| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Omeprazole | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.53 | -8.57 | -8.98 | 38.51% | CHEMBL190298 |
| Metolazone | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.04 | -9.47 | -9.31 | 37.77% | CHEMBL370852 |
| Metformin | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -5.46 | -5.47 | -5.39 | 9.88% | CHEMBL366322 |
| Oseltamivir | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -6.88 | -6.93 | -7.31 | 28.52% | CHEMBL442 |
| Miglitol | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -5.55 | -5.55 | -5.41 | 28.12% | CHEMBL136470 |
| Omeprazole | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.43 | -8.85 | N/A | 34.19% | CHEMBL343529 |
| Metolazone | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.97 | -9.41 | N/A | 56.05% | CHEMBL590482 |
| Metformin | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -4.78 | -4.85 | N/A | 12.36% | CHEMBL582877 |
| Oseltamivir | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.42 | -8.06 | N/A | 51.90% | CHEMBL473765 |
| Miglitol | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -5.24 | -5.45 | N/A | 35.80% | CHEMBL1201203 |
| Omeprazole | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.49 | -8.78 | -8.76 | 33.70% | CHEMBL357995 |
| Metolazone | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -9.53 | -9.50 | -9.98 | 56.05% | CHEMBL590482 |
| Metformin | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -5.34 | -5.07 | -5.07 | 12.36% | CHEMBL582877 |
| Oseltamivir | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.58 | -6.85 | -6.77 | 38.05% | CHEMBL1123 |
| Miglitol | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -5.74 | -5.47 | -5.58 | 35.80% | CHEMBL1201203 |
| Omeprazole | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.61 | -8.33 | N/A | 32.97% | CHEMBL3589583 |
| Metolazone | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -9.33 | -8.70 | N/A | 58.97% | CHEMBL605402 |
| Metformin | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -5.10 | -4.95 | N/A | 12.36% | CHEMBL582877 |
| Oseltamivir | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.99 | -7.71 | N/A | 38.05% | CHEMBL1123 |
| Miglitol | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -5.63 | -5.65 | N/A | 35.80% | CHEMBL1201203 |
| Omeprazole | AA1R_HUMAN | adenosine A1 receptor | -7.69 | -7.91 | -8.26 | 38.16% | CHEMBL125979 |
| Metolazone | AA1R_HUMAN | adenosine A1 receptor | -7.99 | -8.35 | -8.64 | 36.73% | CHEMBL608980 |
| Metformin | AA1R_HUMAN | adenosine A1 receptor | -4.63 | -4.32 | -5.19 | 6.48% | CHEMBL329774 |
| Oseltamivir | AA1R_HUMAN | adenosine A1 receptor | -7.13 | -6.88 | -6.86 | 33.02% | CHEMBL608220 |
| Miglitol | AA1R_HUMAN | adenosine A1 receptor | -4.81 | -5.00 | -5.27 | 26.52% | CHEMBL3770601 |
| Omeprazole | AA2AR_HUMAN | adenosine A2a receptor | -7.86 | -7.78 | -8.43 | 38.16% | CHEMBL125979 |
| Metolazone | AA2AR_HUMAN | adenosine A2a receptor | -7.88 | -7.57 | -9.77 | 36.73% | CHEMBL608980 |
| Metformin | AA2AR_HUMAN | adenosine A2a receptor | -4.84 | -5.03 | -5.13 | 8.91% | CHEMBL1099100 |
| Oseltamivir | AA2AR_HUMAN | adenosine A2a receptor | -6.49 | -6.90 | -7.69 | 32.97% | CHEMBL3350613 |
| Miglitol | AA2AR_HUMAN | adenosine A2a receptor | -4.66 | -4.87 | -5.18 | 26.52% | CHEMBL3770601 |
| Omeprazole | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.48 | -8.83 | -9.58 | 35.53% | CHEMBL374729 |
| Metolazone | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.28 | -9.49 | -8.28 | 49.01% | CHEMBL141810 |
| Metformin | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -5.86 | -5.55 | -5.68 | 18.52% | CHEMBL1956097 |
| Oseltamivir | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.98 | -7.76 | -8.43 | 43.06% | CHEMBL1080631 |
| Miglitol | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -6.09 | -6.02 | -5.88 | 46.51% | CHEMBL345241 |
| Omeprazole | ACE_HUMAN | angiotensin I converting enzyme | -8.51 | -8.76 | -7.09 | 34.00% | CHEMBL3414814 |
| Metolazone | ACE_HUMAN | angiotensin I converting enzyme | -8.65 | -8.34 | -8.09 | 33.52% | CHEMBL2435340 |
| Metformin | ACE_HUMAN | angiotensin I converting enzyme | -5.50 | -5.79 | -5.21 | 5.49% | CHEMBL101360 |
| Oseltamivir | ACE_HUMAN | angiotensin I converting enzyme | -7.17 | -7.02 | -6.23 | 48.03% | CHEMBL1581 |
| Miglitol | ACE_HUMAN | angiotensin I converting enzyme | -5.77 | -5.21 | -5.04 | 44.12% | CHEMBL331575 |
| Omeprazole | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.73 | N/A | N/A | 19.83% | CHEMBL386114 |
| Metolazone | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.72 | N/A | N/A | 19.26% | CHEMBL386114 |
| Metformin | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -4.61 | N/A | N/A | 3.66% | CHEMBL386114 |
| Oseltamivir | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.63 | N/A | N/A | 23.61% | CHEMBL386114 |
| Miglitol | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -4.48 | N/A | N/A | 17.96% | CHEMBL386114 |
| Omeprazole | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.06 | -7.77 | -5.98 | N/A | N/A |
| Metolazone | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.97 | -4.42 | -4.88 | N/A | N/A |
| Metformin | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.16 | -5.79 | -5.14 | N/A | N/A |
| Oseltamivir | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.80 | -5.54 | -5.97 | N/A | N/A |
| Miglitol | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -4.28 | -5.51 | -5.31 | N/A | N/A |
| Omeprazole | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.94 | -3.50 | N/A | 34.74% | CHEMBL1935444 |
| Metolazone | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -4.81 | 1.94 | N/A | 44.87% | CHEMBL3600977 |
| Metformin | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -5.24 | -5.02 | N/A | 15.91% | CHEMBL477542 |
| Oseltamivir | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.61 | -6.78 | N/A | 46.92% | CHEMBL182761 |
| Miglitol | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -5.92 | -4.89 | N/A | 46.67% | CHEMBL2111051 |
| Omeprazole | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.78 | -8.27 | N/A | 31.58% | CHEMBL59939 |
| Metolazone | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.35 | -8.56 | N/A | 39.15% | CHEMBL3633184 |
| Metformin | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -5.29 | -5.19 | N/A | 15.91% | CHEMBL477542 |
| Oseltamivir | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.64 | -6.90 | N/A | 44.35% | CHEMBL313738 |
| Miglitol | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -5.91 | -5.23 | N/A | 47.83% | CHEMBL294273 |
| Omeprazole | ADRB2_HUMAN | adrenoceptor beta 2 | -8.51 | -8.67 | -9.32 | 39.53% | CHEMBL1517798 |
| Metolazone | ADRB2_HUMAN | adrenoceptor beta 2 | -7.55 | -7.64 | -9.84 | 51.85% | CHEMBL1490889 |
| Metformin | ADRB2_HUMAN | adrenoceptor beta 2 | -5.38 | -5.44 | -5.23 | 7.03% | CHEMBL332010 |
| Oseltamivir | ADRB2_HUMAN | adrenoceptor beta 2 | -6.94 | -7.37 | -7.16 | 37.93% | CHEMBL1569630 |
| Miglitol | ADRB2_HUMAN | adrenoceptor beta 2 | -5.77 | -6.20 | -5.82 | 35.29% | CHEMBL2070834 |
| Omeprazole | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.16 | -8.80 | -7.80 | 29.82% | CHEMBL2435831 |
| Metolazone | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.78 | -8.97 | -8.04 | 34.69% | CHEMBL263452 |
| Metformin | AGTR2_HUMAN | angiotensin II receptor type 2 | -4.59 | -4.88 | -4.66 | 5.93% | CHEMBL3350599 |
| Oseltamivir | AGTR2_HUMAN | angiotensin II receptor type 2 | -6.78 | -6.89 | -6.29 | 28.32% | CHEMBL3350599 |
| Miglitol | AGTR2_HUMAN | angiotensin II receptor type 2 | -4.78 | -4.77 | -4.63 | 22.58% | CHEMBL3350599 |
| Omeprazole | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.67 | -8.65 | -9.49 | 29.32% | CHEMBL1917444 |
| Metolazone | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.12 | -8.70 | -7.74 | 45.95% | CHEMBL291854 |
| Metformin | ALDR_HUMAN | aldo-keto reductase family 1 member B | -6.09 | -6.61 | -6.03 | 5.47% | CHEMBL293869 |
| Oseltamivir | ALDR_HUMAN | aldo-keto reductase family 1 member B | -6.82 | -7.00 | -7.31 | 31.43% | CHEMBL6944 |
| Miglitol | ALDR_HUMAN | aldo-keto reductase family 1 member B | -5.18 | -5.16 | -6.50 | 17.24% | CHEMBL269550 |
| Omeprazole | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.56 | -9.06 | -7.90 | 23.05% | CHEMBL1077591 |
| Metolazone | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.66 | -8.42 | -8.53 | 32.12% | CHEMBL2332526 |
| Metformin | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.82 | -5.91 | -6.03 | 7.21% | CHEMBL2022238 |
| Oseltamivir | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.90 | -7.23 | -6.36 | 33.58% | CHEMBL28650 |
| Miglitol | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.48 | -5.71 | -5.62 | 39.51% | CHEMBL28650 |
| Omeprazole | AOFA_HUMAN | monoamine oxidase A | -8.80 | -9.36 | -9.35 | 38.16% | CHEMBL1645554 |
| Metolazone | AOFA_HUMAN | monoamine oxidase A | -9.88 | -10.50 | -9.94 | 38.32% | CHEMBL3319257 |
| Metformin | AOFA_HUMAN | monoamine oxidase A | -5.30 | -5.20 | -5.57 | 7.14% | CHEMBL1796459 |
| Oseltamivir | AOFA_HUMAN | monoamine oxidase A | -7.51 | -7.88 | -7.83 | 25.31% | CHEMBL332223 |
| Miglitol | AOFA_HUMAN | monoamine oxidase A | -5.60 | -6.27 | -5.54 | 25.00% | CHEMBL2426048 |
| Omeprazole | AOFB_HUMAN | monoamine oxidase B | -9.38 | -9.39 | -9.31 | 34.59% | CHEMBL1645548 |
| Metolazone | AOFB_HUMAN | monoamine oxidase B | -10.24 | -10.59 | -10.71 | 40.13% | CHEMBL3319251 |
| Metformin | AOFB_HUMAN | monoamine oxidase B | -5.21 | -5.21 | -5.15 | 10.53% | CHEMBL903 |
| Oseltamivir | AOFB_HUMAN | monoamine oxidase B | -7.78 | -7.54 | -7.74 | 34.04% | CHEMBL4062286 |
| Miglitol | AOFB_HUMAN | monoamine oxidase B | -5.66 | -5.72 | -5.74 | 30.77% | CHEMBL2332210 |
| Omeprazole | BACE1_HUMAN | beta-secretase 1 | -7.11 | -7.19 | -7.93 | 39.49% | CHEMBL1923701 |
| Metolazone | BACE1_HUMAN | beta-secretase 1 | -7.33 | -7.58 | -8.94 | 48.75% | CHEMBL190644 |
| Metformin | BACE1_HUMAN | beta-secretase 1 | -4.98 | -4.59 | -4.92 | 14.55% | CHEMBL583178 |
| Oseltamivir | BACE1_HUMAN | beta-secretase 1 | -5.68 | -6.32 | -6.46 | 43.79% | CHEMBL2047043 |
| Miglitol | BACE1_HUMAN | beta-secretase 1 | -4.77 | -4.62 | -5.10 | 43.66% | CHEMBL461602 |
| Omeprazole | CAH2_HUMAN | carbonic anhydrase 2 | -7.24 | -7.81 | -7.60 | 33.48% | CHEMBL3337911 |
| Metolazone | CAH2_HUMAN | carbonic anhydrase 2 | -8.29 | -8.07 | -8.05 | 69.40% | CHEMBL295343 |
| Metformin | CAH2_HUMAN | carbonic anhydrase 2 | -5.86 | -5.83 | -5.67 | 18.06% | CHEMBL4080055 |
| Oseltamivir | CAH2_HUMAN | carbonic anhydrase 2 | -6.64 | -7.20 | -6.89 | 35.44% | CHEMBL2325975 |
| Miglitol | CAH2_HUMAN | carbonic anhydrase 2 | -5.99 | -5.60 | -5.49 | 51.85% | CHEMBL3400805 |
| Omeprazole | CASP1_HUMAN | caspase 1 | -6.62 | -7.18 | -6.55 | 26.51% | CHEMBL1221690 |
| Metolazone | CASP1_HUMAN | caspase 1 | -6.44 | -7.52 | -6.95 | 47.06% | CHEMBL3133256 |
| Metformin | CASP1_HUMAN | caspase 1 | -4.73 | -5.36 | -5.26 | 6.35% | CHEMBL196571 |
| Oseltamivir | CASP1_HUMAN | caspase 1 | -5.17 | -6.16 | -5.31 | 45.56% | CHEMBL200819 |
| Miglitol | CASP1_HUMAN | caspase 1 | -4.57 | -4.64 | -4.89 | 36.59% | CHEMBL466565 |
| Omeprazole | CDK5_HUMAN | cyclin dependent kinase 5 | -7.77 | -8.00 | -8.29 | 37.50% | CHEMBL2001149 |
| Metolazone | CDK5_HUMAN | cyclin dependent kinase 5 | -8.20 | -8.23 | -6.72 | 42.41% | CHEMBL1981782 |
| Metformin | CDK5_HUMAN | cyclin dependent kinase 5 | -4.68 | -4.72 | -5.42 | 7.14% | CHEMBL1992371 |
| Oseltamivir | CDK5_HUMAN | cyclin dependent kinase 5 | -6.57 | -6.61 | -6.18 | 28.00% | CHEMBL1967878 |
| Miglitol | CDK5_HUMAN | cyclin dependent kinase 5 | -5.43 | -5.41 | -5.93 | 20.25% | CHEMBL1994526 |
| Omeprazole | CHLE_HUMAN | butyrylcholinesterase | -9.02 | -8.58 | -8.81 | 31.86% | CHEMBL4063321 |
| Metolazone | CHLE_HUMAN | butyrylcholinesterase | -8.95 | -8.98 | -9.20 | 37.65% | CHEMBL592673 |
| Metformin | CHLE_HUMAN | butyrylcholinesterase | -5.21 | -5.19 | -5.67 | 18.52% | CHEMBL1956097 |
| Oseltamivir | CHLE_HUMAN | butyrylcholinesterase | -7.52 | -7.32 | -7.80 | 46.46% | CHEMBL504924 |
| Miglitol | CHLE_HUMAN | butyrylcholinesterase | -5.73 | -5.65 | -5.54 | 53.85% | CHEMBL1512936 |
| Omeprazole | CNR1_HUMAN | cannabinoid receptor 1 | -7.90 | -8.85 | -8.92 | 39.59% | CHEMBL3353833 |
| Metolazone | CNR1_HUMAN | cannabinoid receptor 1 | -7.65 | -8.79 | -9.63 | 55.29% | CHEMBL246302 |
| Metformin | CNR1_HUMAN | cannabinoid receptor 1 | -5.34 | -5.39 | -5.84 | 7.84% | CHEMBL515604 |
| Oseltamivir | CNR1_HUMAN | cannabinoid receptor 1 | -5.75 | -7.54 | -7.99 | 47.24% | CHEMBL3597330 |
| Miglitol | CNR1_HUMAN | cannabinoid receptor 1 | -4.61 | -5.06 | -5.54 | 52.73% | CHEMBL483143 |
| Omeprazole | CNR2_HUMAN | cannabinoid receptor 2 | -8.79 | -8.83 | N/A | 40.64% | CHEMBL3353802 |
| Metolazone | CNR2_HUMAN | cannabinoid receptor 2 | -9.45 | -9.56 | N/A | 55.90% | CHEMBL253462 |
| Metformin | CNR2_HUMAN | cannabinoid receptor 2 | -5.05 | -5.49 | N/A | 9.43% | CHEMBL1422818 |
| Oseltamivir | CNR2_HUMAN | cannabinoid receptor 2 | -7.51 | -7.48 | N/A | 46.88% | CHEMBL3597331 |
| Miglitol | CNR2_HUMAN | cannabinoid receptor 2 | -5.13 | -5.28 | N/A | 43.28% | CHEMBL472661 |
| Omeprazole | COLI_HUMAN | proopiomelanocortin | -8.63 | -8.57 | -7.96 | N/A | N/A |
| Metolazone | COLI_HUMAN | proopiomelanocortin | -8.58 | -8.71 | -7.60 | N/A | N/A |
| Metformin | COLI_HUMAN | proopiomelanocortin | -5.04 | -5.05 | -4.71 | N/A | N/A |
| Oseltamivir | COLI_HUMAN | proopiomelanocortin | -6.71 | -6.53 | -5.80 | N/A | N/A |
| Miglitol | COLI_HUMAN | proopiomelanocortin | -5.21 | -5.19 | -4.85 | N/A | N/A |
| Omeprazole | COMT_HUMAN | catechol-O-methyltransferase | -6.41 | -5.87 | -6.33 | 36.65% | CHEMBL3425721 |
| Metolazone | COMT_HUMAN | catechol-O-methyltransferase | -7.60 | -6.79 | -7.24 | 24.42% | CHEMBL3818719 |
| Metformin | COMT_HUMAN | catechol-O-methyltransferase | -4.78 | -4.49 | -5.88 | 4.17% | CHEMBL1089537 |
| Oseltamivir | COMT_HUMAN | catechol-O-methyltransferase | -5.08 | -4.86 | -5.25 | 21.15% | CHEMBL3819488 |
| Miglitol | COMT_HUMAN | catechol-O-methyltransferase | -4.58 | -4.60 | -5.35 | 11.87% | CHEMBL3819488 |
| Omeprazole | CRP_HUMAN | C-reactive protein | -5.71 | -5.65 | N/A | N/A | N/A |
| Metolazone | CRP_HUMAN | C-reactive protein | -6.43 | -6.49 | N/A | N/A | N/A |
| Metformin | CRP_HUMAN | C-reactive protein | -4.33 | -4.83 | N/A | N/A | N/A |
| Oseltamivir | CRP_HUMAN | C-reactive protein | -4.84 | -5.15 | N/A | N/A | N/A |
| Miglitol | CRP_HUMAN | C-reactive protein | -4.25 | -4.76 | N/A | N/A | N/A |
| Omeprazole | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -5.36 | N/A | N/A | 36.84% | CHEMBL3426944 |
| Metolazone | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -2.45 | N/A | N/A | 37.24% | CHEMBL3609013 |
| Metformin | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.02 | N/A | N/A | 7.58% | CHEMBL184637 |
| Oseltamivir | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.08 | N/A | N/A | 24.81% | CHEMBL3701188 |
| Miglitol | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.66 | N/A | N/A | 14.92% | CHEMBL556862 |
| Omeprazole | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.45 | -6.98 | -7.69 | 33.50% | CHEMBL1644072 |
| Metolazone | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.18 | -7.13 | -7.69 | 33.99% | CHEMBL3908835 |
| Metformin | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -5.15 | -5.29 | -5.18 | 12.31% | CHEMBL2347630 |
| Oseltamivir | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.59 | -6.15 | -6.30 | 41.12% | CHEMBL1221944 |
| Miglitol | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -5.59 | -5.57 | -5.09 | 28.99% | CHEMBL2170299 |
| Omeprazole | DRD2_HUMAN | dopamine receptor D2 | -8.31 | N/A | N/A | 37.99% | CHEMBL324619 |
| Metolazone | DRD2_HUMAN | dopamine receptor D2 | -8.00 | N/A | N/A | 44.52% | CHEMBL560177 |
| Metformin | DRD2_HUMAN | dopamine receptor D2 | -5.14 | N/A | N/A | 13.24% | CHEMBL132575 |
| Oseltamivir | DRD2_HUMAN | dopamine receptor D2 | -6.28 | N/A | N/A | 37.75% | CHEMBL282927 |
| Miglitol | DRD2_HUMAN | dopamine receptor D2 | -4.83 | N/A | N/A | 45.45% | CHEMBL282323 |
| Omeprazole | DRD3_HUMAN | dopamine receptor D3 | -8.54 | N/A | N/A | 65.41% | CHEMBL1219 |
| Metolazone | DRD3_HUMAN | dopamine receptor D3 | -8.16 | N/A | N/A | 44.52% | CHEMBL560177 |
| Metformin | DRD3_HUMAN | dopamine receptor D3 | -4.97 | N/A | N/A | 7.59% | CHEMBL552366 |
| Oseltamivir | DRD3_HUMAN | dopamine receptor D3 | -6.61 | N/A | N/A | 38.05% | CHEMBL1123 |
| Miglitol | DRD3_HUMAN | dopamine receptor D3 | -5.45 | N/A | N/A | 45.45% | CHEMBL282323 |
| Omeprazole | DRD4_HUMAN | dopamine receptor D4 | -8.96 | -9.33 | N/A | 35.76% | CHEMBL327782 |
| Metolazone | DRD4_HUMAN | dopamine receptor D4 | -9.29 | -9.25 | N/A | 51.43% | CHEMBL106917 |
| Metformin | DRD4_HUMAN | dopamine receptor D4 | -5.13 | -4.99 | N/A | 7.89% | CHEMBL327310 |
| Oseltamivir | DRD4_HUMAN | dopamine receptor D4 | -7.11 | -7.12 | N/A | 37.75% | CHEMBL282927 |
| Miglitol | DRD4_HUMAN | dopamine receptor D4 | -5.52 | -5.56 | N/A | 45.45% | CHEMBL32402 |
| Omeprazole | EDN1_HUMAN | endothelin 1 | -8.38 | N/A | N/A | N/A | N/A |
| Metolazone | EDN1_HUMAN | endothelin 1 | -7.35 | N/A | N/A | N/A | N/A |
| Metformin | EDN1_HUMAN | endothelin 1 | -4.68 | N/A | N/A | N/A | N/A |
| Oseltamivir | EDN1_HUMAN | endothelin 1 | -6.31 | N/A | N/A | N/A | N/A |
| Miglitol | EDN1_HUMAN | endothelin 1 | -4.84 | N/A | N/A | N/A | N/A |
| Omeprazole | ESR1_HUMAN | estrogen receptor 1 | -7.50 | -7.51 | -6.95 | 33.51% | CHEMBL1254532 |
| Metolazone | ESR1_HUMAN | estrogen receptor 1 | -6.48 | -8.47 | -8.00 | 37.58% | CHEMBL242818 |
| Metformin | ESR1_HUMAN | estrogen receptor 1 | -5.15 | -5.16 | -5.26 | 10.94% | CHEMBL3597502 |
| Oseltamivir | ESR1_HUMAN | estrogen receptor 1 | -6.75 | -6.99 | -6.99 | 37.80% | CHEMBL241041 |
| Miglitol | ESR1_HUMAN | estrogen receptor 1 | -5.35 | -5.35 | -5.31 | 29.59% | CHEMBL3586194 |
| Omeprazole | FABP5_HUMAN | fatty acid binding protein 5 | -8.12 | -6.02 | -5.77 | 25.31% | CHEMBL247920 |
| Metolazone | FABP5_HUMAN | fatty acid binding protein 5 | -8.38 | -6.58 | -7.06 | 31.84% | CHEMBL3941588 |
| Metformin | FABP5_HUMAN | fatty acid binding protein 5 | -4.83 | -4.34 | -4.29 | 3.97% | CHEMBL3959018 |
| Oseltamivir | FABP5_HUMAN | fatty acid binding protein 5 | -6.84 | -5.42 | -4.92 | 25.89% | CHEMBL8659 |
| Miglitol | FABP5_HUMAN | fatty acid binding protein 5 | -5.27 | -4.62 | -4.42 | 22.92% | CHEMBL82293 |
| Omeprazole | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.29 | N/A | N/A | 38.17% | CHEMBL3632717 |
| Metolazone | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.46 | N/A | N/A | 38.76% | CHEMBL12131 |
| Metformin | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -5.42 | N/A | N/A | 6.37% | CHEMBL67237 |
| Oseltamivir | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.63 | N/A | N/A | 31.62% | CHEMBL407135 |
| Miglitol | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -4.90 | N/A | N/A | 36.25% | CHEMBL407135 |
| Omeprazole | GLRA3_HUMAN | glycine receptor alpha 3 | -8.64 | -7.72 | -8.51 | 20.97% | CHEMBL4070615 |
| Omeprazole | GLRA3_HUMAN | glycine receptor alpha 3 | -8.43 | N/A | N/A | 20.97% | CHEMBL4070615 |
| Metolazone | GLRA3_HUMAN | glycine receptor alpha 3 | -8.83 | -8.51 | -8.15 | 25.31% | CHEMBL4074873 |
| Metolazone | GLRA3_HUMAN | glycine receptor alpha 3 | -9.53 | N/A | N/A | 25.31% | CHEMBL4074873 |
| Metformin | GLRA3_HUMAN | glycine receptor alpha 3 | -5.23 | -5.16 | -5.38 | 2.53% | CHEMBL4070615 |
| Metformin | GLRA3_HUMAN | glycine receptor alpha 3 | -5.30 | N/A | N/A | 2.53% | CHEMBL4070615 |
| Oseltamivir | GLRA3_HUMAN | glycine receptor alpha 3 | -7.16 | -7.59 | -7.32 | 15.83% | CHEMBL4070615 |
| Oseltamivir | GLRA3_HUMAN | glycine receptor alpha 3 | -7.17 | N/A | N/A | 15.83% | CHEMBL4070615 |
| Miglitol | GLRA3_HUMAN | glycine receptor alpha 3 | -5.70 | -5.39 | -5.38 | 9.52% | CHEMBL4070615 |
| Miglitol | GLRA3_HUMAN | glycine receptor alpha 3 | -5.49 | N/A | N/A | 9.52% | CHEMBL4070615 |
| Omeprazole | GRM5_HUMAN | glutamate metabotropic receptor 5 | -9.00 | -8.93 | -8.71 | 42.86% | CHEMBL4060880 |
| Metolazone | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.43 | -4.07 | -5.39 | 49.08% | CHEMBL365797 |
| Metformin | GRM5_HUMAN | glutamate metabotropic receptor 5 | -5.56 | -6.13 | -5.99 | 12.77% | CHEMBL204392 |
| Oseltamivir | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.04 | -7.72 | -7.56 | 27.69% | CHEMBL3926962 |
| Miglitol | GRM5_HUMAN | glutamate metabotropic receptor 5 | -5.67 | -4.41 | -4.57 | 37.04% | CHEMBL1783985 |
| Omeprazole | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.47 | -7.98 | -8.36 | 28.50% | CHEMBL3425948 |
| Metolazone | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.58 | -6.90 | -6.70 | 38.50% | CHEMBL3650213 |
| Metformin | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -5.07 | -4.94 | -5.19 | 6.85% | CHEMBL3650195 |
| Oseltamivir | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.01 | -5.12 | -5.77 | 30.89% | CHEMBL3698260 |
| Miglitol | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -5.63 | -4.88 | -5.03 | 18.98% | CHEMBL3650207 |
| Omeprazole | HRH1_HUMAN | histamine receptor H1 | -8.51 | N/A | N/A | 38.54% | CHEMBL1935448 |
| Metolazone | HRH1_HUMAN | histamine receptor H1 | -5.45 | N/A | N/A | 38.02% | CHEMBL1910379 |
| Metformin | HRH1_HUMAN | histamine receptor H1 | -5.57 | N/A | N/A | 9.41% | CHEMBL1096430 |
| Oseltamivir | HRH1_HUMAN | histamine receptor H1 | -6.86 | N/A | N/A | 32.53% | CHEMBL1278020 |
| Miglitol | HRH1_HUMAN | histamine receptor H1 | -5.81 | N/A | N/A | 36.11% | CHEMBL571174 |
| Omeprazole | HYES_HUMAN | epoxide hydrolase 2 | -7.89 | -8.29 | -7.66 | 32.38% | CHEMBL550648 |
| Metolazone | HYES_HUMAN | epoxide hydrolase 2 | -10.11 | -10.39 | -8.25 | 46.21% | CHEMBL1818405 |
| Metformin | HYES_HUMAN | epoxide hydrolase 2 | -5.88 | -5.57 | -5.02 | 12.50% | CHEMBL1458 |
| Oseltamivir | HYES_HUMAN | epoxide hydrolase 2 | -6.99 | -7.00 | -7.08 | 47.90% | CHEMBL561665 |
| Miglitol | HYES_HUMAN | epoxide hydrolase 2 | -6.64 | -6.52 | -4.83 | 43.42% | CHEMBL245158 |
| Omeprazole | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.11 | N/A | N/A | 35.03% | CHEMBL482769 |
| Metolazone | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.05 | N/A | N/A | 39.10% | CHEMBL230488 |
| Metformin | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -4.78 | N/A | N/A | 7.02% | CHEMBL474802 |
| Oseltamivir | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.89 | N/A | N/A | 43.26% | CHEMBL1672879 |
| Miglitol | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -4.92 | N/A | N/A | 24.07% | CHEMBL507333 |
| Omeprazole | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.91 | -7.57 | N/A | 33.33% | CHEMBL343002 |
| Metolazone | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.12 | -8.73 | N/A | 67.36% | CHEMBL376721 |
| Metformin | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -4.52 | -5.08 | N/A | 10.81% | CHEMBL134 |
| Oseltamivir | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.71 | -6.38 | N/A | 55.76% | CHEMBL2075043 |
| Miglitol | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -5.27 | -5.78 | N/A | 55.56% | CHEMBL2075030 |
| Omeprazole | MIF_HUMAN | macrophage migration inhibitory factor | -7.00 | -6.76 | -6.67 | 30.48% | CHEMBL3924400 |
| Metolazone | MIF_HUMAN | macrophage migration inhibitory factor | -5.39 | -6.29 | -6.23 | 35.12% | CHEMBL1604170 |
| Metformin | MIF_HUMAN | macrophage migration inhibitory factor | -5.07 | -4.97 | -4.75 | 9.76% | CHEMBL1253381 |
| Oseltamivir | MIF_HUMAN | macrophage migration inhibitory factor | -5.81 | -5.99 | -5.73 | 31.69% | CHEMBL2375653 |
| Miglitol | MIF_HUMAN | macrophage migration inhibitory factor | -3.66 | -4.43 | -3.99 | 18.49% | CHEMBL554271 |
| Omeprazole | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.74 | -7.55 | -7.32 | 30.38% | CHEMBL4110942 |
| Metolazone | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.39 | -8.48 | -7.40 | 42.41% | CHEMBL1981782 |
| Metformin | MK01_HUMAN | mitogen-activated protein kinase 1 | -5.03 | -4.92 | -5.03 | 5.88% | CHEMBL1975647 |
| Oseltamivir | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.20 | -6.44 | -6.50 | 30.77% | CHEMBL3752989 |
| Miglitol | MK01_HUMAN | mitogen-activated protein kinase 1 | -4.89 | -5.18 | -4.66 | 26.42% | CHEMBL3752989 |
| Omeprazole | MK03_HUMAN | mitogen-activated protein kinase 3 | -8.41 | -8.54 | -8.11 | 29.08% | CHEMBL1336 |
| Metolazone | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.00 | -8.42 | -7.71 | 36.56% | CHEMBL1336 |
| Metformin | MK03_HUMAN | mitogen-activated protein kinase 3 | -4.80 | -5.06 | -5.09 | 4.72% | CHEMBL1336 |
| Oseltamivir | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.48 | -7.02 | -6.04 | 27.33% | CHEMBL3113587 |
| Miglitol | MK03_HUMAN | mitogen-activated protein kinase 3 | -5.21 | -5.31 | -5.28 | 18.92% | CHEMBL1950289 |
| Omeprazole | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.15 | -8.11 | -8.14 | 34.15% | CHEMBL2030445 |
| Metolazone | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.18 | -8.96 | -8.81 | 38.92% | CHEMBL4087157 |
| Metformin | MTOR_HUMAN | mechanistic target of rapamycin kinase | -4.36 | -5.07 | -4.97 | 31.82% | CHEMBL1703 |
| Oseltamivir | MTOR_HUMAN | mechanistic target of rapamycin kinase | -6.84 | -7.36 | -6.89 | 50.00% | CHEMBL269732 |
| Miglitol | MTOR_HUMAN | mechanistic target of rapamycin kinase | -4.66 | -4.89 | -4.69 | 30.95% | CHEMBL3972399 |
| Omeprazole | NEP_HUMAN | membrane metalloendopeptidase | -8.03 | -7.43 | -8.31 | 26.34% | CHEMBL305388 |
| Metolazone | NEP_HUMAN | membrane metalloendopeptidase | -8.17 | -7.80 | -7.97 | 26.25% | CHEMBL3145346 |
| Metformin | NEP_HUMAN | membrane metalloendopeptidase | -5.73 | -6.04 | -6.07 | 6.87% | CHEMBL3695450 |
| Oseltamivir | NEP_HUMAN | membrane metalloendopeptidase | -6.66 | -6.51 | -7.47 | 36.72% | CHEMBL434492 |
| Miglitol | NEP_HUMAN | membrane metalloendopeptidase | -5.76 | -6.02 | -5.92 | 50.82% | CHEMBL3221965 |
| Omeprazole | NK1R_HUMAN | tachykinin receptor 1 | -8.09 | -8.50 | -7.37 | 29.49% | CHEMBL43970 |
| Metolazone | NK1R_HUMAN | tachykinin receptor 1 | -8.67 | -8.35 | -8.52 | 42.33% | CHEMBL419004 |
| Metformin | NK1R_HUMAN | tachykinin receptor 1 | -4.95 | -5.22 | -4.72 | 7.25% | CHEMBL3780820 |
| Oseltamivir | NK1R_HUMAN | tachykinin receptor 1 | -7.16 | -7.04 | -6.44 | 43.28% | CHEMBL1090437 |
| Miglitol | NK1R_HUMAN | tachykinin receptor 1 | -5.10 | -5.25 | -5.06 | 33.33% | CHEMBL2112367 |
| Omeprazole | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.91 | -8.39 | -9.15 | 16.42% | CHEMBL2333945 |
| Metolazone | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.19 | -7.91 | -7.36 | 31.28% | CHEMBL2333945 |
| Metformin | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -5.74 | -5.70 | -5.62 | 3.66% | CHEMBL284237 |
| Oseltamivir | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.49 | -7.19 | -6.80 | 11.66% | CHEMBL284237 |
| Miglitol | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -5.97 | -5.94 | -5.72 | 10.89% | CHEMBL284237 |
| Omeprazole | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.97 | -9.36 | -8.30 | 38.65% | CHEMBL2013202 |
| Metolazone | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.89 | -8.61 | -9.29 | 31.28% | CHEMBL1779013 |
| Metformin | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -5.21 | -5.19 | -5.30 | 10.34% | CHEMBL348360 |
| Oseltamivir | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.70 | -7.87 | -7.45 | 21.02% | CHEMBL218547 |
| Miglitol | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -5.49 | -5.70 | -5.23 | 35.90% | CHEMBL17350 |
| Omeprazole | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -9.21 | -8.49 | -9.15 | 29.57% | CHEMBL162577 |
| Metolazone | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.17 | -7.20 | -7.36 | 43.20% | CHEMBL349729 |
| Metformin | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -5.72 | -5.62 | -5.62 | 4.38% | CHEMBL162293 |
| Oseltamivir | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.42 | -7.09 | -6.80 | 22.94% | CHEMBL354003 |
| Miglitol | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -5.98 | -6.25 | -5.72 | 17.80% | CHEMBL419399 |
| Omeprazole | NOS1_HUMAN | nitric oxide synthase 1 | -8.15 | -8.01 | -8.65 | 46.62% | CHEMBL1800523 |
| Metolazone | NOS1_HUMAN | nitric oxide synthase 1 | -9.09 | -7.74 | -8.98 | 38.66% | CHEMBL491897 |
| Metformin | NOS1_HUMAN | nitric oxide synthase 1 | -6.19 | -6.03 | -5.88 | 25.00% | CHEMBL269058 |
| Oseltamivir | NOS1_HUMAN | nitric oxide synthase 1 | -7.25 | -7.40 | -7.55 | 33.99% | CHEMBL317521 |
| Miglitol | NOS1_HUMAN | nitric oxide synthase 1 | -5.74 | -5.90 | -6.11 | 39.66% | CHEMBL11471 |
| Omeprazole | NOS2_HUMAN | nitric oxide synthase 2 | -7.69 | -8.19 | -7.78 | 60.00% | CHEMBL1800348 |
| Metolazone | NOS2_HUMAN | nitric oxide synthase 2 | -6.78 | -7.92 | -6.87 | 42.02% | CHEMBL522467 |
| Metformin | NOS2_HUMAN | nitric oxide synthase 2 | -6.16 | -5.58 | -6.23 | 25.00% | CHEMBL269058 |
| Oseltamivir | NOS2_HUMAN | nitric oxide synthase 2 | -7.37 | -7.11 | -7.14 | 30.16% | CHEMBL195352 |
| Miglitol | NOS2_HUMAN | nitric oxide synthase 2 | -5.11 | -5.67 | -6.11 | 53.45% | CHEMBL114534 |
| Omeprazole | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.00 | -8.47 | -8.32 | 32.88% | CHEMBL3666424 |
| Metolazone | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.35 | -8.44 | -8.50 | 37.64% | CHEMBL3109646 |
| Metformin | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -4.91 | -4.85 | -4.91 | 7.14% | CHEMBL1992371 |
| Oseltamivir | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.53 | -6.40 | -6.80 | 25.94% | CHEMBL416056 |
| Miglitol | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -4.66 | -4.90 | -4.87 | 26.67% | CHEMBL3403435 |
| Omeprazole | OPRD_HUMAN | opioid receptor delta 1 | -7.10 | -6.40 | -6.84 | 31.10% | CHEMBL420863 |
| Metolazone | OPRD_HUMAN | opioid receptor delta 1 | -7.82 | -6.91 | -7.45 | 45.69% | CHEMBL1332208 |
| Metformin | OPRD_HUMAN | opioid receptor delta 1 | -5.39 | -4.03 | -5.19 | 9.52% | CHEMBL1587149 |
| Oseltamivir | OPRD_HUMAN | opioid receptor delta 1 | -6.35 | -5.85 | -6.10 | 39.57% | CHEMBL1743604 |
| Miglitol | OPRD_HUMAN | opioid receptor delta 1 | -4.67 | -4.42 | -4.37 | 45.31% | CHEMBL3326796 |
| Omeprazole | OPRK_HUMAN | opioid receptor kappa 1 | -8.77 | -8.26 | -8.32 | 34.23% | CHEMBL1703196 |
| Metolazone | OPRK_HUMAN | opioid receptor kappa 1 | -9.53 | -9.35 | -8.12 | 39.62% | CHEMBL1710945 |
| Metformin | OPRK_HUMAN | opioid receptor kappa 1 | -4.89 | -4.87 | -5.09 | 11.11% | CHEMBL125607 |
| Oseltamivir | OPRK_HUMAN | opioid receptor kappa 1 | -7.38 | -7.52 | -6.34 | 44.62% | CHEMBL3219944 |
| Miglitol | OPRK_HUMAN | opioid receptor kappa 1 | -5.06 | -5.36 | -5.22 | 45.31% | CHEMBL3326796 |
| Omeprazole | OPRM_MOUSE | Mu-type opioid receptor | -8.00 | -7.78 | N/A | 30.41% | CHEMBL2147918 |
| Metolazone | OPRM_MOUSE | Mu-type opioid receptor | -8.56 | -8.73 | N/A | 32.67% | CHEMBL185687 |
| Metformin | OPRM_MOUSE | Mu-type opioid receptor | -5.07 | -4.87 | N/A | 6.02% | CHEMBL2368132 |
| Oseltamivir | OPRM_MOUSE | Mu-type opioid receptor | -6.31 | -6.61 | N/A | 46.40% | CHEMBL2057689 |
| Miglitol | OPRM_MOUSE | Mu-type opioid receptor | -4.99 | -5.03 | N/A | 39.51% | CHEMBL2057689 |
| Omeprazole | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.21 | -7.26 | -7.45 | 39.78% | CHEMBL407068 |
| Metolazone | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.73 | -7.73 | -8.00 | 45.45% | CHEMBL1079941 |
| Metformin | OPRX_HUMAN | opioid related nociceptin receptor 1 | -4.74 | -4.85 | -4.51 | 8.33% | CHEMBL26909 |
| Oseltamivir | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.22 | -5.95 | -6.41 | 32.93% | CHEMBL1783822 |
| Miglitol | OPRX_HUMAN | opioid related nociceptin receptor 1 | -4.67 | -5.25 | -5.09 | 38.57% | CHEMBL398039 |
| Omeprazole | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.88 | -5.82 | -6.22 | 30.05% | CHEMBL3091607 |
| Metolazone | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.45 | -6.62 | -6.98 | 43.33% | CHEMBL413145 |
| Metformin | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.35 | -4.64 | -4.65 | 6.25% | CHEMBL3895492 |
| Oseltamivir | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.17 | -4.60 | -5.04 | 35.16% | CHEMBL3669852 |
| Miglitol | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.41 | -4.61 | -5.05 | 21.38% | CHEMBL3669852 |
| Omeprazole | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.63 | -8.94 | -9.34 | 30.61% | CHEMBL2419492 |
| Metolazone | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.98 | -6.21 | -7.98 | 38.64% | CHEMBL591212 |
| Metformin | P2Y12_HUMAN | purinergic receptor P2Y12 | -4.99 | -6.24 | -5.41 | 5.30% | CHEMBL69139 |
| Oseltamivir | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.92 | -5.69 | -6.72 | 30.11% | CHEMBL88444 |
| Miglitol | P2Y12_HUMAN | purinergic receptor P2Y12 | -5.21 | -4.95 | -5.84 | 27.27% | CHEMBL299895 |
| Omeprazole | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.83 | N/A | N/A | 29.74% | CHEMBL207791 |
| Metolazone | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.42 | N/A | N/A | 40.23% | CHEMBL90698 |
| Metformin | PAR1_HUMAN | coagulation factor II thrombin receptor | -5.51 | N/A | N/A | 8.00% | CHEMBL4065100 |
| Oseltamivir | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.85 | N/A | N/A | 38.46% | CHEMBL3892331 |
| Miglitol | PAR1_HUMAN | coagulation factor II thrombin receptor | -5.57 | N/A | N/A | 46.27% | CHEMBL76719 |
| Omeprazole | PDE4B_HUMAN | phosphodiesterase 4B | -8.21 | -8.84 | -8.62 | 35.88% | CHEMBL1224653 |
| Metolazone | PDE4B_HUMAN | phosphodiesterase 4B | -8.70 | -8.48 | -7.98 | 43.26% | CHEMBL380321 |
| Metformin | PDE4B_HUMAN | phosphodiesterase 4B | -5.53 | -5.81 | -5.85 | 6.00% | CHEMBL284970 |
| Oseltamivir | PDE4B_HUMAN | phosphodiesterase 4B | -7.38 | -6.62 | -6.92 | 30.56% | CHEMBL451500 |
| Miglitol | PDE4B_HUMAN | phosphodiesterase 4B | -5.74 | -5.63 | -5.71 | 20.45% | CHEMBL144823 |
| Omeprazole | PDE5A_HUMAN | phosphodiesterase 5A | -7.72 | -8.34 | -8.07 | 34.73% | CHEMBL43795 |
| Metolazone | PDE5A_HUMAN | phosphodiesterase 5A | -8.23 | -9.77 | -8.95 | 44.79% | CHEMBL4092040 |
| Metformin | PDE5A_HUMAN | phosphodiesterase 5A | -5.54 | -5.91 | -5.73 | 6.92% | CHEMBL484065 |
| Oseltamivir | PDE5A_HUMAN | phosphodiesterase 5A | -6.55 | -7.19 | -6.35 | 28.19% | CHEMBL190364 |
| Miglitol | PDE5A_HUMAN | phosphodiesterase 5A | -5.63 | -5.92 | -5.60 | 21.85% | CHEMBL932 |
| Omeprazole | PERM_HUMAN | myeloperoxidase | -8.19 | -7.97 | -7.41 | 32.53% | CHEMBL581893 |
| Metolazone | PERM_HUMAN | myeloperoxidase | -7.96 | -8.12 | -8.34 | 29.59% | CHEMBL86 |
| Metformin | PERM_HUMAN | myeloperoxidase | -5.88 | -5.90 | -6.03 | 9.33% | CHEMBL602365 |
| Oseltamivir | PERM_HUMAN | myeloperoxidase | -6.67 | -6.80 | -6.70 | 19.88% | CHEMBL490 |
| Miglitol | PERM_HUMAN | myeloperoxidase | -5.27 | -5.51 | -5.13 | 23.85% | CHEMBL490 |
| Omeprazole | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -8.01 | -8.64 | -8.81 | 33.33% | CHEMBL438316 |
| Metolazone | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -7.49 | -9.01 | -8.47 | 40.28% | CHEMBL8968 |
| Metformin | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -4.97 | -4.99 | -5.29 | 10.32% | CHEMBL15904 |
| Oseltamivir | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.31 | -7.01 | -7.02 | 45.52% | CHEMBL500387 |
| Miglitol | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.03 | -5.55 | -4.91 | 23.58% | CHEMBL3809863 |
| Omeprazole | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.98 | -6.02 | -7.45 | 32.18% | CHEMBL1950010 |
| Metolazone | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -3.65 | -6.48 | -7.76 | 39.44% | CHEMBL3322421 |
| Metformin | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.08 | -4.92 | -5.14 | 6.67% | CHEMBL572806 |
| Oseltamivir | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.23 | -5.89 | -7.70 | 42.86% | CHEMBL463763 |
| Miglitol | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.15 | -5.30 | -5.65 | 28.36% | CHEMBL3809958 |
| Omeprazole | PPAP_HUMAN | acid phosphatase 3 | -7.62 | N/A | N/A | 17.03% | CHEMBL507996 |
| Metolazone | PPAP_HUMAN | acid phosphatase 3 | -8.61 | N/A | N/A | 19.76% | CHEMBL501717 |
| Metformin | PPAP_HUMAN | acid phosphatase 3 | -5.76 | N/A | N/A | 2.82% | CHEMBL498632 |
| Oseltamivir | PPAP_HUMAN | acid phosphatase 3 | -6.34 | N/A | N/A | 10.47% | CHEMBL507996 |
| Miglitol | PPAP_HUMAN | acid phosphatase 3 | -5.50 | N/A | N/A | 9.28% | CHEMBL501717 |
| Omeprazole | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.84 | -8.58 | -8.44 | 35.81% | CHEMBL461944 |
| Metolazone | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -8.70 | -8.18 | -8.86 | 50.00% | CHEMBL496534 |
| Metformin | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -4.82 | -5.03 | -4.76 | 6.35% | CHEMBL2336643 |
| Oseltamivir | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.69 | -6.55 | -6.48 | 45.69% | CHEMBL1836976 |
| Miglitol | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -4.79 | -5.00 | -4.95 | 33.78% | CHEMBL1836976 |
| Omeprazole | PRGR_HUMAN | progesterone receptor | -6.88 | -7.08 | -8.09 | 32.52% | CHEMBL3605924 |
| Metolazone | PRGR_HUMAN | progesterone receptor | -9.60 | -8.73 | -9.52 | 39.33% | CHEMBL486433 |
| Metformin | PRGR_HUMAN | progesterone receptor | -5.06 | -5.05 | -5.38 | 6.42% | CHEMBL412874 |
| Oseltamivir | PRGR_HUMAN | progesterone receptor | -7.33 | -7.30 | -7.23 | 43.70% | CHEMBL3695612 |
| Miglitol | PRGR_HUMAN | progesterone receptor | -5.49 | -5.64 | -5.23 | 26.04% | CHEMBL3765823 |
| Omeprazole | PTGES_HUMAN | prostaglandin E synthase | -7.72 | N/A | N/A | 34.38% | CHEMBL3342708 |
| Metolazone | PTGES_HUMAN | prostaglandin E synthase | -8.43 | N/A | N/A | 44.38% | CHEMBL2336517 |
| Metformin | PTGES_HUMAN | prostaglandin E synthase | -5.70 | N/A | N/A | 10.26% | CHEMBL1683227 |
| Oseltamivir | PTGES_HUMAN | prostaglandin E synthase | -6.03 | N/A | N/A | 35.04% | CHEMBL3289097 |
| Miglitol | PTGES_HUMAN | prostaglandin E synthase | -4.83 | N/A | N/A | 31.46% | CHEMBL3919693 |
| Omeprazole | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.58 | -8.58 | -8.69 | 38.41% | CHEMBL440584 |
| Metolazone | SC6A4_HUMAN | solute carrier family 6 member 4 | -10.12 | -8.98 | -10.42 | 42.24% | CHEMBL552341 |
| Metformin | SC6A4_HUMAN | solute carrier family 6 member 4 | -5.48 | -5.48 | -5.61 | 7.89% | CHEMBL220766 |
| Oseltamivir | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.15 | -7.16 | -7.61 | 42.29% | CHEMBL421546 |
| Miglitol | SC6A4_HUMAN | solute carrier family 6 member 4 | -5.73 | -5.58 | -5.62 | 48.08% | CHEMBL2021577 |
| Omeprazole | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.95 | N/A | N/A | 32.93% | CHEMBL1313991 |
| Metolazone | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.36 | N/A | N/A | 39.52% | CHEMBL3684307 |
| Metformin | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -5.38 | N/A | N/A | 8.33% | CHEMBL4077213 |
| Oseltamivir | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -5.71 | N/A | N/A | 30.52% | CHEMBL4077213 |
| Miglitol | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -4.60 | N/A | N/A | 29.70% | CHEMBL3632696 |
| Omeprazole | TLR4_HUMAN | toll like receptor 4 | -7.42 | -7.29 | -7.37 | 29.20% | CHEMBL4068003 |
| Metolazone | TLR4_HUMAN | toll like receptor 4 | -8.27 | -8.09 | -7.87 | 24.74% | CHEMBL3823499 |
| Metformin | TLR4_HUMAN | toll like receptor 4 | -5.37 | -4.80 | -5.20 | 4.17% | CHEMBL2364541 |
| Oseltamivir | TLR4_HUMAN | toll like receptor 4 | -6.32 | -5.97 | -6.09 | 38.78% | CHEMBL2364541 |
| Miglitol | TLR4_HUMAN | toll like receptor 4 | -5.21 | -5.04 | -5.21 | 26.76% | CHEMBL3354641 |
| Omeprazole | TNFA_HUMAN | tumor necrosis factor | -7.51 | N/A | N/A | 31.16% | CHEMBL3972551 |
| Metolazone | TNFA_HUMAN | tumor necrosis factor | -7.43 | N/A | N/A | 46.51% | CHEMBL1465706 |
| Metformin | TNFA_HUMAN | tumor necrosis factor | -4.89 | N/A | N/A | 5.65% | CHEMBL1595790 |
| Oseltamivir | TNFA_HUMAN | tumor necrosis factor | -6.26 | N/A | N/A | 33.95% | CHEMBL2337619 |
| Miglitol | TNFA_HUMAN | tumor necrosis factor | -5.04 | N/A | N/A | 23.08% | CHEMBL3806296 |
| Omeprazole | TRBM_HUMAN | thrombomodulin | -8.29 | -7.62 | N/A | N/A | N/A |
| Metolazone | TRBM_HUMAN | thrombomodulin | -7.94 | -7.88 | N/A | N/A | N/A |
| Metformin | TRBM_HUMAN | thrombomodulin | -6.14 | -5.72 | N/A | N/A | N/A |
| Oseltamivir | TRBM_HUMAN | thrombomodulin | -6.49 | -6.25 | N/A | N/A | N/A |
| Miglitol | TRBM_HUMAN | thrombomodulin | -5.62 | -6.07 | N/A | N/A | N/A |
| Omeprazole | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.66 | -8.08 | N/A | N/A | N/A |
| Metolazone | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -8.24 | -6.33 | N/A | N/A | N/A |
| Metformin | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -4.56 | -5.39 | N/A | N/A | N/A |
| Oseltamivir | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.37 | -5.60 | N/A | N/A | N/A |
| Miglitol | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -5.00 | -5.92 | N/A | N/A | N/A |
| Omeprazole | TRPM8_FICAL | Uncharacterized protein | -8.36 | N/A | N/A | N/A | N/A |
| Metolazone | TRPM8_FICAL | Uncharacterized protein | -9.70 | N/A | N/A | N/A | N/A |
| Metformin | TRPM8_FICAL | Uncharacterized protein | -5.58 | N/A | N/A | N/A | N/A |
| Oseltamivir | TRPM8_FICAL | Uncharacterized protein | -7.64 | N/A | N/A | N/A | N/A |
| Miglitol | TRPM8_FICAL | Uncharacterized protein | -5.82 | N/A | N/A | N/A | N/A |
| Omeprazole | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.27 | N/A | N/A | 31.75% | CHEMBL199393 |
| Metolazone | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.51 | N/A | N/A | 48.42% | CHEMBL81925 |
| Metformin | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -5.67 | N/A | N/A | 10.87% | CHEMBL504463 |
| Oseltamivir | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.74 | N/A | N/A | 38.46% | CHEMBL97968 |
| Miglitol | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -5.82 | N/A | N/A | 35.82% | CHEMBL15848 |
| Omeprazole | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.09 | -7.93 | N/A | N/A | N/A |
| Metolazone | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.24 | -8.46 | N/A | N/A | N/A |
| Metformin | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -5.64 | -5.29 | N/A | N/A | N/A |
| Oseltamivir | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.03 | -6.60 | N/A | N/A | N/A |
| Miglitol | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -5.59 | -5.94 | N/A | N/A | N/A |
| Omeprazole | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.78 | -7.36 | N/A | 27.70% | CHEMBL3902585 |
| Metolazone | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.84 | -7.07 | N/A | 36.68% | CHEMBL3692265 |
| Metformin | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -4.01 | -4.65 | N/A | 4.63% | CHEMBL3696426 |
| Oseltamivir | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.90 | -6.46 | N/A | 23.83% | CHEMBL3664218 |
| Miglitol | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -4.51 | -4.86 | N/A | 22.31% | CHEMBL3696473 |
| Omeprazole | TRXR1_HUMAN | thioredoxin reductase 1 | -7.40 | -8.68 | -6.35 | N/A | N/A |
| Metolazone | TRXR1_HUMAN | thioredoxin reductase 1 | -8.01 | -8.03 | -7.72 | N/A | N/A |
| Metformin | TRXR1_HUMAN | thioredoxin reductase 1 | -5.33 | -5.51 | -4.59 | N/A | N/A |
| Oseltamivir | TRXR1_HUMAN | thioredoxin reductase 1 | -6.50 | -7.07 | -5.37 | N/A | N/A |
| Miglitol | TRXR1_HUMAN | thioredoxin reductase 1 | -6.21 | -6.02 | -4.69 | N/A | N/A |
| Omeprazole | TRY1_HUMAN | serine protease 1 | -6.77 | N/A | N/A | 37.89% | CHEMBL24907 |
| Metolazone | TRY1_HUMAN | serine protease 1 | -6.28 | N/A | N/A | 40.10% | CHEMBL1160812 |
| Metformin | TRY1_HUMAN | serine protease 1 | -5.33 | N/A | N/A | 10.53% | CHEMBL149324 |
| Oseltamivir | TRY1_HUMAN | serine protease 1 | -5.36 | N/A | N/A | 40.54% | CHEMBL141574 |
| Miglitol | TRY1_HUMAN | serine protease 1 | -5.19 | N/A | N/A | 35.16% | CHEMBL70155 |