| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Dihydrocodeine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.75 | -8.74 | -7.92 | 67.67% | CHEMBL29951 |
| Oxycodone | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.02 | -9.36 | -8.14 | 59.87% | CHEMBL29951 |
| Diclofenac | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.19 | -8.46 | -8.22 | 30.37% | CHEMBL71091 |
| Codeine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.95 | -8.50 | -8.48 | 52.33% | CHEMBL29951 |
| Morphine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.23 | -9.04 | -8.28 | 52.63% | CHEMBL29951 |
| Dihydrocodeine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.80 | -7.77 | N/A | 64.00% | CHEMBL445106 |
| Oxycodone | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.57 | -7.38 | N/A | 60.90% | CHEMBL3695433 |
| Diclofenac | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.06 | -8.28 | N/A | 46.53% | CHEMBL415 |
| Codeine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.04 | -7.57 | N/A | 51.67% | CHEMBL3695438 |
| Morphine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.82 | -7.97 | N/A | 51.96% | CHEMBL3695438 |
| Dihydrocodeine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.56 | -9.10 | -8.53 | 64.00% | CHEMBL445106 |
| Oxycodone | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.44 | -8.51 | -8.60 | 58.33% | CHEMBL445106 |
| Diclofenac | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.22 | -8.68 | -8.66 | 46.53% | CHEMBL415 |
| Codeine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.37 | -8.84 | -8.69 | 50.79% | CHEMBL445106 |
| Morphine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.43 | -8.69 | -8.74 | 51.06% | CHEMBL445106 |
| Dihydrocodeine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.79 | -8.31 | N/A | 64.00% | CHEMBL445106 |
| Oxycodone | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -7.85 | -9.67 | N/A | 58.33% | CHEMBL445106 |
| Diclofenac | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.44 | -8.58 | N/A | 46.53% | CHEMBL415 |
| Codeine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.42 | -9.08 | N/A | 50.79% | CHEMBL445106 |
| Morphine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.41 | -9.00 | N/A | 51.06% | CHEMBL445106 |
| Dihydrocodeine | AA1R_HUMAN | adenosine A1 receptor | -7.72 | -8.57 | -6.19 | 35.00% | CHEMBL3317575 |
| Oxycodone | AA1R_HUMAN | adenosine A1 receptor | -8.75 | -8.51 | -6.84 | 35.88% | CHEMBL1544 |
| Diclofenac | AA1R_HUMAN | adenosine A1 receptor | -7.29 | -7.36 | -7.74 | 29.75% | CHEMBL2260644 |
| Codeine | AA1R_HUMAN | adenosine A1 receptor | -7.50 | -8.34 | -7.56 | 29.83% | CHEMBL3317575 |
| Morphine | AA1R_HUMAN | adenosine A1 receptor | -7.66 | -8.26 | -4.65 | 29.96% | CHEMBL3317575 |
| Dihydrocodeine | AA2AR_HUMAN | adenosine A2a receptor | -7.71 | -7.90 | -8.95 | 38.46% | CHEMBL539454 |
| Oxycodone | AA2AR_HUMAN | adenosine A2a receptor | -7.44 | -7.35 | -9.34 | 42.25% | CHEMBL541219 |
| Diclofenac | AA2AR_HUMAN | adenosine A2a receptor | -7.76 | -7.71 | -8.16 | 34.91% | CHEMBL603094 |
| Codeine | AA2AR_HUMAN | adenosine A2a receptor | -7.40 | -7.76 | -8.98 | 34.58% | CHEMBL559023 |
| Morphine | AA2AR_HUMAN | adenosine A2a receptor | -8.62 | -9.48 | -10.40 | 34.24% | CHEMBL559023 |
| Dihydrocodeine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.06 | -9.25 | -8.13 | 68.83% | CHEMBL3764305 |
| Oxycodone | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.80 | -9.61 | -8.26 | 64.71% | CHEMBL3764305 |
| Diclofenac | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.71 | -8.16 | -9.38 | 35.43% | CHEMBL1085858 |
| Codeine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.59 | -9.44 | -9.20 | 66.50% | CHEMBL569978 |
| Morphine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.76 | -8.85 | -8.78 | 66.01% | CHEMBL569978 |
| Dihydrocodeine | ACE_HUMAN | angiotensin I converting enzyme | -8.89 | -9.10 | -8.15 | 40.96% | CHEMBL58042 |
| Oxycodone | ACE_HUMAN | angiotensin I converting enzyme | -8.57 | -8.46 | -7.63 | 46.15% | CHEMBL58042 |
| Diclofenac | ACE_HUMAN | angiotensin I converting enzyme | -7.45 | -7.41 | -7.29 | 29.63% | CHEMBL23849 |
| Codeine | ACE_HUMAN | angiotensin I converting enzyme | -8.87 | -8.96 | -8.17 | 37.56% | CHEMBL58042 |
| Morphine | ACE_HUMAN | angiotensin I converting enzyme | -8.53 | -8.74 | -7.71 | 37.12% | CHEMBL1165 |
| Dihydrocodeine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.11 | N/A | N/A | 22.13% | CHEMBL386114 |
| Oxycodone | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.73 | N/A | N/A | 27.39% | CHEMBL386114 |
| Diclofenac | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.09 | N/A | N/A | 17.01% | CHEMBL386114 |
| Codeine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.82 | N/A | N/A | 21.64% | CHEMBL386114 |
| Morphine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.08 | N/A | N/A | 21.72% | CHEMBL386114 |
| Dihydrocodeine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.20 | -3.27 | -7.51 | N/A | N/A |
| Oxycodone | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.68 | -2.98 | -7.00 | N/A | N/A |
| Diclofenac | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.54 | -8.23 | -6.56 | N/A | N/A |
| Codeine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.15 | -2.48 | -6.35 | N/A | N/A |
| Morphine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.44 | -3.29 | -5.96 | N/A | N/A |
| Dihydrocodeine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.21 | 1.85 | N/A | 58.52% | CHEMBL343236 |
| Oxycodone | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.32 | 4.58 | N/A | 50.00% | CHEMBL343236 |
| Diclofenac | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.76 | -4.91 | N/A | 46.53% | CHEMBL415 |
| Codeine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.79 | 6.44 | N/A | 45.40% | CHEMBL343236 |
| Morphine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.02 | 3.46 | N/A | 45.66% | CHEMBL343236 |
| Dihydrocodeine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.90 | -6.23 | N/A | 50.00% | CHEMBL1346 |
| Oxycodone | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -10.21 | -6.87 | N/A | 48.50% | CHEMBL1346 |
| Diclofenac | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.67 | -7.51 | N/A | 46.53% | CHEMBL415 |
| Codeine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.54 | -7.45 | N/A | 39.79% | CHEMBL1346 |
| Morphine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.37 | -6.22 | N/A | 39.27% | CHEMBL1346 |
| Dihydrocodeine | ADRB2_HUMAN | adrenoceptor beta 2 | -7.67 | -7.85 | -9.13 | 56.12% | CHEMBL513389 |
| Oxycodone | ADRB2_HUMAN | adrenoceptor beta 2 | -8.33 | -8.50 | -8.83 | 49.08% | CHEMBL1773265 |
| Diclofenac | ADRB2_HUMAN | adrenoceptor beta 2 | -7.35 | -8.61 | -8.50 | 44.95% | CHEMBL154419 |
| Codeine | ADRB2_HUMAN | adrenoceptor beta 2 | -8.87 | -8.86 | -8.96 | 43.82% | CHEMBL513389 |
| Morphine | ADRB2_HUMAN | adrenoceptor beta 2 | -7.41 | -7.50 | -8.85 | 43.26% | CHEMBL513389 |
| Dihydrocodeine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.36 | -7.96 | -8.30 | 47.57% | CHEMBL156129 |
| Oxycodone | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.32 | -8.29 | -8.18 | 51.50% | CHEMBL154057 |
| Diclofenac | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.57 | -7.50 | -7.34 | 25.67% | CHEMBL40381 |
| Codeine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.46 | -8.46 | -8.38 | 43.12% | CHEMBL156129 |
| Morphine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.15 | -7.81 | -7.80 | 42.67% | CHEMBL154057 |
| Dihydrocodeine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.54 | -7.88 | -7.26 | 39.63% | CHEMBL71562 |
| Oxycodone | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.02 | -8.24 | -7.54 | 44.77% | CHEMBL71562 |
| Diclofenac | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.93 | -7.61 | -7.76 | 35.23% | CHEMBL77283 |
| Codeine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.86 | -7.96 | -7.66 | 32.38% | CHEMBL311679 |
| Morphine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.87 | -6.59 | -7.12 | 32.54% | CHEMBL311679 |
| Dihydrocodeine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.49 | -8.80 | -7.84 | 34.74% | CHEMBL1077584 |
| Oxycodone | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.11 | -8.58 | -8.55 | 40.10% | CHEMBL1077584 |
| Diclofenac | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.15 | -8.06 | -7.99 | 29.69% | CHEMBL3764432 |
| Codeine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.83 | -7.73 | -7.80 | 33.63% | CHEMBL1782887 |
| Morphine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.15 | -8.23 | -8.00 | 33.78% | CHEMBL1782887 |
| Dihydrocodeine | AOFA_HUMAN | monoamine oxidase A | -9.78 | -10.35 | -10.26 | 40.51% | CHEMBL2333926 |
| Oxycodone | AOFA_HUMAN | monoamine oxidase A | -8.95 | -10.08 | -8.28 | 40.54% | CHEMBL4073457 |
| Diclofenac | AOFA_HUMAN | monoamine oxidase A | -8.04 | -8.37 | -8.67 | 35.65% | CHEMBL1642672 |
| Codeine | AOFA_HUMAN | monoamine oxidase A | -8.87 | -8.81 | -7.46 | 34.78% | CHEMBL4073457 |
| Morphine | AOFA_HUMAN | monoamine oxidase A | -8.66 | -9.39 | -8.25 | 34.30% | CHEMBL4073457 |
| Dihydrocodeine | AOFB_HUMAN | monoamine oxidase B | -10.76 | -10.23 | -10.13 | 46.43% | CHEMBL4113794 |
| Oxycodone | AOFB_HUMAN | monoamine oxidase B | -10.39 | -8.26 | -8.64 | 42.77% | CHEMBL3288304 |
| Diclofenac | AOFB_HUMAN | monoamine oxidase B | -8.49 | -8.36 | -8.88 | 36.44% | CHEMBL3319243 |
| Codeine | AOFB_HUMAN | monoamine oxidase B | -9.92 | -7.97 | -8.69 | 36.31% | CHEMBL4113794 |
| Morphine | AOFB_HUMAN | monoamine oxidase B | -9.87 | -8.60 | -9.19 | 35.75% | CHEMBL4113794 |
| Dihydrocodeine | BACE1_HUMAN | beta-secretase 1 | -7.51 | -8.07 | -8.74 | 51.11% | CHEMBL3656239 |
| Oxycodone | BACE1_HUMAN | beta-secretase 1 | -7.34 | -7.75 | -9.18 | 48.58% | CHEMBL3955763 |
| Diclofenac | BACE1_HUMAN | beta-secretase 1 | -6.69 | -6.82 | -7.46 | 33.06% | CHEMBL3627961 |
| Codeine | BACE1_HUMAN | beta-secretase 1 | -6.85 | -7.36 | -9.35 | 43.35% | CHEMBL3955763 |
| Morphine | BACE1_HUMAN | beta-secretase 1 | -6.94 | -7.39 | -8.50 | 43.53% | CHEMBL3955763 |
| Dihydrocodeine | CAH2_HUMAN | carbonic anhydrase 2 | -7.78 | -7.76 | -7.34 | 51.03% | CHEMBL3786651 |
| Oxycodone | CAH2_HUMAN | carbonic anhydrase 2 | -7.56 | -8.24 | -7.98 | 45.73% | CHEMBL3786651 |
| Diclofenac | CAH2_HUMAN | carbonic anhydrase 2 | -7.31 | -7.42 | -7.15 | 44.58% | CHEMBL23832 |
| Codeine | CAH2_HUMAN | carbonic anhydrase 2 | -7.22 | -8.18 | -7.90 | 40.22% | CHEMBL3786651 |
| Morphine | CAH2_HUMAN | carbonic anhydrase 2 | -7.53 | -7.29 | -6.77 | 40.44% | CHEMBL3786651 |
| Dihydrocodeine | CASP1_HUMAN | caspase 1 | -6.49 | -7.42 | -6.33 | 41.33% | CHEMBL3898379 |
| Oxycodone | CASP1_HUMAN | caspase 1 | -7.33 | -7.41 | -6.28 | 45.00% | CHEMBL2371932 |
| Diclofenac | CASP1_HUMAN | caspase 1 | -5.75 | -6.77 | -5.58 | 32.35% | CHEMBL78154 |
| Codeine | CASP1_HUMAN | caspase 1 | -5.80 | -7.68 | -6.21 | 34.47% | CHEMBL3898379 |
| Morphine | CASP1_HUMAN | caspase 1 | -6.89 | -7.24 | -6.96 | 34.62% | CHEMBL3898379 |
| Dihydrocodeine | CDK5_HUMAN | cyclin dependent kinase 5 | -7.54 | -8.01 | -6.70 | 33.02% | CHEMBL422897 |
| Oxycodone | CDK5_HUMAN | cyclin dependent kinase 5 | -7.89 | -7.65 | -5.47 | 33.04% | CHEMBL422897 |
| Diclofenac | CDK5_HUMAN | cyclin dependent kinase 5 | -7.33 | -7.84 | -8.35 | 46.43% | CHEMBL1991734 |
| Codeine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.41 | -7.34 | -5.71 | 29.44% | CHEMBL422897 |
| Morphine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.44 | -6.87 | -5.18 | 29.55% | CHEMBL422897 |
| Dihydrocodeine | CHLE_HUMAN | butyrylcholinesterase | -8.77 | -8.69 | -8.99 | 46.24% | CHEMBL189906 |
| Oxycodone | CHLE_HUMAN | butyrylcholinesterase | -9.35 | -9.12 | -9.35 | 46.43% | CHEMBL3410956 |
| Diclofenac | CHLE_HUMAN | butyrylcholinesterase | -8.65 | -8.20 | -8.70 | 45.59% | CHEMBL3087676 |
| Codeine | CHLE_HUMAN | butyrylcholinesterase | -9.14 | -8.82 | -8.92 | 43.54% | CHEMBL4085222 |
| Morphine | CHLE_HUMAN | butyrylcholinesterase | -9.46 | -9.69 | -9.90 | 43.52% | CHEMBL366411 |
| Dihydrocodeine | CNR1_HUMAN | cannabinoid receptor 1 | -7.64 | -8.72 | -8.99 | 54.48% | CHEMBL228349 |
| Oxycodone | CNR1_HUMAN | cannabinoid receptor 1 | -7.59 | -8.42 | -8.55 | 53.46% | CHEMBL228349 |
| Diclofenac | CNR1_HUMAN | cannabinoid receptor 1 | -7.80 | -8.14 | -8.82 | 46.55% | CHEMBL3936647 |
| Codeine | CNR1_HUMAN | cannabinoid receptor 1 | -8.22 | -8.45 | -9.29 | 57.39% | CHEMBL303479 |
| Morphine | CNR1_HUMAN | cannabinoid receptor 1 | -8.92 | -8.18 | -8.41 | 56.82% | CHEMBL303479 |
| Dihydrocodeine | CNR2_HUMAN | cannabinoid receptor 2 | -9.68 | -9.20 | N/A | 56.05% | CHEMBL3410730 |
| Oxycodone | CNR2_HUMAN | cannabinoid receptor 2 | -8.87 | -9.55 | N/A | 53.16% | CHEMBL223990 |
| Diclofenac | CNR2_HUMAN | cannabinoid receptor 2 | -8.58 | -8.70 | N/A | 38.18% | CHEMBL2326302 |
| Codeine | CNR2_HUMAN | cannabinoid receptor 2 | -9.57 | -8.98 | N/A | 57.39% | CHEMBL303479 |
| Morphine | CNR2_HUMAN | cannabinoid receptor 2 | -9.73 | -9.02 | N/A | 56.82% | CHEMBL303479 |
| Dihydrocodeine | COLI_HUMAN | proopiomelanocortin | -8.16 | -8.06 | -6.92 | N/A | N/A |
| Oxycodone | COLI_HUMAN | proopiomelanocortin | -8.01 | -8.17 | -7.46 | N/A | N/A |
| Diclofenac | COLI_HUMAN | proopiomelanocortin | -7.40 | -7.19 | -7.23 | N/A | N/A |
| Codeine | COLI_HUMAN | proopiomelanocortin | -8.90 | -7.76 | -6.40 | N/A | N/A |
| Morphine | COLI_HUMAN | proopiomelanocortin | -8.00 | -8.20 | -6.57 | N/A | N/A |
| Dihydrocodeine | COMT_HUMAN | catechol-O-methyltransferase | -6.07 | -5.91 | -6.72 | 25.59% | CHEMBL3425740 |
| Oxycodone | COMT_HUMAN | catechol-O-methyltransferase | -5.86 | -5.75 | -5.72 | 25.55% | CHEMBL3425740 |
| Diclofenac | COMT_HUMAN | catechol-O-methyltransferase | -6.26 | -6.12 | -6.36 | 22.76% | CHEMBL1324 |
| Codeine | COMT_HUMAN | catechol-O-methyltransferase | -6.36 | -6.30 | -6.38 | 22.62% | CHEMBL3819488 |
| Morphine | COMT_HUMAN | catechol-O-methyltransferase | -6.29 | -6.70 | -5.75 | 22.70% | CHEMBL3819488 |
| Dihydrocodeine | CRP_HUMAN | C-reactive protein | -6.05 | -6.27 | N/A | N/A | N/A |
| Oxycodone | CRP_HUMAN | C-reactive protein | -6.15 | -6.24 | N/A | N/A | N/A |
| Diclofenac | CRP_HUMAN | C-reactive protein | -5.84 | -5.77 | N/A | N/A | N/A |
| Codeine | CRP_HUMAN | C-reactive protein | -6.25 | -6.41 | N/A | N/A | N/A |
| Morphine | CRP_HUMAN | C-reactive protein | -6.20 | -6.58 | N/A | N/A | N/A |
| Dihydrocodeine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -8.22 | N/A | N/A | 28.95% | CHEMBL490688 |
| Oxycodone | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.74 | N/A | N/A | 27.64% | CHEMBL490688 |
| Diclofenac | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.66 | N/A | N/A | 100.00% | CHEMBL139 |
| Codeine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.09 | N/A | N/A | 28.57% | CHEMBL490688 |
| Morphine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.03 | N/A | N/A | 28.19% | CHEMBL490688 |
| Dihydrocodeine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.93 | -6.79 | -8.09 | 33.33% | CHEMBL1644072 |
| Oxycodone | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.66 | -7.05 | -8.07 | 36.61% | CHEMBL3963508 |
| Diclofenac | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.70 | -6.68 | -7.09 | 28.18% | CHEMBL3908835 |
| Codeine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.25 | -6.63 | -7.67 | 33.77% | CHEMBL2029611 |
| Morphine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.80 | -6.47 | -7.22 | 33.92% | CHEMBL2029611 |
| Dihydrocodeine | DRD2_HUMAN | dopamine receptor D2 | -7.54 | N/A | N/A | 72.39% | CHEMBL170976 |
| Oxycodone | DRD2_HUMAN | dopamine receptor D2 | -8.66 | N/A | N/A | 61.94% | CHEMBL170976 |
| Diclofenac | DRD2_HUMAN | dopamine receptor D2 | -7.22 | N/A | N/A | 46.53% | CHEMBL415 |
| Codeine | DRD2_HUMAN | dopamine receptor D2 | -7.92 | N/A | N/A | 56.07% | CHEMBL170976 |
| Morphine | DRD2_HUMAN | dopamine receptor D2 | -7.56 | N/A | N/A | 55.49% | CHEMBL170976 |
| Dihydrocodeine | DRD3_HUMAN | dopamine receptor D3 | -8.27 | N/A | N/A | 72.39% | CHEMBL170976 |
| Oxycodone | DRD3_HUMAN | dopamine receptor D3 | -8.09 | N/A | N/A | 61.94% | CHEMBL170976 |
| Diclofenac | DRD3_HUMAN | dopamine receptor D3 | -7.96 | N/A | N/A | 46.53% | CHEMBL415 |
| Codeine | DRD3_HUMAN | dopamine receptor D3 | -8.14 | N/A | N/A | 56.07% | CHEMBL170976 |
| Morphine | DRD3_HUMAN | dopamine receptor D3 | -8.83 | N/A | N/A | 55.49% | CHEMBL170976 |
| Dihydrocodeine | DRD4_HUMAN | dopamine receptor D4 | -8.62 | -8.26 | N/A | 60.00% | CHEMBL27441 |
| Oxycodone | DRD4_HUMAN | dopamine receptor D4 | -8.53 | -8.57 | N/A | 52.57% | CHEMBL132261 |
| Diclofenac | DRD4_HUMAN | dopamine receptor D4 | -8.10 | -8.17 | N/A | 38.84% | CHEMBL322326 |
| Codeine | DRD4_HUMAN | dopamine receptor D4 | -8.87 | -9.13 | N/A | 47.42% | CHEMBL132261 |
| Morphine | DRD4_HUMAN | dopamine receptor D4 | -7.98 | -8.26 | N/A | 47.67% | CHEMBL132261 |
| Dihydrocodeine | EDN1_HUMAN | endothelin 1 | -7.90 | N/A | N/A | N/A | N/A |
| Oxycodone | EDN1_HUMAN | endothelin 1 | -7.38 | N/A | N/A | N/A | N/A |
| Diclofenac | EDN1_HUMAN | endothelin 1 | -6.83 | N/A | N/A | N/A | N/A |
| Codeine | EDN1_HUMAN | endothelin 1 | -7.34 | N/A | N/A | N/A | N/A |
| Morphine | EDN1_HUMAN | endothelin 1 | -7.23 | N/A | N/A | N/A | N/A |
| Dihydrocodeine | ESR1_HUMAN | estrogen receptor 1 | -8.66 | -7.75 | -8.18 | 54.49% | CHEMBL178559 |
| Oxycodone | ESR1_HUMAN | estrogen receptor 1 | -7.92 | -8.16 | -8.16 | 52.33% | CHEMBL33890 |
| Diclofenac | ESR1_HUMAN | estrogen receptor 1 | -7.95 | -7.67 | -7.73 | 36.63% | CHEMBL3234617 |
| Codeine | ESR1_HUMAN | estrogen receptor 1 | -9.57 | -9.22 | -9.27 | 45.08% | CHEMBL178559 |
| Morphine | ESR1_HUMAN | estrogen receptor 1 | -9.00 | -8.76 | -8.75 | 44.56% | CHEMBL178559 |
| Dihydrocodeine | FABP5_HUMAN | fatty acid binding protein 5 | -8.99 | -6.58 | -6.01 | 33.33% | CHEMBL212860 |
| Oxycodone | FABP5_HUMAN | fatty acid binding protein 5 | -8.45 | -6.12 | -6.57 | 33.33% | CHEMBL212860 |
| Diclofenac | FABP5_HUMAN | fatty acid binding protein 5 | -7.55 | -5.19 | -5.40 | 34.48% | CHEMBL212860 |
| Codeine | FABP5_HUMAN | fatty acid binding protein 5 | -8.34 | -6.35 | -6.50 | 30.39% | CHEMBL437489 |
| Morphine | FABP5_HUMAN | fatty acid binding protein 5 | -8.76 | -6.97 | -6.27 | 30.54% | CHEMBL437489 |
| Dihydrocodeine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.42 | N/A | N/A | 34.21% | CHEMBL221753 |
| Oxycodone | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.22 | N/A | N/A | 32.29% | CHEMBL432649 |
| Diclofenac | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.93 | N/A | N/A | 46.43% | CHEMBL1991734 |
| Codeine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.16 | N/A | N/A | 29.26% | CHEMBL221753 |
| Morphine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.44 | N/A | N/A | 28.72% | CHEMBL221753 |
| Dihydrocodeine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.68 | -8.54 | -8.74 | 25.49% | CHEMBL4070615 |
| Dihydrocodeine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.69 | N/A | N/A | 25.49% | CHEMBL4070615 |
| Oxycodone | GLRA3_HUMAN | glycine receptor alpha 3 | -9.12 | -8.68 | -8.75 | 25.93% | CHEMBL4070615 |
| Oxycodone | GLRA3_HUMAN | glycine receptor alpha 3 | -9.65 | N/A | N/A | 25.93% | CHEMBL4070615 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.85 | -8.83 | -8.93 | 13.55% | CHEMBL4074873 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.66 | N/A | N/A | 13.55% | CHEMBL4074873 |
| Codeine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.48 | -8.37 | -8.49 | 24.22% | CHEMBL4070615 |
| Codeine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.65 | N/A | N/A | 24.22% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.35 | -8.10 | -7.91 | 24.31% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.51 | N/A | N/A | 24.31% | CHEMBL4070615 |
| Dihydrocodeine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.21 | -2.79 | -6.55 | 40.97% | CHEMBL1289626 |
| Oxycodone | GRM5_HUMAN | glutamate metabotropic receptor 5 | -10.13 | -2.95 | -5.29 | 39.38% | CHEMBL1289626 |
| Diclofenac | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.67 | -7.54 | -6.82 | 37.01% | CHEMBL239594 |
| Codeine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -5.88 | -3.52 | -4.93 | 32.97% | CHEMBL1289626 |
| Morphine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.11 | -4.70 | -4.34 | 33.15% | CHEMBL1289626 |
| Dihydrocodeine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.63 | -6.63 | -7.17 | 23.71% | CHEMBL3134496 |
| Oxycodone | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.04 | -7.05 | -6.56 | 24.69% | CHEMBL3698267 |
| Diclofenac | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.28 | -6.68 | -7.62 | 30.18% | CHEMBL572528 |
| Codeine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.91 | -6.81 | -6.39 | 23.62% | CHEMBL3698265 |
| Morphine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.22 | -6.78 | -6.30 | 23.72% | CHEMBL3698265 |
| Dihydrocodeine | HRH1_HUMAN | histamine receptor H1 | -2.52 | N/A | N/A | 55.24% | CHEMBL476839 |
| Oxycodone | HRH1_HUMAN | histamine receptor H1 | -2.60 | N/A | N/A | 48.47% | CHEMBL476839 |
| Diclofenac | HRH1_HUMAN | histamine receptor H1 | -8.69 | N/A | N/A | 47.06% | CHEMBL2158825 |
| Codeine | HRH1_HUMAN | histamine receptor H1 | -7.46 | N/A | N/A | 45.00% | CHEMBL476839 |
| Morphine | HRH1_HUMAN | histamine receptor H1 | -4.08 | N/A | N/A | 45.25% | CHEMBL476839 |
| Dihydrocodeine | HYES_HUMAN | epoxide hydrolase 2 | -8.37 | -8.28 | -8.46 | 53.74% | CHEMBL1672128 |
| Oxycodone | HYES_HUMAN | epoxide hydrolase 2 | -8.98 | -8.39 | -8.09 | 54.72% | CHEMBL1672128 |
| Diclofenac | HYES_HUMAN | epoxide hydrolase 2 | -8.00 | -8.24 | -6.89 | 37.61% | CHEMBL478147 |
| Codeine | HYES_HUMAN | epoxide hydrolase 2 | -8.41 | -8.37 | -8.59 | 42.47% | CHEMBL1672128 |
| Morphine | HYES_HUMAN | epoxide hydrolase 2 | -8.21 | -8.04 | -8.05 | 42.70% | CHEMBL1672128 |
| Dihydrocodeine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.50 | N/A | N/A | 35.37% | CHEMBL484012 |
| Oxycodone | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.46 | N/A | N/A | 36.95% | CHEMBL184041 |
| Diclofenac | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.95 | N/A | N/A | 29.66% | CHEMBL3823257 |
| Codeine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.30 | N/A | N/A | 31.38% | CHEMBL1672879 |
| Morphine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.24 | N/A | N/A | 31.51% | CHEMBL1672879 |
| Dihydrocodeine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.53 | -8.64 | N/A | 93.08% | CHEMBL258669 |
| Oxycodone | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.39 | -7.90 | N/A | 74.67% | CHEMBL261048 |
| Diclofenac | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.33 | -7.51 | N/A | 41.05% | CHEMBL72 |
| Codeine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.72 | -7.31 | N/A | 100.00% | CHEMBL485 |
| Morphine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.46 | -7.36 | N/A | 100.00% | CHEMBL70 |
| Dihydrocodeine | MIF_HUMAN | macrophage migration inhibitory factor | -6.23 | -7.56 | -6.91 | 27.66% | CHEMBL1289631 |
| Oxycodone | MIF_HUMAN | macrophage migration inhibitory factor | -6.02 | -7.40 | -6.57 | 28.08% | CHEMBL1289631 |
| Diclofenac | MIF_HUMAN | macrophage migration inhibitory factor | -6.09 | -6.49 | -5.81 | 25.89% | CHEMBL223319 |
| Codeine | MIF_HUMAN | macrophage migration inhibitory factor | -6.60 | -7.30 | -7.13 | 30.33% | CHEMBL2375651 |
| Morphine | MIF_HUMAN | macrophage migration inhibitory factor | -5.90 | -6.55 | -6.62 | 30.43% | CHEMBL2375651 |
| Dihydrocodeine | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.65 | -8.66 | -7.23 | 36.82% | CHEMBL3654783 |
| Oxycodone | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.99 | -8.51 | -7.32 | 40.23% | CHEMBL3752989 |
| Diclofenac | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.07 | -7.62 | -7.94 | 33.06% | CHEMBL2003341 |
| Codeine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.77 | -8.18 | -7.26 | 39.92% | CHEMBL555017 |
| Morphine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.98 | -7.80 | -7.41 | 39.53% | CHEMBL555017 |
| Dihydrocodeine | MK03_HUMAN | mitogen-activated protein kinase 3 | -8.50 | -7.75 | -8.32 | 31.43% | CHEMBL555017 |
| Oxycodone | MK03_HUMAN | mitogen-activated protein kinase 3 | -8.18 | -8.27 | -7.74 | 34.65% | CHEMBL555017 |
| Diclofenac | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.75 | -7.65 | -7.67 | 25.49% | CHEMBL3798624 |
| Codeine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.75 | -7.92 | -7.85 | 39.92% | CHEMBL555017 |
| Morphine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.44 | -6.79 | -7.50 | 39.53% | CHEMBL555017 |
| Dihydrocodeine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.48 | -8.73 | -8.61 | 35.40% | CHEMBL4074753 |
| Oxycodone | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.05 | -9.24 | -8.62 | 38.72% | CHEMBL4074753 |
| Diclofenac | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.87 | -8.29 | -8.13 | 37.76% | CHEMBL2348411 |
| Codeine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.88 | -8.91 | -9.19 | 33.72% | CHEMBL4074753 |
| Morphine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.52 | -8.62 | -8.41 | 33.33% | CHEMBL4074753 |
| Dihydrocodeine | NEP_HUMAN | membrane metalloendopeptidase | -7.75 | -7.63 | -7.30 | 48.78% | CHEMBL2062138 |
| Oxycodone | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.64 | -7.35 | 49.15% | CHEMBL2062138 |
| Diclofenac | NEP_HUMAN | membrane metalloendopeptidase | -7.82 | -6.90 | -7.67 | 28.21% | CHEMBL225085 |
| Codeine | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.65 | -6.98 | 38.73% | CHEMBL2062138 |
| Morphine | NEP_HUMAN | membrane metalloendopeptidase | -8.18 | -8.44 | -7.97 | 38.24% | CHEMBL2062138 |
| Dihydrocodeine | NK1R_HUMAN | tachykinin receptor 1 | -9.17 | -9.17 | -8.92 | 50.30% | CHEMBL2112368 |
| Oxycodone | NK1R_HUMAN | tachykinin receptor 1 | -8.72 | -8.75 | -7.67 | 48.07% | CHEMBL2112368 |
| Diclofenac | NK1R_HUMAN | tachykinin receptor 1 | -7.55 | -8.35 | -7.84 | 34.69% | CHEMBL92032 |
| Codeine | NK1R_HUMAN | tachykinin receptor 1 | -9.24 | -8.22 | -8.16 | 45.16% | CHEMBL2114439 |
| Morphine | NK1R_HUMAN | tachykinin receptor 1 | -8.75 | -7.09 | -7.95 | 45.41% | CHEMBL2114439 |
| Dihydrocodeine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.68 | -7.68 | -7.76 | 27.85% | CHEMBL284237 |
| Oxycodone | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.98 | -7.84 | -7.67 | 24.02% | CHEMBL284237 |
| Diclofenac | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.50 | -8.80 | -8.42 | 15.54% | CHEMBL2333945 |
| Codeine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.72 | -7.09 | -6.87 | 25.52% | CHEMBL284237 |
| Morphine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.65 | -7.73 | -7.52 | 25.65% | CHEMBL284237 |
| Dihydrocodeine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.55 | -9.53 | -6.84 | 50.38% | CHEMBL3357784 |
| Oxycodone | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.46 | -8.03 | -6.69 | 44.37% | CHEMBL1289403 |
| Diclofenac | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.62 | -8.19 | -9.62 | 25.53% | CHEMBL161977 |
| Codeine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.82 | -8.60 | -6.54 | 40.00% | CHEMBL3357783 |
| Morphine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.48 | -9.52 | -6.65 | 39.44% | CHEMBL3357783 |
| Dihydrocodeine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.67 | -7.70 | -7.76 | 23.78% | CHEMBL419399 |
| Oxycodone | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.47 | -7.20 | -7.67 | 22.06% | CHEMBL419399 |
| Diclofenac | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.66 | -8.55 | -8.42 | 28.82% | CHEMBL401253 |
| Codeine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.75 | -6.96 | -6.87 | 20.72% | CHEMBL419399 |
| Morphine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.65 | -7.70 | -7.52 | 20.81% | CHEMBL419399 |
| Dihydrocodeine | NOS1_HUMAN | nitric oxide synthase 1 | -8.37 | -8.33 | -8.06 | 41.36% | CHEMBL42968 |
| Oxycodone | NOS1_HUMAN | nitric oxide synthase 1 | -8.49 | -8.68 | -7.68 | 40.78% | CHEMBL42968 |
| Diclofenac | NOS1_HUMAN | nitric oxide synthase 1 | -8.26 | -8.29 | -8.68 | 34.82% | CHEMBL49881 |
| Codeine | NOS1_HUMAN | nitric oxide synthase 1 | -7.20 | -7.33 | -8.61 | 34.93% | CHEMBL42968 |
| Morphine | NOS1_HUMAN | nitric oxide synthase 1 | -8.04 | -7.57 | -8.70 | 34.50% | CHEMBL42968 |
| Dihydrocodeine | NOS2_HUMAN | nitric oxide synthase 2 | -6.64 | -7.70 | -7.72 | 41.36% | CHEMBL42968 |
| Oxycodone | NOS2_HUMAN | nitric oxide synthase 2 | -7.31 | -8.36 | -9.59 | 40.78% | CHEMBL42968 |
| Diclofenac | NOS2_HUMAN | nitric oxide synthase 2 | -7.09 | -7.50 | -8.02 | 34.82% | CHEMBL49881 |
| Codeine | NOS2_HUMAN | nitric oxide synthase 2 | -7.32 | -8.24 | -8.07 | 34.93% | CHEMBL42968 |
| Morphine | NOS2_HUMAN | nitric oxide synthase 2 | -6.89 | -8.84 | -7.90 | 34.50% | CHEMBL42968 |
| Dihydrocodeine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.03 | -8.55 | -8.57 | 33.48% | CHEMBL3676077 |
| Oxycodone | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.47 | -8.68 | -8.79 | 34.50% | CHEMBL444109 |
| Diclofenac | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.08 | -8.11 | -8.12 | 46.43% | CHEMBL1991734 |
| Codeine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.99 | -8.32 | -8.23 | 39.69% | CHEMBL444109 |
| Morphine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.40 | -8.00 | -7.70 | 39.31% | CHEMBL444109 |
| Dihydrocodeine | OPRD_HUMAN | opioid receptor delta 1 | -7.66 | -6.93 | -7.08 | 99.23% | CHEMBL2418739 |
| Oxycodone | OPRD_HUMAN | opioid receptor delta 1 | -8.47 | -6.82 | -7.01 | 99.34% | CHEMBL387016 |
| Diclofenac | OPRD_HUMAN | opioid receptor delta 1 | -7.03 | -6.28 | -7.00 | 39.26% | CHEMBL1642757 |
| Codeine | OPRD_HUMAN | opioid receptor delta 1 | -7.24 | -6.75 | -6.77 | 99.41% | CHEMBL70 |
| Morphine | OPRD_HUMAN | opioid receptor delta 1 | -7.14 | -6.79 | -7.36 | 100.00% | CHEMBL70 |
| Dihydrocodeine | OPRK_HUMAN | opioid receptor kappa 1 | -9.64 | -9.73 | -7.92 | 94.89% | CHEMBL4111313 |
| Oxycodone | OPRK_HUMAN | opioid receptor kappa 1 | -9.52 | -9.20 | -7.55 | 99.34% | CHEMBL387016 |
| Diclofenac | OPRK_HUMAN | opioid receptor kappa 1 | -8.51 | -8.39 | -7.73 | 39.26% | CHEMBL1642757 |
| Codeine | OPRK_HUMAN | opioid receptor kappa 1 | -8.72 | -8.17 | -7.92 | 99.41% | CHEMBL70 |
| Morphine | OPRK_HUMAN | opioid receptor kappa 1 | -9.06 | -8.55 | -7.70 | 100.00% | CHEMBL70 |
| Dihydrocodeine | OPRM_MOUSE | Mu-type opioid receptor | -7.81 | -8.42 | N/A | 100.00% | CHEMBL2418738 |
| Oxycodone | OPRM_MOUSE | Mu-type opioid receptor | -8.45 | -8.31 | N/A | 100.00% | CHEMBL656 |
| Diclofenac | OPRM_MOUSE | Mu-type opioid receptor | -7.68 | -7.10 | N/A | 30.19% | CHEMBL596 |
| Codeine | OPRM_MOUSE | Mu-type opioid receptor | -8.29 | -8.28 | N/A | 99.41% | CHEMBL70 |
| Morphine | OPRM_MOUSE | Mu-type opioid receptor | -8.29 | -8.66 | N/A | 100.00% | CHEMBL70 |
| Dihydrocodeine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.74 | -7.66 | -7.49 | 94.85% | CHEMBL511142 |
| Oxycodone | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.70 | -7.01 | -7.59 | 75.93% | CHEMBL511142 |
| Diclofenac | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.11 | -6.85 | 34.78% | CHEMBL317152 |
| Codeine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.39 | -7.38 | 93.85% | CHEMBL3262362 |
| Morphine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.07 | -7.12 | -7.42 | 94.38% | CHEMBL3262362 |
| Dihydrocodeine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.24 | -5.43 | -6.37 | 34.78% | CHEMBL3679847 |
| Oxycodone | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.23 | -5.88 | -6.07 | 36.70% | CHEMBL3679750 |
| Diclofenac | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.89 | -4.93 | -5.45 | 45.71% | CHEMBL3958199 |
| Codeine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.03 | -5.85 | -5.83 | 35.32% | CHEMBL3679847 |
| Morphine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.39 | -5.93 | -6.38 | 35.47% | CHEMBL3679847 |
| Dihydrocodeine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.67 | -5.18 | -6.30 | 33.33% | CHEMBL92264 |
| Oxycodone | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.26 | -3.41 | -7.67 | 34.31% | CHEMBL88108 |
| Diclofenac | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.30 | -6.08 | -7.72 | 30.00% | CHEMBL223344 |
| Codeine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.26 | -3.78 | -5.99 | 28.38% | CHEMBL2172277 |
| Morphine | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.65 | -4.47 | -6.12 | 28.47% | CHEMBL2172277 |
| Dihydrocodeine | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.42 | N/A | N/A | 35.71% | CHEMBL80942 |
| Oxycodone | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.22 | N/A | N/A | 39.00% | CHEMBL334510 |
| Diclofenac | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.31 | N/A | N/A | 29.75% | CHEMBL2049115 |
| Codeine | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.19 | N/A | N/A | 34.22% | CHEMBL3086083 |
| Morphine | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.16 | N/A | N/A | 34.35% | CHEMBL3086083 |
| Dihydrocodeine | PDE4B_HUMAN | phosphodiesterase 4B | -9.13 | -8.10 | -9.60 | 58.90% | CHEMBL144499 |
| Oxycodone | PDE4B_HUMAN | phosphodiesterase 4B | -8.23 | -8.81 | -9.09 | 57.50% | CHEMBL144499 |
| Diclofenac | PDE4B_HUMAN | phosphodiesterase 4B | -8.10 | -8.03 | -8.13 | 51.82% | CHEMBL3315269 |
| Codeine | PDE4B_HUMAN | phosphodiesterase 4B | -8.37 | -7.91 | -8.55 | 46.49% | CHEMBL144499 |
| Morphine | PDE4B_HUMAN | phosphodiesterase 4B | -8.01 | -7.41 | -8.38 | 45.95% | CHEMBL144499 |
| Dihydrocodeine | PDE5A_HUMAN | phosphodiesterase 5A | -8.17 | -8.47 | -9.49 | 36.36% | CHEMBL190423 |
| Oxycodone | PDE5A_HUMAN | phosphodiesterase 5A | -7.78 | -8.20 | -8.63 | 36.13% | CHEMBL190423 |
| Diclofenac | PDE5A_HUMAN | phosphodiesterase 5A | -7.21 | -8.35 | -7.97 | 28.36% | CHEMBL332898 |
| Codeine | PDE5A_HUMAN | phosphodiesterase 5A | -7.80 | -8.28 | -8.12 | 32.23% | CHEMBL190423 |
| Morphine | PDE5A_HUMAN | phosphodiesterase 5A | -7.82 | -8.14 | -8.24 | 31.75% | CHEMBL190423 |
| Dihydrocodeine | PERM_HUMAN | myeloperoxidase | -8.26 | -8.48 | -8.58 | 43.31% | CHEMBL490 |
| Oxycodone | PERM_HUMAN | myeloperoxidase | -8.33 | -8.16 | -8.10 | 37.64% | CHEMBL490 |
| Diclofenac | PERM_HUMAN | myeloperoxidase | -7.60 | -7.78 | -7.78 | 41.57% | CHEMBL686 |
| Codeine | PERM_HUMAN | myeloperoxidase | -8.20 | -8.53 | -8.29 | 35.38% | CHEMBL490 |
| Morphine | PERM_HUMAN | myeloperoxidase | -7.90 | -7.96 | -8.02 | 35.57% | CHEMBL490 |
| Dihydrocodeine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.20 | -7.48 | -8.24 | 34.71% | CHEMBL229957 |
| Oxycodone | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -5.89 | -7.94 | -7.43 | 35.45% | CHEMBL24798 |
| Diclofenac | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.22 | -8.31 | -8.48 | 100.00% | CHEMBL139 |
| Codeine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -3.68 | -7.33 | -6.64 | 35.35% | CHEMBL229957 |
| Morphine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -3.16 | -7.62 | -7.03 | 34.85% | CHEMBL229957 |
| Dihydrocodeine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -3.50 | -5.84 | -6.89 | 43.75% | CHEMBL13623 |
| Oxycodone | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -1.16 | -4.32 | -9.85 | 42.14% | CHEMBL276663 |
| Diclofenac | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.37 | -7.98 | -8.14 | 100.00% | CHEMBL139 |
| Codeine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -3.35 | -4.99 | -7.14 | 35.45% | CHEMBL13988 |
| Morphine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | 1.36 | -6.24 | -6.70 | 34.92% | CHEMBL13988 |
| Dihydrocodeine | PPAP_HUMAN | acid phosphatase 3 | -7.74 | N/A | N/A | 23.53% | CHEMBL507996 |
| Oxycodone | PPAP_HUMAN | acid phosphatase 3 | -7.86 | N/A | N/A | 22.99% | CHEMBL507996 |
| Diclofenac | PPAP_HUMAN | acid phosphatase 3 | -7.69 | N/A | N/A | 17.24% | CHEMBL501717 |
| Codeine | PPAP_HUMAN | acid phosphatase 3 | -7.85 | N/A | N/A | 20.87% | CHEMBL507996 |
| Morphine | PPAP_HUMAN | acid phosphatase 3 | -8.39 | N/A | N/A | 20.39% | CHEMBL507996 |
| Dihydrocodeine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.81 | -5.77 | -6.87 | 47.48% | CHEMBL592625 |
| Oxycodone | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.26 | -6.35 | -7.52 | 47.93% | CHEMBL419756 |
| Diclofenac | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.57 | -7.17 | -7.92 | 38.89% | CHEMBL167963 |
| Codeine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.71 | -5.64 | -6.72 | 43.78% | CHEMBL1836977 |
| Morphine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.50 | -5.87 | -6.23 | 43.24% | CHEMBL1836977 |
| Dihydrocodeine | PRGR_HUMAN | progesterone receptor | -9.92 | -10.08 | -8.98 | 44.58% | CHEMBL373497 |
| Oxycodone | PRGR_HUMAN | progesterone receptor | -6.90 | -6.73 | -8.21 | 40.21% | CHEMBL1911657 |
| Diclofenac | PRGR_HUMAN | progesterone receptor | -8.19 | -8.40 | -7.81 | 45.87% | CHEMBL117612 |
| Codeine | PRGR_HUMAN | progesterone receptor | -8.47 | -8.07 | -8.86 | 40.51% | CHEMBL51933 |
| Morphine | PRGR_HUMAN | progesterone receptor | -9.04 | -9.47 | -8.73 | 40.72% | CHEMBL51933 |
| Dihydrocodeine | PTGES_HUMAN | prostaglandin E synthase | -6.42 | N/A | N/A | 40.46% | CHEMBL3753433 |
| Oxycodone | PTGES_HUMAN | prostaglandin E synthase | -6.59 | N/A | N/A | 39.60% | CHEMBL538661 |
| Diclofenac | PTGES_HUMAN | prostaglandin E synthase | -6.52 | N/A | N/A | 35.14% | CHEMBL1683859 |
| Codeine | PTGES_HUMAN | prostaglandin E synthase | -6.20 | N/A | N/A | 38.24% | CHEMBL3753433 |
| Morphine | PTGES_HUMAN | prostaglandin E synthase | -6.74 | N/A | N/A | 37.75% | CHEMBL3753433 |
| Dihydrocodeine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.40 | -9.15 | -8.98 | 60.77% | CHEMBL52440 |
| Oxycodone | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.08 | -8.86 | -8.69 | 52.67% | CHEMBL52440 |
| Diclofenac | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.20 | -8.33 | -8.76 | 46.53% | CHEMBL415 |
| Codeine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.24 | -9.33 | -8.65 | 46.95% | CHEMBL434728 |
| Morphine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.44 | -9.20 | -9.29 | 46.48% | CHEMBL434728 |
| Dihydrocodeine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.56 | N/A | N/A | 44.09% | CHEMBL3658010 |
| Oxycodone | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.27 | N/A | N/A | 42.94% | CHEMBL203440 |
| Diclofenac | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.61 | N/A | N/A | 37.41% | CHEMBL3581050 |
| Codeine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.18 | N/A | N/A | 40.45% | CHEMBL3662107 |
| Morphine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.25 | N/A | N/A | 40.00% | CHEMBL3662107 |
| Dihydrocodeine | TLR4_HUMAN | toll like receptor 4 | -8.73 | -9.22 | -7.86 | 46.45% | CHEMBL3261029 |
| Oxycodone | TLR4_HUMAN | toll like receptor 4 | -7.77 | -7.49 | -7.61 | 41.46% | CHEMBL3261030 |
| Diclofenac | TLR4_HUMAN | toll like receptor 4 | -7.37 | -7.23 | -7.52 | 23.74% | CHEMBL2419459 |
| Codeine | TLR4_HUMAN | toll like receptor 4 | -7.32 | -7.92 | -7.47 | 38.29% | CHEMBL3261029 |
| Morphine | TLR4_HUMAN | toll like receptor 4 | -8.26 | -8.29 | -7.17 | 37.84% | CHEMBL3261029 |
| Dihydrocodeine | TNFA_HUMAN | tumor necrosis factor | -8.38 | N/A | N/A | 44.60% | CHEMBL2337619 |
| Oxycodone | TNFA_HUMAN | tumor necrosis factor | -7.83 | N/A | N/A | 49.77% | CHEMBL2337619 |
| Diclofenac | TNFA_HUMAN | tumor necrosis factor | -7.40 | N/A | N/A | 30.83% | CHEMBL1612423 |
| Codeine | TNFA_HUMAN | tumor necrosis factor | -7.62 | N/A | N/A | 54.91% | CHEMBL2337619 |
| Morphine | TNFA_HUMAN | tumor necrosis factor | -7.88 | N/A | N/A | 54.46% | CHEMBL2337619 |
| Dihydrocodeine | TRBM_HUMAN | thrombomodulin | -7.23 | -6.56 | N/A | N/A | N/A |
| Oxycodone | TRBM_HUMAN | thrombomodulin | -7.24 | -7.04 | N/A | N/A | N/A |
| Diclofenac | TRBM_HUMAN | thrombomodulin | -6.91 | -6.85 | N/A | N/A | N/A |
| Codeine | TRBM_HUMAN | thrombomodulin | -7.56 | -7.31 | N/A | N/A | N/A |
| Morphine | TRBM_HUMAN | thrombomodulin | -7.23 | -7.14 | N/A | N/A | N/A |
| Dihydrocodeine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.58 | -7.52 | N/A | N/A | N/A |
| Oxycodone | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.59 | -7.06 | N/A | N/A | N/A |
| Diclofenac | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.40 | -6.18 | N/A | N/A | N/A |
| Codeine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.87 | -6.95 | N/A | N/A | N/A |
| Morphine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.73 | -6.69 | N/A | N/A | N/A |
| Dihydrocodeine | TRPM8_FICAL | Uncharacterized protein | -9.26 | N/A | N/A | N/A | N/A |
| Oxycodone | TRPM8_FICAL | Uncharacterized protein | -9.00 | N/A | N/A | N/A | N/A |
| Diclofenac | TRPM8_FICAL | Uncharacterized protein | -8.27 | N/A | N/A | N/A | N/A |
| Codeine | TRPM8_FICAL | Uncharacterized protein | -9.23 | N/A | N/A | N/A | N/A |
| Morphine | TRPM8_FICAL | Uncharacterized protein | -8.65 | N/A | N/A | N/A | N/A |
| Dihydrocodeine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.61 | N/A | N/A | 46.62% | CHEMBL2057858 |
| Oxycodone | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.61 | N/A | N/A | 44.51% | CHEMBL2057858 |
| Diclofenac | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.36 | N/A | N/A | 37.74% | CHEMBL258265 |
| Codeine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.85 | N/A | N/A | 42.49% | CHEMBL97968 |
| Morphine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.83 | N/A | N/A | 42.71% | CHEMBL97968 |
| Dihydrocodeine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.65 | -7.86 | N/A | N/A | N/A |
| Oxycodone | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -9.02 | -8.00 | N/A | N/A | N/A |
| Diclofenac | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.84 | -7.88 | N/A | N/A | N/A |
| Codeine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.51 | -8.32 | N/A | N/A | N/A |
| Morphine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.54 | -8.15 | N/A | N/A | N/A |
| Dihydrocodeine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.14 | -8.48 | N/A | 48.85% | CHEMBL3664218 |
| Oxycodone | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.99 | -7.95 | N/A | 50.00% | CHEMBL3664218 |
| Diclofenac | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.34 | -6.87 | N/A | 30.89% | CHEMBL3828278 |
| Codeine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.81 | -6.98 | N/A | 44.66% | CHEMBL3664218 |
| Morphine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.52 | -7.86 | N/A | 44.88% | CHEMBL3664218 |
| Dihydrocodeine | TRXR1_HUMAN | thioredoxin reductase 1 | -8.41 | -7.60 | -6.83 | N/A | N/A |
| Oxycodone | TRXR1_HUMAN | thioredoxin reductase 1 | -8.35 | -7.77 | -6.80 | N/A | N/A |
| Diclofenac | TRXR1_HUMAN | thioredoxin reductase 1 | -7.83 | -7.25 | -6.24 | N/A | N/A |
| Codeine | TRXR1_HUMAN | thioredoxin reductase 1 | -7.91 | -7.90 | -7.12 | N/A | N/A |
| Morphine | TRXR1_HUMAN | thioredoxin reductase 1 | -8.46 | -8.10 | -7.03 | N/A | N/A |
| Dihydrocodeine | TRY1_HUMAN | serine protease 1 | -7.00 | N/A | N/A | 35.82% | CHEMBL44710 |
| Oxycodone | TRY1_HUMAN | serine protease 1 | -6.00 | N/A | N/A | 38.81% | CHEMBL69394 |
| Diclofenac | TRY1_HUMAN | serine protease 1 | -6.30 | N/A | N/A | 34.23% | CHEMBL3926197 |
| Codeine | TRY1_HUMAN | serine protease 1 | -5.57 | N/A | N/A | 33.10% | CHEMBL73970 |
| Morphine | TRY1_HUMAN | serine protease 1 | -6.01 | N/A | N/A | 33.22% | CHEMBL73970 |