| Ligand | Protein Symbol | Approved Name | Docking Scores |
Similarity Score |
Best Match | ||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||
| Celecoxib | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -9.71 | -9.92 | -10.12 | 41.50% | CHEMBL328048 |
| Codeine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.95 | -8.50 | -8.48 | 52.33% | CHEMBL29951 |
| Morphine | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B | -8.23 | -9.04 | -8.28 | 52.63% | CHEMBL29951 |
| Celecoxib | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.52 | -9.73 | N/A | 44.72% | CHEMBL4066433 |
| Codeine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -9.04 | -7.57 | N/A | 51.67% | CHEMBL3695438 |
| Morphine | 5HT2A_HUMAN | 5-hydroxytryptamine receptor 2A | -8.82 | -7.97 | N/A | 51.96% | CHEMBL3695438 |
| Celecoxib | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -9.10 | -9.30 | -9.35 | 43.02% | CHEMBL4100216 |
| Codeine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.37 | -8.84 | -8.69 | 50.79% | CHEMBL445106 |
| Morphine | 5HT2B_HUMAN | 5-hydroxytryptamine receptor 2B | -8.43 | -8.69 | -8.74 | 51.06% | CHEMBL445106 |
| Celecoxib | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -9.22 | -10.93 | N/A | 45.24% | CHEMBL4084723 |
| Codeine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.42 | -9.08 | N/A | 50.79% | CHEMBL445106 |
| Morphine | 5HT2C_HUMAN | 5-hydroxytryptamine receptor 2C | -8.41 | -9.00 | N/A | 51.06% | CHEMBL445106 |
| Celecoxib | AA1R_HUMAN | adenosine A1 receptor | -9.61 | -9.46 | -8.44 | 38.32% | CHEMBL1955923 |
| Codeine | AA1R_HUMAN | adenosine A1 receptor | -7.50 | -8.34 | -7.56 | 29.83% | CHEMBL3317575 |
| Morphine | AA1R_HUMAN | adenosine A1 receptor | -7.66 | -8.26 | -4.65 | 29.96% | CHEMBL3317575 |
| Celecoxib | AA2AR_HUMAN | adenosine A2a receptor | -9.59 | -9.79 | -10.26 | 39.47% | CHEMBL270654 |
| Codeine | AA2AR_HUMAN | adenosine A2a receptor | -7.40 | -7.76 | -8.98 | 34.58% | CHEMBL559023 |
| Morphine | AA2AR_HUMAN | adenosine A2a receptor | -8.62 | -9.48 | -10.40 | 34.24% | CHEMBL559023 |
| Celecoxib | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -10.83 | -10.93 | -9.78 | 41.85% | CHEMBL87014 |
| Codeine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.59 | -9.44 | -9.20 | 66.50% | CHEMBL569978 |
| Morphine | ACES_HUMAN | acetylcholinesterase (Cartwright blood group) | -9.76 | -8.85 | -8.78 | 66.01% | CHEMBL569978 |
| Celecoxib | ACE_HUMAN | angiotensin I converting enzyme | -8.65 | -9.04 | -6.36 | 28.64% | CHEMBL3414814 |
| Codeine | ACE_HUMAN | angiotensin I converting enzyme | -8.87 | -8.96 | -8.17 | 37.56% | CHEMBL58042 |
| Morphine | ACE_HUMAN | angiotensin I converting enzyme | -8.53 | -8.74 | -7.71 | 37.12% | CHEMBL1165 |
| Celecoxib | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -8.12 | N/A | N/A | 23.18% | CHEMBL386114 |
| Codeine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -6.82 | N/A | N/A | 21.64% | CHEMBL386114 |
| Morphine | ACHA9_HUMAN | cholinergic receptor nicotinic alpha 9 subunit | -7.08 | N/A | N/A | 21.72% | CHEMBL386114 |
| Celecoxib | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.72 | -5.70 | -6.56 | N/A | N/A |
| Codeine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -6.15 | -2.48 | -6.35 | N/A | N/A |
| Morphine | ACHB2_HUMAN | cholinergic receptor nicotinic beta 2 subunit | -5.44 | -3.29 | -5.96 | N/A | N/A |
| Celecoxib | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.68 | -3.98 | N/A | 46.45% | CHEMBL600217 |
| Codeine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -9.79 | 6.44 | N/A | 45.40% | CHEMBL343236 |
| Morphine | ACM1_HUMAN | cholinergic receptor muscarinic 1 | -10.02 | 3.46 | N/A | 45.66% | CHEMBL343236 |
| Celecoxib | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -10.42 | -8.55 | N/A | 39.53% | CHEMBL244946 |
| Codeine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.54 | -7.45 | N/A | 39.79% | CHEMBL1346 |
| Morphine | ACM4_HUMAN | cholinergic receptor muscarinic 4 | -9.37 | -6.22 | N/A | 39.27% | CHEMBL1346 |
| Celecoxib | ADRB2_HUMAN | adrenoceptor beta 2 | -9.17 | -9.18 | -9.57 | 43.37% | CHEMBL101606 |
| Codeine | ADRB2_HUMAN | adrenoceptor beta 2 | -8.87 | -8.86 | -8.96 | 43.82% | CHEMBL513389 |
| Morphine | ADRB2_HUMAN | adrenoceptor beta 2 | -7.41 | -7.50 | -8.85 | 43.26% | CHEMBL513389 |
| Celecoxib | AGTR2_HUMAN | angiotensin II receptor type 2 | -9.08 | -9.18 | -10.08 | 37.45% | CHEMBL263714 |
| Codeine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.46 | -8.46 | -8.38 | 43.12% | CHEMBL156129 |
| Morphine | AGTR2_HUMAN | angiotensin II receptor type 2 | -8.15 | -7.81 | -7.80 | 42.67% | CHEMBL154057 |
| Celecoxib | ALDR_HUMAN | aldo-keto reductase family 1 member B | -9.48 | -9.48 | -9.26 | 30.66% | CHEMBL274727 |
| Codeine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -8.86 | -7.96 | -7.66 | 32.38% | CHEMBL311679 |
| Morphine | ALDR_HUMAN | aldo-keto reductase family 1 member B | -7.87 | -6.59 | -7.12 | 32.54% | CHEMBL311679 |
| Celecoxib | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.74 | -9.17 | -8.95 | 26.50% | CHEMBL1077591 |
| Codeine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -7.83 | -7.73 | -7.80 | 33.63% | CHEMBL1782887 |
| Morphine | AMPN_HUMAN | alanyl aminopeptidase, membrane | -8.15 | -8.23 | -8.00 | 33.78% | CHEMBL1782887 |
| Celecoxib | AOFA_HUMAN | monoamine oxidase A | -10.37 | -10.33 | -10.04 | 35.98% | CHEMBL3652429 |
| Codeine | AOFA_HUMAN | monoamine oxidase A | -8.87 | -8.81 | -7.46 | 34.78% | CHEMBL4073457 |
| Morphine | AOFA_HUMAN | monoamine oxidase A | -8.66 | -9.39 | -8.25 | 34.30% | CHEMBL4073457 |
| Celecoxib | AOFB_HUMAN | monoamine oxidase B | -11.00 | -10.04 | -10.38 | 30.46% | CHEMBL127774 |
| Codeine | AOFB_HUMAN | monoamine oxidase B | -9.92 | -7.97 | -8.69 | 36.31% | CHEMBL4113794 |
| Morphine | AOFB_HUMAN | monoamine oxidase B | -9.87 | -8.60 | -9.19 | 35.75% | CHEMBL4113794 |
| Celecoxib | BACE1_HUMAN | beta-secretase 1 | -8.13 | -8.52 | -9.57 | 37.04% | CHEMBL1233882 |
| Codeine | BACE1_HUMAN | beta-secretase 1 | -6.85 | -7.36 | -9.35 | 43.35% | CHEMBL3955763 |
| Morphine | BACE1_HUMAN | beta-secretase 1 | -6.94 | -7.39 | -8.50 | 43.53% | CHEMBL3955763 |
| Celecoxib | CAH2_HUMAN | carbonic anhydrase 2 | -8.40 | -9.01 | -9.23 | 100.00% | CHEMBL118 |
| Codeine | CAH2_HUMAN | carbonic anhydrase 2 | -7.22 | -8.18 | -7.90 | 40.22% | CHEMBL3786651 |
| Morphine | CAH2_HUMAN | carbonic anhydrase 2 | -7.53 | -7.29 | -6.77 | 40.44% | CHEMBL3786651 |
| Celecoxib | CASP1_HUMAN | caspase 1 | -6.89 | -8.40 | -6.88 | 31.31% | CHEMBL269599 |
| Codeine | CASP1_HUMAN | caspase 1 | -5.80 | -7.68 | -6.21 | 34.47% | CHEMBL3898379 |
| Morphine | CASP1_HUMAN | caspase 1 | -6.89 | -7.24 | -6.96 | 34.62% | CHEMBL3898379 |
| Celecoxib | CDK5_HUMAN | cyclin dependent kinase 5 | -8.49 | -9.50 | -8.72 | 40.00% | CHEMBL1974574 |
| Codeine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.41 | -7.34 | -5.71 | 29.44% | CHEMBL422897 |
| Morphine | CDK5_HUMAN | cyclin dependent kinase 5 | -6.44 | -6.87 | -5.18 | 29.55% | CHEMBL422897 |
| Celecoxib | CHLE_HUMAN | butyrylcholinesterase | -9.24 | -9.66 | -9.60 | 35.29% | CHEMBL543711 |
| Codeine | CHLE_HUMAN | butyrylcholinesterase | -9.14 | -8.82 | -8.92 | 43.54% | CHEMBL4085222 |
| Morphine | CHLE_HUMAN | butyrylcholinesterase | -9.46 | -9.69 | -9.90 | 43.52% | CHEMBL366411 |
| Celecoxib | CNR1_HUMAN | cannabinoid receptor 1 | -10.25 | -10.76 | -11.48 | 50.75% | CHEMBL1765672 |
| Codeine | CNR1_HUMAN | cannabinoid receptor 1 | -8.22 | -8.45 | -9.29 | 57.39% | CHEMBL303479 |
| Morphine | CNR1_HUMAN | cannabinoid receptor 1 | -8.92 | -8.18 | -8.41 | 56.82% | CHEMBL303479 |
| Celecoxib | CNR2_HUMAN | cannabinoid receptor 2 | -11.22 | -10.54 | N/A | 52.22% | CHEMBL2347041 |
| Codeine | CNR2_HUMAN | cannabinoid receptor 2 | -9.57 | -8.98 | N/A | 57.39% | CHEMBL303479 |
| Morphine | CNR2_HUMAN | cannabinoid receptor 2 | -9.73 | -9.02 | N/A | 56.82% | CHEMBL303479 |
| Celecoxib | COLI_HUMAN | proopiomelanocortin | -9.34 | -9.28 | -8.78 | N/A | N/A |
| Codeine | COLI_HUMAN | proopiomelanocortin | -8.90 | -7.76 | -6.40 | N/A | N/A |
| Morphine | COLI_HUMAN | proopiomelanocortin | -8.00 | -8.20 | -6.57 | N/A | N/A |
| Celecoxib | COMT_HUMAN | catechol-O-methyltransferase | -7.20 | -6.45 | -5.85 | 31.98% | CHEMBL3425732 |
| Codeine | COMT_HUMAN | catechol-O-methyltransferase | -6.36 | -6.30 | -6.38 | 22.62% | CHEMBL3819488 |
| Morphine | COMT_HUMAN | catechol-O-methyltransferase | -6.29 | -6.70 | -5.75 | 22.70% | CHEMBL3819488 |
| Celecoxib | CRP_HUMAN | C-reactive protein | -7.04 | -6.86 | N/A | N/A | N/A |
| Codeine | CRP_HUMAN | C-reactive protein | -6.25 | -6.41 | N/A | N/A | N/A |
| Morphine | CRP_HUMAN | C-reactive protein | -6.20 | -6.58 | N/A | N/A | N/A |
| Celecoxib | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -0.80 | N/A | N/A | 28.65% | CHEMBL3609011 |
| Codeine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.09 | N/A | N/A | 28.57% | CHEMBL490688 |
| Morphine | CXCR1_HUMAN | C-X-C motif chemokine receptor 1 | -9.03 | N/A | N/A | 28.19% | CHEMBL490688 |
| Celecoxib | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -9.31 | -7.88 | -8.59 | 35.27% | CHEMBL4100900 |
| Codeine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -8.25 | -6.63 | -7.67 | 33.77% | CHEMBL2029611 |
| Morphine | CXCR4_HUMAN | C-X-C motif chemokine receptor 4 | -7.80 | -6.47 | -7.22 | 33.92% | CHEMBL2029611 |
| Celecoxib | DRD2_HUMAN | dopamine receptor D2 | -8.93 | N/A | N/A | 46.03% | CHEMBL3084605 |
| Codeine | DRD2_HUMAN | dopamine receptor D2 | -7.92 | N/A | N/A | 56.07% | CHEMBL170976 |
| Morphine | DRD2_HUMAN | dopamine receptor D2 | -7.56 | N/A | N/A | 55.49% | CHEMBL170976 |
| Celecoxib | DRD3_HUMAN | dopamine receptor D3 | -8.14 | N/A | N/A | 46.03% | CHEMBL3084605 |
| Codeine | DRD3_HUMAN | dopamine receptor D3 | -8.14 | N/A | N/A | 56.07% | CHEMBL170976 |
| Morphine | DRD3_HUMAN | dopamine receptor D3 | -8.83 | N/A | N/A | 55.49% | CHEMBL170976 |
| Celecoxib | DRD4_HUMAN | dopamine receptor D4 | -9.19 | -9.52 | N/A | 43.64% | CHEMBL24809 |
| Codeine | DRD4_HUMAN | dopamine receptor D4 | -8.87 | -9.13 | N/A | 47.42% | CHEMBL132261 |
| Morphine | DRD4_HUMAN | dopamine receptor D4 | -7.98 | -8.26 | N/A | 47.67% | CHEMBL132261 |
| Celecoxib | EDN1_HUMAN | endothelin 1 | -7.94 | N/A | N/A | N/A | N/A |
| Codeine | EDN1_HUMAN | endothelin 1 | -7.34 | N/A | N/A | N/A | N/A |
| Morphine | EDN1_HUMAN | endothelin 1 | -7.23 | N/A | N/A | N/A | N/A |
| Celecoxib | ESR1_HUMAN | estrogen receptor 1 | -10.08 | -10.11 | -9.98 | 58.93% | CHEMBL481189 |
| Codeine | ESR1_HUMAN | estrogen receptor 1 | -9.57 | -9.22 | -9.27 | 45.08% | CHEMBL178559 |
| Morphine | ESR1_HUMAN | estrogen receptor 1 | -9.00 | -8.76 | -8.75 | 44.56% | CHEMBL178559 |
| Celecoxib | FABP5_HUMAN | fatty acid binding protein 5 | -9.25 | -7.21 | -6.48 | 44.12% | CHEMBL394440 |
| Codeine | FABP5_HUMAN | fatty acid binding protein 5 | -8.34 | -6.35 | -6.50 | 30.39% | CHEMBL437489 |
| Morphine | FABP5_HUMAN | fatty acid binding protein 5 | -8.76 | -6.97 | -6.27 | 30.54% | CHEMBL437489 |
| Celecoxib | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -9.71 | N/A | N/A | 39.82% | CHEMBL1999590 |
| Codeine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -8.16 | N/A | N/A | 29.26% | CHEMBL221753 |
| Morphine | FYN_HUMAN | FYN proto-oncogene, Src family tyrosine kinase | -7.44 | N/A | N/A | 28.72% | CHEMBL221753 |
| Celecoxib | GLRA3_HUMAN | glycine receptor alpha 3 | -9.83 | -9.77 | -9.36 | 24.51% | CHEMBL4070615 |
| Celecoxib | GLRA3_HUMAN | glycine receptor alpha 3 | -9.95 | N/A | N/A | 24.51% | CHEMBL4070615 |
| Codeine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.48 | -8.37 | -8.49 | 24.22% | CHEMBL4070615 |
| Codeine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.65 | N/A | N/A | 24.22% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -8.35 | -8.10 | -7.91 | 24.31% | CHEMBL4070615 |
| Morphine | GLRA3_HUMAN | glycine receptor alpha 3 | -9.51 | N/A | N/A | 24.31% | CHEMBL4070615 |
| Celecoxib | GRM5_HUMAN | glutamate metabotropic receptor 5 | -8.12 | -8.85 | -8.59 | 51.20% | CHEMBL182558 |
| Codeine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -5.88 | -3.52 | -4.93 | 32.97% | CHEMBL1289626 |
| Morphine | GRM5_HUMAN | glutamate metabotropic receptor 5 | -7.11 | -4.70 | -4.34 | 33.15% | CHEMBL1289626 |
| Celecoxib | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -8.87 | -8.33 | -7.99 | 29.27% | CHEMBL3936099 |
| Codeine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.91 | -6.81 | -6.39 | 23.62% | CHEMBL3698265 |
| Morphine | HPGDS_HUMAN | hematopoietic prostaglandin D synthase | -7.22 | -6.78 | -6.30 | 23.72% | CHEMBL3698265 |
| Celecoxib | HRH1_HUMAN | histamine receptor H1 | -8.21 | N/A | N/A | 39.91% | CHEMBL273199 |
| Codeine | HRH1_HUMAN | histamine receptor H1 | -7.46 | N/A | N/A | 45.00% | CHEMBL476839 |
| Morphine | HRH1_HUMAN | histamine receptor H1 | -4.08 | N/A | N/A | 45.25% | CHEMBL476839 |
| Celecoxib | HYES_HUMAN | epoxide hydrolase 2 | -9.03 | -9.99 | -8.97 | 67.04% | CHEMBL1766295 |
| Codeine | HYES_HUMAN | epoxide hydrolase 2 | -8.41 | -8.37 | -8.59 | 42.47% | CHEMBL1672128 |
| Morphine | HYES_HUMAN | epoxide hydrolase 2 | -8.21 | -8.04 | -8.05 | 42.70% | CHEMBL1672128 |
| Celecoxib | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -9.67 | N/A | N/A | 54.76% | CHEMBL3904297 |
| Codeine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.30 | N/A | N/A | 31.38% | CHEMBL1672879 |
| Morphine | IKKB_HUMAN | inhibitor of nuclear factor kappa B kinase subunit beta | -6.24 | N/A | N/A | 31.51% | CHEMBL1672879 |
| Celecoxib | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -9.71 | -9.26 | N/A | 40.93% | CHEMBL1521418 |
| Codeine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.72 | -7.31 | N/A | 100.00% | CHEMBL485 |
| Morphine | MDR1_HUMAN | ATP binding cassette subfamily B member 1 | -8.46 | -7.36 | N/A | 100.00% | CHEMBL70 |
| Celecoxib | MIF_HUMAN | macrophage migration inhibitory factor | -6.97 | -7.55 | -7.07 | 28.50% | CHEMBL153425 |
| Codeine | MIF_HUMAN | macrophage migration inhibitory factor | -6.60 | -7.30 | -7.13 | 30.33% | CHEMBL2375651 |
| Morphine | MIF_HUMAN | macrophage migration inhibitory factor | -5.90 | -6.55 | -6.62 | 30.43% | CHEMBL2375651 |
| Celecoxib | MK01_HUMAN | mitogen-activated protein kinase 1 | -9.00 | -8.55 | -7.70 | 39.55% | CHEMBL4108598 |
| Codeine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.77 | -8.18 | -7.26 | 39.92% | CHEMBL555017 |
| Morphine | MK01_HUMAN | mitogen-activated protein kinase 1 | -6.98 | -7.80 | -7.41 | 39.53% | CHEMBL555017 |
| Celecoxib | MK03_HUMAN | mitogen-activated protein kinase 3 | -7.96 | -9.79 | -8.31 | 50.00% | CHEMBL2263394 |
| Codeine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.75 | -7.92 | -7.85 | 39.92% | CHEMBL555017 |
| Morphine | MK03_HUMAN | mitogen-activated protein kinase 3 | -6.44 | -6.79 | -7.50 | 39.53% | CHEMBL555017 |
| Celecoxib | MTOR_HUMAN | mechanistic target of rapamycin kinase | -9.66 | -9.72 | -10.07 | 43.09% | CHEMBL2158842 |
| Codeine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.88 | -8.91 | -9.19 | 33.72% | CHEMBL4074753 |
| Morphine | MTOR_HUMAN | mechanistic target of rapamycin kinase | -8.52 | -8.62 | -8.41 | 33.33% | CHEMBL4074753 |
| Celecoxib | NEP_HUMAN | membrane metalloendopeptidase | -8.62 | -8.08 | -8.95 | 34.70% | CHEMBL3145341 |
| Codeine | NEP_HUMAN | membrane metalloendopeptidase | -7.50 | -7.65 | -6.98 | 38.73% | CHEMBL2062138 |
| Morphine | NEP_HUMAN | membrane metalloendopeptidase | -8.18 | -8.44 | -7.97 | 38.24% | CHEMBL2062138 |
| Celecoxib | NK1R_HUMAN | tachykinin receptor 1 | -8.94 | -9.06 | -9.52 | 33.50% | CHEMBL43044 |
| Codeine | NK1R_HUMAN | tachykinin receptor 1 | -9.24 | -8.22 | -8.16 | 45.16% | CHEMBL2114439 |
| Morphine | NK1R_HUMAN | tachykinin receptor 1 | -8.75 | -7.09 | -7.95 | 45.41% | CHEMBL2114439 |
| Celecoxib | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.98 | -9.98 | -7.47 | 26.92% | CHEMBL2333945 |
| Codeine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.72 | -7.09 | -6.87 | 25.52% | CHEMBL284237 |
| Morphine | NMDE1_HUMAN | glutamate ionotropic receptor NMDA type subunit 2A | -7.65 | -7.73 | -7.52 | 25.65% | CHEMBL284237 |
| Celecoxib | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -11.39 | -9.71 | -9.97 | 30.37% | CHEMBL2013201 |
| Codeine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.82 | -8.60 | -6.54 | 40.00% | CHEMBL3357783 |
| Morphine | NMDE2_HUMAN | glutamate ionotropic receptor NMDA type subunit 2B | -7.48 | -9.52 | -6.65 | 39.44% | CHEMBL3357783 |
| Celecoxib | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -8.11 | -7.78 | -7.47 | 29.95% | CHEMBL164322 |
| Codeine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.75 | -6.96 | -6.87 | 20.72% | CHEMBL419399 |
| Morphine | NMDZ1_HUMAN | glutamate ionotropic receptor NMDA type subunit 1 | -7.65 | -7.70 | -7.52 | 20.81% | CHEMBL419399 |
| Celecoxib | NOS1_HUMAN | nitric oxide synthase 1 | -9.28 | -8.38 | -8.87 | 33.87% | CHEMBL185444 |
| Codeine | NOS1_HUMAN | nitric oxide synthase 1 | -7.20 | -7.33 | -8.61 | 34.93% | CHEMBL42968 |
| Morphine | NOS1_HUMAN | nitric oxide synthase 1 | -8.04 | -7.57 | -8.70 | 34.50% | CHEMBL42968 |
| Celecoxib | NOS2_HUMAN | nitric oxide synthase 2 | -8.67 | -10.20 | -9.96 | 30.14% | CHEMBL374300 |
| Codeine | NOS2_HUMAN | nitric oxide synthase 2 | -7.32 | -8.24 | -8.07 | 34.93% | CHEMBL42968 |
| Morphine | NOS2_HUMAN | nitric oxide synthase 2 | -6.89 | -8.84 | -7.90 | 34.50% | CHEMBL42968 |
| Celecoxib | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -10.19 | -10.76 | -10.81 | 39.63% | CHEMBL3901030 |
| Codeine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.99 | -8.32 | -8.23 | 39.69% | CHEMBL444109 |
| Morphine | NTRK1_HUMAN | neurotrophic receptor tyrosine kinase 1 | -7.40 | -8.00 | -7.70 | 39.31% | CHEMBL444109 |
| Celecoxib | OPRD_HUMAN | opioid receptor delta 1 | -9.09 | -7.75 | -8.57 | 35.59% | CHEMBL212368 |
| Codeine | OPRD_HUMAN | opioid receptor delta 1 | -7.24 | -6.75 | -6.77 | 99.41% | CHEMBL70 |
| Morphine | OPRD_HUMAN | opioid receptor delta 1 | -7.14 | -6.79 | -7.36 | 100.00% | CHEMBL70 |
| Celecoxib | OPRK_HUMAN | opioid receptor kappa 1 | -10.11 | -8.75 | -9.15 | 47.89% | CHEMBL1765684 |
| Codeine | OPRK_HUMAN | opioid receptor kappa 1 | -8.72 | -8.17 | -7.92 | 99.41% | CHEMBL70 |
| Morphine | OPRK_HUMAN | opioid receptor kappa 1 | -9.06 | -8.55 | -7.70 | 100.00% | CHEMBL70 |
| Celecoxib | OPRM_MOUSE | Mu-type opioid receptor | -10.05 | -8.74 | N/A | 34.52% | CHEMBL605510 |
| Codeine | OPRM_MOUSE | Mu-type opioid receptor | -8.29 | -8.28 | N/A | 99.41% | CHEMBL70 |
| Morphine | OPRM_MOUSE | Mu-type opioid receptor | -8.29 | -8.66 | N/A | 100.00% | CHEMBL70 |
| Celecoxib | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.63 | -8.63 | -7.90 | 54.10% | CHEMBL558524 |
| Codeine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -7.36 | -7.39 | -7.38 | 93.85% | CHEMBL3262362 |
| Morphine | OPRX_HUMAN | opioid related nociceptin receptor 1 | -8.07 | -7.12 | -7.42 | 94.38% | CHEMBL3262362 |
| Celecoxib | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.40 | -6.31 | -6.92 | 32.08% | CHEMBL3959244 |
| Codeine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.03 | -5.85 | -5.83 | 35.32% | CHEMBL3679847 |
| Morphine | P2RX3_HUMAN | purinergic receptor P2X 3 | -6.39 | -5.93 | -6.38 | 35.47% | CHEMBL3679847 |
| Celecoxib | P2Y12_HUMAN | purinergic receptor P2Y12 | -9.95 | -7.17 | -7.84 | 35.96% | CHEMBL3325792 |
| Codeine | P2Y12_HUMAN | purinergic receptor P2Y12 | -7.26 | -3.78 | -5.99 | 28.38% | CHEMBL2172277 |
| Morphine | P2Y12_HUMAN | purinergic receptor P2Y12 | -6.65 | -4.47 | -6.12 | 28.47% | CHEMBL2172277 |
| Celecoxib | PAR1_HUMAN | coagulation factor II thrombin receptor | -7.56 | N/A | N/A | 30.95% | CHEMBL63426 |
| Codeine | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.19 | N/A | N/A | 34.22% | CHEMBL3086083 |
| Morphine | PAR1_HUMAN | coagulation factor II thrombin receptor | -9.16 | N/A | N/A | 34.35% | CHEMBL3086083 |
| Celecoxib | PDE4B_HUMAN | phosphodiesterase 4B | -10.63 | -11.38 | -11.28 | 38.22% | CHEMBL3629001 |
| Codeine | PDE4B_HUMAN | phosphodiesterase 4B | -8.37 | -7.91 | -8.55 | 46.49% | CHEMBL144499 |
| Morphine | PDE4B_HUMAN | phosphodiesterase 4B | -8.01 | -7.41 | -8.38 | 45.95% | CHEMBL144499 |
| Celecoxib | PDE5A_HUMAN | phosphodiesterase 5A | -10.49 | -11.28 | -10.63 | 40.00% | CHEMBL543016 |
| Codeine | PDE5A_HUMAN | phosphodiesterase 5A | -7.80 | -8.28 | -8.12 | 32.23% | CHEMBL190423 |
| Morphine | PDE5A_HUMAN | phosphodiesterase 5A | -7.82 | -8.14 | -8.24 | 31.75% | CHEMBL190423 |
| Celecoxib | PERM_HUMAN | myeloperoxidase | -9.09 | -9.30 | -9.28 | 31.53% | CHEMBL3633251 |
| Codeine | PERM_HUMAN | myeloperoxidase | -8.20 | -8.53 | -8.29 | 35.38% | CHEMBL490 |
| Morphine | PERM_HUMAN | myeloperoxidase | -7.90 | -7.96 | -8.02 | 35.57% | CHEMBL490 |
| Celecoxib | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -8.15 | -7.62 | -8.64 | 84.21% | CHEMBL280636 |
| Codeine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -3.68 | -7.33 | -6.64 | 35.35% | CHEMBL229957 |
| Morphine | PGH1_SHEEP | Prostaglandin G/H synthase 1 | -3.16 | -7.62 | -7.03 | 34.85% | CHEMBL229957 |
| Celecoxib | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -8.99 | -9.89 | -11.85 | 100.00% | CHEMBL118 |
| Codeine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | -3.35 | -4.99 | -7.14 | 35.45% | CHEMBL13988 |
| Morphine | PGH2_HUMAN | prostaglandin-endoperoxide synthase 2 | 1.36 | -6.24 | -6.70 | 34.92% | CHEMBL13988 |
| Celecoxib | PPAP_HUMAN | acid phosphatase 3 | -8.68 | N/A | N/A | 20.00% | CHEMBL507996 |
| Codeine | PPAP_HUMAN | acid phosphatase 3 | -7.85 | N/A | N/A | 20.87% | CHEMBL507996 |
| Morphine | PPAP_HUMAN | acid phosphatase 3 | -8.39 | N/A | N/A | 20.39% | CHEMBL507996 |
| Celecoxib | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -9.43 | -10.20 | -9.74 | 45.85% | CHEMBL208472 |
| Codeine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.71 | -5.64 | -6.72 | 43.78% | CHEMBL1836977 |
| Morphine | PPARG_HUMAN | peroxisome proliferator activated receptor gamma | -6.50 | -5.87 | -6.23 | 43.24% | CHEMBL1836977 |
| Celecoxib | PRGR_HUMAN | progesterone receptor | -1.79 | -0.68 | -8.65 | 52.83% | CHEMBL1929041 |
| Codeine | PRGR_HUMAN | progesterone receptor | -8.47 | -8.07 | -8.86 | 40.51% | CHEMBL51933 |
| Morphine | PRGR_HUMAN | progesterone receptor | -9.04 | -9.47 | -8.73 | 40.72% | CHEMBL51933 |
| Celecoxib | PTGES_HUMAN | prostaglandin E synthase | -7.39 | N/A | N/A | 100.00% | CHEMBL118 |
| Codeine | PTGES_HUMAN | prostaglandin E synthase | -6.20 | N/A | N/A | 38.24% | CHEMBL3753433 |
| Morphine | PTGES_HUMAN | prostaglandin E synthase | -6.74 | N/A | N/A | 37.75% | CHEMBL3753433 |
| Celecoxib | SC6A4_HUMAN | solute carrier family 6 member 4 | -10.17 | -9.89 | -9.57 | 38.80% | CHEMBL3703730 |
| Codeine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.24 | -9.33 | -8.65 | 46.95% | CHEMBL434728 |
| Morphine | SC6A4_HUMAN | solute carrier family 6 member 4 | -9.44 | -9.20 | -9.29 | 46.48% | CHEMBL434728 |
| Celecoxib | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -8.31 | N/A | N/A | 53.41% | CHEMBL3682673 |
| Codeine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.18 | N/A | N/A | 40.45% | CHEMBL3662107 |
| Morphine | SCN9A_HUMAN | sodium voltage-gated channel alpha subunit 9 | -6.25 | N/A | N/A | 40.00% | CHEMBL3662107 |
| Celecoxib | TLR4_HUMAN | toll like receptor 4 | -8.20 | -8.08 | -9.15 | 30.05% | CHEMBL1824677 |
| Codeine | TLR4_HUMAN | toll like receptor 4 | -7.32 | -7.92 | -7.47 | 38.29% | CHEMBL3261029 |
| Morphine | TLR4_HUMAN | toll like receptor 4 | -8.26 | -8.29 | -7.17 | 37.84% | CHEMBL3261029 |
| Celecoxib | TNFA_HUMAN | tumor necrosis factor | -8.06 | N/A | N/A | 36.87% | CHEMBL143886 |
| Codeine | TNFA_HUMAN | tumor necrosis factor | -7.62 | N/A | N/A | 54.91% | CHEMBL2337619 |
| Morphine | TNFA_HUMAN | tumor necrosis factor | -7.88 | N/A | N/A | 54.46% | CHEMBL2337619 |
| Celecoxib | TRBM_HUMAN | thrombomodulin | -8.53 | -7.82 | N/A | N/A | N/A |
| Codeine | TRBM_HUMAN | thrombomodulin | -7.56 | -7.31 | N/A | N/A | N/A |
| Morphine | TRBM_HUMAN | thrombomodulin | -7.23 | -7.14 | N/A | N/A | N/A |
| Celecoxib | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.89 | -8.72 | N/A | N/A | N/A |
| Codeine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -6.87 | -6.95 | N/A | N/A | N/A |
| Morphine | TRPM4_HUMAN | transient receptor potential cation channel subfamily M member 4 | -7.73 | -6.69 | N/A | N/A | N/A |
| Celecoxib | TRPM8_FICAL | Uncharacterized protein | -10.26 | N/A | N/A | N/A | N/A |
| Codeine | TRPM8_FICAL | Uncharacterized protein | -9.23 | N/A | N/A | N/A | N/A |
| Morphine | TRPM8_FICAL | Uncharacterized protein | -8.65 | N/A | N/A | N/A | N/A |
| Celecoxib | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.97 | N/A | N/A | 48.76% | CHEMBL3689042 |
| Codeine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -6.85 | N/A | N/A | 42.49% | CHEMBL97968 |
| Morphine | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 | -7.83 | N/A | N/A | 42.71% | CHEMBL97968 |
| Celecoxib | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -7.60 | -8.92 | N/A | N/A | N/A |
| Codeine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.51 | -8.32 | N/A | N/A | N/A |
| Morphine | TRPV2_RABIT | Transient receptor potential cation channel subfamily V member 2 | -8.54 | -8.15 | N/A | N/A | N/A |
| Celecoxib | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -7.71 | -8.62 | N/A | 43.88% | CHEMBL3696449 |
| Codeine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.81 | -6.98 | N/A | 44.66% | CHEMBL3664218 |
| Morphine | TRPV3_HUMAN | transient receptor potential cation channel subfamily V member 3 | -6.52 | -7.86 | N/A | 44.88% | CHEMBL3664218 |
| Celecoxib | TRXR1_HUMAN | thioredoxin reductase 1 | -8.54 | -8.03 | -6.95 | N/A | N/A |
| Codeine | TRXR1_HUMAN | thioredoxin reductase 1 | -7.91 | -7.90 | -7.12 | N/A | N/A |
| Morphine | TRXR1_HUMAN | thioredoxin reductase 1 | -8.46 | -8.10 | -7.03 | N/A | N/A |
| Celecoxib | TRY1_HUMAN | serine protease 1 | -7.08 | N/A | N/A | 53.72% | CHEMBL134736 |
| Codeine | TRY1_HUMAN | serine protease 1 | -5.57 | N/A | N/A | 33.10% | CHEMBL73970 |
| Morphine | TRY1_HUMAN | serine protease 1 | -6.01 | N/A | N/A | 33.22% | CHEMBL73970 |