| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Dihydrocodeine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.75 | -8.74 | -7.92 | 67.67% | CHEMBL29951 |
| Acetylsalicylic acid | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -5.93 | -6.16 | -6.49 | 43.48% | CHEMBL2112766 |
| Hydromorphone | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.66 | -8.80 | -7.56 | 64.75% | CHEMBL29951 |
| Ibuprofen | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -6.95 | -7.25 | -7.17 | 38.89% | CHEMBL73281 |
| Codeine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.95 | -8.50 | -8.48 | 52.33% | CHEMBL29951 |
| Dihydrocodeine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.80 | -7.77 | N/A | 64.00% | CHEMBL445106 |
| Acetylsalicylic acid | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -6.45 | -6.45 | N/A | 43.42% | CHEMBL272942 |
| Hydromorphone | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.78 | -7.87 | N/A | 64.58% | CHEMBL3695433 |
| Ibuprofen | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -7.38 | -7.27 | N/A | 50.00% | CHEMBL104088 |
| Codeine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.04 | -7.57 | N/A | 51.67% | CHEMBL3695438 |
| Dihydrocodeine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.56 | -9.10 | -8.53 | 64.00% | CHEMBL445106 |
| Acetylsalicylic acid | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.36 | -6.53 | -6.65 | 44.62% | CHEMBL558 |
| Hydromorphone | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.83 | -8.62 | -8.65 | 62.58% | CHEMBL445106 |
| Ibuprofen | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -7.22 | -8.14 | -7.29 | 52.00% | CHEMBL475643 |
| Codeine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.37 | -8.84 | -8.69 | 50.79% | CHEMBL445106 |
| Dihydrocodeine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.79 | -8.31 | N/A | 64.00% | CHEMBL445106 |
| Acetylsalicylic acid | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.40 | -6.78 | N/A | 43.42% | CHEMBL272942 |
| Hydromorphone | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.21 | -8.59 | N/A | 62.58% | CHEMBL445106 |
| Ibuprofen | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.00 | -8.13 | N/A | 52.00% | CHEMBL475643 |
| Codeine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.42 | -9.08 | N/A | 50.79% | CHEMBL445106 |
| Dihydrocodeine | AA1R_HUMAN | adenosine A1 receptor | -7.72 | -8.57 | -6.19 | 35.00% | CHEMBL3317575 |
| Acetylsalicylic acid | AA1R_HUMAN | adenosine A1 receptor | -5.58 | -5.62 | -6.41 | 32.77% | CHEMBL2151131 |
| Hydromorphone | AA1R_HUMAN | adenosine A1 receptor | -7.58 | -9.00 | -8.09 | 34.78% | CHEMBL1544 |
| Ibuprofen | AA1R_HUMAN | adenosine A1 receptor | -7.23 | -7.03 | -7.92 | 31.46% | CHEMBL1544 |
| Codeine | AA1R_HUMAN | adenosine A1 receptor | -7.50 | -8.34 | -7.56 | 29.83% | CHEMBL3317575 |
| Dihydrocodeine | AA2AR_HUMAN | adenosine A2a receptor | -7.71 | -7.90 | -8.95 | 38.46% | CHEMBL539454 |
| Acetylsalicylic acid | AA2AR_HUMAN | adenosine A2a receptor | -5.99 | -5.92 | -6.00 | 32.79% | CHEMBL197359 |
| Hydromorphone | AA2AR_HUMAN | adenosine A2a receptor | -7.77 | -8.43 | -9.64 | 42.54% | CHEMBL539454 |
| Ibuprofen | AA2AR_HUMAN | adenosine A2a receptor | -7.12 | -7.39 | -7.43 | 26.39% | CHEMBL86771 |
| Codeine | AA2AR_HUMAN | adenosine A2a receptor | -7.40 | -7.76 | -8.98 | 34.58% | CHEMBL559023 |
| Dihydrocodeine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.06 | -9.25 | -8.13 | 68.83% | CHEMBL3764305 |
| Acetylsalicylic acid | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -6.60 | -6.51 | -7.23 | 52.78% | CHEMBL139330 |
| Hydromorphone | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.82 | -9.24 | -9.58 | 65.22% | CHEMBL3764305 |
| Ibuprofen | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -7.67 | -7.22 | -8.03 | 52.73% | CHEMBL157327 |
| Codeine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.59 | -9.44 | -9.20 | 66.50% | CHEMBL569978 |
| Dihydrocodeine | ACE_HUMAN | angiotensin I converting enzyme | -8.89 | -9.10 | -8.15 | 40.96% | CHEMBL58042 |
| Acetylsalicylic acid | ACE_HUMAN | angiotensin I converting enzyme | -5.96 | -6.16 | -5.95 | 29.69% | CHEMBL254493 |
| Hydromorphone | ACE_HUMAN | angiotensin I converting enzyme | -8.67 | -8.96 | -8.71 | 43.39% | CHEMBL58042 |
| Ibuprofen | ACE_HUMAN | angiotensin I converting enzyme | -6.79 | -6.29 | -5.89 | 46.27% | CHEMBL80667 |
| Codeine | ACE_HUMAN | angiotensin I converting enzyme | -8.87 | -8.96 | -8.17 | 37.56% | CHEMBL58042 |
| Dihydrocodeine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.11 | N/A | N/A | 22.13% | CHEMBL386114 |
| Acetylsalicylic acid | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.08 | N/A | N/A | 13.51% | CHEMBL386114 |
| Hydromorphone | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.68 | N/A | N/A | 25.75% | CHEMBL386114 |
| Ibuprofen | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -5.85 | N/A | N/A | 16.97% | CHEMBL386114 |
| Codeine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.82 | N/A | N/A | 21.64% | CHEMBL386114 |
| Dihydrocodeine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.20 | -3.27 | -7.51 | N/A | N/A |
| Acetylsalicylic acid | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.20 | -6.43 | -6.82 | N/A | N/A |
| Hydromorphone | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -3.63 | -3.26 | -5.11 | N/A | N/A |
| Ibuprofen | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.64 | -8.03 | -7.08 | N/A | N/A |
| Codeine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.15 | -2.48 | -6.35 | N/A | N/A |
| Dihydrocodeine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.21 | 1.85 | N/A | 58.52% | CHEMBL343236 |
| Acetylsalicylic acid | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -6.75 | -6.89 | N/A | 40.26% | CHEMBL4102555 |
| Hydromorphone | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.80 | 1.84 | N/A | 54.93% | CHEMBL343236 |
| Ibuprofen | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -7.76 | -7.22 | N/A | 51.52% | CHEMBL2164888 |
| Codeine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.79 | 6.44 | N/A | 45.40% | CHEMBL343236 |
| Dihydrocodeine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.90 | -6.23 | N/A | 50.00% | CHEMBL1346 |
| Acetylsalicylic acid | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -6.68 | -6.42 | N/A | 37.18% | CHEMBL55 |
| Hydromorphone | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -10.38 | -8.12 | N/A | 51.95% | CHEMBL1346 |
| Ibuprofen | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -7.86 | -7.83 | N/A | 50.00% | CHEMBL2377392 |
| Codeine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.54 | -7.45 | N/A | 39.79% | CHEMBL1346 |
| Dihydrocodeine | ADRB2_HUMAN | adrenoceptor beta 2 | -7.67 | -7.85 | -9.13 | 56.12% | CHEMBL513389 |
| Acetylsalicylic acid | ADRB2_HUMAN | adrenoceptor beta 2 | -6.71 | -6.84 | -6.72 | 46.59% | CHEMBL1704973 |
| Hydromorphone | ADRB2_HUMAN | adrenoceptor beta 2 | -8.39 | -9.19 | -9.41 | 51.95% | CHEMBL1346 |
| Ibuprofen | ADRB2_HUMAN | adrenoceptor beta 2 | -6.74 | -8.09 | -7.38 | 37.33% | CHEMBL1332942 |
| Codeine | ADRB2_HUMAN | adrenoceptor beta 2 | -8.87 | -8.86 | -8.96 | 43.82% | CHEMBL513389 |
| Dihydrocodeine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.36 | -7.96 | -8.30 | 47.57% | CHEMBL156129 |
| Acetylsalicylic acid | AGTR2_HUMAN | angiotensin II receptor type 2 | -5.94 | -6.11 | -6.00 | 26.25% | CHEMBL158557 |
| Hydromorphone | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.82 | -8.78 | -8.79 | 49.74% | CHEMBL154057 |
| Ibuprofen | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.17 | -7.19 | -6.89 | 30.69% | CHEMBL128416 |
| Codeine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.46 | -8.46 | -8.38 | 43.12% | CHEMBL156129 |
| Dihydrocodeine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.54 | -7.88 | -7.26 | 39.63% | CHEMBL71562 |
| Acetylsalicylic acid | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.22 | -7.08 | -7.23 | 43.52% | CHEMBL110030 |
| Hydromorphone | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.75 | -8.74 | -7.85 | 44.17% | CHEMBL71562 |
| Ibuprofen | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.64 | -7.40 | -8.22 | 54.55% | CHEMBL77283 |
| Codeine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.86 | -7.96 | -7.66 | 32.38% | CHEMBL311679 |
| Dihydrocodeine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.49 | -8.80 | -7.84 | 34.74% | CHEMBL1077584 |
| Acetylsalicylic acid | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.66 | -6.67 | -6.27 | 25.00% | CHEMBL3805817 |
| Hydromorphone | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.44 | -8.33 | -8.46 | 39.61% | CHEMBL1798008 |
| Ibuprofen | AMPN_HUMAN | alanyl aminopeptidase, membrane | -6.84 | -7.66 | -6.20 | 42.00% | CHEMBL414393 |
| Codeine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.83 | -7.73 | -7.80 | 33.63% | CHEMBL1782887 |
| Dihydrocodeine | AOFA_HUMAN | monoamine oxidase A | -9.78 | -10.35 | -10.26 | 40.51% | CHEMBL2333926 |
| Acetylsalicylic acid | AOFA_HUMAN | monoamine oxidase A | -6.45 | -6.62 | -6.98 | 45.88% | CHEMBL2391739 |
| Hydromorphone | AOFA_HUMAN | monoamine oxidase A | -8.72 | -9.78 | -9.16 | 43.02% | CHEMBL4073457 |
| Ibuprofen | AOFA_HUMAN | monoamine oxidase A | -7.48 | -7.53 | -8.08 | 48.15% | CHEMBL3330339 |
| Codeine | AOFA_HUMAN | monoamine oxidase A | -8.87 | -8.81 | -7.46 | 34.78% | CHEMBL4073457 |
| Dihydrocodeine | AOFB_HUMAN | monoamine oxidase B | -10.76 | -10.23 | -10.13 | 46.43% | CHEMBL4113794 |
| Acetylsalicylic acid | AOFB_HUMAN | monoamine oxidase B | -6.78 | -6.62 | -6.63 | 53.73% | CHEMBL3278090 |
| Hydromorphone | AOFB_HUMAN | monoamine oxidase B | -10.07 | -9.15 | -9.66 | 45.89% | CHEMBL3288304 |
| Ibuprofen | AOFB_HUMAN | monoamine oxidase B | -7.95 | -8.03 | -7.84 | 48.15% | CHEMBL3330339 |
| Codeine | AOFB_HUMAN | monoamine oxidase B | -9.92 | -7.97 | -8.69 | 36.31% | CHEMBL4113794 |
| Dihydrocodeine | BACE1_HUMAN | beta-secretase 1 | -7.51 | -8.07 | -8.74 | 51.11% | CHEMBL3656239 |
| Acetylsalicylic acid | BACE1_HUMAN | beta-secretase 1 | -5.11 | -5.52 | -5.98 | 35.64% | CHEMBL3586198 |
| Hydromorphone | BACE1_HUMAN | beta-secretase 1 | -7.20 | -7.61 | -8.66 | 50.81% | CHEMBL3939118 |
| Ibuprofen | BACE1_HUMAN | beta-secretase 1 | -5.95 | -6.06 | -6.89 | 32.14% | CHEMBL1092504 |
| Codeine | BACE1_HUMAN | beta-secretase 1 | -6.85 | -7.36 | -9.35 | 43.35% | CHEMBL3955763 |
| Dihydrocodeine | CAH2_HUMAN | carbonic anhydrase 2 | -7.78 | -7.76 | -7.34 | 51.03% | CHEMBL3786651 |
| Acetylsalicylic acid | CAH2_HUMAN | carbonic anhydrase 2 | -6.29 | -6.27 | -6.25 | 59.32% | CHEMBL2333586 |
| Hydromorphone | CAH2_HUMAN | carbonic anhydrase 2 | -7.36 | -7.93 | -7.90 | 50.00% | CHEMBL3786651 |
| Ibuprofen | CAH2_HUMAN | carbonic anhydrase 2 | -6.86 | -6.55 | -6.63 | 43.75% | CHEMBL451332 |
| Codeine | CAH2_HUMAN | carbonic anhydrase 2 | -7.22 | -8.18 | -7.90 | 40.22% | CHEMBL3786651 |
| Dihydrocodeine | CASP1_HUMAN | caspase 1 | -6.49 | -7.42 | -6.33 | 41.33% | CHEMBL3898379 |
| Acetylsalicylic acid | CASP1_HUMAN | caspase 1 | -4.81 | -5.70 | -4.75 | 39.20% | CHEMBL101145 |
| Hydromorphone | CASP1_HUMAN | caspase 1 | -6.40 | -7.46 | -6.46 | 46.15% | CHEMBL2371932 |
| Ibuprofen | CASP1_HUMAN | caspase 1 | -5.84 | -6.94 | -5.64 | 38.46% | CHEMBL466565 |
| Codeine | CASP1_HUMAN | caspase 1 | -5.80 | -7.68 | -6.21 | 34.47% | CHEMBL3898379 |
| Dihydrocodeine | CDK5_HUMAN | cyclin dependent kinase 5 | -7.54 | -8.01 | -6.70 | 33.02% | CHEMBL422897 |
| Acetylsalicylic acid | CDK5_HUMAN | cyclin dependent kinase 5 | -6.17 | -6.63 | -6.92 | 36.19% | CHEMBL2007296 |
| Hydromorphone | CDK5_HUMAN | cyclin dependent kinase 5 | -7.59 | -7.51 | -5.44 | 32.11% | CHEMBL422897 |
| Ibuprofen | CDK5_HUMAN | cyclin dependent kinase 5 | -7.10 | -7.44 | -8.10 | 30.23% | CHEMBL1974288 |
| Codeine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.41 | -7.34 | -5.71 | 29.44% | CHEMBL422897 |
| Dihydrocodeine | CHLE_HUMAN | butyrylcholinesterase | -8.77 | -8.69 | -8.99 | 46.24% | CHEMBL189906 |
| Acetylsalicylic acid | CHLE_HUMAN | butyrylcholinesterase | -6.69 | -6.27 | -6.40 | 36.79% | CHEMBL544592 |
| Hydromorphone | CHLE_HUMAN | butyrylcholinesterase | -9.46 | -9.35 | -9.79 | 45.37% | CHEMBL3410956 |
| Ibuprofen | CHLE_HUMAN | butyrylcholinesterase | -7.66 | -7.36 | -7.33 | 41.54% | CHEMBL51931 |
| Codeine | CHLE_HUMAN | butyrylcholinesterase | -9.14 | -8.82 | -8.92 | 43.54% | CHEMBL4085222 |
| Dihydrocodeine | CNR1_HUMAN | cannabinoid receptor 1 | -7.64 | -8.72 | -8.99 | 54.48% | CHEMBL228349 |
| Acetylsalicylic acid | CNR1_HUMAN | cannabinoid receptor 1 | -5.65 | -6.37 | -6.45 | 47.83% | CHEMBL243334 |
| Hydromorphone | CNR1_HUMAN | cannabinoid receptor 1 | -8.78 | -8.50 | -9.02 | 58.62% | CHEMBL228349 |
| Ibuprofen | CNR1_HUMAN | cannabinoid receptor 1 | -7.43 | -7.51 | -7.98 | 51.61% | CHEMBL391380 |
| Codeine | CNR1_HUMAN | cannabinoid receptor 1 | -8.22 | -8.45 | -9.29 | 57.39% | CHEMBL303479 |
| Dihydrocodeine | CNR2_HUMAN | cannabinoid receptor 2 | -9.68 | -9.20 | N/A | 56.05% | CHEMBL3410730 |
| Acetylsalicylic acid | CNR2_HUMAN | cannabinoid receptor 2 | -6.25 | -6.47 | N/A | 47.83% | CHEMBL243334 |
| Hydromorphone | CNR2_HUMAN | cannabinoid receptor 2 | -9.16 | -9.24 | N/A | 55.86% | CHEMBL426923 |
| Ibuprofen | CNR2_HUMAN | cannabinoid receptor 2 | -7.61 | -7.51 | N/A | 55.32% | CHEMBL264412 |
| Codeine | CNR2_HUMAN | cannabinoid receptor 2 | -9.57 | -8.98 | N/A | 57.39% | CHEMBL303479 |
| Dihydrocodeine | COLI_HUMAN | proopiomelanocortin | -8.16 | -8.06 | -6.92 | N/A | N/A |
| Acetylsalicylic acid | COLI_HUMAN | proopiomelanocortin | -6.37 | -6.26 | -5.32 | N/A | N/A |
| Hydromorphone | COLI_HUMAN | proopiomelanocortin | -8.26 | -8.19 | -6.99 | N/A | N/A |
| Ibuprofen | COLI_HUMAN | proopiomelanocortin | -7.62 | -7.61 | -6.34 | N/A | N/A |
| Codeine | COLI_HUMAN | proopiomelanocortin | -8.90 | -7.76 | -6.40 | N/A | N/A |
| Dihydrocodeine | COMT_HUMAN | catechol-O-methyltransferase | -6.07 | -5.91 | -6.72 | 25.59% | CHEMBL3425740 |
| Acetylsalicylic acid | COMT_HUMAN | catechol-O-methyltransferase | -5.38 | -5.25 | -5.76 | 25.62% | CHEMBL3980370 |
| Hydromorphone | COMT_HUMAN | catechol-O-methyltransferase | -6.29 | -6.61 | -6.24 | 27.23% | CHEMBL3425740 |
| Ibuprofen | COMT_HUMAN | catechol-O-methyltransferase | -5.73 | -5.76 | -6.03 | 23.16% | CHEMBL1324 |
| Codeine | COMT_HUMAN | catechol-O-methyltransferase | -6.36 | -6.30 | -6.38 | 22.62% | CHEMBL3819488 |
| Dihydrocodeine | CRP_HUMAN | C-reactive protein | -6.05 | -6.27 | N/A | N/A | N/A |
| Acetylsalicylic acid | CRP_HUMAN | C-reactive protein | -4.90 | -5.22 | N/A | N/A | N/A |
| Hydromorphone | CRP_HUMAN | C-reactive protein | -6.56 | -6.35 | N/A | N/A | N/A |
| Ibuprofen | CRP_HUMAN | C-reactive protein | -5.53 | -5.09 | N/A | N/A | N/A |
| Codeine | CRP_HUMAN | C-reactive protein | -6.25 | -6.41 | N/A | N/A | N/A |
| Dihydrocodeine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -8.22 | N/A | N/A | 28.95% | CHEMBL490688 |
| Acetylsalicylic acid | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.85 | N/A | N/A | 23.78% | CHEMBL464302 |
| Hydromorphone | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.51 | N/A | N/A | 28.76% | CHEMBL490688 |
| Ibuprofen | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.43 | N/A | N/A | 44.62% | CHEMBL191413 |
| Codeine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.09 | N/A | N/A | 28.57% | CHEMBL490688 |
| Dihydrocodeine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.93 | -6.79 | -8.09 | 33.33% | CHEMBL1644072 |
| Acetylsalicylic acid | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.56 | -5.81 | -5.82 | 30.00% | CHEMBL126657 |
| Hydromorphone | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.30 | -6.55 | -8.20 | 36.63% | CHEMBL1949739 |
| Ibuprofen | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.11 | -5.46 | -6.38 | 25.00% | CHEMBL2180085 |
| Codeine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.25 | -6.63 | -7.67 | 33.77% | CHEMBL2029611 |
| Dihydrocodeine | DRD2_HUMAN | dopamine receptor D2 | -7.54 | N/A | N/A | 72.39% | CHEMBL170976 |
| Acetylsalicylic acid | DRD2_HUMAN | dopamine receptor D2 | -5.97 | N/A | N/A | 40.26% | CHEMBL128313 |
| Hydromorphone | DRD2_HUMAN | dopamine receptor D2 | -7.57 | N/A | N/A | 66.90% | CHEMBL170976 |
| Ibuprofen | DRD2_HUMAN | dopamine receptor D2 | -7.04 | N/A | N/A | 38.89% | CHEMBL1258270 |
| Codeine | DRD2_HUMAN | dopamine receptor D2 | -7.92 | N/A | N/A | 56.07% | CHEMBL170976 |
| Dihydrocodeine | DRD3_HUMAN | dopamine receptor D3 | -8.27 | N/A | N/A | 72.39% | CHEMBL170976 |
| Acetylsalicylic acid | DRD3_HUMAN | dopamine receptor D3 | -6.08 | N/A | N/A | 39.24% | CHEMBL334545 |
| Hydromorphone | DRD3_HUMAN | dopamine receptor D3 | -7.88 | N/A | N/A | 66.90% | CHEMBL170976 |
| Ibuprofen | DRD3_HUMAN | dopamine receptor D3 | -7.07 | N/A | N/A | 39.71% | CHEMBL1765637 |
| Codeine | DRD3_HUMAN | dopamine receptor D3 | -8.14 | N/A | N/A | 56.07% | CHEMBL170976 |
| Dihydrocodeine | DRD4_HUMAN | dopamine receptor D4 | -8.62 | -8.26 | N/A | 60.00% | CHEMBL27441 |
| Acetylsalicylic acid | DRD4_HUMAN | dopamine receptor D4 | -7.02 | -6.67 | N/A | 42.86% | CHEMBL59326 |
| Hydromorphone | DRD4_HUMAN | dopamine receptor D4 | -8.34 | -8.42 | N/A | 57.35% | CHEMBL27441 |
| Ibuprofen | DRD4_HUMAN | dopamine receptor D4 | -7.20 | -7.21 | N/A | 38.89% | CHEMBL1258270 |
| Codeine | DRD4_HUMAN | dopamine receptor D4 | -8.87 | -9.13 | N/A | 47.42% | CHEMBL132261 |
| Dihydrocodeine | EDN1_HUMAN | endothelin 1 | -7.90 | N/A | N/A | N/A | N/A |
| Acetylsalicylic acid | EDN1_HUMAN | endothelin 1 | -6.27 | N/A | N/A | N/A | N/A |
| Hydromorphone | EDN1_HUMAN | endothelin 1 | -7.93 | N/A | N/A | N/A | N/A |
| Ibuprofen | EDN1_HUMAN | endothelin 1 | -7.29 | N/A | N/A | N/A | N/A |
| Codeine | EDN1_HUMAN | endothelin 1 | -7.34 | N/A | N/A | N/A | N/A |
| Dihydrocodeine | ESR1_HUMAN | estrogen receptor 1 | -8.66 | -7.75 | -8.18 | 54.49% | CHEMBL178559 |
| Acetylsalicylic acid | ESR1_HUMAN | estrogen receptor 1 | -6.08 | -5.90 | -5.70 | 63.08% | CHEMBL1082743 |
| Hydromorphone | ESR1_HUMAN | estrogen receptor 1 | -9.19 | -8.98 | -8.99 | 50.54% | CHEMBL33890 |
| Ibuprofen | ESR1_HUMAN | estrogen receptor 1 | -7.15 | -6.98 | -7.31 | 61.82% | CHEMBL335412 |
| Codeine | ESR1_HUMAN | estrogen receptor 1 | -9.57 | -9.22 | -9.27 | 45.08% | CHEMBL178559 |
| Dihydrocodeine | FABP5_HUMAN | fatty acid binding protein 5 | -8.99 | -6.58 | -6.01 | 33.33% | CHEMBL212860 |
| Acetylsalicylic acid | FABP5_HUMAN | fatty acid binding protein 5 | -6.12 | -4.52 | -4.52 | 53.49% | CHEMBL247298 |
| Hydromorphone | FABP5_HUMAN | fatty acid binding protein 5 | -8.70 | -6.09 | -6.37 | 34.55% | CHEMBL212860 |
| Ibuprofen | FABP5_HUMAN | fatty acid binding protein 5 | -6.80 | -4.79 | -5.02 | 35.56% | CHEMBL212860 |
| Codeine | FABP5_HUMAN | fatty acid binding protein 5 | -8.34 | -6.35 | -6.50 | 30.39% | CHEMBL437489 |
| Dihydrocodeine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.42 | N/A | N/A | 34.21% | CHEMBL221753 |
| Acetylsalicylic acid | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.04 | N/A | N/A | 32.00% | CHEMBL2004025 |
| Hydromorphone | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.24 | N/A | N/A | 31.66% | CHEMBL24828 |
| Ibuprofen | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -6.96 | N/A | N/A | 41.79% | CHEMBL1975923 |
| Codeine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.16 | N/A | N/A | 29.26% | CHEMBL221753 |
| Dihydrocodeine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.68 | -8.54 | -8.74 | 25.49% | CHEMBL4070615 |
| Dihydrocodeine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.69 | N/A | N/A | 25.49% | CHEMBL4070615 |
| Acetylsalicylic acid | GLRA3_HUMAN | glycine receptor alpha 3 | -6.77 | -6.95 | -6.81 | 10.96% | CHEMBL4070615 |
| Acetylsalicylic acid | GLRA3_HUMAN | glycine receptor alpha 3 | -6.59 | N/A | N/A | 10.96% | CHEMBL4070615 |
| Hydromorphone | GLRA3_HUMAN | glycine receptor alpha 3 | -8.51 | -8.46 | -8.39 | 27.34% | CHEMBL4070615 |
| Hydromorphone | GLRA3_HUMAN | glycine receptor alpha 3 | -9.34 | N/A | N/A | 27.34% | CHEMBL4070615 |
| Ibuprofen | GLRA3_HUMAN | glycine receptor alpha 3 | -7.26 | -7.35 | -7.50 | 11.17% | CHEMBL4074873 |
| Ibuprofen | GLRA3_HUMAN | glycine receptor alpha 3 | -7.98 | N/A | N/A | 11.17% | CHEMBL4074873 |
| Codeine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.48 | -8.37 | -8.49 | 24.22% | CHEMBL4070615 |
| Codeine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.65 | N/A | N/A | 24.22% | CHEMBL4070615 |
| Dihydrocodeine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.21 | -2.79 | -6.55 | 40.97% | CHEMBL1289626 |
| Acetylsalicylic acid | GRM5_HUMAN | glutamate metabotropic receptor 5 | -6.61 | -7.52 | -7.37 | 51.65% | CHEMBL1682821 |
| Hydromorphone | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.54 | -4.78 | -4.90 | 39.33% | CHEMBL1289626 |
| Ibuprofen | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.45 | -8.06 | -8.11 | 42.65% | CHEMBL1682794 |
| Codeine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -5.88 | -3.52 | -4.93 | 32.97% | CHEMBL1289626 |
| Dihydrocodeine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.63 | -6.63 | -7.17 | 23.71% | CHEMBL3134496 |
| Acetylsalicylic acid | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.04 | -6.12 | -7.11 | 33.33% | CHEMBL2035654 |
| Hydromorphone | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.92 | -6.80 | -6.60 | 25.45% | CHEMBL3698265 |
| Ibuprofen | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -6.73 | -6.80 | -7.49 | 22.45% | CHEMBL3907283 |
| Codeine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.91 | -6.81 | -6.39 | 23.62% | CHEMBL3698265 |
| Dihydrocodeine | HRH1_HUMAN | histamine receptor H1 | -2.52 | N/A | N/A | 55.24% | CHEMBL476839 |
| Acetylsalicylic acid | HRH1_HUMAN | histamine receptor H1 | -7.17 | N/A | N/A | 38.46% | CHEMBL2158833 |
| Hydromorphone | HRH1_HUMAN | histamine receptor H1 | -7.18 | N/A | N/A | 53.02% | CHEMBL476839 |
| Ibuprofen | HRH1_HUMAN | histamine receptor H1 | -8.05 | N/A | N/A | 54.55% | CHEMBL914 |
| Codeine | HRH1_HUMAN | histamine receptor H1 | -7.46 | N/A | N/A | 45.00% | CHEMBL476839 |
| Dihydrocodeine | HYES_HUMAN | epoxide hydrolase 2 | -8.37 | -8.28 | -8.46 | 53.74% | CHEMBL1672128 |
| Acetylsalicylic acid | HYES_HUMAN | epoxide hydrolase 2 | -6.41 | -6.70 | -6.36 | 47.92% | CHEMBL244407 |
| Hydromorphone | HYES_HUMAN | epoxide hydrolase 2 | -9.32 | -8.19 | -8.55 | 60.00% | CHEMBL1672128 |
| Ibuprofen | HYES_HUMAN | epoxide hydrolase 2 | -7.03 | -7.58 | -7.41 | 38.71% | CHEMBL3763278 |
| Codeine | HYES_HUMAN | epoxide hydrolase 2 | -8.41 | -8.37 | -8.59 | 42.47% | CHEMBL1672128 |
| Dihydrocodeine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.50 | N/A | N/A | 35.37% | CHEMBL484012 |
| Acetylsalicylic acid | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.20 | N/A | N/A | 32.98% | CHEMBL3318321 |
| Hydromorphone | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.94 | N/A | N/A | 38.22% | CHEMBL184041 |
| Ibuprofen | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.80 | N/A | N/A | 36.71% | CHEMBL3318321 |
| Codeine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.30 | N/A | N/A | 31.38% | CHEMBL1672879 |
| Dihydrocodeine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.53 | -8.64 | N/A | 93.08% | CHEMBL258669 |
| Acetylsalicylic acid | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.01 | -5.60 | N/A | 42.00% | CHEMBL9352 |
| Hydromorphone | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.12 | -7.69 | N/A | 82.35% | CHEMBL261048 |
| Ibuprofen | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -6.53 | -6.95 | N/A | 54.55% | CHEMBL914 |
| Codeine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.72 | -7.31 | N/A | 100.00% | CHEMBL485 |
| Dihydrocodeine | MIF_HUMAN | macrophage migration inhibitory factor | -6.23 | -7.56 | -6.91 | 27.66% | CHEMBL1289631 |
| Acetylsalicylic acid | MIF_HUMAN | macrophage migration inhibitory factor | -5.01 | -6.21 | -5.15 | 32.94% | CHEMBL224086 |
| Hydromorphone | MIF_HUMAN | macrophage migration inhibitory factor | -5.80 | -6.70 | -7.02 | 28.80% | CHEMBL1289631 |
| Ibuprofen | MIF_HUMAN | macrophage migration inhibitory factor | -7.81 | -7.69 | -8.05 | 25.45% | CHEMBL209588 |
| Codeine | MIF_HUMAN | macrophage migration inhibitory factor | -6.60 | -7.30 | -7.13 | 30.33% | CHEMBL2375651 |
| Dihydrocodeine | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.65 | -8.66 | -7.23 | 36.82% | CHEMBL3654783 |
| Acetylsalicylic acid | MK01_HUMAN | mitogen-activated protein kinase 1 | -5.92 | -5.73 | -6.23 | 33.33% | CHEMBL2004872 |
| Hydromorphone | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.31 | -7.80 | -7.58 | 39.39% | CHEMBL3752989 |
| Ibuprofen | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.63 | -6.30 | -6.59 | 36.84% | CHEMBL1909070 |
| Codeine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.77 | -8.18 | -7.26 | 39.92% | CHEMBL555017 |
| Dihydrocodeine | MK03_HUMAN | mitogen-activated protein kinase 3 | -8.50 | -7.75 | -8.32 | 31.43% | CHEMBL555017 |
| Acetylsalicylic acid | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.05 | -6.28 | -6.48 | 31.45% | CHEMBL3797548 |
| Hydromorphone | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.73 | -7.54 | -8.11 | 32.79% | CHEMBL555017 |
| Ibuprofen | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.04 | -6.86 | -5.94 | 23.58% | CHEMBL3113587 |
| Codeine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.75 | -7.92 | -7.85 | 39.92% | CHEMBL555017 |
| Dihydrocodeine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.48 | -8.73 | -8.61 | 35.40% | CHEMBL4074753 |
| Acetylsalicylic acid | MTOR_HUMAN | mechanistic target of rapamycin kinase | -6.33 | -6.36 | -6.18 | 28.80% | CHEMBL1241300 |
| Hydromorphone | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.72 | -9.20 | -9.06 | 37.44% | CHEMBL4074753 |
| Ibuprofen | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.90 | -7.89 | -7.42 | 32.89% | CHEMBL2348411 |
| Codeine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.88 | -8.91 | -9.19 | 33.72% | CHEMBL4074753 |
| Dihydrocodeine | NEP_HUMAN | membrane metalloendopeptidase | -7.75 | -7.63 | -7.30 | 48.78% | CHEMBL2062138 |
| Acetylsalicylic acid | NEP_HUMAN | membrane metalloendopeptidase | -6.69 | -6.58 | -6.88 | 29.69% | CHEMBL254493 |
| Hydromorphone | NEP_HUMAN | membrane metalloendopeptidase | -7.94 | -7.89 | -7.83 | 49.70% | CHEMBL2062138 |
| Ibuprofen | NEP_HUMAN | membrane metalloendopeptidase | -8.04 | -7.32 | -7.52 | 42.86% | CHEMBL4070297 |
| Codeine | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.65 | -6.98 | 38.73% | CHEMBL2062138 |
| Dihydrocodeine | NK1R_HUMAN | tachykinin receptor 1 | -9.17 | -9.17 | -8.92 | 50.30% | CHEMBL2112368 |
| Acetylsalicylic acid | NK1R_HUMAN | tachykinin receptor 1 | -6.09 | -6.16 | -6.29 | 30.43% | CHEMBL93909 |
| Hydromorphone | NK1R_HUMAN | tachykinin receptor 1 | -9.33 | -8.72 | -8.23 | 45.98% | CHEMBL2112368 |
| Ibuprofen | NK1R_HUMAN | tachykinin receptor 1 | -6.92 | -7.25 | -6.57 | 43.75% | CHEMBL56811 |
| Codeine | NK1R_HUMAN | tachykinin receptor 1 | -9.24 | -8.22 | -8.16 | 45.16% | CHEMBL2114439 |
| Dihydrocodeine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.68 | -7.68 | -7.76 | 27.85% | CHEMBL284237 |
| Acetylsalicylic acid | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.35 | -6.92 | -7.27 | 16.67% | CHEMBL2333945 |
| Hydromorphone | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.71 | -7.44 | -7.55 | 26.06% | CHEMBL284237 |
| Ibuprofen | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.13 | -7.89 | -8.40 | 24.14% | CHEMBL284237 |
| Codeine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.72 | -7.09 | -6.87 | 25.52% | CHEMBL284237 |
| Dihydrocodeine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.55 | -9.53 | -6.84 | 50.38% | CHEMBL3357784 |
| Acetylsalicylic acid | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -6.83 | -6.61 | -7.18 | 32.14% | CHEMBL161421 |
| Hydromorphone | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.93 | -9.66 | -6.43 | 47.10% | CHEMBL3357784 |
| Ibuprofen | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.30 | -8.29 | -8.32 | 33.78% | CHEMBL305187 |
| Codeine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.82 | -8.60 | -6.54 | 40.00% | CHEMBL3357783 |
| Dihydrocodeine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.67 | -7.70 | -7.76 | 23.78% | CHEMBL419399 |
| Acetylsalicylic acid | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.32 | -6.93 | -7.27 | 22.47% | CHEMBL162577 |
| Hydromorphone | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.74 | -7.34 | -7.55 | 23.04% | CHEMBL419399 |
| Ibuprofen | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.17 | -8.01 | -8.40 | 26.17% | CHEMBL419399 |
| Codeine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.75 | -6.96 | -6.87 | 20.72% | CHEMBL419399 |
| Dihydrocodeine | NOS1_HUMAN | nitric oxide synthase 1 | -8.37 | -8.33 | -8.06 | 41.36% | CHEMBL42968 |
| Acetylsalicylic acid | NOS1_HUMAN | nitric oxide synthase 1 | -6.64 | -6.86 | -6.31 | 33.03% | CHEMBL4060083 |
| Hydromorphone | NOS1_HUMAN | nitric oxide synthase 1 | -7.79 | -7.94 | -8.73 | 40.10% | CHEMBL42968 |
| Ibuprofen | NOS1_HUMAN | nitric oxide synthase 1 | -7.96 | -7.83 | -7.40 | 36.84% | CHEMBL298404 |
| Codeine | NOS1_HUMAN | nitric oxide synthase 1 | -7.20 | -7.33 | -8.61 | 34.93% | CHEMBL42968 |
| Dihydrocodeine | NOS2_HUMAN | nitric oxide synthase 2 | -6.64 | -7.70 | -7.72 | 41.36% | CHEMBL42968 |
| Acetylsalicylic acid | NOS2_HUMAN | nitric oxide synthase 2 | -5.95 | -5.83 | -6.25 | 35.92% | CHEMBL1762473 |
| Hydromorphone | NOS2_HUMAN | nitric oxide synthase 2 | -6.11 | -8.83 | -8.31 | 40.10% | CHEMBL42968 |
| Ibuprofen | NOS2_HUMAN | nitric oxide synthase 2 | -7.52 | -7.58 | -7.92 | 33.87% | CHEMBL450583 |
| Codeine | NOS2_HUMAN | nitric oxide synthase 2 | -7.32 | -8.24 | -8.07 | 34.93% | CHEMBL42968 |
| Dihydrocodeine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.03 | -8.55 | -8.57 | 33.48% | CHEMBL3676077 |
| Acetylsalicylic acid | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -6.38 | -6.45 | -6.31 | 32.00% | CHEMBL2004025 |
| Hydromorphone | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.61 | -7.95 | -8.05 | 33.19% | CHEMBL3676077 |
| Ibuprofen | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.78 | -8.23 | -8.00 | 23.85% | CHEMBL1978371 |
| Codeine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.99 | -8.32 | -8.23 | 39.69% | CHEMBL444109 |
| Dihydrocodeine | OPRD_HUMAN | opioid receptor delta 1 | -7.66 | -6.93 | -7.08 | 99.23% | CHEMBL2418739 |
| Acetylsalicylic acid | OPRD_HUMAN | opioid receptor delta 1 | -5.82 | -4.82 | -5.15 | 34.75% | CHEMBL149074 |
| Hydromorphone | OPRD_HUMAN | opioid receptor delta 1 | -7.15 | -6.84 | -7.11 | 100.00% | CHEMBL398707 |
| Ibuprofen | OPRD_HUMAN | opioid receptor delta 1 | -6.63 | -6.50 | -6.30 | 38.46% | CHEMBL201038 |
| Codeine | OPRD_HUMAN | opioid receptor delta 1 | -7.24 | -6.75 | -6.77 | 99.41% | CHEMBL70 |
| Dihydrocodeine | OPRK_HUMAN | opioid receptor kappa 1 | -9.64 | -9.73 | -7.92 | 94.89% | CHEMBL4111313 |
| Acetylsalicylic acid | OPRK_HUMAN | opioid receptor kappa 1 | -5.96 | -6.23 | -6.36 | 37.36% | CHEMBL942 |
| Hydromorphone | OPRK_HUMAN | opioid receptor kappa 1 | -9.72 | -8.40 | -7.55 | 100.00% | CHEMBL398707 |
| Ibuprofen | OPRK_HUMAN | opioid receptor kappa 1 | -7.68 | -7.49 | -6.96 | 42.86% | CHEMBL651 |
| Codeine | OPRK_HUMAN | opioid receptor kappa 1 | -8.72 | -8.17 | -7.92 | 99.41% | CHEMBL70 |
| Dihydrocodeine | OPRM_MOUSE | Mu-type opioid receptor | -7.81 | -8.42 | N/A | 100.00% | CHEMBL2418738 |
| Acetylsalicylic acid | OPRM_MOUSE | Mu-type opioid receptor | -6.50 | -5.50 | N/A | 28.97% | CHEMBL13470 |
| Hydromorphone | OPRM_MOUSE | Mu-type opioid receptor | -7.57 | -8.24 | N/A | 99.27% | CHEMBL318361 |
| Ibuprofen | OPRM_MOUSE | Mu-type opioid receptor | -6.47 | -6.85 | N/A | 31.58% | CHEMBL151341 |
| Codeine | OPRM_MOUSE | Mu-type opioid receptor | -8.29 | -8.28 | N/A | 99.41% | CHEMBL70 |
| Dihydrocodeine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.74 | -7.66 | -7.49 | 94.85% | CHEMBL511142 |
| Acetylsalicylic acid | OPRX_HUMAN | opioid related nociceptin receptor 1 | -5.82 | -5.74 | -5.84 | 35.00% | CHEMBL201805 |
| Hydromorphone | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.74 | -7.90 | -7.38 | 78.29% | CHEMBL511142 |
| Ibuprofen | OPRX_HUMAN | opioid related nociceptin receptor 1 | -6.35 | -6.38 | -6.89 | 41.86% | CHEMBL186300 |
| Codeine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.39 | -7.38 | 93.85% | CHEMBL3262362 |
| Dihydrocodeine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.24 | -5.43 | -6.37 | 34.78% | CHEMBL3679847 |
| Acetylsalicylic acid | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.33 | -4.52 | -4.69 | 28.57% | CHEMBL3919713 |
| Hydromorphone | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.22 | -6.52 | -6.34 | 39.02% | CHEMBL3679847 |
| Ibuprofen | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.85 | -4.65 | -5.29 | 23.86% | CHEMBL2180149 |
| Codeine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.03 | -5.85 | -5.83 | 35.32% | CHEMBL3679847 |
| Dihydrocodeine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.67 | -5.18 | -6.30 | 33.33% | CHEMBL92264 |
| Acetylsalicylic acid | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.87 | -6.37 | -6.94 | 33.64% | CHEMBL327374 |
| Hydromorphone | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.56 | -4.70 | -6.18 | 35.87% | CHEMBL92264 |
| Ibuprofen | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.79 | -8.09 | -8.16 | 35.11% | CHEMBL91127 |
| Codeine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.26 | -3.78 | -5.99 | 28.38% | CHEMBL2172277 |
| Dihydrocodeine | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.42 | N/A | N/A | 35.71% | CHEMBL80942 |
| Acetylsalicylic acid | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.46 | N/A | N/A | 30.00% | CHEMBL2048425 |
| Hydromorphone | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.79 | N/A | N/A | 39.78% | CHEMBL80942 |
| Ibuprofen | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.30 | N/A | N/A | 30.59% | CHEMBL3658406 |
| Codeine | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.19 | N/A | N/A | 34.22% | CHEMBL3086083 |
| Dihydrocodeine | PDE4B_HUMAN | phosphodiesterase 4B | -9.13 | -8.10 | -9.60 | 58.90% | CHEMBL144499 |
| Acetylsalicylic acid | PDE4B_HUMAN | phosphodiesterase 4B | -6.36 | -7.14 | -7.15 | 32.69% | CHEMBL2172710 |
| Hydromorphone | PDE4B_HUMAN | phosphodiesterase 4B | -8.12 | -8.51 | -8.88 | 61.90% | CHEMBL144499 |
| Ibuprofen | PDE4B_HUMAN | phosphodiesterase 4B | -7.37 | -7.59 | -7.75 | 31.68% | CHEMBL3315269 |
| Codeine | PDE4B_HUMAN | phosphodiesterase 4B | -8.37 | -7.91 | -8.55 | 46.49% | CHEMBL144499 |
| Dihydrocodeine | PDE5A_HUMAN | phosphodiesterase 5A | -8.17 | -8.47 | -9.49 | 36.36% | CHEMBL190423 |
| Acetylsalicylic acid | PDE5A_HUMAN | phosphodiesterase 5A | -6.61 | -6.38 | -6.44 | 40.57% | CHEMBL363889 |
| Hydromorphone | PDE5A_HUMAN | phosphodiesterase 5A | -8.55 | -8.42 | -8.25 | 38.20% | CHEMBL190423 |
| Ibuprofen | PDE5A_HUMAN | phosphodiesterase 5A | -7.69 | -7.38 | -7.24 | 22.94% | CHEMBL362755 |
| Codeine | PDE5A_HUMAN | phosphodiesterase 5A | -7.80 | -8.28 | -8.12 | 32.23% | CHEMBL190423 |
| Dihydrocodeine | PERM_HUMAN | myeloperoxidase | -8.26 | -8.48 | -8.58 | 43.31% | CHEMBL490 |
| Acetylsalicylic acid | PERM_HUMAN | myeloperoxidase | -6.04 | -7.00 | -5.98 | 38.24% | CHEMBL309339 |
| Hydromorphone | PERM_HUMAN | myeloperoxidase | -8.21 | -8.60 | -8.53 | 40.00% | CHEMBL490 |
| Ibuprofen | PERM_HUMAN | myeloperoxidase | -6.67 | -6.65 | -6.70 | 32.35% | CHEMBL3892909 |
| Codeine | PERM_HUMAN | myeloperoxidase | -8.20 | -8.53 | -8.29 | 35.38% | CHEMBL490 |
| Dihydrocodeine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.20 | -7.48 | -8.24 | 34.71% | CHEMBL229957 |
| Acetylsalicylic acid | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.16 | -6.65 | -6.06 | 100.00% | CHEMBL25 |
| Hydromorphone | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -4.04 | -6.34 | -7.12 | 33.96% | CHEMBL24798 |
| Ibuprofen | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -7.27 | -7.29 | -7.36 | 100.00% | CHEMBL175 |
| Codeine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -3.68 | -7.33 | -6.64 | 35.35% | CHEMBL229957 |
| Dihydrocodeine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -3.50 | -5.84 | -6.89 | 43.75% | CHEMBL13623 |
| Acetylsalicylic acid | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -6.19 | -6.20 | -6.55 | 72.60% | CHEMBL1958348 |
| Hydromorphone | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -0.13 | -4.23 | -6.94 | 45.21% | CHEMBL276663 |
| Ibuprofen | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.38 | -7.47 | -7.29 | 100.00% | CHEMBL427526 |
| Codeine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -3.35 | -4.99 | -7.14 | 35.45% | CHEMBL13988 |
| Dihydrocodeine | PPAP_HUMAN | acid phosphatase 3 | -7.74 | N/A | N/A | 23.53% | CHEMBL507996 |
| Acetylsalicylic acid | PPAP_HUMAN | acid phosphatase 3 | -6.47 | N/A | N/A | 22.02% | CHEMBL507996 |
| Hydromorphone | PPAP_HUMAN | acid phosphatase 3 | -8.77 | N/A | N/A | 23.43% | CHEMBL507996 |
| Ibuprofen | PPAP_HUMAN | acid phosphatase 3 | -6.28 | N/A | N/A | 20.00% | CHEMBL501717 |
| Codeine | PPAP_HUMAN | acid phosphatase 3 | -7.85 | N/A | N/A | 20.87% | CHEMBL507996 |
| Dihydrocodeine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.81 | -5.77 | -6.87 | 47.48% | CHEMBL592625 |
| Acetylsalicylic acid | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -5.58 | -6.46 | -5.74 | 46.99% | CHEMBL207570 |
| Hydromorphone | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.03 | -6.49 | -7.08 | 47.50% | CHEMBL419756 |
| Ibuprofen | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.46 | -6.84 | -6.75 | 55.00% | CHEMBL396109 |
| Codeine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.71 | -5.64 | -6.72 | 43.78% | CHEMBL1836977 |
| Dihydrocodeine | PRGR_HUMAN | progesterone receptor | -9.92 | -10.08 | -8.98 | 44.58% | CHEMBL373497 |
| Acetylsalicylic acid | PRGR_HUMAN | progesterone receptor | -6.28 | -6.24 | -6.04 | 32.46% | CHEMBL50849 |
| Hydromorphone | PRGR_HUMAN | progesterone receptor | -7.86 | -7.83 | -8.60 | 41.67% | CHEMBL1254419 |
| Ibuprofen | PRGR_HUMAN | progesterone receptor | -7.33 | -7.39 | -6.85 | 45.31% | CHEMBL566982 |
| Codeine | PRGR_HUMAN | progesterone receptor | -8.47 | -8.07 | -8.86 | 40.51% | CHEMBL51933 |
| Dihydrocodeine | PTGES_HUMAN | prostaglandin E synthase | -6.42 | N/A | N/A | 40.46% | CHEMBL3753433 |
| Acetylsalicylic acid | PTGES_HUMAN | prostaglandin E synthase | -5.88 | N/A | N/A | 42.72% | CHEMBL3134416 |
| Hydromorphone | PTGES_HUMAN | prostaglandin E synthase | -6.57 | N/A | N/A | 38.33% | CHEMBL3753433 |
| Ibuprofen | PTGES_HUMAN | prostaglandin E synthase | -6.31 | N/A | N/A | 34.48% | CHEMBL584927 |
| Codeine | PTGES_HUMAN | prostaglandin E synthase | -6.20 | N/A | N/A | 38.24% | CHEMBL3753433 |
| Dihydrocodeine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.40 | -9.15 | -8.98 | 60.77% | CHEMBL52440 |
| Acetylsalicylic acid | SC6A4_HUMAN | solute carrier family 6 member 4 | -6.16 | -6.18 | -6.35 | 41.03% | CHEMBL272002 |
| Hydromorphone | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.35 | -9.29 | -9.16 | 56.93% | CHEMBL52440 |
| Ibuprofen | SC6A4_HUMAN | solute carrier family 6 member 4 | -7.42 | -7.28 | -7.76 | 51.06% | CHEMBL3769872 |
| Codeine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.24 | -9.33 | -8.65 | 46.95% | CHEMBL434728 |
| Dihydrocodeine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.56 | N/A | N/A | 44.09% | CHEMBL3658010 |
| Acetylsalicylic acid | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.07 | N/A | N/A | 34.15% | CHEMBL3945925 |
| Hydromorphone | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.04 | N/A | N/A | 44.94% | CHEMBL203440 |
| Ibuprofen | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.75 | N/A | N/A | 30.12% | CHEMBL381488 |
| Codeine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.18 | N/A | N/A | 40.45% | CHEMBL3662107 |
| Dihydrocodeine | TLR4_HUMAN | toll like receptor 4 | -8.73 | -9.22 | -7.86 | 46.45% | CHEMBL3261029 |
| Acetylsalicylic acid | TLR4_HUMAN | toll like receptor 4 | -5.66 | -6.08 | -6.26 | 29.70% | CHEMBL1223752 |
| Hydromorphone | TLR4_HUMAN | toll like receptor 4 | -8.11 | -7.35 | -7.84 | 40.82% | CHEMBL3261030 |
| Ibuprofen | TLR4_HUMAN | toll like receptor 4 | -7.22 | -7.80 | -7.59 | 25.00% | CHEMBL2419464 |
| Codeine | TLR4_HUMAN | toll like receptor 4 | -7.32 | -7.92 | -7.47 | 38.29% | CHEMBL3261029 |
| Dihydrocodeine | TNFA_HUMAN | tumor necrosis factor | -8.38 | N/A | N/A | 44.60% | CHEMBL2337619 |
| Acetylsalicylic acid | TNFA_HUMAN | tumor necrosis factor | -5.73 | N/A | N/A | 27.43% | CHEMBL1700405 |
| Hydromorphone | TNFA_HUMAN | tumor necrosis factor | -8.07 | N/A | N/A | 51.69% | CHEMBL2337619 |
| Ibuprofen | TNFA_HUMAN | tumor necrosis factor | -6.38 | N/A | N/A | 32.99% | CHEMBL306090 |
| Codeine | TNFA_HUMAN | tumor necrosis factor | -7.62 | N/A | N/A | 54.91% | CHEMBL2337619 |
| Dihydrocodeine | TRBM_HUMAN | thrombomodulin | -7.23 | -6.56 | N/A | N/A | N/A |
| Acetylsalicylic acid | TRBM_HUMAN | thrombomodulin | -5.81 | -5.48 | N/A | N/A | N/A |
| Hydromorphone | TRBM_HUMAN | thrombomodulin | -7.55 | -6.88 | N/A | N/A | N/A |
| Ibuprofen | TRBM_HUMAN | thrombomodulin | -6.25 | -6.32 | N/A | N/A | N/A |
| Codeine | TRBM_HUMAN | thrombomodulin | -7.56 | -7.31 | N/A | N/A | N/A |
| Dihydrocodeine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.58 | -7.52 | N/A | N/A | N/A |
| Acetylsalicylic acid | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -5.91 | -5.58 | N/A | N/A | N/A |
| Hydromorphone | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.65 | -6.98 | N/A | N/A | N/A |
| Ibuprofen | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.09 | -6.20 | N/A | N/A | N/A |
| Codeine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.87 | -6.95 | N/A | N/A | N/A |
| Dihydrocodeine | TRPM8_FICAL | Uncharacterized protein | -9.26 | N/A | N/A | N/A | N/A |
| Acetylsalicylic acid | TRPM8_FICAL | Uncharacterized protein | -6.35 | N/A | N/A | N/A | N/A |
| Hydromorphone | TRPM8_FICAL | Uncharacterized protein | -8.94 | N/A | N/A | N/A | N/A |
| Ibuprofen | TRPM8_FICAL | Uncharacterized protein | -7.50 | N/A | N/A | N/A | N/A |
| Codeine | TRPM8_FICAL | Uncharacterized protein | -9.23 | N/A | N/A | N/A | N/A |
| Dihydrocodeine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.61 | N/A | N/A | 46.62% | CHEMBL2057858 |
| Acetylsalicylic acid | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.79 | N/A | N/A | 33.33% | CHEMBL1779679 |
| Hydromorphone | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.33 | N/A | N/A | 46.71% | CHEMBL2057858 |
| Ibuprofen | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.72 | N/A | N/A | 39.02% | CHEMBL2057857 |
| Codeine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.85 | N/A | N/A | 42.49% | CHEMBL97968 |
| Dihydrocodeine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.65 | -7.86 | N/A | N/A | N/A |
| Acetylsalicylic acid | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -5.66 | -6.16 | N/A | N/A | N/A |
| Hydromorphone | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.63 | -7.98 | N/A | N/A | N/A |
| Ibuprofen | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.29 | -7.13 | N/A | N/A | N/A |
| Codeine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.51 | -8.32 | N/A | N/A | N/A |
| Dihydrocodeine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.14 | -8.48 | N/A | 48.85% | CHEMBL3664218 |
| Acetylsalicylic acid | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.23 | -5.53 | N/A | 24.22% | CHEMBL3692228 |
| Hydromorphone | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.68 | -7.78 | N/A | 53.18% | CHEMBL3664218 |
| Ibuprofen | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.89 | -6.72 | N/A | 29.59% | CHEMBL3828278 |
| Codeine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.81 | -6.98 | N/A | 44.66% | CHEMBL3664218 |
| Dihydrocodeine | TRXR1_HUMAN | thioredoxin reductase 1 | -8.41 | -7.60 | -6.83 | N/A | N/A |
| Acetylsalicylic acid | TRXR1_HUMAN | thioredoxin reductase 1 | -6.51 | -6.54 | -5.09 | N/A | N/A |
| Hydromorphone | TRXR1_HUMAN | thioredoxin reductase 1 | -8.46 | -7.88 | -7.12 | N/A | N/A |
| Ibuprofen | TRXR1_HUMAN | thioredoxin reductase 1 | -6.10 | -6.37 | -4.92 | N/A | N/A |
| Codeine | TRXR1_HUMAN | thioredoxin reductase 1 | -7.91 | -7.90 | -7.12 | N/A | N/A |
| Dihydrocodeine | TRY1_HUMAN | serine protease 1 | -7.00 | N/A | N/A | 35.82% | CHEMBL44710 |
| Acetylsalicylic acid | TRY1_HUMAN | serine protease 1 | -5.51 | N/A | N/A | 62.35% | CHEMBL148957 |
| Hydromorphone | TRY1_HUMAN | serine protease 1 | -5.82 | N/A | N/A | 40.20% | CHEMBL44710 |
| Ibuprofen | TRY1_HUMAN | serine protease 1 | -5.41 | N/A | N/A | 44.44% | CHEMBL102081 |
| Codeine | TRY1_HUMAN | serine protease 1 | -5.57 | N/A | N/A | 33.10% | CHEMBL73970 |