| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Acetaminophen | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -6.67 | -6.64 | -5.91 | 52.83% | CHEMBL129661 |
| Diclofenac | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.19 | -8.46 | -8.22 | 30.37% | CHEMBL71091 |
| Morphine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.64 | -8.78 | -9.66 | 52.63% | CHEMBL29951 |
| Fentanyl | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.36 | -8.48 | -9.08 | 60.00% | CHEMBL361061 |
| Acetaminophen | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -6.12 | -6.18 | N/A | 48.94% | CHEMBL277120 |
| Diclofenac | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.06 | -8.28 | N/A | 46.53% | CHEMBL415 |
| Morphine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -10.11 | -8.39 | N/A | 51.96% | CHEMBL3695438 |
| Fentanyl | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.08 | -8.90 | N/A | 57.69% | CHEMBL352194 |
| Acetaminophen | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -6.01 | -5.91 | -6.02 | 44.62% | CHEMBL57135 |
| Diclofenac | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.22 | -8.68 | -8.66 | 46.53% | CHEMBL415 |
| Morphine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.81 | -9.07 | -8.64 | 51.06% | CHEMBL445106 |
| Fentanyl | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.81 | -9.10 | -9.38 | 56.67% | CHEMBL3919861 |
| Acetaminophen | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -6.24 | -6.31 | N/A | 44.62% | CHEMBL57135 |
| Diclofenac | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.44 | -8.58 | N/A | 46.53% | CHEMBL415 |
| Morphine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.58 | -10.28 | N/A | 51.06% | CHEMBL445106 |
| Fentanyl | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.49 | -9.12 | N/A | 57.69% | CHEMBL352194 |
| Acetaminophen | AA1R_HUMAN | adenosine A1 receptor | -5.56 | -5.73 | -5.75 | 36.27% | CHEMBL1814055 |
| Diclofenac | AA1R_HUMAN | adenosine A1 receptor | -7.29 | -7.36 | -7.74 | 29.75% | CHEMBL2260644 |
| Morphine | AA1R_HUMAN | adenosine A1 receptor | -8.76 | -8.54 | -7.57 | 29.96% | CHEMBL3317575 |
| Fentanyl | AA1R_HUMAN | adenosine A1 receptor | -8.66 | -8.83 | -7.66 | 36.02% | CHEMBL1095812 |
| Acetaminophen | AA2AR_HUMAN | adenosine A2a receptor | -5.97 | -5.95 | -5.88 | 36.27% | CHEMBL1814055 |
| Diclofenac | AA2AR_HUMAN | adenosine A2a receptor | -7.76 | -7.71 | -8.16 | 34.91% | CHEMBL603094 |
| Morphine | AA2AR_HUMAN | adenosine A2a receptor | -9.67 | -9.75 | -10.19 | 34.24% | CHEMBL559023 |
| Fentanyl | AA2AR_HUMAN | adenosine A2a receptor | -7.45 | -8.09 | -8.77 | 47.29% | CHEMBL539454 |
| Acetaminophen | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -6.48 | -6.28 | -6.89 | 66.67% | CHEMBL60745 |
| Diclofenac | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.71 | -8.16 | -9.38 | 35.43% | CHEMBL1085858 |
| Morphine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.57 | -8.95 | -9.04 | 66.01% | CHEMBL569978 |
| Fentanyl | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.87 | -9.06 | -7.24 | 65.43% | CHEMBL141853 |
| Acetaminophen | ACE_HUMAN | angiotensin I converting enzyme | -6.06 | -5.47 | -5.44 | 46.03% | CHEMBL322069 |
| Diclofenac | ACE_HUMAN | angiotensin I converting enzyme | -7.45 | -7.41 | -7.29 | 29.63% | CHEMBL23849 |
| Morphine | ACE_HUMAN | angiotensin I converting enzyme | -9.14 | -8.53 | -8.16 | 37.12% | CHEMBL1165 |
| Fentanyl | ACE_HUMAN | angiotensin I converting enzyme | -8.15 | -8.40 | -6.98 | 50.00% | CHEMBL98 |
| Acetaminophen | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -4.80 | N/A | N/A | 12.79% | CHEMBL386114 |
| Diclofenac | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.09 | N/A | N/A | 17.01% | CHEMBL386114 |
| Morphine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.21 | N/A | N/A | 21.72% | CHEMBL386114 |
| Fentanyl | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.45 | N/A | N/A | 28.57% | CHEMBL386114 |
| Acetaminophen | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.76 | -6.43 | -6.28 | N/A | N/A |
| Diclofenac | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.54 | -8.23 | -6.56 | N/A | N/A |
| Morphine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.14 | -4.62 | -6.38 | N/A | N/A |
| Fentanyl | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.17 | -6.86 | -4.84 | N/A | N/A |
| Acetaminophen | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -6.40 | -7.19 | N/A | 37.63% | CHEMBL1092460 |
| Diclofenac | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.76 | -4.91 | N/A | 46.53% | CHEMBL415 |
| Morphine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.26 | 3.91 | N/A | 45.66% | CHEMBL343236 |
| Fentanyl | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.03 | -2.80 | N/A | 73.91% | CHEMBL1243110 |
| Acetaminophen | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -6.42 | -5.80 | N/A | 34.09% | CHEMBL7568 |
| Diclofenac | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.67 | -7.51 | N/A | 46.53% | CHEMBL415 |
| Morphine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -10.12 | -7.54 | N/A | 39.27% | CHEMBL1346 |
| Fentanyl | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.29 | -7.78 | N/A | 68.48% | CHEMBL3354065 |
| Acetaminophen | ADRB2_HUMAN | adrenoceptor beta 2 | -6.09 | -6.39 | -6.58 | 41.18% | CHEMBL13102 |
| Diclofenac | ADRB2_HUMAN | adrenoceptor beta 2 | -7.35 | -8.61 | -8.50 | 44.95% | CHEMBL154419 |
| Morphine | ADRB2_HUMAN | adrenoceptor beta 2 | -8.78 | -8.72 | -8.70 | 43.26% | CHEMBL513389 |
| Fentanyl | ADRB2_HUMAN | adrenoceptor beta 2 | -7.73 | -8.30 | -9.28 | 54.72% | CHEMBL1306990 |
| Acetaminophen | AGTR2_HUMAN | angiotensin II receptor type 2 | -5.86 | -6.03 | -5.90 | 29.00% | CHEMBL290829 |
| Diclofenac | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.57 | -7.50 | -7.34 | 25.67% | CHEMBL40381 |
| Morphine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.76 | -8.81 | -8.62 | 42.67% | CHEMBL154057 |
| Fentanyl | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.61 | -9.85 | -9.62 | 36.50% | CHEMBL268815 |
| Acetaminophen | ALDR_HUMAN | aldo-keto reductase family 1 member B | -6.71 | -6.22 | -7.00 | 25.00% | CHEMBL240719 |
| Diclofenac | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.93 | -7.61 | -7.76 | 35.23% | CHEMBL77283 |
| Morphine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.49 | -7.83 | -7.14 | 32.54% | CHEMBL311679 |
| Fentanyl | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.41 | -7.68 | -9.72 | 39.07% | CHEMBL281620 |
| Acetaminophen | AMPN_HUMAN | alanyl aminopeptidase, membrane | -5.89 | -6.18 | -5.50 | 34.02% | CHEMBL2332527 |
| Diclofenac | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.15 | -8.06 | -7.99 | 29.69% | CHEMBL3764432 |
| Morphine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.58 | -8.97 | -8.01 | 33.78% | CHEMBL1782887 |
| Fentanyl | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.02 | -8.37 | -7.69 | 41.38% | CHEMBL3764432 |
| Acetaminophen | AOFA_HUMAN | monoamine oxidase A | -6.26 | -6.14 | -6.29 | 39.19% | CHEMBL3546846 |
| Diclofenac | AOFA_HUMAN | monoamine oxidase A | -8.04 | -8.37 | -8.67 | 35.65% | CHEMBL1642672 |
| Morphine | AOFA_HUMAN | monoamine oxidase A | -8.76 | -9.26 | -8.02 | 34.30% | CHEMBL4073457 |
| Fentanyl | AOFA_HUMAN | monoamine oxidase A | -10.09 | -9.07 | -8.63 | 57.45% | CHEMBL3781494 |
| Acetaminophen | AOFB_HUMAN | monoamine oxidase B | -6.27 | -6.40 | -6.62 | 47.30% | CHEMBL3319245 |
| Diclofenac | AOFB_HUMAN | monoamine oxidase B | -8.49 | -8.36 | -8.88 | 36.44% | CHEMBL3319243 |
| Morphine | AOFB_HUMAN | monoamine oxidase B | -9.24 | -7.86 | -8.29 | 35.75% | CHEMBL4113794 |
| Fentanyl | AOFB_HUMAN | monoamine oxidase B | -8.68 | -8.70 | -10.07 | 50.51% | CHEMBL3604126 |
| Acetaminophen | BACE1_HUMAN | beta-secretase 1 | -4.81 | -5.36 | -5.45 | 37.23% | CHEMBL3354259 |
| Diclofenac | BACE1_HUMAN | beta-secretase 1 | -6.69 | -6.82 | -7.46 | 33.06% | CHEMBL3627961 |
| Morphine | BACE1_HUMAN | beta-secretase 1 | -7.07 | -7.64 | -8.51 | 43.53% | CHEMBL3955763 |
| Fentanyl | BACE1_HUMAN | beta-secretase 1 | -6.92 | -7.39 | -8.46 | 59.60% | CHEMBL2181988 |
| Acetaminophen | CAH2_HUMAN | carbonic anhydrase 2 | -5.71 | -5.78 | -5.66 | 62.71% | CHEMBL68590 |
| Diclofenac | CAH2_HUMAN | carbonic anhydrase 2 | -7.31 | -7.42 | -7.15 | 44.58% | CHEMBL23832 |
| Morphine | CAH2_HUMAN | carbonic anhydrase 2 | -8.38 | -7.92 | -6.98 | 40.44% | CHEMBL3786651 |
| Fentanyl | CAH2_HUMAN | carbonic anhydrase 2 | -7.37 | -7.43 | -7.59 | 61.62% | CHEMBL182523 |
| Acetaminophen | CASP1_HUMAN | caspase 1 | -4.67 | -5.09 | -5.06 | 28.57% | CHEMBL1221595 |
| Diclofenac | CASP1_HUMAN | caspase 1 | -5.75 | -6.77 | -5.58 | 32.35% | CHEMBL78154 |
| Morphine | CASP1_HUMAN | caspase 1 | -6.31 | -7.74 | -6.69 | 34.62% | CHEMBL3898379 |
| Fentanyl | CASP1_HUMAN | caspase 1 | -6.46 | -6.95 | -6.03 | 46.88% | CHEMBL1221597 |
| Acetaminophen | CDK5_HUMAN | cyclin dependent kinase 5 | -5.94 | -6.39 | -6.50 | 42.17% | CHEMBL1988141 |
| Diclofenac | CDK5_HUMAN | cyclin dependent kinase 5 | -7.33 | -7.84 | -8.35 | 46.43% | CHEMBL1991734 |
| Morphine | CDK5_HUMAN | cyclin dependent kinase 5 | -7.79 | -7.12 | -5.73 | 29.55% | CHEMBL422897 |
| Fentanyl | CDK5_HUMAN | cyclin dependent kinase 5 | -7.76 | -7.70 | -7.16 | 43.33% | CHEMBL1998121 |
| Acetaminophen | CHLE_HUMAN | butyrylcholinesterase | -6.00 | -5.90 | -6.12 | 40.62% | CHEMBL54126 |
| Diclofenac | CHLE_HUMAN | butyrylcholinesterase | -8.65 | -8.20 | -8.70 | 45.59% | CHEMBL3087676 |
| Morphine | CHLE_HUMAN | butyrylcholinesterase | -9.17 | -9.17 | -9.23 | 43.52% | CHEMBL366411 |
| Fentanyl | CHLE_HUMAN | butyrylcholinesterase | -8.47 | -8.99 | -9.56 | 52.63% | CHEMBL4077192 |
| Acetaminophen | CNR1_HUMAN | cannabinoid receptor 1 | -5.92 | -6.14 | -6.28 | 49.33% | CHEMBL200094 |
| Diclofenac | CNR1_HUMAN | cannabinoid receptor 1 | -7.80 | -8.14 | -8.82 | 46.55% | CHEMBL3936647 |
| Morphine | CNR1_HUMAN | cannabinoid receptor 1 | -7.51 | -8.54 | -7.86 | 56.82% | CHEMBL303479 |
| Fentanyl | CNR1_HUMAN | cannabinoid receptor 1 | -8.98 | -9.23 | -9.76 | 55.95% | CHEMBL479095 |
| Acetaminophen | CNR2_HUMAN | cannabinoid receptor 2 | -6.16 | -6.08 | N/A | 41.82% | CHEMBL2336559 |
| Diclofenac | CNR2_HUMAN | cannabinoid receptor 2 | -8.58 | -8.70 | N/A | 38.18% | CHEMBL2326302 |
| Morphine | CNR2_HUMAN | cannabinoid receptor 2 | -9.08 | -9.18 | N/A | 56.82% | CHEMBL303479 |
| Fentanyl | CNR2_HUMAN | cannabinoid receptor 2 | -9.18 | -9.97 | N/A | 70.11% | CHEMBL2338188 |
| Acetaminophen | COLI_HUMAN | proopiomelanocortin | -5.99 | -5.90 | -5.86 | N/A | N/A |
| Diclofenac | COLI_HUMAN | proopiomelanocortin | -7.40 | -7.19 | -7.23 | N/A | N/A |
| Morphine | COLI_HUMAN | proopiomelanocortin | -8.01 | -7.73 | -7.00 | N/A | N/A |
| Fentanyl | COLI_HUMAN | proopiomelanocortin | -8.18 | -7.94 | -7.52 | N/A | N/A |
| Acetaminophen | COMT_HUMAN | catechol-O-methyltransferase | -4.92 | -4.82 | -5.02 | 28.57% | CHEMBL3818719 |
| Diclofenac | COMT_HUMAN | catechol-O-methyltransferase | -6.26 | -6.12 | -6.36 | 22.76% | CHEMBL1324 |
| Morphine | COMT_HUMAN | catechol-O-methyltransferase | -6.78 | -6.88 | -6.54 | 22.70% | CHEMBL3819488 |
| Fentanyl | COMT_HUMAN | catechol-O-methyltransferase | -5.90 | -6.36 | -5.94 | 25.74% | CHEMBL3425731 |
| Acetaminophen | CRP_HUMAN | C-reactive protein | -4.82 | -5.01 | N/A | N/A | N/A |
| Diclofenac | CRP_HUMAN | C-reactive protein | -5.84 | -5.77 | N/A | N/A | N/A |
| Morphine | CRP_HUMAN | C-reactive protein | -6.65 | -6.38 | N/A | N/A | N/A |
| Fentanyl | CRP_HUMAN | C-reactive protein | -6.37 | -5.93 | N/A | N/A | N/A |
| Acetaminophen | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -6.41 | N/A | N/A | 50.79% | CHEMBL184637 |
| Diclofenac | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.66 | N/A | N/A | 100.00% | CHEMBL139 |
| Morphine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.18 | N/A | N/A | 28.19% | CHEMBL490688 |
| Fentanyl | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -5.19 | N/A | N/A | 31.10% | CHEMBL561812 |
| Acetaminophen | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -6.73 | -5.63 | -5.82 | 29.33% | CHEMBL2347630 |
| Diclofenac | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.70 | -6.68 | -7.09 | 28.18% | CHEMBL3908835 |
| Morphine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.80 | -7.26 | -7.71 | 33.92% | CHEMBL2029611 |
| Fentanyl | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.98 | -6.61 | -7.56 | 41.88% | CHEMBL2371850 |
| Acetaminophen | DRD2_HUMAN | dopamine receptor D2 | -6.47 | N/A | N/A | 50.91% | CHEMBL447809 |
| Diclofenac | DRD2_HUMAN | dopamine receptor D2 | -7.22 | N/A | N/A | 46.53% | CHEMBL415 |
| Morphine | DRD2_HUMAN | dopamine receptor D2 | -7.97 | N/A | N/A | 55.49% | CHEMBL170976 |
| Fentanyl | DRD2_HUMAN | dopamine receptor D2 | -7.60 | N/A | N/A | 70.79% | CHEMBL4091231 |
| Acetaminophen | DRD3_HUMAN | dopamine receptor D3 | -6.05 | N/A | N/A | 49.12% | CHEMBL2165674 |
| Diclofenac | DRD3_HUMAN | dopamine receptor D3 | -7.96 | N/A | N/A | 46.53% | CHEMBL415 |
| Morphine | DRD3_HUMAN | dopamine receptor D3 | -8.13 | N/A | N/A | 55.49% | CHEMBL170976 |
| Fentanyl | DRD3_HUMAN | dopamine receptor D3 | -8.25 | N/A | N/A | 70.79% | CHEMBL4091231 |
| Acetaminophen | DRD4_HUMAN | dopamine receptor D4 | -6.38 | -6.37 | N/A | 55.22% | CHEMBL184772 |
| Diclofenac | DRD4_HUMAN | dopamine receptor D4 | -8.10 | -8.17 | N/A | 38.84% | CHEMBL322326 |
| Morphine | DRD4_HUMAN | dopamine receptor D4 | -8.50 | -8.44 | N/A | 47.67% | CHEMBL132261 |
| Fentanyl | DRD4_HUMAN | dopamine receptor D4 | -8.89 | -8.94 | N/A | 70.79% | CHEMBL4074104 |
| Acetaminophen | EDN1_HUMAN | endothelin 1 | -5.63 | N/A | N/A | N/A | N/A |
| Diclofenac | EDN1_HUMAN | endothelin 1 | -6.83 | N/A | N/A | N/A | N/A |
| Morphine | EDN1_HUMAN | endothelin 1 | -7.31 | N/A | N/A | N/A | N/A |
| Fentanyl | EDN1_HUMAN | endothelin 1 | -7.64 | N/A | N/A | N/A | N/A |
| Acetaminophen | ESR1_HUMAN | estrogen receptor 1 | -5.88 | -5.81 | -5.84 | 61.67% | CHEMBL3645266 |
| Diclofenac | ESR1_HUMAN | estrogen receptor 1 | -7.95 | -7.67 | -7.73 | 36.63% | CHEMBL3234617 |
| Morphine | ESR1_HUMAN | estrogen receptor 1 | -9.40 | -9.33 | -9.35 | 44.56% | CHEMBL178559 |
| Fentanyl | ESR1_HUMAN | estrogen receptor 1 | -8.30 | -8.48 | -8.48 | 50.89% | CHEMBL3360843 |
| Acetaminophen | FABP5_HUMAN | fatty acid binding protein 5 | -5.25 | -4.46 | -4.70 | 19.15% | CHEMBL3941588 |
| Diclofenac | FABP5_HUMAN | fatty acid binding protein 5 | -7.55 | -5.19 | -5.40 | 34.48% | CHEMBL212860 |
| Morphine | FABP5_HUMAN | fatty acid binding protein 5 | -8.48 | -6.74 | -6.61 | 30.54% | CHEMBL437489 |
| Fentanyl | FABP5_HUMAN | fatty acid binding protein 5 | -7.92 | -6.05 | -6.03 | 30.07% | CHEMBL3941588 |
| Acetaminophen | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -5.86 | N/A | N/A | 42.17% | CHEMBL1988141 |
| Diclofenac | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.93 | N/A | N/A | 46.43% | CHEMBL1991734 |
| Morphine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.18 | N/A | N/A | 28.72% | CHEMBL221753 |
| Fentanyl | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.45 | N/A | N/A | 43.33% | CHEMBL1998121 |
| Acetaminophen | GLRA3_HUMAN | glycine receptor alpha 3 | -5.86 | -6.01 | -6.05 | 15.23% | CHEMBL4070615 |
| Acetaminophen | GLRA3_HUMAN | glycine receptor alpha 3 | -6.43 | N/A | N/A | 15.23% | CHEMBL4070615 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.85 | -8.83 | -8.93 | 13.55% | CHEMBL4074873 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.66 | N/A | N/A | 13.55% | CHEMBL4074873 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.39 | -8.86 | -9.07 | 24.31% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.49 | N/A | N/A | 24.31% | CHEMBL4070615 |
| Fentanyl | GLRA3_HUMAN | glycine receptor alpha 3 | -9.32 | -8.16 | -8.77 | 28.19% | CHEMBL4074873 |
| Fentanyl | GLRA3_HUMAN | glycine receptor alpha 3 | -9.63 | N/A | N/A | 28.19% | CHEMBL4074873 |
| Acetaminophen | GRM5_HUMAN | glutamate metabotropic receptor 5 | -6.77 | -6.97 | -7.16 | 41.18% | CHEMBL1080481 |
| Diclofenac | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.67 | -7.54 | -6.82 | 37.01% | CHEMBL239594 |
| Morphine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.12 | -3.34 | -5.07 | 33.15% | CHEMBL1289626 |
| Fentanyl | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.50 | -6.98 | -7.52 | 47.52% | CHEMBL2338572 |
| Acetaminophen | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -5.40 | -5.76 | -6.36 | 28.69% | CHEMBL2035649 |
| Diclofenac | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.28 | -6.68 | -7.62 | 30.18% | CHEMBL572528 |
| Morphine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.26 | -6.83 | -6.34 | 23.72% | CHEMBL3698265 |
| Fentanyl | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.25 | -7.69 | -7.23 | 45.24% | CHEMBL3425957 |
| Acetaminophen | HRH1_HUMAN | histamine receptor H1 | -6.90 | N/A | N/A | 40.58% | CHEMBL1940414 |
| Diclofenac | HRH1_HUMAN | histamine receptor H1 | -8.69 | N/A | N/A | 47.06% | CHEMBL2158825 |
| Morphine | HRH1_HUMAN | histamine receptor H1 | -7.01 | N/A | N/A | 45.25% | CHEMBL476839 |
| Fentanyl | HRH1_HUMAN | histamine receptor H1 | -8.53 | N/A | N/A | 61.82% | CHEMBL1242923 |
| Acetaminophen | HYES_HUMAN | epoxide hydrolase 2 | -6.17 | -6.04 | -5.88 | 54.24% | CHEMBL2031937 |
| Diclofenac | HYES_HUMAN | epoxide hydrolase 2 | -8.00 | -8.24 | -6.89 | 37.61% | CHEMBL478147 |
| Morphine | HYES_HUMAN | epoxide hydrolase 2 | -9.52 | -8.27 | -7.83 | 42.70% | CHEMBL1672128 |
| Fentanyl | HYES_HUMAN | epoxide hydrolase 2 | -8.50 | -8.26 | -8.71 | 68.18% | CHEMBL1672132 |
| Acetaminophen | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -5.87 | N/A | N/A | 35.85% | CHEMBL1725279 |
| Diclofenac | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.95 | N/A | N/A | 29.66% | CHEMBL3823257 |
| Morphine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.00 | N/A | N/A | 31.51% | CHEMBL1672879 |
| Fentanyl | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.28 | N/A | N/A | 40.91% | CHEMBL3823257 |
| Acetaminophen | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -5.31 | -6.00 | N/A | 37.66% | CHEMBL311469 |
| Diclofenac | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.33 | -7.51 | N/A | 41.05% | CHEMBL72 |
| Morphine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.41 | -7.77 | N/A | 100.00% | CHEMBL70 |
| Fentanyl | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.93 | -8.39 | N/A | 46.34% | CHEMBL2398178 |
| Acetaminophen | MIF_HUMAN | macrophage migration inhibitory factor | -7.37 | -6.90 | -7.42 | 25.97% | CHEMBL224086 |
| Diclofenac | MIF_HUMAN | macrophage migration inhibitory factor | -6.09 | -6.49 | -5.81 | 25.89% | CHEMBL223319 |
| Morphine | MIF_HUMAN | macrophage migration inhibitory factor | -5.85 | -8.08 | -6.94 | 30.43% | CHEMBL2375651 |
| Fentanyl | MIF_HUMAN | macrophage migration inhibitory factor | -8.01 | -8.45 | -7.18 | 25.78% | CHEMBL1604170 |
| Acetaminophen | MK01_HUMAN | mitogen-activated protein kinase 1 | -5.62 | -5.80 | -5.14 | 46.67% | CHEMBL24944 |
| Diclofenac | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.07 | -7.62 | -7.94 | 33.06% | CHEMBL2003341 |
| Morphine | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.88 | -8.10 | -7.29 | 39.53% | CHEMBL555017 |
| Fentanyl | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.20 | -7.37 | -7.83 | 47.06% | CHEMBL3356128 |
| Acetaminophen | MK03_HUMAN | mitogen-activated protein kinase 3 | -5.52 | -6.01 | -5.64 | 28.69% | CHEMBL1336 |
| Diclofenac | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.75 | -7.65 | -7.67 | 25.49% | CHEMBL3798624 |
| Morphine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.94 | -8.39 | -7.92 | 39.53% | CHEMBL555017 |
| Fentanyl | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.90 | -8.11 | -8.19 | 38.14% | CHEMBL3113587 |
| Acetaminophen | MTOR_HUMAN | mechanistic target of rapamycin kinase | -6.16 | -6.01 | -6.01 | 30.17% | CHEMBL3594042 |
| Diclofenac | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.87 | -8.29 | -8.13 | 37.76% | CHEMBL2348411 |
| Morphine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.23 | -9.22 | -8.89 | 33.33% | CHEMBL4074753 |
| Fentanyl | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.53 | -9.08 | -8.99 | 39.01% | CHEMBL592619 |
| Acetaminophen | NEP_HUMAN | membrane metalloendopeptidase | -6.09 | -6.59 | -6.47 | 45.12% | CHEMBL467602 |
| Diclofenac | NEP_HUMAN | membrane metalloendopeptidase | -7.82 | -6.90 | -7.67 | 28.21% | CHEMBL225085 |
| Morphine | NEP_HUMAN | membrane metalloendopeptidase | -8.56 | -8.79 | -7.19 | 38.24% | CHEMBL2062138 |
| Fentanyl | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.21 | -7.56 | 50.00% | CHEMBL467602 |
| Acetaminophen | NK1R_HUMAN | tachykinin receptor 1 | -5.62 | -6.00 | -5.77 | 37.97% | CHEMBL40262 |
| Diclofenac | NK1R_HUMAN | tachykinin receptor 1 | -7.55 | -8.35 | -7.84 | 34.69% | CHEMBL92032 |
| Morphine | NK1R_HUMAN | tachykinin receptor 1 | -8.97 | -9.09 | -8.82 | 45.41% | CHEMBL2114439 |
| Fentanyl | NK1R_HUMAN | tachykinin receptor 1 | -8.76 | -8.19 | -7.69 | 63.92% | CHEMBL89245 |
| Acetaminophen | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -6.44 | -6.33 | -6.76 | 12.37% | CHEMBL284237 |
| Diclofenac | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.50 | -8.80 | -8.42 | 15.54% | CHEMBL2333945 |
| Morphine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.31 | -8.27 | -7.16 | 25.65% | CHEMBL284237 |
| Fentanyl | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.31 | -7.38 | -7.70 | 28.44% | CHEMBL284237 |
| Acetaminophen | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -6.33 | -6.51 | -6.64 | 27.71% | CHEMBL3357789 |
| Diclofenac | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.62 | -8.19 | -9.62 | 25.53% | CHEMBL161977 |
| Morphine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.26 | -9.51 | -7.12 | 39.44% | CHEMBL3357783 |
| Fentanyl | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.06 | -10.50 | -6.61 | 43.64% | CHEMBL444384 |
| Acetaminophen | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -6.42 | -6.36 | -6.76 | 22.42% | CHEMBL162577 |
| Diclofenac | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.66 | -8.55 | -8.42 | 28.82% | CHEMBL401253 |
| Morphine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -9.30 | -8.27 | -7.16 | 20.81% | CHEMBL419399 |
| Fentanyl | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.18 | -7.40 | -7.70 | 29.46% | CHEMBL419399 |
| Acetaminophen | NOS1_HUMAN | nitric oxide synthase 1 | -7.45 | -7.54 | -6.73 | 41.94% | CHEMBL500924 |
| Diclofenac | NOS1_HUMAN | nitric oxide synthase 1 | -8.26 | -8.29 | -8.68 | 34.82% | CHEMBL49881 |
| Morphine | NOS1_HUMAN | nitric oxide synthase 1 | -8.11 | -8.23 | -8.41 | 34.50% | CHEMBL42968 |
| Fentanyl | NOS1_HUMAN | nitric oxide synthase 1 | -8.43 | -8.29 | -8.20 | 43.51% | CHEMBL3216789 |
| Acetaminophen | NOS2_HUMAN | nitric oxide synthase 2 | -6.57 | -6.55 | -6.75 | 32.35% | CHEMBL555584 |
| Diclofenac | NOS2_HUMAN | nitric oxide synthase 2 | -7.09 | -7.50 | -8.02 | 34.82% | CHEMBL49881 |
| Morphine | NOS2_HUMAN | nitric oxide synthase 2 | -7.45 | -7.86 | -8.96 | 34.50% | CHEMBL42968 |
| Fentanyl | NOS2_HUMAN | nitric oxide synthase 2 | -6.98 | -8.72 | -8.17 | 44.92% | CHEMBL112747 |
| Acetaminophen | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -5.78 | -6.08 | -6.09 | 42.17% | CHEMBL1988141 |
| Diclofenac | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.08 | -8.11 | -8.12 | 46.43% | CHEMBL1991734 |
| Morphine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -9.08 | -9.30 | -9.24 | 39.31% | CHEMBL444109 |
| Fentanyl | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.73 | -9.20 | -9.11 | 43.00% | CHEMBL1984131 |
| Acetaminophen | OPRD_HUMAN | opioid receptor delta 1 | -5.63 | -4.77 | -5.46 | 43.04% | CHEMBL416930 |
| Diclofenac | OPRD_HUMAN | opioid receptor delta 1 | -7.03 | -6.28 | -7.00 | 39.26% | CHEMBL1642757 |
| Morphine | OPRD_HUMAN | opioid receptor delta 1 | -8.52 | -6.85 | -7.24 | 100.00% | CHEMBL70 |
| Fentanyl | OPRD_HUMAN | opioid receptor delta 1 | -8.18 | -7.13 | -7.16 | 100.00% | CHEMBL12391 |
| Acetaminophen | OPRK_HUMAN | opioid receptor kappa 1 | -5.65 | -6.23 | -6.55 | 41.18% | CHEMBL283552 |
| Diclofenac | OPRK_HUMAN | opioid receptor kappa 1 | -8.51 | -8.39 | -7.73 | 39.26% | CHEMBL1642757 |
| Morphine | OPRK_HUMAN | opioid receptor kappa 1 | -9.53 | -8.83 | -8.09 | 100.00% | CHEMBL70 |
| Fentanyl | OPRK_HUMAN | opioid receptor kappa 1 | -9.67 | -8.24 | -8.53 | 100.00% | CHEMBL12391 |
| Acetaminophen | OPRM_MOUSE | Mu-type opioid receptor | -6.32 | -5.26 | N/A | 41.18% | CHEMBL283552 |
| Diclofenac | OPRM_MOUSE | Mu-type opioid receptor | -7.68 | -7.10 | N/A | 30.19% | CHEMBL596 |
| Morphine | OPRM_MOUSE | Mu-type opioid receptor | -8.15 | -8.64 | N/A | 100.00% | CHEMBL70 |
| Fentanyl | OPRM_MOUSE | Mu-type opioid receptor | -8.44 | -8.64 | N/A | 100.00% | CHEMBL596 |
| Acetaminophen | OPRX_HUMAN | opioid related nociceptin receptor 1 | -5.31 | -5.57 | -5.43 | 38.96% | CHEMBL3665425 |
| Diclofenac | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.11 | -6.85 | 34.78% | CHEMBL317152 |
| Morphine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.61 | -7.23 | -7.54 | 94.38% | CHEMBL3262362 |
| Fentanyl | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.55 | -7.44 | -7.63 | 80.00% | CHEMBL317152 |
| Acetaminophen | P2RX3_HUMAN | purinergic receptor P2X 3 | -4.53 | -4.48 | -4.71 | 33.33% | CHEMBL3958199 |
| Diclofenac | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.89 | -4.93 | -5.45 | 45.71% | CHEMBL3958199 |
| Morphine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.78 | -5.66 | -6.34 | 35.47% | CHEMBL3679847 |
| Fentanyl | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.63 | -5.63 | -6.10 | 42.34% | CHEMBL3669705 |
| Acetaminophen | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.12 | -6.33 | -6.64 | 24.32% | CHEMBL90958 |
| Diclofenac | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.30 | -6.08 | -7.72 | 30.00% | CHEMBL223344 |
| Morphine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.08 | -3.61 | -8.02 | 28.47% | CHEMBL2172277 |
| Fentanyl | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.13 | -7.40 | -7.05 | 36.72% | CHEMBL88708 |
| Acetaminophen | PAR1_HUMAN | coagulation factor II thrombin receptor | -6.67 | N/A | N/A | 38.04% | CHEMBL2048425 |
| Diclofenac | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.31 | N/A | N/A | 29.75% | CHEMBL2049115 |
| Morphine | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.79 | N/A | N/A | 34.35% | CHEMBL3086083 |
| Fentanyl | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.10 | N/A | N/A | 73.91% | CHEMBL3658401 |
| Acetaminophen | PDE4B_HUMAN | phosphodiesterase 4B | -6.02 | -6.41 | -6.11 | 31.82% | CHEMBL3884788 |
| Diclofenac | PDE4B_HUMAN | phosphodiesterase 4B | -8.10 | -8.03 | -8.13 | 51.82% | CHEMBL3315269 |
| Morphine | PDE4B_HUMAN | phosphodiesterase 4B | -8.23 | -9.32 | -9.60 | 45.95% | CHEMBL144499 |
| Fentanyl | PDE4B_HUMAN | phosphodiesterase 4B | -7.99 | -8.12 | -8.66 | 39.84% | CHEMBL37386 |
| Acetaminophen | PDE5A_HUMAN | phosphodiesterase 5A | -5.66 | -5.84 | -5.81 | 28.57% | CHEMBL41236 |
| Diclofenac | PDE5A_HUMAN | phosphodiesterase 5A | -7.21 | -8.35 | -7.97 | 28.36% | CHEMBL332898 |
| Morphine | PDE5A_HUMAN | phosphodiesterase 5A | -8.81 | -9.06 | -8.68 | 31.75% | CHEMBL190423 |
| Fentanyl | PDE5A_HUMAN | phosphodiesterase 5A | -8.25 | -8.36 | -8.02 | 31.82% | CHEMBL555171 |
| Acetaminophen | PERM_HUMAN | myeloperoxidase | -5.83 | -6.24 | -6.40 | 33.33% | CHEMBL251689 |
| Diclofenac | PERM_HUMAN | myeloperoxidase | -7.60 | -7.78 | -7.78 | 41.57% | CHEMBL686 |
| Morphine | PERM_HUMAN | myeloperoxidase | -9.13 | -9.56 | -9.07 | 35.57% | CHEMBL490 |
| Fentanyl | PERM_HUMAN | myeloperoxidase | -7.81 | -8.46 | -8.03 | 38.94% | CHEMBL2347029 |
| Acetaminophen | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.34 | -5.93 | -7.17 | 42.86% | CHEMBL9020 |
| Diclofenac | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.22 | -8.31 | -8.48 | 100.00% | CHEMBL139 |
| Morphine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -4.39 | -7.17 | -7.88 | 34.85% | CHEMBL229957 |
| Fentanyl | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -9.40 | -8.71 | -8.01 | 40.83% | CHEMBL3775653 |
| Acetaminophen | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -5.85 | -6.12 | -6.31 | 42.68% | CHEMBL291338 |
| Diclofenac | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.37 | -7.98 | -8.14 | 100.00% | CHEMBL139 |
| Morphine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -2.19 | -6.36 | -7.16 | 34.92% | CHEMBL13988 |
| Fentanyl | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -4.93 | -5.22 | -6.33 | 44.63% | CHEMBL49775 |
| Acetaminophen | PPAP_HUMAN | acid phosphatase 3 | -5.49 | N/A | N/A | 17.00% | CHEMBL507996 |
| Diclofenac | PPAP_HUMAN | acid phosphatase 3 | -7.69 | N/A | N/A | 17.24% | CHEMBL501717 |
| Morphine | PPAP_HUMAN | acid phosphatase 3 | -8.17 | N/A | N/A | 20.39% | CHEMBL507996 |
| Fentanyl | PPAP_HUMAN | acid phosphatase 3 | -8.05 | N/A | N/A | 24.07% | CHEMBL501717 |
| Acetaminophen | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -5.61 | -5.93 | -5.53 | 32.46% | CHEMBL119798 |
| Diclofenac | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.57 | -7.17 | -7.92 | 38.89% | CHEMBL167963 |
| Morphine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.93 | -6.93 | -6.68 | 43.24% | CHEMBL1836977 |
| Fentanyl | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.69 | -9.34 | -7.47 | 47.11% | CHEMBL340011 |
| Acetaminophen | PRGR_HUMAN | progesterone receptor | -6.16 | -6.27 | -5.81 | 40.85% | CHEMBL3397781 |
| Diclofenac | PRGR_HUMAN | progesterone receptor | -8.19 | -8.40 | -7.81 | 45.87% | CHEMBL117612 |
| Morphine | PRGR_HUMAN | progesterone receptor | -8.66 | -8.88 | -9.18 | 40.72% | CHEMBL51933 |
| Fentanyl | PRGR_HUMAN | progesterone receptor | -8.55 | -7.85 | -9.53 | 48.00% | CHEMBL332502 |
| Acetaminophen | PTGES_HUMAN | prostaglandin E synthase | -5.15 | N/A | N/A | 37.18% | CHEMBL3770196 |
| Diclofenac | PTGES_HUMAN | prostaglandin E synthase | -6.52 | N/A | N/A | 35.14% | CHEMBL1683859 |
| Morphine | PTGES_HUMAN | prostaglandin E synthase | -6.61 | N/A | N/A | 37.75% | CHEMBL3753433 |
| Fentanyl | PTGES_HUMAN | prostaglandin E synthase | -6.97 | N/A | N/A | 53.33% | CHEMBL4086788 |
| Acetaminophen | SC6A4_HUMAN | solute carrier family 6 member 4 | -6.07 | -6.08 | -6.06 | 43.48% | CHEMBL3317705 |
| Diclofenac | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.20 | -8.33 | -8.76 | 46.53% | CHEMBL415 |
| Morphine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.57 | -8.97 | -8.95 | 46.48% | CHEMBL434728 |
| Fentanyl | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.64 | -9.19 | -9.51 | 65.48% | CHEMBL564288 |
| Acetaminophen | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.20 | N/A | N/A | 33.33% | CHEMBL2152694 |
| Diclofenac | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.61 | N/A | N/A | 37.41% | CHEMBL3581050 |
| Morphine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.75 | N/A | N/A | 40.00% | CHEMBL3662107 |
| Fentanyl | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.54 | N/A | N/A | 59.09% | CHEMBL2152693 |
| Acetaminophen | TLR4_HUMAN | toll like receptor 4 | -5.34 | -5.13 | -5.16 | 47.44% | CHEMBL1223752 |
| Diclofenac | TLR4_HUMAN | toll like receptor 4 | -7.37 | -7.23 | -7.52 | 23.74% | CHEMBL2419459 |
| Morphine | TLR4_HUMAN | toll like receptor 4 | -7.91 | -7.60 | -7.30 | 37.84% | CHEMBL3261029 |
| Fentanyl | TLR4_HUMAN | toll like receptor 4 | -8.33 | -8.16 | -8.74 | 39.05% | CHEMBL1223752 |
| Acetaminophen | TNFA_HUMAN | tumor necrosis factor | -5.33 | N/A | N/A | 40.66% | CHEMBL1700405 |
| Diclofenac | TNFA_HUMAN | tumor necrosis factor | -7.40 | N/A | N/A | 30.83% | CHEMBL1612423 |
| Morphine | TNFA_HUMAN | tumor necrosis factor | -8.03 | N/A | N/A | 54.46% | CHEMBL2337619 |
| Fentanyl | TNFA_HUMAN | tumor necrosis factor | -7.78 | N/A | N/A | 44.86% | CHEMBL1612423 |
| Acetaminophen | TRBM_HUMAN | thrombomodulin | -6.07 | -5.85 | N/A | N/A | N/A |
| Diclofenac | TRBM_HUMAN | thrombomodulin | -6.91 | -6.85 | N/A | N/A | N/A |
| Morphine | TRBM_HUMAN | thrombomodulin | -7.42 | -7.23 | N/A | N/A | N/A |
| Fentanyl | TRBM_HUMAN | thrombomodulin | -7.60 | -6.70 | N/A | N/A | N/A |
| Acetaminophen | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -5.29 | -5.43 | N/A | N/A | N/A |
| Diclofenac | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.40 | -6.18 | N/A | N/A | N/A |
| Morphine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.46 | -6.77 | N/A | N/A | N/A |
| Fentanyl | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.92 | -7.11 | N/A | N/A | N/A |
| Acetaminophen | TRPM8_FICAL | Uncharacterized protein | -5.64 | N/A | N/A | N/A | N/A |
| Diclofenac | TRPM8_FICAL | Uncharacterized protein | -8.27 | N/A | N/A | N/A | N/A |
| Morphine | TRPM8_FICAL | Uncharacterized protein | -9.21 | N/A | N/A | N/A | N/A |
| Fentanyl | TRPM8_FICAL | Uncharacterized protein | -9.23 | N/A | N/A | N/A | N/A |
| Acetaminophen | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.80 | N/A | N/A | 65.96% | CHEMBL342003 |
| Diclofenac | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.36 | N/A | N/A | 37.74% | CHEMBL258265 |
| Morphine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.89 | N/A | N/A | 42.71% | CHEMBL97968 |
| Fentanyl | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.17 | N/A | N/A | 47.37% | CHEMBL2057855 |
| Acetaminophen | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.24 | -6.02 | N/A | N/A | N/A |
| Diclofenac | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.84 | -7.88 | N/A | N/A | N/A |
| Morphine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.54 | -9.14 | N/A | N/A | N/A |
| Fentanyl | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.27 | -8.55 | N/A | N/A | N/A |
| Acetaminophen | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -5.27 | -5.43 | N/A | 24.64% | CHEMBL3940143 |
| Diclofenac | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.34 | -6.87 | N/A | 30.89% | CHEMBL3828278 |
| Morphine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.57 | -7.27 | N/A | 44.88% | CHEMBL3664218 |
| Fentanyl | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.99 | -6.85 | N/A | 36.24% | CHEMBL3943107 |
| Acetaminophen | TRXR1_HUMAN | thioredoxin reductase 1 | -5.96 | -6.04 | -4.64 | N/A | N/A |
| Diclofenac | TRXR1_HUMAN | thioredoxin reductase 1 | -7.83 | -7.25 | -6.24 | N/A | N/A |
| Morphine | TRXR1_HUMAN | thioredoxin reductase 1 | -8.43 | -7.69 | -7.24 | N/A | N/A |
| Fentanyl | TRXR1_HUMAN | thioredoxin reductase 1 | -8.00 | -7.73 | -6.52 | N/A | N/A |
| Acetaminophen | TRY1_HUMAN | serine protease 1 | -5.81 | N/A | N/A | 46.03% | CHEMBL104937 |
| Diclofenac | TRY1_HUMAN | serine protease 1 | -6.30 | N/A | N/A | 34.23% | CHEMBL3926197 |
| Morphine | TRY1_HUMAN | serine protease 1 | -5.88 | N/A | N/A | 33.22% | CHEMBL73970 |
| Fentanyl | TRY1_HUMAN | serine protease 1 | -6.25 | N/A | N/A | 48.28% | CHEMBL421370 |