| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Saxagliptin | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.26 | -8.25 | -8.00 | 33.65% | CHEMBL191460 |
| Linagliptin | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -10.25 | -10.95 | -8.13 | 39.13% | CHEMBL318901 |
| Chlorpropamide | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -7.02 | -7.31 | -7.33 | 38.98% | CHEMBL97596 |
| Gliclazide | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.31 | -9.49 | -9.30 | 37.97% | CHEMBL606547 |
| Miglitol | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -5.55 | -5.55 | -5.41 | 28.12% | CHEMBL136470 |
| Saxagliptin | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.39 | -8.80 | N/A | 44.44% | CHEMBL49 |
| Linagliptin | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -10.22 | -9.09 | N/A | 62.56% | CHEMBL2237155 |
| Chlorpropamide | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.29 | -7.06 | N/A | 53.76% | CHEMBL1471412 |
| Gliclazide | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.79 | -9.63 | N/A | 48.80% | CHEMBL383530 |
| Miglitol | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -5.24 | -5.45 | N/A | 35.80% | CHEMBL1201203 |
| Saxagliptin | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.50 | -8.72 | -9.29 | 44.44% | CHEMBL49 |
| Linagliptin | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -9.87 | -9.92 | -10.43 | 41.75% | CHEMBL51 |
| Chlorpropamide | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.76 | -7.01 | -7.32 | 48.08% | CHEMBL333784 |
| Gliclazide | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.52 | -8.99 | -9.78 | 46.46% | CHEMBL455039 |
| Miglitol | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -5.74 | -5.47 | -5.58 | 35.80% | CHEMBL1201203 |
| Saxagliptin | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.72 | -7.93 | N/A | 42.86% | CHEMBL2260568 |
| Linagliptin | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -10.19 | -10.46 | N/A | 44.71% | CHEMBL583192 |
| Chlorpropamide | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.86 | -7.54 | N/A | 48.08% | CHEMBL333784 |
| Gliclazide | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.73 | -9.14 | N/A | 49.55% | CHEMBL1933399 |
| Miglitol | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -5.63 | -5.65 | N/A | 35.80% | CHEMBL1201203 |
| Saxagliptin | AA1R_HUMAN | adenosine A1 receptor | -7.38 | -8.39 | -6.79 | 32.03% | CHEMBL3913293 |
| Linagliptin | AA1R_HUMAN | adenosine A1 receptor | -9.11 | -10.48 | -4.20 | 63.49% | CHEMBL3091482 |
| Chlorpropamide | AA1R_HUMAN | adenosine A1 receptor | -6.94 | -6.76 | -7.13 | 28.83% | CHEMBL209230 |
| Gliclazide | AA1R_HUMAN | adenosine A1 receptor | -7.97 | -9.27 | -8.43 | 32.58% | CHEMBL209230 |
| Miglitol | AA1R_HUMAN | adenosine A1 receptor | -4.81 | -5.00 | -5.27 | 26.52% | CHEMBL3770601 |
| Saxagliptin | AA2AR_HUMAN | adenosine A2a receptor | -8.19 | -7.96 | -8.17 | 29.17% | CHEMBL217541 |
| Linagliptin | AA2AR_HUMAN | adenosine A2a receptor | -8.39 | -8.78 | -8.97 | 63.96% | CHEMBL3093324 |
| Chlorpropamide | AA2AR_HUMAN | adenosine A2a receptor | -6.77 | -6.58 | -6.99 | 29.21% | CHEMBL482436 |
| Gliclazide | AA2AR_HUMAN | adenosine A2a receptor | -8.31 | -8.74 | -10.02 | 33.68% | CHEMBL486282 |
| Miglitol | AA2AR_HUMAN | adenosine A2a receptor | -4.66 | -4.87 | -5.18 | 26.52% | CHEMBL3770601 |
| Saxagliptin | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.23 | -8.23 | -7.91 | 46.15% | CHEMBL1783535 |
| Linagliptin | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -11.63 | -10.64 | -7.37 | 39.47% | CHEMBL342413 |
| Chlorpropamide | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.65 | -7.60 | -8.15 | 55.56% | CHEMBL573102 |
| Gliclazide | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.88 | -9.41 | -8.38 | 55.24% | CHEMBL575620 |
| Miglitol | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -6.09 | -6.02 | -5.88 | 46.51% | CHEMBL345241 |
| Saxagliptin | ACE_HUMAN | angiotensin I converting enzyme | -8.27 | -8.09 | -7.90 | 65.75% | CHEMBL430630 |
| Linagliptin | ACE_HUMAN | angiotensin I converting enzyme | -10.08 | -8.79 | -7.70 | 36.47% | CHEMBL1242210 |
| Chlorpropamide | ACE_HUMAN | angiotensin I converting enzyme | -7.47 | -7.60 | -6.13 | 29.45% | CHEMBL514138 |
| Gliclazide | ACE_HUMAN | angiotensin I converting enzyme | -8.47 | -9.00 | -7.40 | 32.09% | CHEMBL86915 |
| Miglitol | ACE_HUMAN | angiotensin I converting enzyme | -5.77 | -5.21 | -5.04 | 44.12% | CHEMBL331575 |
| Saxagliptin | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.91 | N/A | N/A | 23.26% | CHEMBL386114 |
| Linagliptin | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -8.07 | N/A | N/A | 25.76% | CHEMBL386114 |
| Chlorpropamide | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.63 | N/A | N/A | 15.90% | CHEMBL386114 |
| Gliclazide | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.80 | N/A | N/A | 21.15% | CHEMBL386114 |
| Miglitol | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -4.48 | N/A | N/A | 17.96% | CHEMBL386114 |
| Saxagliptin | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.17 | -8.22 | -8.66 | N/A | N/A |
| Linagliptin | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -0.61 | -1.76 | -2.65 | N/A | N/A |
| Chlorpropamide | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.35 | -7.37 | -7.81 | N/A | N/A |
| Gliclazide | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.87 | -7.09 | -8.05 | N/A | N/A |
| Miglitol | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -4.28 | -5.51 | -5.31 | N/A | N/A |
| Saxagliptin | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.64 | -5.60 | N/A | 51.35% | CHEMBL355193 |
| Linagliptin | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -5.88 | 18.19 | N/A | 100.00% | CHEMBL237500 |
| Chlorpropamide | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.51 | -6.98 | N/A | 39.13% | CHEMBL179993 |
| Gliclazide | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.11 | -2.72 | N/A | 48.80% | CHEMBL179993 |
| Miglitol | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -5.92 | -4.89 | N/A | 46.67% | CHEMBL2111051 |
| Saxagliptin | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.48 | -6.69 | N/A | 44.44% | CHEMBL479224 |
| Linagliptin | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.90 | -6.89 | N/A | 40.29% | CHEMBL1200406 |
| Chlorpropamide | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.68 | -7.00 | N/A | 38.39% | CHEMBL1455766 |
| Gliclazide | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.35 | -8.32 | N/A | 38.17% | CHEMBL1455766 |
| Miglitol | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -5.91 | -5.23 | N/A | 47.83% | CHEMBL294273 |
| Saxagliptin | ADRB2_HUMAN | adrenoceptor beta 2 | -7.04 | -6.83 | -8.98 | 34.23% | CHEMBL417709 |
| Linagliptin | ADRB2_HUMAN | adrenoceptor beta 2 | -8.00 | -9.72 | -11.19 | 56.25% | CHEMBL1570111 |
| Chlorpropamide | ADRB2_HUMAN | adrenoceptor beta 2 | -6.82 | -7.91 | -7.73 | 47.06% | CHEMBL154906 |
| Gliclazide | ADRB2_HUMAN | adrenoceptor beta 2 | -8.42 | -9.55 | -9.55 | 41.61% | CHEMBL516056 |
| Miglitol | ADRB2_HUMAN | adrenoceptor beta 2 | -5.77 | -6.20 | -5.82 | 35.29% | CHEMBL2070834 |
| Saxagliptin | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.09 | -7.58 | -8.02 | 31.50% | CHEMBL3350599 |
| Linagliptin | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.75 | -10.47 | -10.42 | 34.84% | CHEMBL130896 |
| Chlorpropamide | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.14 | -6.95 | -7.04 | 33.51% | CHEMBL384462 |
| Gliclazide | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.13 | -8.46 | -7.99 | 36.81% | CHEMBL214525 |
| Miglitol | AGTR2_HUMAN | angiotensin II receptor type 2 | -4.78 | -4.77 | -4.63 | 22.58% | CHEMBL3350599 |
| Saxagliptin | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.44 | -8.34 | -7.81 | 20.00% | CHEMBL249447 |
| Linagliptin | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.94 | -9.33 | -9.18 | 37.75% | CHEMBL344526 |
| Chlorpropamide | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.68 | -8.22 | -7.94 | 43.70% | CHEMBL19744 |
| Gliclazide | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.69 | -9.51 | -9.97 | 32.14% | CHEMBL282245 |
| Miglitol | ALDR_HUMAN | aldo-keto reductase family 1 member B | -5.18 | -5.16 | -6.50 | 17.24% | CHEMBL269550 |
| Saxagliptin | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.86 | -7.59 | -7.91 | 47.13% | CHEMBL28650 |
| Linagliptin | AMPN_HUMAN | alanyl aminopeptidase, membrane | -9.45 | -10.22 | -9.22 | 29.66% | CHEMBL1077591 |
| Chlorpropamide | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.33 | -7.31 | -7.06 | 28.33% | CHEMBL2332518 |
| Gliclazide | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.44 | -9.06 | -8.07 | 28.49% | CHEMBL1077584 |
| Miglitol | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.48 | -5.71 | -5.62 | 39.51% | CHEMBL28650 |
| Saxagliptin | AOFA_HUMAN | monoamine oxidase A | -9.28 | -9.44 | -8.36 | 25.00% | CHEMBL4073457 |
| Linagliptin | AOFA_HUMAN | monoamine oxidase A | -9.56 | -10.14 | -9.03 | 40.00% | CHEMBL2313296 |
| Chlorpropamide | AOFA_HUMAN | monoamine oxidase A | -8.01 | -7.94 | -8.11 | 27.64% | CHEMBL2158242 |
| Gliclazide | AOFA_HUMAN | monoamine oxidase A | -9.70 | -10.03 | -9.36 | 33.16% | CHEMBL3780199 |
| Miglitol | AOFA_HUMAN | monoamine oxidase A | -5.60 | -6.27 | -5.54 | 25.00% | CHEMBL2426048 |
| Saxagliptin | AOFB_HUMAN | monoamine oxidase B | -9.71 | -9.78 | -9.65 | 29.52% | CHEMBL3604126 |
| Linagliptin | AOFB_HUMAN | monoamine oxidase B | -10.95 | -9.53 | -10.19 | 57.71% | CHEMBL239230 |
| Chlorpropamide | AOFB_HUMAN | monoamine oxidase B | -7.64 | -8.67 | -7.81 | 29.57% | CHEMBL2158247 |
| Gliclazide | AOFB_HUMAN | monoamine oxidase B | -9.36 | -9.14 | -9.33 | 28.91% | CHEMBL1201142 |
| Miglitol | AOFB_HUMAN | monoamine oxidase B | -5.66 | -5.72 | -5.74 | 30.77% | CHEMBL2332210 |
| Saxagliptin | BACE1_HUMAN | beta-secretase 1 | -7.10 | -7.18 | -8.11 | 62.50% | CHEMBL461602 |
| Linagliptin | BACE1_HUMAN | beta-secretase 1 | -9.16 | -8.80 | -9.22 | 38.05% | CHEMBL575326 |
| Chlorpropamide | BACE1_HUMAN | beta-secretase 1 | -5.98 | -5.98 | -6.59 | 32.96% | CHEMBL1097325 |
| Gliclazide | BACE1_HUMAN | beta-secretase 1 | -7.24 | -7.67 | -8.43 | 38.82% | CHEMBL1087742 |
| Miglitol | BACE1_HUMAN | beta-secretase 1 | -4.77 | -4.62 | -5.10 | 43.66% | CHEMBL461602 |
| Saxagliptin | CAH2_HUMAN | carbonic anhydrase 2 | -6.80 | -6.75 | -6.76 | 43.59% | CHEMBL3400156 |
| Linagliptin | CAH2_HUMAN | carbonic anhydrase 2 | -9.37 | -8.68 | -8.65 | 36.29% | CHEMBL2203353 |
| Chlorpropamide | CAH2_HUMAN | carbonic anhydrase 2 | -7.10 | -7.07 | -6.94 | 80.23% | CHEMBL3354134 |
| Gliclazide | CAH2_HUMAN | carbonic anhydrase 2 | -8.25 | -7.86 | -7.46 | 62.28% | CHEMBL359546 |
| Miglitol | CAH2_HUMAN | carbonic anhydrase 2 | -5.99 | -5.60 | -5.49 | 51.85% | CHEMBL3400805 |
| Saxagliptin | CASP1_HUMAN | caspase 1 | -6.45 | -6.90 | -6.06 | 50.62% | CHEMBL285638 |
| Linagliptin | CASP1_HUMAN | caspase 1 | -7.08 | -8.51 | -7.64 | 37.16% | CHEMBL1221691 |
| Chlorpropamide | CASP1_HUMAN | caspase 1 | -5.94 | -5.88 | -5.68 | 32.19% | CHEMBL422849 |
| Gliclazide | CASP1_HUMAN | caspase 1 | -7.03 | -7.08 | -6.93 | 33.96% | CHEMBL212981 |
| Miglitol | CASP1_HUMAN | caspase 1 | -4.57 | -4.64 | -4.89 | 36.59% | CHEMBL466565 |
| Saxagliptin | CDK5_HUMAN | cyclin dependent kinase 5 | -7.06 | -8.59 | -4.91 | 32.53% | CHEMBL1994526 |
| Linagliptin | CDK5_HUMAN | cyclin dependent kinase 5 | -8.77 | -9.36 | -8.54 | 41.85% | CHEMBL1080583 |
| Chlorpropamide | CDK5_HUMAN | cyclin dependent kinase 5 | -6.95 | -6.67 | -7.43 | 49.51% | CHEMBL1967612 |
| Gliclazide | CDK5_HUMAN | cyclin dependent kinase 5 | -8.57 | -8.13 | -7.84 | 36.36% | CHEMBL1967612 |
| Miglitol | CDK5_HUMAN | cyclin dependent kinase 5 | -5.43 | -5.41 | -5.93 | 20.25% | CHEMBL1994526 |
| Saxagliptin | CHLE_HUMAN | butyrylcholinesterase | -8.66 | -8.26 | -8.13 | 61.02% | CHEMBL1512936 |
| Linagliptin | CHLE_HUMAN | butyrylcholinesterase | -10.74 | -10.61 | -10.53 | 37.94% | CHEMBL572811 |
| Chlorpropamide | CHLE_HUMAN | butyrylcholinesterase | -7.93 | -7.53 | -7.77 | 35.40% | CHEMBL3918754 |
| Gliclazide | CHLE_HUMAN | butyrylcholinesterase | -8.73 | -8.27 | -9.08 | 40.94% | CHEMBL3918754 |
| Miglitol | CHLE_HUMAN | butyrylcholinesterase | -5.73 | -5.65 | -5.54 | 53.85% | CHEMBL1512936 |
| Saxagliptin | CNR1_HUMAN | cannabinoid receptor 1 | -7.01 | -8.71 | -8.98 | 57.14% | CHEMBL483143 |
| Linagliptin | CNR1_HUMAN | cannabinoid receptor 1 | -7.85 | -8.82 | -7.38 | 38.37% | CHEMBL562668 |
| Chlorpropamide | CNR1_HUMAN | cannabinoid receptor 1 | -7.16 | -7.41 | -8.12 | 46.73% | CHEMBL445204 |
| Gliclazide | CNR1_HUMAN | cannabinoid receptor 1 | -7.93 | -9.42 | -9.33 | 46.10% | CHEMBL3942936 |
| Miglitol | CNR1_HUMAN | cannabinoid receptor 1 | -4.61 | -5.06 | -5.54 | 52.73% | CHEMBL483143 |
| Saxagliptin | CNR2_HUMAN | cannabinoid receptor 2 | -8.47 | -9.09 | N/A | 48.91% | CHEMBL1765271 |
| Linagliptin | CNR2_HUMAN | cannabinoid receptor 2 | -8.64 | -10.95 | N/A | 42.72% | CHEMBL4104265 |
| Chlorpropamide | CNR2_HUMAN | cannabinoid receptor 2 | -7.98 | -7.74 | N/A | 44.44% | CHEMBL2336561 |
| Gliclazide | CNR2_HUMAN | cannabinoid receptor 2 | -9.57 | -9.99 | N/A | 46.10% | CHEMBL3921018 |
| Miglitol | CNR2_HUMAN | cannabinoid receptor 2 | -5.13 | -5.28 | N/A | 43.28% | CHEMBL472661 |
| Saxagliptin | COLI_HUMAN | proopiomelanocortin | -8.32 | -7.36 | -6.57 | N/A | N/A |
| Linagliptin | COLI_HUMAN | proopiomelanocortin | -9.06 | -8.90 | -8.86 | N/A | N/A |
| Chlorpropamide | COLI_HUMAN | proopiomelanocortin | -7.51 | -7.30 | -6.37 | N/A | N/A |
| Gliclazide | COLI_HUMAN | proopiomelanocortin | -9.05 | -9.39 | -7.47 | N/A | N/A |
| Miglitol | COLI_HUMAN | proopiomelanocortin | -5.21 | -5.19 | -4.85 | N/A | N/A |
| Saxagliptin | COMT_HUMAN | catechol-O-methyltransferase | -6.06 | -5.92 | -5.89 | 18.18% | CHEMBL3819488 |
| Linagliptin | COMT_HUMAN | catechol-O-methyltransferase | -7.44 | -7.51 | -7.45 | 28.50% | CHEMBL3954860 |
| Chlorpropamide | COMT_HUMAN | catechol-O-methyltransferase | -5.27 | -5.17 | -5.08 | 17.76% | CHEMBL3798524 |
| Gliclazide | COMT_HUMAN | catechol-O-methyltransferase | -6.22 | -6.73 | -5.94 | 19.52% | CHEMBL3819488 |
| Miglitol | COMT_HUMAN | catechol-O-methyltransferase | -4.58 | -4.60 | -5.35 | 11.87% | CHEMBL3819488 |
| Saxagliptin | CRP_HUMAN | C-reactive protein | -6.16 | -6.42 | N/A | N/A | N/A |
| Linagliptin | CRP_HUMAN | C-reactive protein | -6.56 | -6.88 | N/A | N/A | N/A |
| Chlorpropamide | CRP_HUMAN | C-reactive protein | -5.34 | -5.13 | N/A | N/A | N/A |
| Gliclazide | CRP_HUMAN | C-reactive protein | -6.41 | -6.27 | N/A | N/A | N/A |
| Miglitol | CRP_HUMAN | C-reactive protein | -4.25 | -4.76 | N/A | N/A | N/A |
| Saxagliptin | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -5.22 | N/A | N/A | 20.54% | CHEMBL556862 |
| Linagliptin | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | 10.25 | N/A | N/A | 30.47% | CHEMBL3609018 |
| Chlorpropamide | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.75 | N/A | N/A | 35.93% | CHEMBL386072 |
| Gliclazide | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.72 | N/A | N/A | 31.77% | CHEMBL386072 |
| Miglitol | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.66 | N/A | N/A | 14.92% | CHEMBL556862 |
| Saxagliptin | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.22 | -6.36 | -7.94 | 33.88% | CHEMBL366033 |
| Linagliptin | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -10.77 | -8.57 | -9.60 | 37.40% | CHEMBL570967 |
| Chlorpropamide | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.10 | -6.46 | -6.62 | 28.88% | CHEMBL3627862 |
| Gliclazide | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.75 | -7.19 | -8.62 | 31.79% | CHEMBL3627858 |
| Miglitol | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -5.59 | -5.57 | -5.09 | 28.99% | CHEMBL2170299 |
| Saxagliptin | DRD2_HUMAN | dopamine receptor D2 | -7.14 | N/A | N/A | 50.75% | CHEMBL317488 |
| Linagliptin | DRD2_HUMAN | dopamine receptor D2 | -10.13 | N/A | N/A | 50.73% | CHEMBL3423339 |
| Chlorpropamide | DRD2_HUMAN | dopamine receptor D2 | -7.61 | N/A | N/A | 40.83% | CHEMBL195247 |
| Gliclazide | DRD2_HUMAN | dopamine receptor D2 | -8.67 | N/A | N/A | 49.57% | CHEMBL329443 |
| Miglitol | DRD2_HUMAN | dopamine receptor D2 | -4.83 | N/A | N/A | 45.45% | CHEMBL282323 |
| Saxagliptin | DRD3_HUMAN | dopamine receptor D3 | -8.28 | N/A | N/A | 47.44% | CHEMBL80571 |
| Linagliptin | DRD3_HUMAN | dopamine receptor D3 | -9.95 | N/A | N/A | 46.45% | CHEMBL200026 |
| Chlorpropamide | DRD3_HUMAN | dopamine receptor D3 | -6.86 | N/A | N/A | 40.83% | CHEMBL195247 |
| Gliclazide | DRD3_HUMAN | dopamine receptor D3 | -8.98 | N/A | N/A | 49.57% | CHEMBL329443 |
| Miglitol | DRD3_HUMAN | dopamine receptor D3 | -5.45 | N/A | N/A | 45.45% | CHEMBL282323 |
| Saxagliptin | DRD4_HUMAN | dopamine receptor D4 | -8.51 | -8.39 | N/A | 45.05% | CHEMBL274047 |
| Linagliptin | DRD4_HUMAN | dopamine receptor D4 | -10.80 | -10.53 | N/A | 43.86% | CHEMBL556288 |
| Chlorpropamide | DRD4_HUMAN | dopamine receptor D4 | -7.51 | -7.56 | N/A | 40.83% | CHEMBL195247 |
| Gliclazide | DRD4_HUMAN | dopamine receptor D4 | -9.29 | -9.38 | N/A | 32.98% | CHEMBL3290012 |
| Miglitol | DRD4_HUMAN | dopamine receptor D4 | -5.52 | -5.56 | N/A | 45.45% | CHEMBL32402 |
| Saxagliptin | EDN1_HUMAN | endothelin 1 | -8.23 | N/A | N/A | N/A | N/A |
| Linagliptin | EDN1_HUMAN | endothelin 1 | -9.07 | N/A | N/A | N/A | N/A |
| Chlorpropamide | EDN1_HUMAN | endothelin 1 | -7.02 | N/A | N/A | N/A | N/A |
| Gliclazide | EDN1_HUMAN | endothelin 1 | -8.64 | N/A | N/A | N/A | N/A |
| Miglitol | EDN1_HUMAN | endothelin 1 | -4.84 | N/A | N/A | N/A | N/A |
| Saxagliptin | ESR1_HUMAN | estrogen receptor 1 | -8.15 | -7.40 | -7.51 | 42.39% | CHEMBL1222035 |
| Linagliptin | ESR1_HUMAN | estrogen receptor 1 | -7.64 | -8.17 | -7.67 | 40.98% | CHEMBL1318094 |
| Chlorpropamide | ESR1_HUMAN | estrogen receptor 1 | -6.78 | -6.71 | -6.77 | 41.23% | CHEMBL264655 |
| Gliclazide | ESR1_HUMAN | estrogen receptor 1 | -8.48 | -8.66 | -8.72 | 42.45% | CHEMBL243571 |
| Miglitol | ESR1_HUMAN | estrogen receptor 1 | -5.35 | -5.35 | -5.31 | 29.59% | CHEMBL3586194 |
| Saxagliptin | FABP5_HUMAN | fatty acid binding protein 5 | -8.61 | -5.94 | -5.70 | 32.14% | CHEMBL82293 |
| Linagliptin | FABP5_HUMAN | fatty acid binding protein 5 | -7.54 | -7.11 | -7.20 | 32.47% | CHEMBL3941588 |
| Chlorpropamide | FABP5_HUMAN | fatty acid binding protein 5 | -7.17 | -5.20 | -4.93 | 16.39% | CHEMBL3959018 |
| Gliclazide | FABP5_HUMAN | fatty acid binding protein 5 | -8.40 | -6.40 | -6.51 | 19.59% | CHEMBL3950316 |
| Miglitol | FABP5_HUMAN | fatty acid binding protein 5 | -5.27 | -4.62 | -4.42 | 22.92% | CHEMBL82293 |
| Saxagliptin | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.00 | N/A | N/A | 49.40% | CHEMBL407135 |
| Linagliptin | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.93 | N/A | N/A | 42.40% | CHEMBL3115681 |
| Chlorpropamide | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.58 | N/A | N/A | 24.57% | CHEMBL1971029 |
| Gliclazide | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.01 | N/A | N/A | 36.00% | CHEMBL588119 |
| Miglitol | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -4.90 | N/A | N/A | 36.25% | CHEMBL407135 |
| Saxagliptin | GLRA3_HUMAN | glycine receptor alpha 3 | -8.46 | -8.37 | -8.39 | 13.43% | CHEMBL4070615 |
| Saxagliptin | GLRA3_HUMAN | glycine receptor alpha 3 | -9.21 | N/A | N/A | 13.43% | CHEMBL4070615 |
| Linagliptin | GLRA3_HUMAN | glycine receptor alpha 3 | -9.37 | -9.82 | -9.59 | 20.07% | CHEMBL4070615 |
| Linagliptin | GLRA3_HUMAN | glycine receptor alpha 3 | -10.39 | N/A | N/A | 20.07% | CHEMBL4070615 |
| Chlorpropamide | GLRA3_HUMAN | glycine receptor alpha 3 | -7.72 | -7.65 | -7.83 | 22.22% | CHEMBL4074873 |
| Chlorpropamide | GLRA3_HUMAN | glycine receptor alpha 3 | -6.94 | N/A | N/A | 22.22% | CHEMBL4074873 |
| Gliclazide | GLRA3_HUMAN | glycine receptor alpha 3 | -9.80 | -9.18 | -9.06 | 26.67% | CHEMBL4070615 |
| Gliclazide | GLRA3_HUMAN | glycine receptor alpha 3 | -9.24 | N/A | N/A | 26.67% | CHEMBL4070615 |
| Miglitol | GLRA3_HUMAN | glycine receptor alpha 3 | -5.70 | -5.39 | -5.38 | 9.52% | CHEMBL4070615 |
| Miglitol | GLRA3_HUMAN | glycine receptor alpha 3 | -5.49 | N/A | N/A | 9.52% | CHEMBL4070615 |
| Saxagliptin | GRM5_HUMAN | glutamate metabotropic receptor 5 | -9.12 | -5.47 | -6.65 | 58.93% | CHEMBL1783985 |
| Linagliptin | GRM5_HUMAN | glutamate metabotropic receptor 5 | -2.63 | -3.52 | -1.80 | 34.34% | CHEMBL3914940 |
| Chlorpropamide | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.47 | -7.28 | -7.20 | 27.50% | CHEMBL1451902 |
| Gliclazide | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.82 | -5.58 | -6.14 | 30.40% | CHEMBL2338596 |
| Miglitol | GRM5_HUMAN | glutamate metabotropic receptor 5 | -5.67 | -4.41 | -4.57 | 37.04% | CHEMBL1783985 |
| Saxagliptin | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.63 | -5.92 | -5.91 | 26.39% | CHEMBL3650202 |
| Linagliptin | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -10.30 | -8.98 | -7.57 | 32.00% | CHEMBL3650206 |
| Chlorpropamide | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.75 | -5.98 | -6.37 | 20.00% | CHEMBL1490019 |
| Gliclazide | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.10 | -7.43 | -7.93 | 24.12% | CHEMBL1233897 |
| Miglitol | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -5.63 | -4.88 | -5.03 | 18.98% | CHEMBL3650207 |
| Saxagliptin | HRH1_HUMAN | histamine receptor H1 | -6.92 | N/A | N/A | 34.95% | CHEMBL1276860 |
| Linagliptin | HRH1_HUMAN | histamine receptor H1 | -2.03 | N/A | N/A | 47.24% | CHEMBL94454 |
| Chlorpropamide | HRH1_HUMAN | histamine receptor H1 | -7.31 | N/A | N/A | 58.97% | CHEMBL2171035 |
| Gliclazide | HRH1_HUMAN | histamine receptor H1 | -8.41 | N/A | N/A | 48.57% | CHEMBL2171049 |
| Miglitol | HRH1_HUMAN | histamine receptor H1 | -5.81 | N/A | N/A | 36.11% | CHEMBL571174 |
| Saxagliptin | HYES_HUMAN | epoxide hydrolase 2 | -8.42 | -7.74 | -7.74 | 60.00% | CHEMBL192273 |
| Linagliptin | HYES_HUMAN | epoxide hydrolase 2 | -9.61 | -11.03 | -9.38 | 34.98% | CHEMBL2336737 |
| Chlorpropamide | HYES_HUMAN | epoxide hydrolase 2 | -7.05 | -7.59 | -6.54 | 51.52% | CHEMBL438838 |
| Gliclazide | HYES_HUMAN | epoxide hydrolase 2 | -8.88 | -8.97 | -8.94 | 56.91% | CHEMBL512310 |
| Miglitol | HYES_HUMAN | epoxide hydrolase 2 | -6.64 | -6.52 | -4.83 | 43.42% | CHEMBL245158 |
| Saxagliptin | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.02 | N/A | N/A | 28.57% | CHEMBL1762621 |
| Linagliptin | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -9.03 | N/A | N/A | 42.45% | CHEMBL522011 |
| Chlorpropamide | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.52 | N/A | N/A | 35.71% | CHEMBL230488 |
| Gliclazide | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.86 | N/A | N/A | 39.44% | CHEMBL230055 |
| Miglitol | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -4.92 | N/A | N/A | 24.07% | CHEMBL507333 |
| Saxagliptin | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.86 | -8.71 | N/A | 65.00% | CHEMBL2075030 |
| Linagliptin | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -9.06 | -9.88 | N/A | 39.53% | CHEMBL296419 |
| Chlorpropamide | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.36 | -6.33 | N/A | 100.00% | CHEMBL498 |
| Gliclazide | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.38 | -8.99 | N/A | 46.43% | CHEMBL498 |
| Miglitol | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -5.27 | -5.78 | N/A | 55.56% | CHEMBL2075030 |
| Saxagliptin | MIF_HUMAN | macrophage migration inhibitory factor | -4.93 | -7.21 | -5.89 | 21.29% | CHEMBL554271 |
| Linagliptin | MIF_HUMAN | macrophage migration inhibitory factor | -5.09 | -7.87 | -6.78 | 24.33% | CHEMBL3943378 |
| Chlorpropamide | MIF_HUMAN | macrophage migration inhibitory factor | -6.18 | -7.48 | -7.06 | 34.07% | CHEMBL3409229 |
| Gliclazide | MIF_HUMAN | macrophage migration inhibitory factor | -7.86 | -7.24 | -8.32 | 35.78% | CHEMBL3409229 |
| Miglitol | MIF_HUMAN | macrophage migration inhibitory factor | -3.66 | -4.43 | -3.99 | 18.49% | CHEMBL554271 |
| Saxagliptin | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.03 | -7.82 | -6.89 | 39.25% | CHEMBL3752989 |
| Linagliptin | MK01_HUMAN | mitogen-activated protein kinase 1 | -8.92 | -9.36 | -9.43 | 40.09% | CHEMBL3680608 |
| Chlorpropamide | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.74 | -6.74 | -7.01 | 27.61% | CHEMBL1987756 |
| Gliclazide | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.06 | -8.17 | -8.12 | 28.00% | CHEMBL3917319 |
| Miglitol | MK01_HUMAN | mitogen-activated protein kinase 1 | -4.89 | -5.18 | -4.66 | 26.42% | CHEMBL3752989 |
| Saxagliptin | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.75 | -7.19 | -7.60 | 35.14% | CHEMBL3113587 |
| Linagliptin | MK03_HUMAN | mitogen-activated protein kinase 3 | -9.54 | -9.73 | -9.79 | 40.72% | CHEMBL1950289 |
| Chlorpropamide | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.01 | -7.19 | -6.52 | 24.67% | CHEMBL3798692 |
| Gliclazide | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.87 | -7.77 | -7.83 | 26.67% | CHEMBL3113587 |
| Miglitol | MK03_HUMAN | mitogen-activated protein kinase 3 | -5.21 | -5.31 | -5.28 | 18.92% | CHEMBL1950289 |
| Saxagliptin | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.45 | -8.41 | -8.12 | 43.68% | CHEMBL3972399 |
| Linagliptin | MTOR_HUMAN | mechanistic target of rapamycin kinase | -10.84 | -10.80 | -11.40 | 45.78% | CHEMBL3681101 |
| Chlorpropamide | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.30 | -7.60 | -7.15 | 29.61% | CHEMBL4059778 |
| Gliclazide | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.13 | -9.36 | -9.44 | 30.77% | CHEMBL1259105 |
| Miglitol | MTOR_HUMAN | mechanistic target of rapamycin kinase | -4.66 | -4.89 | -4.69 | 30.95% | CHEMBL3972399 |
| Saxagliptin | NEP_HUMAN | membrane metalloendopeptidase | -7.60 | -7.42 | -7.15 | 69.49% | CHEMBL211529 |
| Linagliptin | NEP_HUMAN | membrane metalloendopeptidase | -9.01 | -8.55 | -10.05 | 33.19% | CHEMBL34369 |
| Chlorpropamide | NEP_HUMAN | membrane metalloendopeptidase | -7.10 | -7.72 | -7.92 | 24.17% | CHEMBL225085 |
| Gliclazide | NEP_HUMAN | membrane metalloendopeptidase | -7.64 | -7.45 | -8.21 | 33.33% | CHEMBL213404 |
| Miglitol | NEP_HUMAN | membrane metalloendopeptidase | -5.76 | -6.02 | -5.92 | 50.82% | CHEMBL3221965 |
| Saxagliptin | NK1R_HUMAN | tachykinin receptor 1 | -8.31 | -8.44 | -8.88 | 38.89% | CHEMBL156933 |
| Linagliptin | NK1R_HUMAN | tachykinin receptor 1 | -9.82 | -10.59 | -10.09 | 41.41% | CHEMBL311712 |
| Chlorpropamide | NK1R_HUMAN | tachykinin receptor 1 | -6.84 | -7.01 | -6.36 | 29.34% | CHEMBL33194 |
| Gliclazide | NK1R_HUMAN | tachykinin receptor 1 | -8.76 | -7.66 | -8.23 | 38.04% | CHEMBL319653 |
| Miglitol | NK1R_HUMAN | tachykinin receptor 1 | -5.10 | -5.25 | -5.06 | 33.33% | CHEMBL2112367 |
| Saxagliptin | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.44 | -7.96 | -7.62 | 10.43% | CHEMBL284237 |
| Linagliptin | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.28 | -9.37 | -9.63 | 15.42% | CHEMBL284237 |
| Chlorpropamide | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.16 | -7.24 | -7.75 | 39.34% | CHEMBL2333945 |
| Gliclazide | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.21 | -8.57 | -8.90 | 38.03% | CHEMBL2333945 |
| Miglitol | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -5.97 | -5.94 | -5.72 | 10.89% | CHEMBL284237 |
| Saxagliptin | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.52 | -7.80 | -6.65 | 30.69% | CHEMBL217955 |
| Linagliptin | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.58 | -8.74 | -10.22 | 33.80% | CHEMBL3797704 |
| Chlorpropamide | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.21 | -7.86 | -7.14 | 23.30% | CHEMBL159879 |
| Gliclazide | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -10.04 | -10.53 | -8.58 | 33.61% | CHEMBL151489 |
| Miglitol | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -5.49 | -5.70 | -5.23 | 35.90% | CHEMBL17350 |
| Saxagliptin | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.41 | -8.06 | -7.62 | 21.71% | CHEMBL354003 |
| Linagliptin | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -9.31 | -9.45 | -9.63 | 31.73% | CHEMBL419399 |
| Chlorpropamide | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.18 | -7.20 | -7.75 | 38.85% | CHEMBL159739 |
| Gliclazide | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.29 | -8.51 | -8.90 | 29.79% | CHEMBL159739 |
| Miglitol | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -5.98 | -6.25 | -5.72 | 17.80% | CHEMBL419399 |
| Saxagliptin | NOS1_HUMAN | nitric oxide synthase 1 | -7.86 | -8.12 | -8.31 | 45.45% | CHEMBL11471 |
| Linagliptin | NOS1_HUMAN | nitric oxide synthase 1 | -9.54 | -9.24 | -9.57 | 36.40% | CHEMBL1801495 |
| Chlorpropamide | NOS1_HUMAN | nitric oxide synthase 1 | -7.41 | -7.60 | -7.38 | 23.58% | CHEMBL256069 |
| Gliclazide | NOS1_HUMAN | nitric oxide synthase 1 | -8.72 | -8.68 | -8.35 | 26.00% | CHEMBL1270460 |
| Miglitol | NOS1_HUMAN | nitric oxide synthase 1 | -5.74 | -5.90 | -6.11 | 39.66% | CHEMBL11471 |
| Saxagliptin | NOS2_HUMAN | nitric oxide synthase 2 | -7.22 | -7.81 | -8.16 | 51.56% | CHEMBL7889 |
| Linagliptin | NOS2_HUMAN | nitric oxide synthase 2 | -5.81 | -9.60 | 1.42 | 36.40% | CHEMBL1801495 |
| Chlorpropamide | NOS2_HUMAN | nitric oxide synthase 2 | -7.42 | -7.25 | -7.74 | 37.38% | CHEMBL490886 |
| Gliclazide | NOS2_HUMAN | nitric oxide synthase 2 | -8.09 | -8.87 | -8.57 | 38.40% | CHEMBL490886 |
| Miglitol | NOS2_HUMAN | nitric oxide synthase 2 | -5.11 | -5.67 | -6.11 | 53.45% | CHEMBL114534 |
| Saxagliptin | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.49 | -7.48 | -7.37 | 23.75% | CHEMBL485556 |
| Linagliptin | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -9.43 | -9.33 | -9.60 | 39.75% | CHEMBL403776 |
| Chlorpropamide | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.83 | -7.11 | -6.82 | 31.94% | CHEMBL1996795 |
| Gliclazide | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.03 | -8.85 | -7.78 | 39.35% | CHEMBL1996795 |
| Miglitol | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -4.66 | -4.90 | -4.87 | 26.67% | CHEMBL3403435 |
| Saxagliptin | OPRD_HUMAN | opioid receptor delta 1 | -6.84 | -6.45 | -6.75 | 50.00% | CHEMBL3912364 |
| Linagliptin | OPRD_HUMAN | opioid receptor delta 1 | -8.83 | -7.77 | -9.54 | 46.05% | CHEMBL493973 |
| Chlorpropamide | OPRD_HUMAN | opioid receptor delta 1 | -6.48 | -5.62 | -5.91 | 38.10% | CHEMBL339621 |
| Gliclazide | OPRD_HUMAN | opioid receptor delta 1 | -8.17 | -6.70 | -7.40 | 39.74% | CHEMBL192998 |
| Miglitol | OPRD_HUMAN | opioid receptor delta 1 | -4.67 | -4.42 | -4.37 | 45.31% | CHEMBL3326796 |
| Saxagliptin | OPRK_HUMAN | opioid receptor kappa 1 | -8.67 | -9.23 | -7.89 | 51.79% | CHEMBL3890935 |
| Linagliptin | OPRK_HUMAN | opioid receptor kappa 1 | -11.29 | -9.74 | -9.85 | 44.19% | CHEMBL3394005 |
| Chlorpropamide | OPRK_HUMAN | opioid receptor kappa 1 | -7.43 | -7.46 | -7.22 | 40.91% | CHEMBL499352 |
| Gliclazide | OPRK_HUMAN | opioid receptor kappa 1 | -9.25 | -9.61 | -8.24 | 45.86% | CHEMBL1725537 |
| Miglitol | OPRK_HUMAN | opioid receptor kappa 1 | -5.06 | -5.36 | -5.22 | 45.31% | CHEMBL3326796 |
| Saxagliptin | OPRM_MOUSE | Mu-type opioid receptor | -7.85 | -7.55 | N/A | 44.33% | CHEMBL440765 |
| Linagliptin | OPRM_MOUSE | Mu-type opioid receptor | -10.74 | -10.31 | N/A | 29.45% | CHEMBL2419123 |
| Chlorpropamide | OPRM_MOUSE | Mu-type opioid receptor | -7.47 | -6.94 | N/A | 25.00% | CHEMBL2311130 |
| Gliclazide | OPRM_MOUSE | Mu-type opioid receptor | -9.20 | -8.05 | N/A | 34.71% | CHEMBL186281 |
| Miglitol | OPRM_MOUSE | Mu-type opioid receptor | -4.99 | -5.03 | N/A | 39.51% | CHEMBL2057689 |
| Saxagliptin | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.26 | -7.30 | -7.67 | 44.00% | CHEMBL282195 |
| Linagliptin | OPRX_HUMAN | opioid related nociceptin receptor 1 | -9.35 | -9.46 | -9.84 | 44.44% | CHEMBL408909 |
| Chlorpropamide | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.24 | -6.17 | -6.18 | 46.79% | CHEMBL3942616 |
| Gliclazide | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.07 | -7.89 | -8.54 | 44.19% | CHEMBL3942616 |
| Miglitol | OPRX_HUMAN | opioid related nociceptin receptor 1 | -4.67 | -5.25 | -5.09 | 38.57% | CHEMBL398039 |
| Saxagliptin | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.04 | -5.26 | -5.47 | 29.05% | CHEMBL3669852 |
| Linagliptin | P2RX3_HUMAN | purinergic receptor P2X 3 | -7.29 | -7.57 | -7.11 | 42.73% | CHEMBL3916705 |
| Chlorpropamide | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.66 | -5.02 | -5.17 | 24.68% | CHEMBL3901056 |
| Gliclazide | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.96 | -5.76 | -6.08 | 27.18% | CHEMBL3679748 |
| Miglitol | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.41 | -4.61 | -5.05 | 21.38% | CHEMBL3669852 |
| Saxagliptin | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.98 | -7.74 | -6.80 | 33.61% | CHEMBL599606 |
| Linagliptin | P2Y12_HUMAN | purinergic receptor P2Y12 | -9.35 | -0.83 | -6.39 | 35.04% | CHEMBL2402268 |
| Chlorpropamide | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.70 | -7.42 | -8.01 | 38.75% | CHEMBL2402155 |
| Gliclazide | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.26 | -7.98 | -8.91 | 30.33% | CHEMBL2402146 |
| Miglitol | P2Y12_HUMAN | purinergic receptor P2Y12 | -5.21 | -4.95 | -5.84 | 27.27% | CHEMBL299895 |
| Saxagliptin | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.44 | N/A | N/A | 49.30% | CHEMBL80672 |
| Linagliptin | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.15 | N/A | N/A | 37.39% | CHEMBL2322664 |
| Chlorpropamide | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.62 | N/A | N/A | 25.71% | CHEMBL313645 |
| Gliclazide | PAR1_HUMAN | coagulation factor II thrombin receptor | -10.19 | N/A | N/A | 32.91% | CHEMBL3658411 |
| Miglitol | PAR1_HUMAN | coagulation factor II thrombin receptor | -5.57 | N/A | N/A | 46.27% | CHEMBL76719 |
| Saxagliptin | PDE4B_HUMAN | phosphodiesterase 4B | -8.02 | -7.39 | -8.22 | 31.93% | CHEMBL144499 |
| Linagliptin | PDE4B_HUMAN | phosphodiesterase 4B | -9.19 | -10.59 | -9.00 | 38.91% | CHEMBL3354172 |
| Chlorpropamide | PDE4B_HUMAN | phosphodiesterase 4B | -7.07 | -7.24 | -7.21 | 28.19% | CHEMBL517590 |
| Gliclazide | PDE4B_HUMAN | phosphodiesterase 4B | -8.37 | -9.51 | -9.39 | 31.68% | CHEMBL3934464 |
| Miglitol | PDE4B_HUMAN | phosphodiesterase 4B | -5.74 | -5.63 | -5.71 | 20.45% | CHEMBL144823 |
| Saxagliptin | PDE5A_HUMAN | phosphodiesterase 5A | -7.19 | -8.35 | -8.21 | 28.91% | CHEMBL190423 |
| Linagliptin | PDE5A_HUMAN | phosphodiesterase 5A | -9.97 | -9.91 | -8.98 | 60.53% | CHEMBL321229 |
| Chlorpropamide | PDE5A_HUMAN | phosphodiesterase 5A | -6.66 | -7.24 | -6.67 | 25.64% | CHEMBL146373 |
| Gliclazide | PDE5A_HUMAN | phosphodiesterase 5A | -8.88 | -8.81 | -8.52 | 29.11% | CHEMBL86512 |
| Miglitol | PDE5A_HUMAN | phosphodiesterase 5A | -5.63 | -5.92 | -5.60 | 21.85% | CHEMBL932 |
| Saxagliptin | PERM_HUMAN | myeloperoxidase | -7.66 | -7.81 | -7.74 | 25.62% | CHEMBL1409565 |
| Linagliptin | PERM_HUMAN | myeloperoxidase | -9.13 | -9.95 | -9.70 | 58.76% | CHEMBL2170247 |
| Chlorpropamide | PERM_HUMAN | myeloperoxidase | -7.43 | -7.74 | -7.54 | 24.36% | CHEMBL3741401 |
| Gliclazide | PERM_HUMAN | myeloperoxidase | -9.10 | -9.50 | -9.11 | 29.41% | CHEMBL3741401 |
| Miglitol | PERM_HUMAN | myeloperoxidase | -5.27 | -5.51 | -5.13 | 23.85% | CHEMBL490 |
| Saxagliptin | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -7.37 | -8.95 | -5.85 | 33.94% | CHEMBL3809863 |
| Linagliptin | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -2.62 | -5.51 | -5.07 | 29.18% | CHEMBL3331465 |
| Chlorpropamide | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -7.37 | -7.29 | -7.40 | 27.42% | CHEMBL2041695 |
| Gliclazide | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.37 | -8.96 | -8.58 | 30.92% | CHEMBL9123 |
| Miglitol | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.03 | -5.55 | -4.91 | 23.58% | CHEMBL3809863 |
| Saxagliptin | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.86 | -6.46 | -6.76 | 42.25% | CHEMBL3809958 |
| Linagliptin | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | 4.76 | -3.73 | -8.28 | 36.68% | CHEMBL85139 |
| Chlorpropamide | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.57 | -6.85 | -7.55 | 40.82% | CHEMBL52820 |
| Gliclazide | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.61 | -5.88 | -6.91 | 38.74% | CHEMBL296384 |
| Miglitol | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.15 | -5.30 | -5.65 | 28.36% | CHEMBL3809958 |
| Saxagliptin | PPAP_HUMAN | acid phosphatase 3 | -7.63 | N/A | N/A | 8.04% | CHEMBL501717 |
| Linagliptin | PPAP_HUMAN | acid phosphatase 3 | -8.43 | N/A | N/A | 11.06% | CHEMBL501717 |
| Chlorpropamide | PPAP_HUMAN | acid phosphatase 3 | -5.99 | N/A | N/A | 17.39% | CHEMBL501717 |
| Gliclazide | PPAP_HUMAN | acid phosphatase 3 | -8.21 | N/A | N/A | 19.26% | CHEMBL501717 |
| Miglitol | PPAP_HUMAN | acid phosphatase 3 | -5.50 | N/A | N/A | 9.28% | CHEMBL501717 |
| Saxagliptin | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.73 | -6.71 | -7.04 | 54.05% | CHEMBL1836976 |
| Linagliptin | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -9.77 | -7.14 | -9.56 | 39.44% | CHEMBL1821831 |
| Chlorpropamide | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.16 | -7.69 | -7.31 | 40.00% | CHEMBL218176 |
| Gliclazide | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.55 | -7.70 | -8.68 | 34.95% | CHEMBL4097121 |
| Miglitol | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -4.79 | -5.00 | -4.95 | 33.78% | CHEMBL1836976 |
| Saxagliptin | PRGR_HUMAN | progesterone receptor | -9.06 | -9.13 | -8.49 | 30.00% | CHEMBL503848 |
| Linagliptin | PRGR_HUMAN | progesterone receptor | 5.53 | 10.67 | -1.53 | 35.61% | CHEMBL188220 |
| Chlorpropamide | PRGR_HUMAN | progesterone receptor | -7.31 | -7.17 | -6.99 | 42.86% | CHEMBL3915906 |
| Gliclazide | PRGR_HUMAN | progesterone receptor | -9.14 | -8.89 | -8.80 | 40.98% | CHEMBL3094480 |
| Miglitol | PRGR_HUMAN | progesterone receptor | -5.49 | -5.64 | -5.23 | 26.04% | CHEMBL3765823 |
| Saxagliptin | PTGES_HUMAN | prostaglandin E synthase | -7.01 | N/A | N/A | 43.48% | CHEMBL3919693 |
| Linagliptin | PTGES_HUMAN | prostaglandin E synthase | -6.97 | N/A | N/A | 44.56% | CHEMBL3770411 |
| Chlorpropamide | PTGES_HUMAN | prostaglandin E synthase | -7.06 | N/A | N/A | 35.59% | CHEMBL3356955 |
| Gliclazide | PTGES_HUMAN | prostaglandin E synthase | -8.22 | N/A | N/A | 45.39% | CHEMBL3092283 |
| Miglitol | PTGES_HUMAN | prostaglandin E synthase | -4.83 | N/A | N/A | 31.46% | CHEMBL3919693 |
| Saxagliptin | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.65 | -8.56 | -8.96 | 41.54% | CHEMBL2021577 |
| Linagliptin | SC6A4_HUMAN | solute carrier family 6 member 4 | -11.29 | -11.32 | -12.09 | 39.53% | CHEMBL296419 |
| Chlorpropamide | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.12 | -7.29 | -7.50 | 41.24% | CHEMBL512665 |
| Gliclazide | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.52 | -9.70 | -8.89 | 42.98% | CHEMBL512665 |
| Miglitol | SC6A4_HUMAN | solute carrier family 6 member 4 | -5.73 | -5.58 | -5.62 | 48.08% | CHEMBL2021577 |
| Saxagliptin | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.67 | N/A | N/A | 34.29% | CHEMBL206758 |
| Linagliptin | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.76 | N/A | N/A | 37.55% | CHEMBL252239 |
| Chlorpropamide | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.57 | N/A | N/A | 33.08% | CHEMBL3682646 |
| Gliclazide | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.47 | N/A | N/A | 42.86% | CHEMBL361138 |
| Miglitol | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -4.60 | N/A | N/A | 29.70% | CHEMBL3632696 |
| Saxagliptin | TLR4_HUMAN | toll like receptor 4 | -7.70 | -7.21 | -7.59 | 30.39% | CHEMBL1223752 |
| Linagliptin | TLR4_HUMAN | toll like receptor 4 | -9.05 | -9.27 | -10.18 | 31.50% | CHEMBL4068003 |
| Chlorpropamide | TLR4_HUMAN | toll like receptor 4 | -6.57 | -6.22 | -6.62 | 19.59% | CHEMBL3823499 |
| Gliclazide | TLR4_HUMAN | toll like receptor 4 | -8.45 | -8.58 | -8.20 | 23.90% | CHEMBL4068003 |
| Miglitol | TLR4_HUMAN | toll like receptor 4 | -5.21 | -5.04 | -5.21 | 26.76% | CHEMBL3354641 |
| Saxagliptin | TNFA_HUMAN | tumor necrosis factor | -7.73 | N/A | N/A | 30.82% | CHEMBL3806296 |
| Linagliptin | TNFA_HUMAN | tumor necrosis factor | -8.21 | N/A | N/A | 38.34% | CHEMBL3984643 |
| Chlorpropamide | TNFA_HUMAN | tumor necrosis factor | -6.89 | N/A | N/A | 32.69% | CHEMBL1709705 |
| Gliclazide | TNFA_HUMAN | tumor necrosis factor | -8.16 | N/A | N/A | 36.71% | CHEMBL1607187 |
| Miglitol | TNFA_HUMAN | tumor necrosis factor | -5.04 | N/A | N/A | 23.08% | CHEMBL3806296 |
| Saxagliptin | TRBM_HUMAN | thrombomodulin | -7.08 | -7.45 | N/A | N/A | N/A |
| Linagliptin | TRBM_HUMAN | thrombomodulin | -8.62 | -7.70 | N/A | N/A | N/A |
| Chlorpropamide | TRBM_HUMAN | thrombomodulin | -6.80 | -6.80 | N/A | N/A | N/A |
| Gliclazide | TRBM_HUMAN | thrombomodulin | -7.85 | -7.26 | N/A | N/A | N/A |
| Miglitol | TRBM_HUMAN | thrombomodulin | -5.62 | -6.07 | N/A | N/A | N/A |
| Saxagliptin | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.41 | -6.59 | N/A | N/A | N/A |
| Linagliptin | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -9.47 | -7.85 | N/A | N/A | N/A |
| Chlorpropamide | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.09 | -6.67 | N/A | N/A | N/A |
| Gliclazide | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.39 | -7.85 | N/A | N/A | N/A |
| Miglitol | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -5.00 | -5.92 | N/A | N/A | N/A |
| Saxagliptin | TRPM8_FICAL | Uncharacterized protein | -8.78 | N/A | N/A | N/A | N/A |
| Linagliptin | TRPM8_FICAL | Uncharacterized protein | -11.34 | N/A | N/A | N/A | N/A |
| Chlorpropamide | TRPM8_FICAL | Uncharacterized protein | -6.91 | N/A | N/A | N/A | N/A |
| Gliclazide | TRPM8_FICAL | Uncharacterized protein | -9.04 | N/A | N/A | N/A | N/A |
| Miglitol | TRPM8_FICAL | Uncharacterized protein | -5.82 | N/A | N/A | N/A | N/A |
| Saxagliptin | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.54 | N/A | N/A | 37.66% | CHEMBL15848 |
| Linagliptin | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -9.41 | N/A | N/A | 39.73% | CHEMBL380205 |
| Chlorpropamide | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.51 | N/A | N/A | 36.94% | CHEMBL197770 |
| Gliclazide | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.95 | N/A | N/A | 34.48% | CHEMBL1940379 |
| Miglitol | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -5.82 | N/A | N/A | 35.82% | CHEMBL15848 |
| Saxagliptin | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -9.05 | -6.76 | N/A | N/A | N/A |
| Linagliptin | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.67 | -9.19 | N/A | N/A | N/A |
| Chlorpropamide | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.48 | -7.25 | N/A | N/A | N/A |
| Gliclazide | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.78 | -9.08 | N/A | N/A | N/A |
| Miglitol | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -5.59 | -5.94 | N/A | N/A | N/A |
| Saxagliptin | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.22 | -7.29 | N/A | 29.21% | CHEMBL73188 |
| Linagliptin | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.54 | -8.36 | N/A | 28.28% | CHEMBL3696423 |
| Chlorpropamide | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.11 | -5.88 | N/A | 28.57% | CHEMBL3692265 |
| Gliclazide | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.14 | -8.02 | N/A | 32.79% | CHEMBL3692262 |
| Miglitol | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -4.51 | -4.86 | N/A | 22.31% | CHEMBL3696473 |
| Saxagliptin | TRXR1_HUMAN | thioredoxin reductase 1 | -7.72 | -7.41 | -6.36 | N/A | N/A |
| Linagliptin | TRXR1_HUMAN | thioredoxin reductase 1 | -9.91 | -9.57 | -7.72 | N/A | N/A |
| Chlorpropamide | TRXR1_HUMAN | thioredoxin reductase 1 | -7.20 | -7.16 | -5.21 | N/A | N/A |
| Gliclazide | TRXR1_HUMAN | thioredoxin reductase 1 | -7.68 | -7.60 | -6.98 | N/A | N/A |
| Miglitol | TRXR1_HUMAN | thioredoxin reductase 1 | -6.21 | -6.02 | -4.69 | N/A | N/A |
| Saxagliptin | TRY1_HUMAN | serine protease 1 | -5.67 | N/A | N/A | 58.21% | CHEMBL289395 |
| Linagliptin | TRY1_HUMAN | serine protease 1 | -7.51 | N/A | N/A | 36.29% | CHEMBL25351 |
| Chlorpropamide | TRY1_HUMAN | serine protease 1 | -6.58 | N/A | N/A | 37.50% | CHEMBL156858 |
| Gliclazide | TRY1_HUMAN | serine protease 1 | -6.05 | N/A | N/A | 40.26% | CHEMBL38626 |
| Miglitol | TRY1_HUMAN | serine protease 1 | -5.19 | N/A | N/A | 35.16% | CHEMBL70155 |