| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Fenbufen | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.42 | -8.41 | -8.65 | 34.65% | CHEMBL191460 |
| Celecoxib | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.71 | -9.92 | -10.12 | 41.50% | CHEMBL328048 |
| Diclofenac | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.19 | -8.46 | -8.22 | 30.37% | CHEMBL71091 |
| Fenbufen | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.03 | -8.54 | N/A | 50.53% | CHEMBL3104518 |
| Celecoxib | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.52 | -9.73 | N/A | 44.72% | CHEMBL4066433 |
| Diclofenac | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.06 | -8.28 | N/A | 46.53% | CHEMBL415 |
| Fenbufen | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.11 | -8.49 | -8.55 | 46.03% | CHEMBL475643 |
| Celecoxib | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -9.10 | -9.30 | -9.35 | 43.02% | CHEMBL4100216 |
| Diclofenac | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.22 | -8.68 | -8.66 | 46.53% | CHEMBL415 |
| Fenbufen | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.05 | -8.88 | N/A | 46.03% | CHEMBL475643 |
| Celecoxib | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -9.22 | -10.93 | N/A | 45.24% | CHEMBL4084723 |
| Diclofenac | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.44 | -8.58 | N/A | 46.53% | CHEMBL415 |
| Fenbufen | AA1R_HUMAN | adenosine A1 receptor | -8.39 | -9.30 | -8.69 | 30.36% | CHEMBL221407 |
| Celecoxib | AA1R_HUMAN | adenosine A1 receptor | -9.61 | -9.46 | -8.44 | 38.32% | CHEMBL1955923 |
| Diclofenac | AA1R_HUMAN | adenosine A1 receptor | -7.29 | -7.36 | -7.74 | 29.75% | CHEMBL2260644 |
| Fenbufen | AA2AR_HUMAN | adenosine A2a receptor | -8.52 | -8.62 | -8.64 | 29.31% | CHEMBL225460 |
| Celecoxib | AA2AR_HUMAN | adenosine A2a receptor | -9.59 | -9.79 | -10.26 | 39.47% | CHEMBL270654 |
| Diclofenac | AA2AR_HUMAN | adenosine A2a receptor | -7.76 | -7.71 | -8.16 | 34.91% | CHEMBL603094 |
| Fenbufen | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.61 | -8.39 | -9.47 | 58.73% | CHEMBL157327 |
| Celecoxib | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.83 | -10.93 | -9.78 | 41.85% | CHEMBL87014 |
| Diclofenac | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -8.71 | -8.16 | -9.38 | 35.43% | CHEMBL1085858 |
| Fenbufen | ACE_HUMAN | angiotensin I converting enzyme | -8.59 | -7.26 | -7.07 | 43.82% | CHEMBL258333 |
| Celecoxib | ACE_HUMAN | angiotensin I converting enzyme | -8.65 | -9.04 | -6.36 | 28.64% | CHEMBL3414814 |
| Diclofenac | ACE_HUMAN | angiotensin I converting enzyme | -7.45 | -7.41 | -7.29 | 29.63% | CHEMBL23849 |
| Fenbufen | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.17 | N/A | N/A | 20.81% | CHEMBL386114 |
| Celecoxib | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -8.12 | N/A | N/A | 23.18% | CHEMBL386114 |
| Diclofenac | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.09 | N/A | N/A | 17.01% | CHEMBL386114 |
| Fenbufen | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -7.00 | -8.38 | -8.60 | N/A | N/A |
| Celecoxib | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.72 | -5.70 | -6.56 | N/A | N/A |
| Diclofenac | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.54 | -8.23 | -6.56 | N/A | N/A |
| Fenbufen | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.91 | -7.13 | N/A | 46.34% | CHEMBL2107687 |
| Celecoxib | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.68 | -3.98 | N/A | 46.45% | CHEMBL600217 |
| Diclofenac | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -8.76 | -4.91 | N/A | 46.53% | CHEMBL415 |
| Fenbufen | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.85 | -8.71 | N/A | 46.34% | CHEMBL2107687 |
| Celecoxib | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -10.42 | -8.55 | N/A | 39.53% | CHEMBL244946 |
| Diclofenac | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -8.67 | -7.51 | N/A | 46.53% | CHEMBL415 |
| Fenbufen | ADRB2_HUMAN | adrenoceptor beta 2 | -7.91 | -9.23 | -8.67 | 39.80% | CHEMBL270964 |
| Celecoxib | ADRB2_HUMAN | adrenoceptor beta 2 | -9.17 | -9.18 | -9.57 | 43.37% | CHEMBL101606 |
| Diclofenac | ADRB2_HUMAN | adrenoceptor beta 2 | -7.35 | -8.61 | -8.50 | 44.95% | CHEMBL154419 |
| Fenbufen | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.87 | -8.93 | -8.57 | 31.71% | CHEMBL290286 |
| Celecoxib | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.08 | -9.18 | -10.08 | 37.45% | CHEMBL263714 |
| Diclofenac | AGTR2_HUMAN | angiotensin II receptor type 2 | -7.57 | -7.50 | -7.34 | 25.67% | CHEMBL40381 |
| Fenbufen | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.70 | -8.63 | -9.33 | 44.30% | CHEMBL51483 |
| Celecoxib | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.48 | -9.48 | -9.26 | 30.66% | CHEMBL274727 |
| Diclofenac | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.93 | -7.61 | -7.76 | 35.23% | CHEMBL77283 |
| Fenbufen | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.31 | -9.30 | -7.68 | 48.19% | CHEMBL1821978 |
| Celecoxib | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.74 | -9.17 | -8.95 | 26.50% | CHEMBL1077591 |
| Diclofenac | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.15 | -8.06 | -7.99 | 29.69% | CHEMBL3764432 |
| Fenbufen | AOFA_HUMAN | monoamine oxidase A | -8.69 | -8.78 | -10.02 | 44.62% | CHEMBL1070 |
| Celecoxib | AOFA_HUMAN | monoamine oxidase A | -10.37 | -10.33 | -10.04 | 35.98% | CHEMBL3652429 |
| Diclofenac | AOFA_HUMAN | monoamine oxidase A | -8.04 | -8.37 | -8.67 | 35.65% | CHEMBL1642672 |
| Fenbufen | AOFB_HUMAN | monoamine oxidase B | -9.21 | -9.71 | -9.59 | 44.32% | CHEMBL3288305 |
| Celecoxib | AOFB_HUMAN | monoamine oxidase B | -11.00 | -10.04 | -10.38 | 30.46% | CHEMBL127774 |
| Diclofenac | AOFB_HUMAN | monoamine oxidase B | -8.49 | -8.36 | -8.88 | 36.44% | CHEMBL3319243 |
| Fenbufen | BACE1_HUMAN | beta-secretase 1 | -6.67 | -7.56 | -8.43 | 38.04% | CHEMBL1092504 |
| Celecoxib | BACE1_HUMAN | beta-secretase 1 | -8.13 | -8.52 | -9.57 | 37.04% | CHEMBL1233882 |
| Diclofenac | BACE1_HUMAN | beta-secretase 1 | -6.69 | -6.82 | -7.46 | 33.06% | CHEMBL3627961 |
| Fenbufen | CAH2_HUMAN | carbonic anhydrase 2 | -7.34 | -7.20 | -7.33 | 47.44% | CHEMBL4068228 |
| Celecoxib | CAH2_HUMAN | carbonic anhydrase 2 | -8.40 | -9.01 | -9.23 | 100.00% | CHEMBL118 |
| Diclofenac | CAH2_HUMAN | carbonic anhydrase 2 | -7.31 | -7.42 | -7.15 | 44.58% | CHEMBL23832 |
| Fenbufen | CASP1_HUMAN | caspase 1 | -6.42 | -7.66 | -6.64 | 41.76% | CHEMBL1221546 |
| Celecoxib | CASP1_HUMAN | caspase 1 | -6.89 | -8.40 | -6.88 | 31.31% | CHEMBL269599 |
| Diclofenac | CASP1_HUMAN | caspase 1 | -5.75 | -6.77 | -5.58 | 32.35% | CHEMBL78154 |
| Fenbufen | CDK5_HUMAN | cyclin dependent kinase 5 | -8.10 | -8.22 | -9.49 | 37.63% | CHEMBL1974288 |
| Celecoxib | CDK5_HUMAN | cyclin dependent kinase 5 | -8.49 | -9.50 | -8.72 | 40.00% | CHEMBL1974574 |
| Diclofenac | CDK5_HUMAN | cyclin dependent kinase 5 | -7.33 | -7.84 | -8.35 | 46.43% | CHEMBL1991734 |
| Fenbufen | CHLE_HUMAN | butyrylcholinesterase | -8.19 | -8.11 | -8.28 | 47.95% | CHEMBL51931 |
| Celecoxib | CHLE_HUMAN | butyrylcholinesterase | -9.24 | -9.66 | -9.60 | 35.29% | CHEMBL543711 |
| Diclofenac | CHLE_HUMAN | butyrylcholinesterase | -8.65 | -8.20 | -8.70 | 45.59% | CHEMBL3087676 |
| Fenbufen | CNR1_HUMAN | cannabinoid receptor 1 | -8.19 | -8.76 | -9.17 | 62.50% | CHEMBL234014 |
| Celecoxib | CNR1_HUMAN | cannabinoid receptor 1 | -10.25 | -10.76 | -11.48 | 50.75% | CHEMBL1765672 |
| Diclofenac | CNR1_HUMAN | cannabinoid receptor 1 | -7.80 | -8.14 | -8.82 | 46.55% | CHEMBL3936647 |
| Fenbufen | CNR2_HUMAN | cannabinoid receptor 2 | -9.28 | -9.03 | N/A | 62.50% | CHEMBL234014 |
| Celecoxib | CNR2_HUMAN | cannabinoid receptor 2 | -11.22 | -10.54 | N/A | 52.22% | CHEMBL2347041 |
| Diclofenac | CNR2_HUMAN | cannabinoid receptor 2 | -8.58 | -8.70 | N/A | 38.18% | CHEMBL2326302 |
| Fenbufen | COLI_HUMAN | proopiomelanocortin | -8.41 | -8.60 | -7.59 | N/A | N/A |
| Celecoxib | COLI_HUMAN | proopiomelanocortin | -9.34 | -9.28 | -8.78 | N/A | N/A |
| Diclofenac | COLI_HUMAN | proopiomelanocortin | -7.40 | -7.19 | -7.23 | N/A | N/A |
| Fenbufen | COMT_HUMAN | catechol-O-methyltransferase | -6.42 | -7.03 | -6.90 | 26.35% | CHEMBL3425740 |
| Celecoxib | COMT_HUMAN | catechol-O-methyltransferase | -7.20 | -6.45 | -5.85 | 31.98% | CHEMBL3425732 |
| Diclofenac | COMT_HUMAN | catechol-O-methyltransferase | -6.26 | -6.12 | -6.36 | 22.76% | CHEMBL1324 |
| Fenbufen | CRP_HUMAN | C-reactive protein | -5.91 | -6.04 | N/A | N/A | N/A |
| Celecoxib | CRP_HUMAN | C-reactive protein | -7.04 | -6.86 | N/A | N/A | N/A |
| Diclofenac | CRP_HUMAN | C-reactive protein | -5.84 | -5.77 | N/A | N/A | N/A |
| Fenbufen | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.43 | N/A | N/A | 30.95% | CHEMBL191413 |
| Celecoxib | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -0.80 | N/A | N/A | 28.65% | CHEMBL3609011 |
| Diclofenac | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -7.66 | N/A | N/A | 100.00% | CHEMBL139 |
| Fenbufen | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.31 | -7.00 | -7.54 | 27.20% | CHEMBL366033 |
| Celecoxib | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -9.31 | -7.88 | -8.59 | 35.27% | CHEMBL4100900 |
| Diclofenac | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.70 | -6.68 | -7.09 | 28.18% | CHEMBL3908835 |
| Fenbufen | DRD2_HUMAN | dopamine receptor D2 | -9.03 | N/A | N/A | 45.00% | CHEMBL1258270 |
| Celecoxib | DRD2_HUMAN | dopamine receptor D2 | -8.93 | N/A | N/A | 46.03% | CHEMBL3084605 |
| Diclofenac | DRD2_HUMAN | dopamine receptor D2 | -7.22 | N/A | N/A | 46.53% | CHEMBL415 |
| Fenbufen | DRD3_HUMAN | dopamine receptor D3 | -8.20 | N/A | N/A | 45.00% | CHEMBL1258270 |
| Celecoxib | DRD3_HUMAN | dopamine receptor D3 | -8.14 | N/A | N/A | 46.03% | CHEMBL3084605 |
| Diclofenac | DRD3_HUMAN | dopamine receptor D3 | -7.96 | N/A | N/A | 46.53% | CHEMBL415 |
| Fenbufen | DRD4_HUMAN | dopamine receptor D4 | -7.94 | -8.05 | N/A | 45.00% | CHEMBL1258270 |
| Celecoxib | DRD4_HUMAN | dopamine receptor D4 | -9.19 | -9.52 | N/A | 43.64% | CHEMBL24809 |
| Diclofenac | DRD4_HUMAN | dopamine receptor D4 | -8.10 | -8.17 | N/A | 38.84% | CHEMBL322326 |
| Fenbufen | EDN1_HUMAN | endothelin 1 | -7.91 | N/A | N/A | N/A | N/A |
| Celecoxib | EDN1_HUMAN | endothelin 1 | -7.94 | N/A | N/A | N/A | N/A |
| Diclofenac | EDN1_HUMAN | endothelin 1 | -6.83 | N/A | N/A | N/A | N/A |
| Fenbufen | ESR1_HUMAN | estrogen receptor 1 | -8.25 | -7.71 | -7.78 | 47.14% | CHEMBL45068 |
| Celecoxib | ESR1_HUMAN | estrogen receptor 1 | -10.08 | -10.11 | -9.98 | 58.93% | CHEMBL481189 |
| Diclofenac | ESR1_HUMAN | estrogen receptor 1 | -7.95 | -7.67 | -7.73 | 36.63% | CHEMBL3234617 |
| Fenbufen | FABP5_HUMAN | fatty acid binding protein 5 | -7.50 | -5.37 | -5.85 | 26.79% | CHEMBL82293 |
| Celecoxib | FABP5_HUMAN | fatty acid binding protein 5 | -9.25 | -7.21 | -6.48 | 44.12% | CHEMBL394440 |
| Diclofenac | FABP5_HUMAN | fatty acid binding protein 5 | -7.55 | -5.19 | -5.40 | 34.48% | CHEMBL212860 |
| Fenbufen | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.63 | N/A | N/A | 48.00% | CHEMBL1975923 |
| Celecoxib | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -9.71 | N/A | N/A | 39.82% | CHEMBL1999590 |
| Diclofenac | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.93 | N/A | N/A | 46.43% | CHEMBL1991734 |
| Fenbufen | GLRA3_HUMAN | glycine receptor alpha 3 | -8.02 | -8.18 | -8.10 | 13.08% | CHEMBL4070615 |
| Fenbufen | GLRA3_HUMAN | glycine receptor alpha 3 | -9.70 | N/A | N/A | 13.08% | CHEMBL4070615 |
| Celecoxib | GLRA3_HUMAN | glycine receptor alpha 3 | -9.83 | -9.77 | -9.36 | 24.51% | CHEMBL4070615 |
| Celecoxib | GLRA3_HUMAN | glycine receptor alpha 3 | -9.95 | N/A | N/A | 24.51% | CHEMBL4070615 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.85 | -8.83 | -8.93 | 13.55% | CHEMBL4074873 |
| Diclofenac | GLRA3_HUMAN | glycine receptor alpha 3 | -8.66 | N/A | N/A | 13.55% | CHEMBL4074873 |
| Fenbufen | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.83 | -9.77 | -9.42 | 53.95% | CHEMBL1682795 |
| Celecoxib | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.12 | -8.85 | -8.59 | 51.20% | CHEMBL182558 |
| Diclofenac | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.67 | -7.54 | -6.82 | 37.01% | CHEMBL239594 |
| Fenbufen | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.14 | -7.68 | -8.68 | 31.58% | CHEMBL2035656 |
| Celecoxib | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.87 | -8.33 | -7.99 | 29.27% | CHEMBL3936099 |
| Diclofenac | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.28 | -6.68 | -7.62 | 30.18% | CHEMBL572528 |
| Fenbufen | HRH1_HUMAN | histamine receptor H1 | -8.41 | N/A | N/A | 48.72% | CHEMBL570033 |
| Celecoxib | HRH1_HUMAN | histamine receptor H1 | -8.21 | N/A | N/A | 39.91% | CHEMBL273199 |
| Diclofenac | HRH1_HUMAN | histamine receptor H1 | -8.69 | N/A | N/A | 47.06% | CHEMBL2158825 |
| Fenbufen | HYES_HUMAN | epoxide hydrolase 2 | -8.36 | -8.76 | -9.08 | 47.67% | CHEMBL3765160 |
| Celecoxib | HYES_HUMAN | epoxide hydrolase 2 | -9.03 | -9.99 | -8.97 | 67.04% | CHEMBL1766295 |
| Diclofenac | HYES_HUMAN | epoxide hydrolase 2 | -8.00 | -8.24 | -6.89 | 37.61% | CHEMBL478147 |
| Fenbufen | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -8.69 | N/A | N/A | 53.09% | CHEMBL3318321 |
| Celecoxib | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -9.67 | N/A | N/A | 54.76% | CHEMBL3904297 |
| Diclofenac | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -7.95 | N/A | N/A | 29.66% | CHEMBL3823257 |
| Fenbufen | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.62 | -8.67 | N/A | 47.14% | CHEMBL45068 |
| Celecoxib | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -9.71 | -9.26 | N/A | 40.93% | CHEMBL1521418 |
| Diclofenac | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -7.33 | -7.51 | N/A | 41.05% | CHEMBL72 |
| Fenbufen | MIF_HUMAN | macrophage migration inhibitory factor | -8.65 | -8.63 | -8.70 | 31.62% | CHEMBL209588 |
| Celecoxib | MIF_HUMAN | macrophage migration inhibitory factor | -6.97 | -7.55 | -7.07 | 28.50% | CHEMBL153425 |
| Diclofenac | MIF_HUMAN | macrophage migration inhibitory factor | -6.09 | -6.49 | -5.81 | 25.89% | CHEMBL223319 |
| Fenbufen | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.85 | -7.57 | -7.26 | 40.40% | CHEMBL1998545 |
| Celecoxib | MK01_HUMAN | mitogen-activated protein kinase 1 | -9.00 | -8.55 | -7.70 | 39.55% | CHEMBL4108598 |
| Diclofenac | MK01_HUMAN | mitogen-activated protein kinase 1 | -7.07 | -7.62 | -7.94 | 33.06% | CHEMBL2003341 |
| Fenbufen | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.94 | -8.42 | -7.09 | 32.50% | CHEMBL3798926 |
| Celecoxib | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.96 | -9.79 | -8.31 | 50.00% | CHEMBL2263394 |
| Diclofenac | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.75 | -7.65 | -7.67 | 25.49% | CHEMBL3798624 |
| Fenbufen | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.95 | -9.15 | -8.98 | 36.05% | CHEMBL2348411 |
| Celecoxib | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.66 | -9.72 | -10.07 | 43.09% | CHEMBL2158842 |
| Diclofenac | MTOR_HUMAN | mechanistic target of rapamycin kinase | -7.87 | -8.29 | -8.13 | 37.76% | CHEMBL2348411 |
| Fenbufen | NEP_HUMAN | membrane metalloendopeptidase | -8.34 | -8.95 | -9.29 | 68.12% | CHEMBL4070297 |
| Celecoxib | NEP_HUMAN | membrane metalloendopeptidase | -8.62 | -8.08 | -8.95 | 34.70% | CHEMBL3145341 |
| Diclofenac | NEP_HUMAN | membrane metalloendopeptidase | -7.82 | -6.90 | -7.67 | 28.21% | CHEMBL225085 |
| Fenbufen | NK1R_HUMAN | tachykinin receptor 1 | -7.96 | -8.33 | -7.98 | 39.56% | CHEMBL212173 |
| Celecoxib | NK1R_HUMAN | tachykinin receptor 1 | -8.94 | -9.06 | -9.52 | 33.50% | CHEMBL43044 |
| Diclofenac | NK1R_HUMAN | tachykinin receptor 1 | -7.55 | -8.35 | -7.84 | 34.69% | CHEMBL92032 |
| Fenbufen | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -9.33 | -9.23 | -9.43 | 21.57% | CHEMBL284237 |
| Celecoxib | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.98 | -9.98 | -7.47 | 26.92% | CHEMBL2333945 |
| Diclofenac | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -8.50 | -8.80 | -8.42 | 15.54% | CHEMBL2333945 |
| Fenbufen | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -9.47 | -9.15 | -9.90 | 32.89% | CHEMBL296601 |
| Celecoxib | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -11.39 | -9.71 | -9.97 | 30.37% | CHEMBL2013201 |
| Diclofenac | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -8.62 | -8.19 | -9.62 | 25.53% | CHEMBL161977 |
| Fenbufen | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -9.34 | -9.04 | -9.43 | 24.79% | CHEMBL419399 |
| Celecoxib | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.11 | -7.78 | -7.47 | 29.95% | CHEMBL164322 |
| Diclofenac | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.66 | -8.55 | -8.42 | 28.82% | CHEMBL401253 |
| Fenbufen | NOS1_HUMAN | nitric oxide synthase 1 | -9.56 | -9.59 | -8.52 | 33.33% | CHEMBL298404 |
| Celecoxib | NOS1_HUMAN | nitric oxide synthase 1 | -9.28 | -8.38 | -8.87 | 33.87% | CHEMBL185444 |
| Diclofenac | NOS1_HUMAN | nitric oxide synthase 1 | -8.26 | -8.29 | -8.68 | 34.82% | CHEMBL49881 |
| Fenbufen | NOS2_HUMAN | nitric oxide synthase 2 | -8.18 | -8.45 | -8.46 | 29.13% | CHEMBL49881 |
| Celecoxib | NOS2_HUMAN | nitric oxide synthase 2 | -8.67 | -10.20 | -9.96 | 30.14% | CHEMBL374300 |
| Diclofenac | NOS2_HUMAN | nitric oxide synthase 2 | -7.09 | -7.50 | -8.02 | 34.82% | CHEMBL49881 |
| Fenbufen | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.84 | -8.98 | -8.89 | 31.87% | CHEMBL1976290 |
| Celecoxib | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -10.19 | -10.76 | -10.81 | 39.63% | CHEMBL3901030 |
| Diclofenac | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -8.08 | -8.11 | -8.12 | 46.43% | CHEMBL1991734 |
| Fenbufen | OPRD_HUMAN | opioid receptor delta 1 | -7.27 | -6.72 | -6.68 | 44.87% | CHEMBL126918 |
| Celecoxib | OPRD_HUMAN | opioid receptor delta 1 | -9.09 | -7.75 | -8.57 | 35.59% | CHEMBL212368 |
| Diclofenac | OPRD_HUMAN | opioid receptor delta 1 | -7.03 | -6.28 | -7.00 | 39.26% | CHEMBL1642757 |
| Fenbufen | OPRK_HUMAN | opioid receptor kappa 1 | -8.29 | -8.06 | -8.69 | 54.43% | CHEMBL2022019 |
| Celecoxib | OPRK_HUMAN | opioid receptor kappa 1 | -10.11 | -8.75 | -9.15 | 47.89% | CHEMBL1765684 |
| Diclofenac | OPRK_HUMAN | opioid receptor kappa 1 | -8.51 | -8.39 | -7.73 | 39.26% | CHEMBL1642757 |
| Fenbufen | OPRM_MOUSE | Mu-type opioid receptor | -7.99 | -7.75 | N/A | 33.96% | CHEMBL71301 |
| Celecoxib | OPRM_MOUSE | Mu-type opioid receptor | -10.05 | -8.74 | N/A | 34.52% | CHEMBL605510 |
| Diclofenac | OPRM_MOUSE | Mu-type opioid receptor | -7.68 | -7.10 | N/A | 30.19% | CHEMBL596 |
| Fenbufen | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.53 | -7.37 | -7.57 | 40.00% | CHEMBL3937167 |
| Celecoxib | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.63 | -8.63 | -7.90 | 54.10% | CHEMBL558524 |
| Diclofenac | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.11 | -6.85 | 34.78% | CHEMBL317152 |
| Fenbufen | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.89 | -5.87 | -6.13 | 31.94% | CHEMBL3669699 |
| Celecoxib | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.40 | -6.31 | -6.92 | 32.08% | CHEMBL3959244 |
| Diclofenac | P2RX3_HUMAN | purinergic receptor P2X 3 | -5.89 | -4.93 | -5.45 | 45.71% | CHEMBL3958199 |
| Fenbufen | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.61 | -9.03 | -8.77 | 39.81% | CHEMBL420980 |
| Celecoxib | P2Y12_HUMAN | purinergic receptor P2Y12 | -9.95 | -7.17 | -7.84 | 35.96% | CHEMBL3325792 |
| Diclofenac | P2Y12_HUMAN | purinergic receptor P2Y12 | -8.30 | -6.08 | -7.72 | 30.00% | CHEMBL223344 |
| Fenbufen | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.15 | N/A | N/A | 37.70% | CHEMBL2012487 |
| Celecoxib | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.56 | N/A | N/A | 30.95% | CHEMBL63426 |
| Diclofenac | PAR1_HUMAN | coagulation factor II thrombin receptor | -8.31 | N/A | N/A | 29.75% | CHEMBL2049115 |
| Fenbufen | PDE4B_HUMAN | phosphodiesterase 4B | -8.63 | -9.00 | -8.92 | 39.13% | CHEMBL253083 |
| Celecoxib | PDE4B_HUMAN | phosphodiesterase 4B | -10.63 | -11.38 | -11.28 | 38.22% | CHEMBL3629001 |
| Diclofenac | PDE4B_HUMAN | phosphodiesterase 4B | -8.10 | -8.03 | -8.13 | 51.82% | CHEMBL3315269 |
| Fenbufen | PDE5A_HUMAN | phosphodiesterase 5A | -8.55 | -8.56 | -9.13 | 27.56% | CHEMBL190423 |
| Celecoxib | PDE5A_HUMAN | phosphodiesterase 5A | -10.49 | -11.28 | -10.63 | 40.00% | CHEMBL543016 |
| Diclofenac | PDE5A_HUMAN | phosphodiesterase 5A | -7.21 | -8.35 | -7.97 | 28.36% | CHEMBL332898 |
| Fenbufen | PERM_HUMAN | myeloperoxidase | -7.94 | -8.57 | -7.98 | 32.53% | CHEMBL4096954 |
| Celecoxib | PERM_HUMAN | myeloperoxidase | -9.09 | -9.30 | -9.28 | 31.53% | CHEMBL3633251 |
| Diclofenac | PERM_HUMAN | myeloperoxidase | -7.60 | -7.78 | -7.78 | 41.57% | CHEMBL686 |
| Fenbufen | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -8.54 | -8.46 | -8.03 | 56.90% | CHEMBL317434 |
| Celecoxib | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -8.15 | -7.62 | -8.64 | 84.21% | CHEMBL280636 |
| Diclofenac | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -6.22 | -8.31 | -8.48 | 100.00% | CHEMBL139 |
| Fenbufen | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -8.12 | -8.38 | -8.37 | 57.14% | CHEMBL441414 |
| Celecoxib | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -8.99 | -9.89 | -11.85 | 100.00% | CHEMBL118 |
| Diclofenac | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -7.37 | -7.98 | -8.14 | 100.00% | CHEMBL139 |
| Fenbufen | PPAP_HUMAN | acid phosphatase 3 | -7.82 | N/A | N/A | 18.00% | CHEMBL501717 |
| Celecoxib | PPAP_HUMAN | acid phosphatase 3 | -8.68 | N/A | N/A | 20.00% | CHEMBL507996 |
| Diclofenac | PPAP_HUMAN | acid phosphatase 3 | -7.69 | N/A | N/A | 17.24% | CHEMBL501717 |
| Fenbufen | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.52 | -8.69 | -8.31 | 51.39% | CHEMBL396109 |
| Celecoxib | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -9.43 | -10.20 | -9.74 | 45.85% | CHEMBL208472 |
| Diclofenac | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -7.57 | -7.17 | -7.92 | 38.89% | CHEMBL167963 |
| Fenbufen | PRGR_HUMAN | progesterone receptor | -8.74 | -8.53 | -8.54 | 70.31% | CHEMBL566982 |
| Celecoxib | PRGR_HUMAN | progesterone receptor | -1.79 | -0.68 | -8.65 | 52.83% | CHEMBL1929041 |
| Diclofenac | PRGR_HUMAN | progesterone receptor | -8.19 | -8.40 | -7.81 | 45.87% | CHEMBL117612 |
| Fenbufen | PTGES_HUMAN | prostaglandin E synthase | -6.92 | N/A | N/A | 37.04% | CHEMBL3608374 |
| Celecoxib | PTGES_HUMAN | prostaglandin E synthase | -7.39 | N/A | N/A | 100.00% | CHEMBL118 |
| Diclofenac | PTGES_HUMAN | prostaglandin E synthase | -6.52 | N/A | N/A | 35.14% | CHEMBL1683859 |
| Fenbufen | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.90 | -8.60 | -8.50 | 55.22% | CHEMBL2111613 |
| Celecoxib | SC6A4_HUMAN | solute carrier family 6 member 4 | -10.17 | -9.89 | -9.57 | 38.80% | CHEMBL3703730 |
| Diclofenac | SC6A4_HUMAN | solute carrier family 6 member 4 | -8.20 | -8.33 | -8.76 | 46.53% | CHEMBL415 |
| Fenbufen | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -9.31 | N/A | N/A | 36.63% | CHEMBL206758 |
| Celecoxib | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.31 | N/A | N/A | 53.41% | CHEMBL3682673 |
| Diclofenac | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -7.61 | N/A | N/A | 37.41% | CHEMBL3581050 |
| Fenbufen | TLR4_HUMAN | toll like receptor 4 | -7.89 | -8.43 | -7.89 | 25.35% | CHEMBL382272 |
| Celecoxib | TLR4_HUMAN | toll like receptor 4 | -8.20 | -8.08 | -9.15 | 30.05% | CHEMBL1824677 |
| Diclofenac | TLR4_HUMAN | toll like receptor 4 | -7.37 | -7.23 | -7.52 | 23.74% | CHEMBL2419459 |
| Fenbufen | TNFA_HUMAN | tumor necrosis factor | -6.98 | N/A | N/A | 29.46% | CHEMBL306090 |
| Celecoxib | TNFA_HUMAN | tumor necrosis factor | -8.06 | N/A | N/A | 36.87% | CHEMBL143886 |
| Diclofenac | TNFA_HUMAN | tumor necrosis factor | -7.40 | N/A | N/A | 30.83% | CHEMBL1612423 |
| Fenbufen | TRBM_HUMAN | thrombomodulin | -7.81 | -6.69 | N/A | N/A | N/A |
| Celecoxib | TRBM_HUMAN | thrombomodulin | -8.53 | -7.82 | N/A | N/A | N/A |
| Diclofenac | TRBM_HUMAN | thrombomodulin | -6.91 | -6.85 | N/A | N/A | N/A |
| Fenbufen | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.87 | -6.67 | N/A | N/A | N/A |
| Celecoxib | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.89 | -8.72 | N/A | N/A | N/A |
| Diclofenac | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.40 | -6.18 | N/A | N/A | N/A |
| Fenbufen | TRPM8_FICAL | Uncharacterized protein | -8.36 | N/A | N/A | N/A | N/A |
| Celecoxib | TRPM8_FICAL | Uncharacterized protein | -10.26 | N/A | N/A | N/A | N/A |
| Diclofenac | TRPM8_FICAL | Uncharacterized protein | -8.27 | N/A | N/A | N/A | N/A |
| Fenbufen | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -8.71 | N/A | N/A | 34.78% | CHEMBL183835 |
| Celecoxib | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.97 | N/A | N/A | 48.76% | CHEMBL3689042 |
| Diclofenac | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.36 | N/A | N/A | 37.74% | CHEMBL258265 |
| Fenbufen | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.76 | -8.14 | N/A | N/A | N/A |
| Celecoxib | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.60 | -8.92 | N/A | N/A | N/A |
| Diclofenac | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -6.84 | -7.88 | N/A | N/A | N/A |
| Fenbufen | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.75 | -7.74 | N/A | 28.83% | CHEMBL3828278 |
| Celecoxib | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.71 | -8.62 | N/A | 43.88% | CHEMBL3696449 |
| Diclofenac | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.34 | -6.87 | N/A | 30.89% | CHEMBL3828278 |
| Fenbufen | TRXR1_HUMAN | thioredoxin reductase 1 | -7.33 | -7.33 | -6.07 | N/A | N/A |
| Celecoxib | TRXR1_HUMAN | thioredoxin reductase 1 | -8.54 | -8.03 | -6.95 | N/A | N/A |
| Diclofenac | TRXR1_HUMAN | thioredoxin reductase 1 | -7.83 | -7.25 | -6.24 | N/A | N/A |
| Fenbufen | TRY1_HUMAN | serine protease 1 | -6.34 | N/A | N/A | 55.70% | CHEMBL155871 |
| Celecoxib | TRY1_HUMAN | serine protease 1 | -7.08 | N/A | N/A | 53.72% | CHEMBL134736 |
| Diclofenac | TRY1_HUMAN | serine protease 1 | -6.30 | N/A | N/A | 34.23% | CHEMBL3926197 |