About The blood-brain barrier (BBB) Prediction Server
The blood-brain barrier (BBB) is a separation of circulating blood and cerebrospinal fluid (CSF) in the central nervous system (CNS). It occurs along all capillaries and consists of tight junctions around the capillaries that don't exist in normal circulation. Endothelial cells restrict the diffusion of microscopic objects (e.g. bacteria) and large or hydrophilic molecules into the CSF, while allowing the diffusion of small hydrophobic molecules (O2, hormones, CO2). Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins.
(From http://en.wikipedia.org/wiki/Blood-brain_barrier)
This predictor was built by applying the support vector machine (SVM) and LiCABEDS algorithms on four types of fingerprints of 1593 reported compounds.
Liu, HB, Wang, L, Su, WW and Xie* X.-Q., ALzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research. J Comput Info Modeling. 2014, 54(4):1050-60.
http://pubs.acs.org/doi/full/10.1021/ci500004h
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