63 | N/A | N/A | 28.19% | CHEMBL4074873 |
| Oxycodone | GRM5_HUMAN | glutamate metabotropic receptor 5 | -10.13 | -2.95 | -5.29 | 39.38% | CHEMBL1289626 |
| Morphine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.54 | -4.44 | -4.12 | 33.15% | CHEMBL1289626 |
| Methadone | GRM5_HUMAN | glutamate metabotropic receptor 5 | -6.29 | -3.35 | -3.49 | 42.86% | CHEMBL92162 |
| Pethidine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.88 | -5.44 | -5.25 | 38.14% | CHEMBL1289349 |
| Fentanyl | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.50 | -6.98 | -7.52 | 47.52% | CHEMBL2338572 |
| Oxycodone | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.04 | -7.05 | -6.56 | 24.69% | CHEMBL3698267 |
| Morphine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.24 | -6.77 | -6.38 | 23.72% | CHEMBL3698265 |
| Methadone | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.08 | -6.09 | -6.06 | 27.21% | CHEMBL3425953 |
| Pethidine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.57 | -5.50 | -5.22 | 30.00% | CHEMBL3650199 |
| Fentanyl | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.25 | -7.69 | -7.23 | 45.24% | CHEMBL3425957 |
| Oxycodone | HRH1_HUMAN | histamine receptor H1 | -2.60 | N/A | N/A | 48.47% | CHEMBL476839 |
| Morphine | HRH1_HUMAN | histamine receptor H1 | -4.38 | N/A | N/A | 45.25% | CHEMBL476839 |
| Methadone | HRH1_HUMAN | histamine receptor H1 | -8.22 | N/A | N/A | 69.09% | CHEMBL594138 |
| Pethidine | HRH1_HUMAN | histamine receptor H1 | -8.37 | N/A | N/A | 63.41% | CHEMBL914 |
| Fentanyl | HRH1_HUMAN | histamine receptor H1 | -8.53 | N/A | N/A | 61.82% | CHEMBL1242923 |
| Oxycodone | HYES_HUMAN | epoxide hydrolase 2 | -8.98 | -8.39 | -8.09 | 54.72% | CHEMBL1672128 |
| Morphine | HYES_HUMAN | epoxide hydrolase 2 | -8.55 | -7.98 | -8.25 | 42.70% | CHEMBL1672128 |
| Methadone | HYES_HUMAN | epoxide hydrolase 2 | -7.51 | -6.76 | -7.58 | 57.35% | CHEMBL2031923 |
| Pethidine | HYES_HUMAN | epoxide hydrolase 2 | -7.24 | -7.26 | -7.04 | 56.73% | CHEMBL67521 |
| Fentanyl | HYES_HUMAN | epoxide hydrolase 2 | -8.50 | -8.26 | -8.71 | 68.18% | CHEMBL1672132 |
| Oxycodone | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.46 | N/A | N/A | 36.95% | CHEMBL184041 |
| Morphine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.13 | N/A | N/A | 31.51% | CHEMBL1672879 |
| Methadone | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.66 | N/A | N/A | 32.31% | CHEMBL3823257 |
| Pethidine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.47 | N/A | N/A | 33.81% | CHEMBL3823257 |
| Fentanyl | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.28 | N/A | N/A | 40.91% | CHEMBL3823257 |
| Oxycodone | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.39 | -7.90 | N/A | 74.67% | CHEMBL261048 |
| Morphine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.83 | -7.65 | N/A | 100.00% | CHEMBL70 |
| Methadone | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.80 | -7.59 | N/A | 62.12% | CHEMBL21731 |
| Pethidine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.78 | -6.65 | N/A | 63.41% | CHEMBL914 |
| Fentanyl | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.93 | -8.39 | N/A | 46.34% | CHEMBL2398178 |
| Oxycodone | MIF_HUMAN | macrophage migration inhibitory factor | -6.02 | -7.40 | -6.57 | 28.08% | CHEMBL1289631 |
| Morphine | MIF_HUMAN | macrophage migration inhibitory factor | -5.89 | -6.62 | -6.86 | 30.43% | CHEMBL2375651 |
| Methadone | MIF_HUMAN | macrophage migration inhibitory factor | -6.65 | -7.09 | -6.12 | 26.83% | CHEMBL209588 |
| Pethidine | MIF_HUMAN | macrophage migration inhibitory factor | -5.61 | -6.49 | -5.95 | 30.43% | CHEMBL497598 |
| Fentanyl | MIF_HUMAN | macrophage migration inhibitory factor | -8.01 | -8.45 | -7.18 | 25.78% | CHEMBL1604170 |
| Oxycodone | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.99 | -8.51 | -7.32 | 40.23% | CHEMBL3752989 |
| Morphine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.84 | -7.84 | -7.38 | 39.53% | CHEMBL555017 |
| Methadone | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.30 | -6.75 | -6.49 | 39.62% | CHEMBL3752989 |
| Pethidine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.49 | -6.37 | -5.87 | 40.87% | CHEMBL3752989 |
| Fentanyl | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.20 | -7.37 | -7.83 | 47.06% | CHEMBL3356128 |
| Oxycodone | MK03_HUMAN | mitogen-activated protein kinase 3 | -8.18 | -8.27 | -7.74 | 34.65% | CHEMBL555017 |
| Morphine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.29 | -6.63 | -7.60 | 39.53% | CHEMBL555017 |
| Methadone | MK03_HUMAN | mitogen-activated protein kinase 3 | -5.80 | -7.24 | -6.86 | 33.04% | CHEMBL3113587 |
| Pethidine | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.16 | -6.64 | -6.12 | 33.61% | CHEMBL3113587 |
| Fentanyl | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.90 | -8.11 | -8.19 | 38.14% | CHEMBL3113587 |
| Oxycodone | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.05 | -9.24 | -8.62 | 38.72% | CHEMBL4074753 |
| Morphine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.61 | -8.56 | -8.39 | 33.33% | CHEMBL4074753 |
| Methadone | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.13 | -8.57 | -9.17 | 31.91% | CHEMBL3972399 |
| Pethidine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.81 | -7.74 | -7.50 | 40.82% | CHEMBL3972399 |
| Fentanyl | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.53 | -9.08 | -8.99 | 39.01% | CHEMBL592619 |
| Oxycodone | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.64 | -7.35 | 49.15% | CHEMBL2062138 |
| Morphine | NEP_HUMAN | membrane metalloendopeptidase | -7.99 | -8.13 | -7.65 | 38.24% | CHEMBL2062138 |
| Methadone | NEP_HUMAN | membrane metalloendopeptidase | -6.04 | -6.05 | -6.12 | 57.69% | CHEMBL213404 |
| Pethidine | NEP_HUMAN | membrane metalloendopeptidase | -6.81 | -6.24 | -5.70 | 52.22% | CHEMBL213404 |
| Fentanyl | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.21 | -7.56 | 50.00% | CHEMBL467602 |
| Oxycodone | NK1R_HUMAN | tachykinin receptor 1 | -8.72 | -8.75 | -7.67 | 48.07% | CHEMBL2112368 |
| Morphine | NK1R_HUMAN | tachykinin receptor 1 | -8.85 | -7.66 | -7.99 | 45.41% | CHEMBL2114439 |
| Methadone | NK1R_HUMAN | tachykinin receptor 1 | -7.99 | -7.56 | -7.63 | 61.84% | CHEMBL1817817 |
| Pethidine | NK1R_HUMAN | tachykinin receptor 1 | -7.48 | -7.14 | -6.92 | 69.14% | CHEMBL277918 |
| Fentanyl | NK1R_HUMAN | tachykinin receptor 1 | -8.76 | -8.19 | -7.69 | 63.92% | CHEMBL89245 |
| Oxycodone | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.98 | -7.84 | -7.67 | 24.02% | CHEMBL284237 |
| Morphine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.54 | -7.57 | -7.47 | 25.65% | CHEMBL284237 |
| Methadone | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -6.88 | -6.84 | -6.85 | 34.04% | CHEMBL284237 |
| Pethidine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.18 | -7.75 | -7.39 | 26.13% | CHEMBL284237 |
| Fentanyl | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.31 | -7.38 | -7.70 | 28.44% | CHEMBL284237 |
| Oxycodone | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.46 | -8.03 | -6.69 | 44.37% | CHEMBL1289403 |
| Morphine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.54 | -9.47 | -6.61 | 39.44% | CHEMBL3357783 |
| Methadone | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.34 | -8.52 | -5.87 | 58.82% | CHEMBL3357791 |
| Pethidine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -6.52 | -7.71 | -5.83 | 48.15% | CHEMBL3357788 |
| Fentanyl | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.06 | -10.50 | -6.61 | 43.64% | CHEMBL444384 |
| Oxycodone | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.47 | -7.20 | -7.67 | 22.06% | CHEMBL419399 |
| Morphine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.53 | -7.59 | -7.47 | 20.81% | CHEMBL419399 |
| Methadone | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.03 | -6.88 | -6.85 | 30.77% | CHEMBL419399 |
| Pethidine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.28 | -7.82 | -7.39 | 34.68% | CHEMBL419399 |
| Fentanyl | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.18 | -7.40 | -7.70 | 29.46% | CHEMBL419399 |
| Oxycodone | NOS1_HUMAN | nitric oxide synthase 1 | -8.49 | -8.68 | -7.68 | 40.78% | CHEMBL42968 |
| Morphine | NOS1_HUMAN | nitric oxide synthase 1 | -8.16 | -7.62 | -9.01 | 34.50% | CHEMBL42968 |
| Methadone | NOS1_HUMAN | nitric oxide synthase 1 | -6.49 | -6.33 | -7.02 | 36.78% | CHEMBL6875 |
| Pethidine | NOS1_HUMAN | nitric oxide synthase 1 | -6.64 | -6.43 | -6.36 | 38.46% | CHEMBL1270460 |
| Fentanyl | NOS1_HUMAN | nitric oxide synthase 1 | -8.43 | -8.29 | -8.20 | 43.51% | CHEMBL3216789 |
| Oxycodone | NOS2_HUMAN | nitric oxide synthase 2 | -7.31 | -8.36 | -9.59 | 40.78% | CHEMBL42968 |
| Morphine | NOS2_HUMAN | nitric oxide synthase 2 | -6.74 | -8.72 | -8.11 | 34.50% | CHEMBL42968 |
| Methadone | NOS2_HUMAN | nitric oxide synthase 2 | -5.96 | -6.23 | -8.08 | 38.36% | CHEMBL450583 |
| Pethidine | NOS2_HUMAN | nitric oxide synthase 2 | -5.22 | -6.71 | -7.29 | 35.29% | CHEMBL450583 |
| Fentanyl | NOS2_HUMAN | nitric oxide synthase 2 | -6.98 | -8.72 | -8.17 | 44.92% | CHEMBL112747 |
| Oxycodone | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.47 | -8.68 | -8.79 | 34.50% | CHEMBL444109 |
| Morphine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.37 | -7.91 | -7.78 | 39.31% | CHEMBL444109 |
| Methadone | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.60 | -7.25 | -7.18 | 29.66% | CHEMBL1978371 |
| Pethidine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.75 | -7.77 | -7.68 | 31.19% | CHEMBL1984131 |
| Fentanyl | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.73 | -9.20 | -9.11 | 43.00% | CHEMBL1984131 |
| Oxycodone | OPRD_HUMAN | opioid receptor delta 1 | -8.47 | -6.82 | -7.01 | 99.34% | CHEMBL387016 |
| Morphine | OPRD_HUMAN | opioid receptor delta 1 | -7.19 | -6.77 | -7.10 | 100.00% | CHEMBL70 |
| Methadone | OPRD_HUMAN | opioid receptor delta 1 | -7.54 | -6.85 | -6.89 | 62.50% | CHEMBL243091 |
| Pethidine | OPRD_HUMAN | opioid receptor delta 1 | -6.80 | -5.97 | -5.51 | 56.00% | CHEMBL3915012 |
| Fentanyl | OPRD_HUMAN | opioid receptor delta 1 | -8.18 | -7.13 | -7.16 | 100.00% | CHEMBL12391 |
| Oxycodone | OPRK_HUMAN | opioid receptor kappa 1 | -9.52 | -9.20 | -7.55 | 99.34% | CHEMBL387016 |
| Morphine | OPRK_HUMAN | opioid receptor kappa 1 | -9.09 | -8.48 | -8.01 | 100.00% | CHEMBL70 |
| Methadone | OPRK_HUMAN | opioid receptor kappa 1 | -8.47 | -7.79 | -7.01 | 100.00% | CHEMBL651 |
| Pethidine | OPRK_HUMAN | opioid receptor kappa 1 | -7.49 | -7.33 | -7.47 | 60.26% | CHEMBL2260849 |
| Fentanyl | OPRK_HUMAN | opioid receptor kappa 1 | -9.67 | -8.24 | -8.53 | 100.00% | CHEMBL12391 |
| Oxycodone | OPRM_MOUSE | Mu-type opioid receptor | -8.45 | -8.31 | N/A | 100.00% | CHEMBL656 |
| Morphine | OPRM_MOUSE | Mu-type opioid receptor | -8.25 | -8.66 | N/A | 100.00% | CHEMBL70 |
| Methadone | OPRM_MOUSE | Mu-type opioid receptor | -7.66 | -7.15 | N/A | 50.00% | CHEMBL2017141 |
| Pethidine | OPRM_MOUSE | Mu-type opioid receptor | -6.79 | -6.38 | N/A | 49.07% | CHEMBL430441 |
| Fentanyl | OPRM_MOUSE | Mu-type opioid receptor | -8.44 | -8.64 | N/A | 100.00% | CHEMBL596 |
| Oxycodone | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.70 | -7.01 | -7.59 | 75.93% | CHEMBL511142 |
| Morphine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.08 | -7.76 | -8.75 | 94.38% | CHEMBL3262362 |
| Methadone | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.25 | -6.86 | -6.63 | 71.21% | CHEMBL272896 |
| Pethidine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.64 | -6.73 | -6.72 | 71.11% | CHEMBL364625 |
| Fentanyl | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.55 | -7.44 | -7.63 | 80.00% | CHEMBL317152 |
| Oxycodone | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.23 | -5.88 | -6.07 | 36.70% | CHEMBL3679750 |
| Morphine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.32 | -5.86 | -6.39 | 35.47% | CHEMBL3679847 |
| Methadone | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.88 | -4.80 | -4.79 | 35.07% | CHEMBL3669705 |
| Pethidine | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.60 | -4.57 | -5.06 | 31.76% | CHEMBL3669705 |
| Fentanyl | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.63 | -5.63 | -6.10 | 42.34% | CHEMBL3669705 |
| Oxycodone | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.26 | -3.41 | -7.67 | 34.31% | CHEMBL88108 |
| Morphine | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.79 | -4.47 | -6.12 | 28.47% | CHEMBL2172277 |
| Methadone | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.44 | -4.07 | -4.35 | 37.29% | CHEMBL88799 |
| Pethidine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.26 | -5.14 | -7.46 | 37.78% | CHEMBL328149 |
| Fentanyl | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.13 | -7.40 | -7.05 | 36.72% | CHEMBL88708 |
| Oxycodone | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.22 | N/A | N/A | 39.00% | CHEMBL334510 |
| Morphine | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.26 | N/A | N/A | 34.35% | CHEMBL3086083 |
| Methadone | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.41 | N/A | N/A | 51.76% | CHEMBL3658406 |
| Pethidine | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.73 | N/A | N/A | 43.00% | CHEMBL3658406 |
| Fentanyl | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.10 | N/A | N/A | 73.91% | CHEMBL3658401 |
| Oxycodone | PDE4B_HUMAN | phosphodiesterase 4B | -8.23 | -8.81 | -9.09 | 57.50% | CHEMBL144499 |
| Morphine | PDE4B_HUMAN | phosphodiesterase 4B | -7.99 | -7.30 | -8.08 | 45.95% | CHEMBL144499 |
| Methadone | PDE4B_HUMAN | phosphodiesterase 4B | -7.55 | -7.66 | -7.72 | 43.12% | CHEMBL144499 |
| Pethidine | PDE4B_HUMAN | phosphodiesterase 4B | -7.28 | -7.73 | -7.88 | 41.94% | CHEMBL61727 |
| Fentanyl | PDE4B_HUMAN | phosphodiesterase 4B | -7.99 | -8.12 | -8.66 | 39.84% | CHEMBL37386 |
| Oxycodone | PDE5A_HUMAN | phosphodiesterase 5A | -7.78 | -8.20 | -8.63 | 36.13% | CHEMBL190423 |
| Morphine | PDE5A_HUMAN | phosphodiesterase 5A | -7.86 | -8.21 | -8.32 | 31.75% | CHEMBL190423 |
| Methadone | PDE5A_HUMAN | phosphodiesterase 5A | -6.65 | -7.94 | -6.80 | 29.13% | CHEMBL190423 |
| Pethidine | PDE5A_HUMAN | phosphodiesterase 5A | -7.16 | -7.86 | -7.28 | 30.88% | CHEMBL190423 |
| Fentanyl | PDE5A_HUMAN | phosphodiesterase 5A | -8.25 | -8.36 | -8.02 | 31.82% | CHEMBL555171 |
| Oxycodone | PERM_HUMAN | myeloperoxidase | -8.33 | -8.16 | -8.10 | 37.64% | CHEMBL490 |
| Morphine | PERM_HUMAN | myeloperoxidase | -7.97 | -8.16 | -8.18 | 35.57% | CHEMBL490 |
| Methadone | PERM_HUMAN | myeloperoxidase | -7.44 | -7.72 | -7.69 | 42.11% | CHEMBL3892909 |
| Pethidine | PERM_HUMAN | myeloperoxidase | -6.94 | -7.20 | -6.62 | 41.86% | CHEMBL3892909 |
| Fentanyl | PERM_HUMAN | myeloperoxidase | -7.81 | -8.46 | -8.03 | 38.94% | CHEMBL2347029 |
| Oxycodone | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.89 | -7.94 | -7.43 | 35.45% | CHEMBL24798 |
| Morphine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -4.37 | -7.37 | -7.34 | 34.85% | CHEMBL229957 |
| Methadone | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.44 | -6.68 | -8.10 | 47.76% | CHEMBL1945285 |
| Pethidine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.16 | -7.15 | -7.09 | 50.67% | CHEMBL1945285 |
| Fentanyl | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -9.40 | -8.71 | -8.01 | 40.83% | CHEMBL3775653 |
| Oxycodone | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -1.16 | -4.32 | -9.85 | 42.14% | CHEMBL276663 |
| Morphine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | 1.98 | -2.82 | -6.73 | 34.92% | CHEMBL13988 |
| Methadone | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -0.21 | -5.52 | -5.91 | 47.76% | CHEMBL1945285 |
| Pethidine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.45 | -6.13 | -7.32 | 50.67% | CHEMBL1945285 |
| Fentanyl | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.93 | -5.22 | -6.33 | 44.63% | CHEMBL49775 |
| Oxycodone | PPAP_HUMAN | acid phosphatase 3 | -7.86 | N/A | N/A | 22.99% | CHEMBL507996 |
| Morphine | PPAP_HUMAN | acid phosphatase 3 | -8.29 | N/A | N/A | 20.39% | CHEMBL507996 |
| Methadone | PPAP_HUMAN | acid phosphatase 3 | -7.46 | N/A | N/A | 23.71% | CHEMBL501717 |
| Pethidine | PPAP_HUMAN | acid phosphatase 3 | -6.75 | N/A | N/A | 21.82% | CHEMBL501717 |
| Fentanyl | PPAP_HUMAN | acid phosphatase 3 | -8.05 | N/A | N/A | 24.07% | CHEMBL501717 |
| Oxycodone | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.26 | -6.35 | -7.52 | 47.93% | CHEMBL419756 |
| Morphine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.59 | -6.06 | -6.50 | 43.24% | CHEMBL1836977 |
| Methadone | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.71 | -6.96 | -6.79 | 37.89% | CHEMBL3765141 |
| Pethidine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -5.88 | -6.17 | -5.93 | 47.06% | CHEMBL396109 |
| Fentanyl | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.69 | -9.34 | -7.47 | 47.11% | CHEMBL340011 |
| Oxycodone | PRGR_HUMAN | progesterone receptor | -6.90 | -6.73 | -8.21 | 40.21% | CHEMBL1911657 |
| Morphine | PRGR_HUMAN | progesterone receptor | -9.19 | -9.49 | -9.01 | 40.72% | CHEMBL51933 |
| Methadone | PRGR_HUMAN | progesterone receptor | -6.75 | -6.63 | -8.73 | 47.37% | CHEMBL1165353 |
| Pethidine | PRGR_HUMAN | progesterone receptor | -7.47 | -7.25 | -7.41 | 38.17% | CHEMBL197161 |
| Fentanyl | PRGR_HUMAN | progesterone receptor | -8.55 | -7.85 | -9.53 | 48.00% | CHEMBL332502 |
| Oxycodone | PTGES_HUMAN | prostaglandin E synthase | -6.59 | N/A | N/A | 39.60% | CHEMBL538661 |
| Morphine | PTGES_HUMAN | prostaglandin E synthase | -6.67 | N/A | N/A | 37.75% | CHEMBL3753433 |
| Methadone | PTGES_HUMAN | prostaglandin E synthase | -5.80 | N/A | N/A | 39.09% | CHEMBL4071976 |
| Pethidine | PTGES_HUMAN | prostaglandin E synthase | -5.89 | N/A | N/A | 40.78% | CHEMBL3919693 |
| Fentanyl | PTGES_HUMAN | prostaglandin E synthase | -6.97 | N/A | N/A | 53.33% | CHEMBL4086788 |
| Oxycodone | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.08 | -8.86 | -8.69 | 52.67% | CHEMBL52440 |
| Morphine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.38 | -9.37 | -9.17 | 46.48% | CHEMBL434728 |
| Methadone | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.26 | -8.02 | -8.29 | 68.97% | CHEMBL109571 |
| Pethidine | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.57 | -7.60 | -7.58 | 66.67% | CHEMBL2407323 |
| Fentanyl | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.64 | -9.19 | -9.51 | 65.48% | CHEMBL564288 |
| Oxycodone | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.27 | N/A | N/A | 42.94% | CHEMBL203440 |
| Morphine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.30 | N/A | N/A | 40.00% | CHEMBL3662107 |
| Methadone | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.74 | N/A | N/A | 42.86% | CHEMBL206758 |
| Pethidine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.30 | N/A | N/A | 41.28% | CHEMBL206758 |
| Fentanyl | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.54 | N/A | N/A | 59.09% | CHEMBL2152693 |
| Oxycodone | TLR4_HUMAN | toll like receptor 4 | -7.77 | -7.49 | -7.61 | 41.46% | CHEMBL3261030 |
| Morphine | TLR4_HUMAN | toll like receptor 4 | -8.14 | -7.73 | -7.33 | 37.84% | CHEMBL3261029 |
| Methadone | TLR4_HUMAN | toll like receptor 4 | -7.29 | -6.87 | -7.09 | 31.39% | CHEMBL382272 |
| Pethidine | TLR4_HUMAN | toll like receptor 4 | -6.72 | -6.55 | -5.99 | 38.57% | CHEMBL382272 |
| Fentanyl | TLR4_HUMAN | toll like receptor 4 | -8.33 | -8.16 | -8.74 | 39.05% | CHEMBL1223752 |
| Oxycodone | TNFA_HUMAN | tumor necrosis factor | -7.83 | N/A | N/A | 49.77% | CHEMBL2337619 |
| Morphine | TNFA_HUMAN | tumor necrosis factor | -7.80 | N/A | N/A | 54.46% | CHEMBL2337619 |
| Methadone | TNFA_HUMAN | tumor necrosis factor | -7.52 | N/A | N/A | 38.10% | CHEMBL76297 |
| Pethidine | TNFA_HUMAN | tumor necrosis factor | -6.63 | N/A | N/A | 44.55% | CHEMBL76297 |
| Fentanyl | TNFA_HUMAN | tumor necrosis factor | -7.78 | N/A | N/A | 44.86% | CHEMBL1612423 |
| Oxycodone | TRBM_HUMAN | thrombomodulin | -7.24 | -7.04 | N/A | N/A | N/A |
| Morphine | TRBM_HUMAN | thrombomodulin | -7.48 | -6.80 | N/A | N/A | N/A |
| Methadone | TRBM_HUMAN | thrombomodulin | -6.58 | -5.85 | N/A | N/A | N/A |
| Pethidine | TRBM_HUMAN | thrombomodulin | -6.04 | -5.97 | N/A | N/A | N/A |
| Fentanyl | TRBM_HUMAN | thrombomodulin | -7.60 | -6.70 | N/A | N/A | N/A |
| Oxycodone | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.59 | -7.06 | N/A | N/A | N/A |
| Morphine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.65 | -6.60 | N/A | N/A | N/A |
| Methadone | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.53 | -6.46 | N/A | N/A | N/A |
| Pethidine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.33 | -6.01 | N/A | N/A | N/A |
| Fentanyl | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.92 | -7.11 | N/A | N/A | N/A |
| Oxycodone | TRPM8_FICAL | Uncharacterized protein | -9.00 | N/A | N/A | N/A | N/A |
| Morphine | TRPM8_FICAL | Uncharacterized protein | -8.54 | N/A | N/A | N/A | N/A |
| Methadone | TRPM8_FICAL | Uncharacterized protein | -8.04 | N/A | N/A | N/A | N/A |
| Pethidine | TRPM8_FICAL | Uncharacterized protein | -7.12 | N/A | N/A | N/A | N/A |
| Fentanyl | TRPM8_FICAL | Uncharacterized protein | -9.23 | N/A | N/A | N/A | N/A |
| Oxycodone | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.61 | N/A | N/A | 44.51% | CHEMBL2057858 |
| Morphine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.74 | N/A | N/A | 42.71% | CHEMBL97968 |
| Methadone | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.42 | N/A | N/A | 43.93% | CHEMBL1940379 |
| Pethidine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.09 | N/A | N/A | 50.00% | CHEMBL1277028 |
| Fentanyl | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.17 | N/A | N/A | 47.37% | CHEMBL2057855 |
| Oxycodone | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -9.02 | -8.00 | N/A | N/A | N/A |
| Morphine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.71 | -8.66 | N/A | N/A | N/A |
| Methadone | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.54 | -6.88 | N/A | N/A | N/A |
| Pethidine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.86 | -6.79 | N/A | N/A | N/A |
| Fentanyl | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.27 | -8.55 | N/A | N/A | N/A |
| Oxycodone | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.99 | -7.95 | N/A | 50.00% | CHEMBL3664218 |
| Morphine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.45 | -7.87 | N/A | 44.88% | CHEMBL3664218 |
| Methadone | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.44 | -5.82 | N/A | 32.61% | CHEMBL3664218 |
| Pethidine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.42 | -6.49 | N/A | 32.21% | CHEMBL3664218 |
| Fentanyl | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.99 | -6.85 | N/A | 36.24% | CHEMBL3943107 |
| Oxycodone | TRXR1_HUMAN | thioredoxin reductase 1 | -8.35 | -7.77 | -6.80 | N/A | N/A |
| Morphine | TRXR1_HUMAN | thioredoxin reductase 1 | -8.44 | -7.81 | -7.04 | N/A | N/A |
| Methadone | TRXR1_HUMAN | thioredoxin reductase 1 | -6.95 | -6.50 | -6.33 | N/A | N/A |
| Pethidine | TRXR1_HUMAN | thioredoxin reductase 1 | -6.55 | -6.81 | -5.69 | N/A | N/A |
| Fentanyl | TRXR1_HUMAN | thioredoxin reductase 1 | -8.00 | -7.73 | -6.52 | N/A | N/A |
| Oxycodone | TRY1_HUMAN | serine protease 1 | -6.00 | N/A | N/A | 38.81% | CHEMBL69394 |
| Morphine | TRY1_HUMAN | serine protease 1 | -6.03 | N/A | N/A | 33.22% | CHEMBL73970 |
| Methadone | TRY1_HUMAN | serine protease 1 | -5.46 | N/A | N/A | 55.00% | CHEMBL156472 |
| Pethidine | TRY1_HUMAN | serine protease 1 | -5.29 | N/A | N/A | 46.79% | CHEMBL134821 |
| Fentanyl | TRY1_HUMAN | serine protease 1 | -6.25 | N/A | N/A | 48.28% | CHEMBL421370 |